UniProtKB - Q8MXY0 (AMT3_DICDI)
Protein
Ammonium transporter 3
Gene
amtC
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Ammonium transporter that mediates the import of ammonium in prespore cells. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development. May function as an ammonia sensor that relays information concerning ammonia concentrations to the signaling pathway involved in the slug versus culmination choice and regulates prestalk gene expression.2 Publications
GO - Molecular functioni
- ammonium transmembrane transporter activity Source: dictyBase
GO - Biological processi
- ammonium transmembrane transport Source: GO_Central
- ammonium transport Source: dictyBase
- culmination involved in sorocarp development Source: dictyBase
- excretion Source: dictyBase
- regulation of developmental process Source: dictyBase
Keywordsi
Biological process | Ammonia transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Ammonium transporter 3 |
Gene namesi | Name:amtC ORF Names:DDB_G0267424 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0267424, amtC |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endosome
- Endosome membrane 1 Publication; Multi-pass membrane protein 1 Publication
Other locations
- phagosome membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endosome
- endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: dictyBase
Other locations
- perinuclear region of cytoplasm Source: dictyBase
- phagocytic vesicle membrane Source: dictyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularBy similarityAdd BLAST | 27 | |
Transmembranei | 28 – 48 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 49 – 63 | CytoplasmicBy similarityAdd BLAST | 15 | |
Transmembranei | 64 – 84 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 85 – 102 | ExtracellularBy similarityAdd BLAST | 18 | |
Transmembranei | 103 – 125 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 126 – 134 | CytoplasmicBy similarity | 9 | |
Transmembranei | 135 – 155 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 156 – 160 | ExtracellularBy similarity | 5 | |
Transmembranei | 161 – 181 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 182 – 211 | CytoplasmicBy similarityAdd BLAST | 30 | |
Transmembranei | 212 – 232 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 233 – 249 | ExtracellularBy similarityAdd BLAST | 17 | |
Transmembranei | 250 – 270 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 271 – 300 | CytoplasmicBy similarityAdd BLAST | 30 | |
Transmembranei | 301 – 321 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 322 – 333 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 334 – 354 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 355 – 357 | CytoplasmicBy similarity | 3 | |
Transmembranei | 358 – 378 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 379 | ExtracellularBy similarity | 1 | |
Transmembranei | 380 – 400 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 401 – 431 | CytoplasmicBy similarityAdd BLAST | 31 |
Keywords - Cellular componenti
Cell membrane, Cytoplasmic vesicle, Endosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000365575 | 1 – 431 | Ammonium transporter 3Add BLAST | 431 |
Proteomic databases
PaxDbi | Q8MXY0 |
Expressioni
Developmental stagei
Predominantly found in the prespores of the slug.1 Publication
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0682, Eukaryota |
HOGENOMi | CLU_000445_33_1_1 |
InParanoidi | Q8MXY0 |
OMAi | IFFMHAG |
PhylomeDBi | Q8MXY0 |
Family and domain databases
Gene3Di | 1.10.3430.10, 1 hit |
InterProi | View protein in InterPro IPR029020, Ammonium/urea_transptr IPR001905, Ammonium_transpt IPR024041, NH4_transpt_AmtB-like_dom |
Pfami | View protein in Pfam PF00909, Ammonium_transp, 1 hit |
TIGRFAMsi | TIGR00836, amt, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8MXY0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQFSTSSSE SSDSSSEYSL EFYMDTSWVL DAANLVFFMQ AGFGMLEAGM
60 70 80 90 100
VRAKNTKSIL LKNLINTAIC AISYYCVGHS FAYGKVNPNS FVGFGNFFLM
110 120 130 140 150
DYTHYAYWMI QWAYAATATT IATGAMAERL QLHCYILFTL VQTILIYPFV
160 170 180 190 200
AHWIWSQNGW LFDLGIVDFA GGAVIHIVAG ITGACGSFLL GPRIGRFNQE
210 220 230 240 250
SGKPKNLPGH SVVLMSLGAM ILWYSWYGYT AGASLGMTRS RVLPASRVSV
260 270 280 290 300
VVTLSGATGL ITVLGIGKIF NGHYDLVKGI NGLIAGLVSS TSSCAYIEPW
310 320 330 340 350
AAIIIGFIGG IVYWFSSWAL LNWLRLDDPV DSTAIHLFGG CWSLISVAFF
360 370 380 390 400
ATHGRVRNPD IILPGGIFYG GGISLLWVQL VGMVLAILWA GFLSGIFFFT
410 420 430
MDYFGKLRVD VDTELAGLDN SNHGGSAYIF D
Sequence cautioni
The sequence AAP47147 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 353 | H → P in AAP47147 (Ref. 1) Curated | 1 | |
Sequence conflicti | 362 | I → L in AAP47147 (Ref. 1) Curated | 1 | |
Sequence conflicti | 368 | F → I in AAP47147 (Ref. 1) Curated | 1 | |
Sequence conflicti | 379 | Q → P in AAP47147 (Ref. 1) Curated | 1 | |
Sequence conflicti | 413 | T → S in AAP47147 (Ref. 1) Curated | 1 | |
Sequence conflicti | 426 | S → R in AAP47147 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF510718 mRNA Translation: AAP47147.1 Frameshift. AB089904 Genomic DNA Translation: BAC07553.1 AAFI02000003 Genomic DNA Translation: EAL73164.1 |
RefSeqi | XP_647385.1, XM_642293.1 |
Genome annotation databases
EnsemblProtistsi | EAL73164; EAL73164; DDB_G0267424 |
GeneIDi | 8616194 |
KEGGi | ddi:DDB_G0267424 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF510718 mRNA Translation: AAP47147.1 Frameshift. AB089904 Genomic DNA Translation: BAC07553.1 AAFI02000003 Genomic DNA Translation: EAL73164.1 |
RefSeqi | XP_647385.1, XM_642293.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 44689.DDB0191130 |
Proteomic databases
PaxDbi | Q8MXY0 |
Genome annotation databases
EnsemblProtistsi | EAL73164; EAL73164; DDB_G0267424 |
GeneIDi | 8616194 |
KEGGi | ddi:DDB_G0267424 |
Organism-specific databases
dictyBasei | DDB_G0267424, amtC |
Phylogenomic databases
eggNOGi | KOG0682, Eukaryota |
HOGENOMi | CLU_000445_33_1_1 |
InParanoidi | Q8MXY0 |
OMAi | IFFMHAG |
PhylomeDBi | Q8MXY0 |
Miscellaneous databases
PROi | PR:Q8MXY0 |
Family and domain databases
Gene3Di | 1.10.3430.10, 1 hit |
InterProi | View protein in InterPro IPR029020, Ammonium/urea_transptr IPR001905, Ammonium_transpt IPR024041, NH4_transpt_AmtB-like_dom |
Pfami | View protein in Pfam PF00909, Ammonium_transp, 1 hit |
TIGRFAMsi | TIGR00836, amt, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AMT3_DICDI | |
Accessioni | Q8MXY0Primary (citable) accession number: Q8MXY0 Secondary accession number(s): Q55FZ8, Q7Z1M2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 3, 2009 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - SIMILARITY comments
Index of protein domains and families