UniProtKB - Q8N0V3 (RBFA_HUMAN)
Protein
Putative ribosome-binding factor A, mitochondrial
Gene
RBFA
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- rRNA processing Source: UniProtKB-KW
Keywordsi
Biological process | rRNA processing |
Enzyme and pathway databases
PathwayCommonsi | Q8N0V3 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative ribosome-binding factor A, mitochondrial |
Gene namesi | Name:RBFA Synonyms:C18orf22 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000101546.12 |
HGNCi | HGNC:26120, RBFA |
neXtProti | NX_Q8N0V3 |
Subcellular locationi
Mitochondrion
- Mitochondrion Curated
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 79863 |
OpenTargetsi | ENSG00000101546 |
PharmGKBi | PA134885774 |
Miscellaneous databases
Pharosi | Q8N0V3, Tbio |
Polymorphism and mutation databases
BioMutai | RBFA |
DMDMi | 146334837 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 41 | MitochondrionSequence analysisAdd BLAST | 41 | |
ChainiPRO_0000030226 | 42 – 343 | Putative ribosome-binding factor A, mitochondrialAdd BLAST | 302 |
Proteomic databases
EPDi | Q8N0V3 |
jPOSTi | Q8N0V3 |
MassIVEi | Q8N0V3 |
MaxQBi | Q8N0V3 |
PaxDbi | Q8N0V3 |
PeptideAtlasi | Q8N0V3 |
PRIDEi | Q8N0V3 |
ProteomicsDBi | 71465 [Q8N0V3-1] 71466 [Q8N0V3-2] |
PTM databases
iPTMneti | Q8N0V3 |
PhosphoSitePlusi | Q8N0V3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000101546, Expressed in quadriceps femoris and 210 other tissues |
Genevisiblei | Q8N0V3, HS |
Organism-specific databases
HPAi | ENSG00000101546, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8N0V3
Protein-protein interaction databases
BioGRIDi | 122951, 43 interactors |
IntActi | Q8N0V3, 38 interactors |
MINTi | Q8N0V3 |
STRINGi | 9606.ENSP00000305696 |
Miscellaneous databases
RNActi | Q8N0V3, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8N0V3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8N0V3 |
Family & Domainsi
Sequence similaritiesi
Belongs to the RbfA family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG4700, Eukaryota |
GeneTreei | ENSGT00390000011362 |
HOGENOMi | CLU_067827_0_0_1 |
InParanoidi | Q8N0V3 |
OMAi | VCGINHE |
OrthoDBi | 1420734at2759 |
PhylomeDBi | Q8N0V3 |
TreeFami | TF328637 |
Family and domain databases
Gene3Di | 3.30.300.20, 1 hit |
InterProi | View protein in InterPro IPR015946, KH_dom-like_a/b IPR000238, RbfA IPR023799, RbfA_dom_sf IPR039212, RBFA_mitochondrial IPR020053, Ribosome-bd_factorA_CS |
PANTHERi | PTHR14725, PTHR14725, 1 hit |
Pfami | View protein in Pfam PF02033, RBFA, 1 hit |
SUPFAMi | SSF89919, SSF89919, 1 hit |
PROSITEi | View protein in PROSITE PS01319, RBFA, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8N0V3-1) [UniParc]FASTAAdd to basket
Also known as: p38
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWAAAGGLWR SRAGLRALFR SRDAALFPGC ERGLHCSAVS CKNWLKKFAS
60 70 80 90 100
KTKKKVWYES PSLGSHSTYK PSKLEFLMRS TSKKTRKEDH ARLRALNGLL
110 120 130 140 150
YKALTDLLCT PEVSQELYDL NVELSKVSLT PDFSACRAYW KTTLSAEQNA
160 170 180 190 200
HMEAVLQRSA AHMRHLLMSQ QTLRNVPPIV FVQDKGNAAL AELDQLLAVA
210 220 230 240 250
DFGPRDERDN FVQNDFRDPD APQPCGTTEP TTSSSLCGID HEALNKQIME
260 270 280 290 300
YKRRKDKGLG GLVWQGQVAE LTTQMKKGRK RAKPRLEQDS SLKSYLSGEE
310 320 330 340
VEDDLDLVGA PEYECYAPDT EELEAERGGG RTEDGHSCGA SRE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 326 | E → G in AAM20740 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023233 | 122 | V → M. Corresponds to variant dbSNP:rs748338Ensembl. | 1 | |
Natural variantiVAR_023234 | 245 | N → H1 PublicationCorresponds to variant dbSNP:rs3744872Ensembl. | 1 | |
Natural variantiVAR_023235 | 276 | K → Q2 PublicationsCorresponds to variant dbSNP:rs3744873Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015118 | 164 – 242 | RHLLM…GIDHE → SLISYWQSQTLDPGMKETTL YKMISGTLMPHNPAAPQSRP QAPVCVGSIMRRSTSRLWST KGGKIKGSGAWCGRGRWLS in isoform 2. 1 PublicationAdd BLAST | 79 | |
Alternative sequenceiVSP_015119 | 243 – 343 | Missing in isoform 2. 1 PublicationAdd BLAST | 101 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF261073 mRNA Translation: AAM20740.1 AF439745 mRNA Translation: AAL32051.1 AK024825 mRNA Translation: BAB15022.1 BC014195 mRNA Translation: AAH14195.1 BC057772 mRNA Translation: AAH57772.1 |
CCDSi | CCDS12021.1 [Q8N0V3-1] CCDS54194.1 [Q8N0V3-2] |
RefSeqi | NP_001165438.1, NM_001171967.1 [Q8N0V3-2] NP_079081.2, NM_024805.2 [Q8N0V3-1] |
Genome annotation databases
Ensembli | ENST00000262197; ENSP00000262197; ENSG00000101546 [Q8N0V3-2] ENST00000306735; ENSP00000305696; ENSG00000101546 [Q8N0V3-1] |
GeneIDi | 79863 |
KEGGi | hsa:79863 |
UCSCi | uc002lns.4, human [Q8N0V3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF261073 mRNA Translation: AAM20740.1 AF439745 mRNA Translation: AAL32051.1 AK024825 mRNA Translation: BAB15022.1 BC014195 mRNA Translation: AAH14195.1 BC057772 mRNA Translation: AAH57772.1 |
CCDSi | CCDS12021.1 [Q8N0V3-1] CCDS54194.1 [Q8N0V3-2] |
RefSeqi | NP_001165438.1, NM_001171967.1 [Q8N0V3-2] NP_079081.2, NM_024805.2 [Q8N0V3-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2E7G | NMR | - | A | 86-201 | [»] | |
SMRi | Q8N0V3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122951, 43 interactors |
IntActi | Q8N0V3, 38 interactors |
MINTi | Q8N0V3 |
STRINGi | 9606.ENSP00000305696 |
PTM databases
iPTMneti | Q8N0V3 |
PhosphoSitePlusi | Q8N0V3 |
Polymorphism and mutation databases
BioMutai | RBFA |
DMDMi | 146334837 |
Proteomic databases
EPDi | Q8N0V3 |
jPOSTi | Q8N0V3 |
MassIVEi | Q8N0V3 |
MaxQBi | Q8N0V3 |
PaxDbi | Q8N0V3 |
PeptideAtlasi | Q8N0V3 |
PRIDEi | Q8N0V3 |
ProteomicsDBi | 71465 [Q8N0V3-1] 71466 [Q8N0V3-2] |
Protocols and materials databases
Antibodypediai | 23520, 78 antibodies |
DNASUi | 79863 |
Genome annotation databases
Ensembli | ENST00000262197; ENSP00000262197; ENSG00000101546 [Q8N0V3-2] ENST00000306735; ENSP00000305696; ENSG00000101546 [Q8N0V3-1] |
GeneIDi | 79863 |
KEGGi | hsa:79863 |
UCSCi | uc002lns.4, human [Q8N0V3-1] |
Organism-specific databases
CTDi | 79863 |
DisGeNETi | 79863 |
EuPathDBi | HostDB:ENSG00000101546.12 |
GeneCardsi | RBFA |
HGNCi | HGNC:26120, RBFA |
HPAi | ENSG00000101546, Low tissue specificity |
neXtProti | NX_Q8N0V3 |
OpenTargetsi | ENSG00000101546 |
PharmGKBi | PA134885774 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4700, Eukaryota |
GeneTreei | ENSGT00390000011362 |
HOGENOMi | CLU_067827_0_0_1 |
InParanoidi | Q8N0V3 |
OMAi | VCGINHE |
OrthoDBi | 1420734at2759 |
PhylomeDBi | Q8N0V3 |
TreeFami | TF328637 |
Enzyme and pathway databases
PathwayCommonsi | Q8N0V3 |
Miscellaneous databases
BioGRID-ORCSi | 79863, 70 hits in 846 CRISPR screens |
ChiTaRSi | RBFA, human |
EvolutionaryTracei | Q8N0V3 |
GenomeRNAii | 79863 |
Pharosi | Q8N0V3, Tbio |
PROi | PR:Q8N0V3 |
RNActi | Q8N0V3, protein |
Gene expression databases
Bgeei | ENSG00000101546, Expressed in quadriceps femoris and 210 other tissues |
Genevisiblei | Q8N0V3, HS |
Family and domain databases
Gene3Di | 3.30.300.20, 1 hit |
InterProi | View protein in InterPro IPR015946, KH_dom-like_a/b IPR000238, RbfA IPR023799, RbfA_dom_sf IPR039212, RBFA_mitochondrial IPR020053, Ribosome-bd_factorA_CS |
PANTHERi | PTHR14725, PTHR14725, 1 hit |
Pfami | View protein in Pfam PF02033, RBFA, 1 hit |
SUPFAMi | SSF89919, SSF89919, 1 hit |
PROSITEi | View protein in PROSITE PS01319, RBFA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBFA_HUMAN | |
Accessioni | Q8N0V3Primary (citable) accession number: Q8N0V3 Secondary accession number(s): Q6PF07, Q8WZ65, Q9H776 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | March 6, 2007 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations