Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat LGI family member 2

Gene

LGI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-5682910 LGI-ADAM interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat LGI family member 2
Alternative name(s):
LGI1-like protein 2
Leucine-rich glioma-inactivated protein 2
Gene namesi
Name:LGI2
Synonyms:KIAA1916, LGIL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000153012.11
HGNCiHGNC:18710 LGI2
MIMi608301 gene
neXtProtiNX_Q8N0V4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi55203
OpenTargetsiENSG00000153012
PharmGKBiPA38654

Polymorphism and mutation databases

BioMutaiLGI2
DMDMi32469740

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001770829 – 545Leucine-rich repeat LGI family member 2Add BLAST517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N0V4
PeptideAtlasiQ8N0V4
PRIDEiQ8N0V4
ProteomicsDBi71467

2D gel databases

REPRODUCTION-2DPAGEiQ8N0V4

PTM databases

iPTMnetiQ8N0V4
PhosphoSitePlusiQ8N0V4

Expressioni

Tissue specificityi

Brain, heart and placenta.1 Publication

Gene expression databases

BgeeiENSG00000153012 Expressed in 149 organ(s), highest expression level in lower esophagus
CleanExiHS_LGI2
ExpressionAtlasiQ8N0V4 baseline and differential
GenevisibleiQ8N0V4 HS

Organism-specific databases

HPAiHPA017140

Interactioni

Protein-protein interaction databases

BioGridi120499, 1 interactor
STRINGi9606.ENSP00000371548

Structurei

3D structure databases

ProteinModelPortaliQ8N0V4
SMRiQ8N0V4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 65LRRNTAdd BLAST37
Repeati86 – 107LRR 1Add BLAST22
Repeati110 – 131LRR 2Add BLAST22
Repeati134 – 155LRR 3Add BLAST22
Domaini167 – 217LRRCTAdd BLAST51
Repeati219 – 261EAR 1PROSITE-ProRule annotationAdd BLAST43
Repeati265 – 307EAR 2PROSITE-ProRule annotationAdd BLAST43
Repeati311 – 358EAR 3PROSITE-ProRule annotationAdd BLAST48
Repeati360 – 403EAR 4PROSITE-ProRule annotationAdd BLAST44
Repeati407 – 450EAR 5PROSITE-ProRule annotationAdd BLAST44
Repeati452 – 494EAR 6PROSITE-ProRule annotationAdd BLAST43
Repeati498 – 540EAR 7PROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIXR Eukaryota
ENOG410XSZV LUCA
GeneTreeiENSGT00930000150915
HOGENOMiHOG000286015
HOVERGENiHBG036744
InParanoidiQ8N0V4
OMAiNTQIFEH
OrthoDBiEOG091G03ZX
PhylomeDBiQ8N0V4
TreeFamiTF333155

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR009039 EAR
IPR005492 EPTP
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF03736 EPTP, 6 hits
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS50912 EAR, 7 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N0V4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRRGGCGA LGLLLLLLGA ACLIPRSAQV RRLARCPATC SCTKESIICV
60 70 80 90 100
GSSWVPRIVP GDISSLSLVN GTFSEIKDRM FSHLPSLQLL LLNSNSFTII
110 120 130 140 150
RDDAFAGLFH LEYLFIEGNK IETISRNAFR GLRDLTHLSL ANNHIKALPR
160 170 180 190 200
DVFSDLDSLI ELDLRGNKFE CDCKAKWLYL WLKMTNSTVS DVLCIGPPEY
210 220 230 240 250
QEKKLNDVTS FDYECTTTDF VVHQTLPYQS VSVDTFNSKN DVYVAIAQPS
260 270 280 290 300
MENCMVLEWD HIEMNFRSYD NITGQSIVGC KAILIDDQVF VVVAQLFGGS
310 320 330 340 350
HIYKYDESWT KFVKFQDIEV SRISKPNDIE LFQIDDETFF VIADSSKAGL
360 370 380 390 400
STVYKWNSKG FYSYQSLHEW FRDTDAEFVD IDGKSHLILS SRSQVPIILQ
410 420 430 440 450
WNKSSKKFVP HGDIPNMEDV LAVKSFRMQN TLYLSLTRFI GDSRVMRWNS
460 470 480 490 500
KQFVEIQALP SRGAMTLQPF SFKDNHYLAL GSDYTFSQIY QWDKEKQLFK
510 520 530 540
KFKEIYVQAP RSFTAVSTDR RDFFFASSFK GKTKIFEHII VDLSL
Length:545
Mass (Da):62,298
Last modified:October 1, 2002 - v1
Checksum:iFD29B51F01B3D7E2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YA65H0YA65_HUMAN
Leucine-rich repeat LGI family memb...
LGI2
256Annotation score:

Sequence cautioni

The sequence BAA91746 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti524F → L in CAD32305 (PubMed:12095917).Curated1
Sequence conflicti524F → L in BAB67809 (PubMed:11572484).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030536444R → Q. Corresponds to variant dbSNP:rs2232026Ensembl.1
Natural variantiVAR_030537452Q → R. Corresponds to variant dbSNP:rs2232027Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467955 mRNA Translation: AAM49553.1
AJ487958 mRNA Translation: CAD32305.1
AJ487516 mRNA Translation: CAD31784.1
BC101759 mRNA Translation: AAI01760.1
BC101761 mRNA Translation: AAI01762.1
AB067503 mRNA Translation: BAB67809.1
AK001537 mRNA Translation: BAA91746.1 Different initiation.
CCDSiCCDS3431.1
RefSeqiNP_060646.2, NM_018176.3
UniGeneiHs.12488

Genome annotation databases

EnsembliENST00000382114; ENSP00000371548; ENSG00000153012
GeneIDi55203
KEGGihsa:55203
UCSCiuc003grf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467955 mRNA Translation: AAM49553.1
AJ487958 mRNA Translation: CAD32305.1
AJ487516 mRNA Translation: CAD31784.1
BC101759 mRNA Translation: AAI01760.1
BC101761 mRNA Translation: AAI01762.1
AB067503 mRNA Translation: BAB67809.1
AK001537 mRNA Translation: BAA91746.1 Different initiation.
CCDSiCCDS3431.1
RefSeqiNP_060646.2, NM_018176.3
UniGeneiHs.12488

3D structure databases

ProteinModelPortaliQ8N0V4
SMRiQ8N0V4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120499, 1 interactor
STRINGi9606.ENSP00000371548

PTM databases

iPTMnetiQ8N0V4
PhosphoSitePlusiQ8N0V4

Polymorphism and mutation databases

BioMutaiLGI2
DMDMi32469740

2D gel databases

REPRODUCTION-2DPAGEiQ8N0V4

Proteomic databases

PaxDbiQ8N0V4
PeptideAtlasiQ8N0V4
PRIDEiQ8N0V4
ProteomicsDBi71467

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382114; ENSP00000371548; ENSG00000153012
GeneIDi55203
KEGGihsa:55203
UCSCiuc003grf.3 human

Organism-specific databases

CTDi55203
DisGeNETi55203
EuPathDBiHostDB:ENSG00000153012.11
GeneCardsiLGI2
HGNCiHGNC:18710 LGI2
HPAiHPA017140
MIMi608301 gene
neXtProtiNX_Q8N0V4
OpenTargetsiENSG00000153012
PharmGKBiPA38654
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIXR Eukaryota
ENOG410XSZV LUCA
GeneTreeiENSGT00930000150915
HOGENOMiHOG000286015
HOVERGENiHBG036744
InParanoidiQ8N0V4
OMAiNTQIFEH
OrthoDBiEOG091G03ZX
PhylomeDBiQ8N0V4
TreeFamiTF333155

Enzyme and pathway databases

ReactomeiR-HSA-5682910 LGI-ADAM interactions

Miscellaneous databases

GeneWikiiLGI2
GenomeRNAii55203
PROiPR:Q8N0V4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153012 Expressed in 149 organ(s), highest expression level in lower esophagus
CleanExiHS_LGI2
ExpressionAtlasiQ8N0V4 baseline and differential
GenevisibleiQ8N0V4 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR009039 EAR
IPR005492 EPTP
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF03736 EPTP, 6 hits
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS50912 EAR, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLGI2_HUMAN
AccessioniPrimary (citable) accession number: Q8N0V4
Secondary accession number(s): Q3MIN2
, Q8NDW6, Q96PX2, Q9NVK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again