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Protein

Ras-related protein Rab-18

Gene

rab-18

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in apical endocytosis/recycling (PubMed:24843160). May be implicated in transport between the plasma membrane and early endosomes (By similarity). Plays a role in the shedding of pathogen spores from intestinal cells (PubMed:24843160).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25GTPBy similarity8
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-6798695 Neutrophil degranulation
R-CEL-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-CEL-8873719 RAB geranylgeranylation
R-CEL-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-18
Gene namesi
Name:rab-18
ORF Names:Y92C3B.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiY92C3B.3a ; CE34438 ; WBGene00004277 ; rab-18
Y92C3B.3b ; CE27340 ; WBGene00004277 ; rab-18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in disrupted clearance of intracellular pathogen N.parisii from intestinal cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212001 – 203Ras-related protein Rab-18Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi201S-geranylgeranyl cysteineBy similarity1
Modified residuei203Cysteine methyl esterBy similarity1
Lipidationi203S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ8MXS1
PaxDbiQ8MXS1
PeptideAtlasiQ8MXS1
PRIDEiQ8MXS1

Expressioni

Gene expression databases

BgeeiWBGene00004277 Expressed in 3 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

STRINGi6239.Y92C3B.3b

Structurei

3D structure databases

ProteinModelPortaliQ8MXS1
SMRiQ8MXS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0080 Eukaryota
ENOG410XPD0 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
InParanoidiQ8MXS1
KOiK07910
OMAiMQSTVGM
OrthoDBiEOG091G0MOO
PhylomeDBiQ8MXS1

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR025662 Sigma_54_int_dom_ATP-bd_1
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform b (identifier: Q8MXS1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDDSSSPLT TLKILIIGES GVGKSSLMLR FVDDVFDPEQ AATIGVDFRV
60 70 80 90 100
TSMAIDGNRV KLAIWDTAGQ ERFRTLTPSY YRGAQGVICV YDVTSRSSFE
110 120 130 140 150
KLNHWMQEVD TYCTNDNIIK MMVANKIDMP NRVVTREEGL KFAKRHRTLF
160 170 180 190 200
IEASAKTKEG VQCTFEELIE KIIQTPDLWD NDRPSFRLGQ PTGSSGGGGM

CGC
Note: No experimental confirmation available.
Length:203
Mass (Da):22,620
Last modified:October 1, 2002 - v1
Checksum:i3A5C72AE8FA16761
GO
Isoform a (identifier: Q8MXS1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.
     129-129: M → MVRKSRFCSIFGLKNNFQ

Note: No experimental confirmation available.
Show »
Length:193
Mass (Da):21,928
Checksum:iA41AFBF6AA39215F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0207841 – 27Missing in isoform a. CuratedAdd BLAST27
Alternative sequenceiVSP_020785129M → MVRKSRFCSIFGLKNNFQ in isoform a. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080242 Genomic DNA Translation: CCD62282.1
FO080242 Genomic DNA Translation: CCD62283.1
RefSeqiNP_741092.1, NM_171081.4 [Q8MXS1-1]
NP_741093.2, NM_171861.4 [Q8MXS1-2]
UniGeneiCel.17517

Genome annotation databases

EnsemblMetazoaiY92C3B.3a; Y92C3B.3a; WBGene00004277 [Q8MXS1-2]
Y92C3B.3b.1; Y92C3B.3b.1; WBGene00004277 [Q8MXS1-1]
Y92C3B.3b.2; Y92C3B.3b.2; WBGene00004277 [Q8MXS1-1]
GeneIDi175272
KEGGicel:CELE_Y92C3B.3
UCSCiY92C3B.3b c. elegans [Q8MXS1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080242 Genomic DNA Translation: CCD62282.1
FO080242 Genomic DNA Translation: CCD62283.1
RefSeqiNP_741092.1, NM_171081.4 [Q8MXS1-1]
NP_741093.2, NM_171861.4 [Q8MXS1-2]
UniGeneiCel.17517

3D structure databases

ProteinModelPortaliQ8MXS1
SMRiQ8MXS1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y92C3B.3b

Proteomic databases

EPDiQ8MXS1
PaxDbiQ8MXS1
PeptideAtlasiQ8MXS1
PRIDEiQ8MXS1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY92C3B.3a; Y92C3B.3a; WBGene00004277 [Q8MXS1-2]
Y92C3B.3b.1; Y92C3B.3b.1; WBGene00004277 [Q8MXS1-1]
Y92C3B.3b.2; Y92C3B.3b.2; WBGene00004277 [Q8MXS1-1]
GeneIDi175272
KEGGicel:CELE_Y92C3B.3
UCSCiY92C3B.3b c. elegans [Q8MXS1-1]

Organism-specific databases

CTDi175272
WormBaseiY92C3B.3a ; CE34438 ; WBGene00004277 ; rab-18
Y92C3B.3b ; CE27340 ; WBGene00004277 ; rab-18

Phylogenomic databases

eggNOGiKOG0080 Eukaryota
ENOG410XPD0 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
InParanoidiQ8MXS1
KOiK07910
OMAiMQSTVGM
OrthoDBiEOG091G0MOO
PhylomeDBiQ8MXS1

Enzyme and pathway databases

ReactomeiR-CEL-6798695 Neutrophil degranulation
R-CEL-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-CEL-8873719 RAB geranylgeranylation
R-CEL-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

PROiPR:Q8MXS1

Gene expression databases

BgeeiWBGene00004277 Expressed in 3 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR025662 Sigma_54_int_dom_ATP-bd_1
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB18_CAEEL
AccessioniPrimary (citable) accession number: Q8MXS1
Secondary accession number(s): Q9BL22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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