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Entry version 150 (18 Sep 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Spartin

Gene

SPART

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SpartinCurated
Alternative name(s):
Spastic paraplegia 20 protein
Trans-activated by hepatitis C virus core protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPARTImported
Synonyms:KIAA0610, SPG20Imported, TAHCCP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18514 SPART

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607111 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N0X7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spastic paraplegia 20, autosomal recessive (SPG20)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG20 is characterized by dysarthria, distal amyotrophy, mild developmental delay and short stature.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079569330M → V in SPG20; significant decrease in protein expression; significantly reduced COX respiratory chain complex IV activity in muscle mitochondria. 1 PublicationCorresponds to variant dbSNP:rs1399213398Ensembl.1
Natural variantiVAR_079570442A → P in SPG20; unknown pathological significance. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi24F → D: Abolishes interaction with IST1. Does not localize to the midbody. 1 Publication1
Mutagenesisi171 – 174PPAY → AAAA: Abolishes interaction with ITCH and WWP1. 1 Publication4

Keywords - Diseasei

Disease mutation, Hereditary spastic paraplegia, Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
23111

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SPART

MalaCards human disease database

More...
MalaCardsi
SPART
MIMi275900 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000133104

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
101000 Autosomal recessive spastic paraplegia type 20

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134871645

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPART

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50401600

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000721191 – 666SpartinAdd BLAST666

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki362Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei470PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; ubiquitination does not require ITCH and WWP1.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N0X7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8N0X7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N0X7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N0X7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N0X7

PeptideAtlas

More...
PeptideAtlasi
Q8N0X7

PRoteomics IDEntifications database

More...
PRIDEi
Q8N0X7

ProteomicsDB human proteome resource

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ProteomicsDBi
71485

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N0X7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N0X7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8N0X7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed, with highest levels of expression detected in adipose tissue.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133104 Expressed in 227 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N0X7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N0X7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039053
HPA039054

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ITCH and WWP1 (PubMed:19580544).

Interacts (via MIT domain) with IST1; leading to the recruitment of SPART to midbodies (PubMed:20719964).

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116734, 43 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N0X7, 41 interactors

Molecular INTeraction database

More...
MINTi
Q8N0X7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000414147

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1666
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N0X7

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8N0X7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 94MITAdd BLAST79
Domaini427 – 611SenescenceSequence analysisAdd BLAST185

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2709 Eukaryota
ENOG410ZEPM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012235

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015747

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N0X7

KEGG Orthology (KO)

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KOi
K19366

Identification of Orthologs from Complete Genome Data

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OMAi
YGHTAGE

Database of Orthologous Groups

More...
OrthoDBi
650471at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N0X7

TreeFam database of animal gene trees

More...
TreeFami
TF105252

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR009686 Senescence/spartin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06911 Senescence, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00745 MIT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF116846 SSF116846, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N0X7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQEPQNGEP AEIKIIREAY KKAFLFVNKG LNTDELGQKE EAKNYYKQGI
60 70 80 90 100
GHLLRGISIS SKESEHTGPG WESARQMQQK MKETLQNVRT RLEILEKGLA
110 120 130 140 150
TSLQNDLQEV PKLYPEFPPK DMCEKLPEPQ SFSSAPQHAE VNGNTSTPSA
160 170 180 190 200
GAVAAPASLS LPSQSCPAEA PPAYTPQAAE GHYTVSYGTD SGEFSSVGEE
210 220 230 240 250
FYRNHSQPPP LETLGLDADE LILIPNGVQI FFVNPAGEVS APSYPGYLRI
260 270 280 290 300
VRFLDNSLDT VLNRPPGFLQ VCDWLYPLVP DRSPVLKCTA GAYMFPDTML
310 320 330 340 350
QAAGCFVGVV LSSELPEDDR ELFEDLLRQM SDLRLQANWN RAEEENEFQI
360 370 380 390 400
PGRTRPSSDQ LKEASGTDVK QLDQGNKDVR HKGKRGKRAK DTSSEEVNLS
410 420 430 440 450
HIVPCEPVPE EKPKELPEWS EKVAHNILSG ASWVSWGLVK GAEITGKAIQ
460 470 480 490 500
KGASKLRERI QPEEKPVEVS PAVTKGLYIA KQATGGAAKV SQFLVDGVCT
510 520 530 540 550
VANCVGKELA PHVKKHGSKL VPESLKKDKD GKSPLDGAMV VAASSVQGFS
560 570 580 590 600
TVWQGLECAA KCIVNNVSAE TVQTVRYKYG YNAGEATHHA VDSAVNVGVT
610 620 630 640 650
AYNINNIGIK AMVKKTATQT GHTLLEDYQI VDNSQRENQE GAANVNVRGE
660
KDEQTKEVKE AKKKDK
Length:666
Mass (Da):72,833
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFC8DF65494427CE
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25536 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69P → T in AAH47083 (PubMed:15489334).Curated1
Sequence conflicti417P → H in AAH47083 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079569330M → V in SPG20; significant decrease in protein expression; significantly reduced COX respiratory chain complex IV activity in muscle mitochondria. 1 PublicationCorresponds to variant dbSNP:rs1399213398Ensembl.1
Natural variantiVAR_079570442A → P in SPG20; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY123329 mRNA Translation: AAM76671.1
AY123337
, AY123331, AY123332, AY123333, AY123334, AY123335, AY123336 Genomic DNA Translation: AAM76672.1
AY038934 Genomic DNA Translation: AAK71883.1
AY038359 mRNA Translation: AAK72374.1
AB011182 mRNA Translation: BAA25536.1 Different initiation.
AL139377 Genomic DNA No translation available.
BC047083 mRNA Translation: AAH47083.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9356.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T00255

NCBI Reference Sequences

More...
RefSeqi
NP_001135766.1, NM_001142294.1
NP_001135767.1, NM_001142295.1
NP_001135768.1, NM_001142296.1
NP_055902.1, NM_015087.4
XP_005266370.1, XM_005266313.4
XP_005266371.1, XM_005266314.3
XP_005266372.1, XM_005266315.3
XP_005266374.1, XM_005266317.3
XP_011533314.1, XM_011535012.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355182; ENSP00000347314; ENSG00000133104
ENST00000438666; ENSP00000406061; ENSG00000133104
ENST00000451493; ENSP00000414147; ENSG00000133104
ENST00000494062; ENSP00000473599; ENSG00000133104
ENST00000650221; ENSP00000497209; ENSG00000133104

Database of genes from NCBI RefSeq genomes

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GeneIDi
23111

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23111

UCSC genome browser

More...
UCSCi
uc001uvm.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY123329 mRNA Translation: AAM76671.1
AY123337
, AY123331, AY123332, AY123333, AY123334, AY123335, AY123336 Genomic DNA Translation: AAM76672.1
AY038934 Genomic DNA Translation: AAK71883.1
AY038359 mRNA Translation: AAK72374.1
AB011182 mRNA Translation: BAA25536.1 Different initiation.
AL139377 Genomic DNA No translation available.
BC047083 mRNA Translation: AAH47083.1
CCDSiCCDS9356.1
PIRiT00255
RefSeqiNP_001135766.1, NM_001142294.1
NP_001135767.1, NM_001142295.1
NP_001135768.1, NM_001142296.1
NP_055902.1, NM_015087.4
XP_005266370.1, XM_005266313.4
XP_005266371.1, XM_005266314.3
XP_005266372.1, XM_005266315.3
XP_005266374.1, XM_005266317.3
XP_011533314.1, XM_011535012.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DL1NMR-A9-111[»]
4U7IX-ray1.79A8-101[»]
SMRiQ8N0X7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116734, 43 interactors
IntActiQ8N0X7, 41 interactors
MINTiQ8N0X7
STRINGi9606.ENSP00000414147

PTM databases

iPTMnetiQ8N0X7
PhosphoSitePlusiQ8N0X7
SwissPalmiQ8N0X7

Polymorphism and mutation databases

BioMutaiSPART
DMDMi50401600

Proteomic databases

EPDiQ8N0X7
jPOSTiQ8N0X7
MassIVEiQ8N0X7
MaxQBiQ8N0X7
PaxDbiQ8N0X7
PeptideAtlasiQ8N0X7
PRIDEiQ8N0X7
ProteomicsDBi71485

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355182; ENSP00000347314; ENSG00000133104
ENST00000438666; ENSP00000406061; ENSG00000133104
ENST00000451493; ENSP00000414147; ENSG00000133104
ENST00000494062; ENSP00000473599; ENSG00000133104
ENST00000650221; ENSP00000497209; ENSG00000133104
GeneIDi23111
KEGGihsa:23111
UCSCiuc001uvm.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23111
DisGeNETi23111

GeneCards: human genes, protein and diseases

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GeneCardsi
SPART
GeneReviewsiSPART
HGNCiHGNC:18514 SPART
HPAiHPA039053
HPA039054
MalaCardsiSPART
MIMi275900 phenotype
607111 gene
neXtProtiNX_Q8N0X7
OpenTargetsiENSG00000133104
Orphaneti101000 Autosomal recessive spastic paraplegia type 20
PharmGKBiPA134871645

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2709 Eukaryota
ENOG410ZEPM LUCA
GeneTreeiENSGT00390000012235
HOGENOMiHOG000015747
InParanoidiQ8N0X7
KOiK19366
OMAiYGHTAGE
OrthoDBi650471at2759
PhylomeDBiQ8N0X7
TreeFamiTF105252

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SPG20 human
EvolutionaryTraceiQ8N0X7

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SPG20

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23111

Pharos

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Pharosi
Q8N0X7

Protein Ontology

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PROi
PR:Q8N0X7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000133104 Expressed in 227 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ8N0X7 baseline and differential
GenevisibleiQ8N0X7 HS

Family and domain databases

InterProiView protein in InterPro
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR009686 Senescence/spartin
PfamiView protein in Pfam
PF06911 Senescence, 1 hit
SMARTiView protein in SMART
SM00745 MIT, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPART_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N0X7
Secondary accession number(s): O60349
, Q86Y67, Q9H1T2, Q9H1T3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: September 18, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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