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UniProtKB - Q8MXY0 (AMT3_DICDI)

Entry version 92 (02 Dec 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Ammonium transporter 3

Gene

amtC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ammonium transporter that mediates the import of ammonium in prespore cells. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development. May function as an ammonia sensor that relays information concerning ammonia concentrations to the signaling pathway involved in the slug versus culmination choice and regulates prestalk gene expression.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ammonium transmembrane transporter activity Source: dictyBase
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmmonia transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ammonium transporter 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:amtC
ORF Names:DDB_G0267424
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...dictyBasei		DDB_G0267424, amtC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 27ExtracellularBy similarityAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Topological domaini49 – 63CytoplasmicBy similarityAdd BLAST15
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 102ExtracellularBy similarityAdd BLAST18
Transmembranei103 – 125HelicalSequence analysisAdd BLAST23
Topological domaini126 – 134CytoplasmicBy similarity9
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 160ExtracellularBy similarity5
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 211CytoplasmicBy similarityAdd BLAST30
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 249ExtracellularBy similarityAdd BLAST17
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Topological domaini271 – 300CytoplasmicBy similarityAdd BLAST30
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 333ExtracellularBy similarityAdd BLAST12
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Topological domaini355 – 357CytoplasmicBy similarity3
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Topological domaini379ExtracellularBy similarity1
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 431CytoplasmicBy similarityAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003655751 – 431Ammonium transporter 3Add BLAST431

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8MXY0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Predominantly found in the prespores of the slug.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		44689.DDB0191130

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ammonia transporter channel (TC 1.A.11.2) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0682, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000445_33_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8MXY0

Identification of Orthologs from Complete Genome Data

More...OMAi		IFFMHAG

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8MXY0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.3430.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029020, Ammonium/urea_transptr
IPR001905, Ammonium_transpt
IPR024041, NH4_transpt_AmtB-like_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00909, Ammonium_transp, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00836, amt, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8MXY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQFSTSSSE SSDSSSEYSL EFYMDTSWVL DAANLVFFMQ AGFGMLEAGM 
        60         70         80         90        100
VRAKNTKSIL LKNLINTAIC AISYYCVGHS FAYGKVNPNS FVGFGNFFLM 
       110        120        130        140        150
DYTHYAYWMI QWAYAATATT IATGAMAERL QLHCYILFTL VQTILIYPFV 
       160        170        180        190        200
AHWIWSQNGW LFDLGIVDFA GGAVIHIVAG ITGACGSFLL GPRIGRFNQE 
       210        220        230        240        250
SGKPKNLPGH SVVLMSLGAM ILWYSWYGYT AGASLGMTRS RVLPASRVSV 
       260        270        280        290        300
VVTLSGATGL ITVLGIGKIF NGHYDLVKGI NGLIAGLVSS TSSCAYIEPW 
       310        320        330        340        350
AAIIIGFIGG IVYWFSSWAL LNWLRLDDPV DSTAIHLFGG CWSLISVAFF 
       360        370        380        390        400
ATHGRVRNPD IILPGGIFYG GGISLLWVQL VGMVLAILWA GFLSGIFFFT 
       410        420        430 
MDYFGKLRVD VDTELAGLDN SNHGGSAYIF D
Length:431
Mass (Da):46,992
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i163A1B4D2BA3C2FB
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAP47147 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti353H → P in AAP47147 (Ref. 1) Curated1
Sequence conflicti362I → L in AAP47147 (Ref. 1) Curated1
Sequence conflicti368F → I in AAP47147 (Ref. 1) Curated1
Sequence conflicti379Q → P in AAP47147 (Ref. 1) Curated1
Sequence conflicti413T → S in AAP47147 (Ref. 1) Curated1
Sequence conflicti426S → R in AAP47147 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF510718 mRNA Translation: AAP47147.1 Frameshift.
AB089904 Genomic DNA Translation: BAC07553.1
AAFI02000003 Genomic DNA Translation: EAL73164.1

NCBI Reference Sequences

More...RefSeqi		XP_647385.1, XM_642293.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		EAL73164; EAL73164; DDB_G0267424

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8616194

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ddi:DDB_G0267424

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF510718 mRNA Translation: AAP47147.1 Frameshift.
AB089904 Genomic DNA Translation: BAC07553.1
AAFI02000003 Genomic DNA Translation: EAL73164.1
RefSeqiXP_647385.1, XM_642293.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0191130

Proteomic databases

PaxDbiQ8MXY0

Genome annotation databases

EnsemblProtistsiEAL73164; EAL73164; DDB_G0267424
GeneIDi8616194
KEGGiddi:DDB_G0267424

Organism-specific databases

dictyBaseiDDB_G0267424, amtC

Phylogenomic databases

eggNOGiKOG0682, Eukaryota
HOGENOMiCLU_000445_33_1_1
InParanoidiQ8MXY0
OMAiIFFMHAG
PhylomeDBiQ8MXY0

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q8MXY0

Family and domain databases

Gene3Di1.10.3430.10, 1 hit
InterProiView protein in InterPro
IPR029020, Ammonium/urea_transptr
IPR001905, Ammonium_transpt
IPR024041, NH4_transpt_AmtB-like_dom
PfamiView protein in Pfam
PF00909, Ammonium_transp, 1 hit
TIGRFAMsiTIGR00836, amt, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMT3_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MXY0
Secondary accession number(s): Q55FZ8, Q7Z1M2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 1, 2002
Last modified: December 2, 2020
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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