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Entry version 128 (16 Oct 2019)
Sequence version 2 (16 Aug 2004)
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Protein

Vitamin K epoxide reductase complex subunit 1-like protein 1

Gene

VKORC1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.3 Publications

Miscellaneous

The location of two cysteine active-site residues within a proposed transmembrane is consistent both with the known hydrophobic environment of the thiol redox site of the enzyme and with the lipophilicity of vitamin K and warfarin (coumadin).

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by warfarin (coumadin).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei50Important for the reduction of the redox-active cysteinesCurated1
Sitei58Important for the reduction of the redox-active cysteinesCurated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:G66-30969-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.1.4.2 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6806664 Metabolism of vitamin K

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vitamin K epoxide reductase complex subunit 1-like protein 1 (EC:1.17.4.43 Publications)
Short name:
VKORC1-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21492 VKORC1L1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608838 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N0U8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16Cytoplasmic1 PublicationAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 91LumenalSequence analysisAdd BLAST54
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113CytoplasmicSequence analysis1
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 176Cytoplasmic1 PublicationAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi50C → S: Abolishes enzyme activity in cell-based assays. Reduces enzyme activity moderately in assays that regenerate the redox-active cysteines with dithiothreitol (in vitro). 1 Publication1
Mutagenesisi58C → S: Abolishes enzyme activity in cell-based assays. Reduces enzyme activity moderately in assays that regenerate the redox-active cysteines with dithiothreitol (in vitro). 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000196715

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134931578

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N0U8

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00170 Menadione

DrugCentral

More...
DrugCentrali
Q8N0U8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VKORC1L1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62511214

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001916711 – 176Vitamin K epoxide reductase complex subunit 1-like protein 1Add BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi139 ↔ 142Redox-activeBy similarity

Keywords - PTMi

Disulfide bond, Quinone

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N0U8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N0U8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N0U8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N0U8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N0U8

PeptideAtlas

More...
PeptideAtlasi
Q8N0U8

PRoteomics IDEntifications database

More...
PRIDEi
Q8N0U8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
18242
71463 [Q8N0U8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N0U8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N0U8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8N0U8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in response to oxidative stress induced by hydrogen peroxide treatment.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196715 Expressed in 201 organ(s), highest expression level in adipose tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N0U8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N0U8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053954

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PCYT1BQ9Y5K3-34EBI-11337915,EBI-12280028

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127558, 21 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N0U8, 21 interactors

Molecular INTeraction database

More...
MINTi
Q8N0U8

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8N0U8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N0U8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VKOR family.Curated

Keywords - Domaini

Redox-active center, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0HT Eukaryota
ENOG4111UX7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157044

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230752

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N0U8

KEGG Orthology (KO)

More...
KOi
K05357

Identification of Orthologs from Complete Genome Data

More...
OMAi
GWVGPRR

Database of Orthologous Groups

More...
OrthoDBi
1351312at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N0U8

TreeFam database of animal gene trees

More...
TreeFami
TF328467

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12917 VKOR_euk, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1440.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012932 VKOR
IPR038354 VKOR_sf
IPR042406 VKORC1/VKORC1L1

The PANTHER Classification System

More...
PANTHERi
PTHR14519 PTHR14519, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07884 VKOR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00756 VKc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N0U8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPVLLRVS VPRWERVARY AVCAAGILLS IYAYHVEREK ERDPEHRALC
60 70 80 90 100
DLGPWVKCSA ALASRWGRGF GLLGSIFGKD GVLNQPNSVF GLIFYILQLL
110 120 130 140 150
LGMTASAVAA LILMTSSIMS VVGSLYLAYI LYFVLKEFCI ICIVTYVLNF
160 170
LLLIINYKRL VYLNEAWKRQ LQPKQD
Length:176
Mass (Da):19,836
Last modified:August 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1AB0FCDCC2B00E00
GO
Isoform 2 (identifier: Q8N0U8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-176: WGRGFGLLGS...WKRQLQPKQD → HDSKRCGGFD...IIIIHNRHFP

Show »
Length:177
Mass (Da):19,753
Checksum:i0B2CCE4956AF46A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ISV4A0A3B3ISV4_HUMAN
Vitamin K epoxide reductase complex...
VKORC1L1
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q8N0U8-2)
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti163F → FI in BAG64984 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05570966 – 176WGRGF…QPKQD → HDSKRCGGFDPHDVLHHVGR GVPVPGLHSVLCAEGVLHHL HRHVRAELPSSHYQLQTTSL LERGLEAAAATQAGLTPDRL HPNSLKPLSIQFILQQVFII IIIIIIHNRHFP in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY423045 mRNA Translation: AAR82915.1
AK304077 mRNA Translation: BAG64984.1
AC073261 Genomic DNA No translation available.
AC093485 Genomic DNA No translation available.
AC093582 Genomic DNA No translation available.
BC027734 mRNA Translation: AAH27734.2
CR627471 mRNA Translation: CAH10673.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5529.1 [Q8N0U8-1]
CCDS64663.1 [Q8N0U8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001271271.1, NM_001284342.2 [Q8N0U8-2]
NP_775788.2, NM_173517.5 [Q8N0U8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360768; ENSP00000353998; ENSG00000196715 [Q8N0U8-1]
ENST00000434382; ENSP00000403077; ENSG00000196715 [Q8N0U8-2]
ENST00000648179; ENSP00000497394; ENSG00000196715 [Q8N0U8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
154807

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:154807

UCSC genome browser

More...
UCSCi
uc003tum.3 human [Q8N0U8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY423045 mRNA Translation: AAR82915.1
AK304077 mRNA Translation: BAG64984.1
AC073261 Genomic DNA No translation available.
AC093485 Genomic DNA No translation available.
AC093582 Genomic DNA No translation available.
BC027734 mRNA Translation: AAH27734.2
CR627471 mRNA Translation: CAH10673.1
CCDSiCCDS5529.1 [Q8N0U8-1]
CCDS64663.1 [Q8N0U8-2]
RefSeqiNP_001271271.1, NM_001284342.2 [Q8N0U8-2]
NP_775788.2, NM_173517.5 [Q8N0U8-1]

3D structure databases

SMRiQ8N0U8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127558, 21 interactors
IntActiQ8N0U8, 21 interactors
MINTiQ8N0U8

Chemistry databases

BindingDBiQ8N0U8
DrugBankiDB00170 Menadione
DrugCentraliQ8N0U8

PTM databases

iPTMnetiQ8N0U8
PhosphoSitePlusiQ8N0U8
SwissPalmiQ8N0U8

Polymorphism and mutation databases

BioMutaiVKORC1L1
DMDMi62511214

Proteomic databases

EPDiQ8N0U8
jPOSTiQ8N0U8
MassIVEiQ8N0U8
MaxQBiQ8N0U8
PaxDbiQ8N0U8
PeptideAtlasiQ8N0U8
PRIDEiQ8N0U8
ProteomicsDBi18242
71463 [Q8N0U8-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
154807

Genome annotation databases

EnsembliENST00000360768; ENSP00000353998; ENSG00000196715 [Q8N0U8-1]
ENST00000434382; ENSP00000403077; ENSG00000196715 [Q8N0U8-2]
ENST00000648179; ENSP00000497394; ENSG00000196715 [Q8N0U8-1]
GeneIDi154807
KEGGihsa:154807
UCSCiuc003tum.3 human [Q8N0U8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
154807

GeneCards: human genes, protein and diseases

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GeneCardsi
VKORC1L1
HGNCiHGNC:21492 VKORC1L1
HPAiHPA053954
MIMi608838 gene
neXtProtiNX_Q8N0U8
OpenTargetsiENSG00000196715
PharmGKBiPA134931578

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410J0HT Eukaryota
ENOG4111UX7 LUCA
GeneTreeiENSGT00940000157044
HOGENOMiHOG000230752
InParanoidiQ8N0U8
KOiK05357
OMAiGWVGPRR
OrthoDBi1351312at2759
PhylomeDBiQ8N0U8
TreeFamiTF328467

Enzyme and pathway databases

BioCyciMetaCyc:G66-30969-MONOMER
BRENDAi1.1.4.2 2681
ReactomeiR-HSA-6806664 Metabolism of vitamin K

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
VKORC1L1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
154807
PharosiQ8N0U8

Protein Ontology

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PROi
PR:Q8N0U8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000196715 Expressed in 201 organ(s), highest expression level in adipose tissue
ExpressionAtlasiQ8N0U8 baseline and differential
GenevisibleiQ8N0U8 HS

Family and domain databases

CDDicd12917 VKOR_euk, 1 hit
Gene3Di1.20.1440.130, 1 hit
InterProiView protein in InterPro
IPR012932 VKOR
IPR038354 VKOR_sf
IPR042406 VKORC1/VKORC1L1
PANTHERiPTHR14519 PTHR14519, 1 hit
PfamiView protein in Pfam
PF07884 VKOR, 1 hit
SMARTiView protein in SMART
SM00756 VKc, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVKORL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N0U8
Secondary accession number(s): B4E222
, E7ETM5, Q6AHW9, Q6TEK6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: August 16, 2004
Last modified: October 16, 2019
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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