Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 108 (16 Oct 2019)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Cyclic GMP-binding protein C

Gene

gbpC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase.By similarity5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei905ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1023Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi336 – 343GTPPROSITE-ProRule annotation8
Nucleotide bindingi402 – 406GTPPROSITE-ProRule annotation5
Nucleotide bindingi458 – 461GTPPROSITE-ProRule annotation4
Nucleotide bindingi884 – 892ATPPROSITE-ProRule annotation9
Nucleotide bindingi2014 – 2133cNMP 1Add BLAST120
Nucleotide bindingi2490 – 2616cNMP 2Add BLAST127

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, cGMP, cGMP-binding, GTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclic GMP-binding protein C (EC:2.7.11.1)
Alternative name(s):
Ras guanine nucleotide exchange factor T
RasGEF domain-containing protein T
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gbpC
Synonyms:gefT, rasGEFT
ORF Names:DDB_G0291079
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0291079 gbpC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi342K → N: Loss of nucleotide binding activity. 1 Publication1
Mutagenesisi905K → N: Loss of chemotax. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003531031 – 2631Cyclic GMP-binding protein CAdd BLAST2631

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8MVR1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Increases dramatically after starvation is initiated with a peak between 4-12 hours.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0191359

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati170 – 194LRR 1Add BLAST25
Repeati196 – 217LRR 2Add BLAST22
Repeati218 – 240LRR 3Add BLAST23
Repeati242 – 262LRR 4Add BLAST21
Repeati263 – 285LRR 5Add BLAST23
Repeati287 – 308LRR 6Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini323 – 515RocPROSITE-ProRule annotationAdd BLAST193
Domaini878 – 1172Protein kinasePROSITE-ProRule annotationAdd BLAST295
Domaini1366 – 1539N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST174
Domaini1620 – 1706DEPPROSITE-ProRule annotationAdd BLAST87
Domaini1708 – 1971Ras-GEFPROSITE-ProRule annotationAdd BLAST264
Domaini2354 – 2414GRAMAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi127 – 139Asn-richAdd BLAST13
Compositional biasi140 – 146Poly-Thr7
Compositional biasi350 – 355Poly-Lys6
Compositional biasi1207 – 1218Poly-AsnAdd BLAST12
Compositional biasi1226 – 1304Ser-richAdd BLAST79
Compositional biasi1315 – 1320Poly-Asn6
Compositional biasi2153 – 2156Poly-Ser4
Compositional biasi2200 – 2223Pro-richAdd BLAST24
Compositional biasi2231 – 2238Poly-Thr8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0192 Eukaryota
COG0515 LUCA
COG1100 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8MVR1

Identification of Orthologs from Complete Genome Data

More...
OMAi
THEPNSR

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00038 CAP_ED, 2 hits
cd06224 REM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
1.10.840.10, 1 hit
2.30.29.30, 1 hit
2.60.120.10, 2 hits
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR032171 COR
IPR000591 DEP_dom
IPR004182 GRAM
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR014710 RmlC-like_jellyroll
IPR020859 ROC_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00027 cNMP_binding, 2 hits
PF16095 COR, 1 hit
PF00610 DEP, 1 hit
PF02893 GRAM, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00049 DEP, 1 hit
SM00568 GRAM, 1 hit
SM00369 LRR_TYP, 2 hits
SM00147 RasGEF, 1 hit
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF48366 SSF48366, 1 hit
SSF51206 SSF51206, 2 hits
SSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50042 CNMP_BINDING_3, 2 hits
PS50186 DEP, 1 hit
PS51450 LRR, 4 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS51424 ROC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8MVR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQKQKPIRF QDYQFTATKD EAYGRSDRYV KQFLNKNLLK KKDGTLGTAE
60 70 80 90 100
ELLTLIQQSN INVVTASTGG AAMGAMLNHT VSTINLTGSG SVPTYNPSDN
110 120 130 140 150
RNSGSHVITS TNSVISNSSI SSTGVINNNI NNNSNINSNT GTTTTTISLP
160 170 180 190 200
NNTEIKTALV STGSQNASDT AQIDIEFHLS YTQLVTLPPS IFSLIWIQKL
210 220 230 240 250
VLTHHNIKTL SEDIGKLQQL QVLVLENNRL INLPQSIGDL VNLKRLEVDN
260 270 280 290 300
NHLVSLCSLE RLSKLEVLSV NNNKLTLLPT SIASLSSLKT LNIKSNPIIT
310 320 330 340 350
PPSTVVSKGL KDIVSFLREL ETGARPCLRS KLVVLGDPGV GKTSVVQCMK
360 370 380 390 400
GKKKKTNVTS SSINIGGSSG SEVGIEIDQY DFDVVFDEDD KKRRVITLST
410 420 430 440 450
WDIANQDVYF ASSQLFDSER SVYIVVFNLN NDDFSAIEYW LHCIMSTSPN
460 470 480 490 500
SPIVLVGTHI DAFENLNVVN AVLESVASRF QKRFTNIQAI ISVSCTTGYD
510 520 530 540 550
VDKLRQLIED IIKTQPYLKE KVPSSFFTLE EALIEVKKKR IPPVMMWQEY
560 570 580 590 600
INLANICNLK DSVQIQRATE FLHNIGSIVY FNDLNSSTVG KMVILDQQWI
610 620 630 640 650
INCMSSLITS KLLINNCNGI VRQSDLELVW KAPTYPEHLH PALLSIMQAF
660 670 680 690 700
EICRSLSPSD LVRPEEVNEK EVMGDRNLVP NLLSDNTNIV AQWDDFIDPD
710 720 730 740 750
TILLNRQYHL PFLPEKFFGK LIIHLMNFTK VESCQKRAVI LRNQDNHEAL
760 770 780 790 800
IELKTIKDNK DGTFKKILTV DVRGLVSPVS LLRIVTDTIE SLFSQWYKLD
810 820 830 840 850
IKRYISCYEC AILYDRNPTL FTIEECELAV IDGKTVLTCN QKSDSDRVST
860 870 880 890 900
SHRLKLDILA PDISMVDIPI PRFNLSEVKI NKEVGRGAFG IVYEAEWMSE
910 920 930 940 950
WIALKKLLLP SSTDTTNLNG NGEVMVYDDP DQLIEDRLRV FREFRHEVYY
960 970 980 990 1000
MSGLNHPNVM KISGFCIQPL CMALEYVRYG SLYSLLSNSS IEISWGLRLQ
1010 1020 1030 1040 1050
IASEIAKGMQ HLHSHNPPVI HRDLKSPNIL LNGITEGQNS VATIIDFGTS
1060 1070 1080 1090 1100
TALYGGAALI RCVDQPLWLG PEVLAGTAYS EPSDVYSFGI ILWELYTRAH
1110 1120 1130 1140 1150
PFDEFQFGQW MSKLEDEIIR GLRPTIPPTC PPEYVELIQS CWTHEPNSRP
1160 1170 1180 1190 1200
TFTSIVEILG QIKKKFAPLP FTHPPHIRNM MRKSRSSSIS EAMLPSNLLH
1210 1220 1230 1240 1250
LNLNGINNNN NNSNNNNNSI PVTTISLTSS GTSPTNSPVG GLLSQSLTQP
1260 1270 1280 1290 1300
ITSGGSTSGI LSTSVNRDNS SLVSASSLGN NTSTSSLASL VSNNSGLHHS
1310 1320 1330 1340 1350
PSASDGLNDY YGADNNNNNN DSTMDFFQDI FTEEENEQPY PFADDDQQKG
1360 1370 1380 1390 1400
ILFGFDEEQT NPSASSVSII IAATMAKMIE MMTKGESSAT LKSEHISTRR
1410 1420 1430 1440 1450
RSDTAGKNGV PPHWRNSVPL STNSSTTLDE TFIDDFIYVY RSFTTPRNIF
1460 1470 1480 1490 1500
KLLVRRFFGP RHTDKVDTFT IKKFEQKKAA IRQGIAVFLR KWVADITELE
1510 1520 1530 1540 1550
FRQEEFWLYH NTVAFTKQFI ASEFPTIATQ IYGTLTTHED EVNLTNQRFL
1560 1570 1580 1590 1600
QIAFSESEIQ IDRAMSSMQL TTPKPFRSQK NLANSYNSQS GGGDSSFYYQ
1610 1620 1630 1640 1650
PSSNDVSRVF LNLATGMRDP LLGITVKEKK FKKDKVSTLC CSGSEIIDWI
1660 1670 1680 1690 1700
TKCMPIKREE ASILVLDMLM KQFFIQISDD GIPISNQKGT NPTFSDSPTS
1710 1720 1730 1740 1750
FYMFLEDDPE LIARQYTFLE LKYLQNIHPR ELLGFSVGLV MPNENEKDPE
1760 1770 1780 1790 1800
KWRQSNFPHI YDYFRWFNKM TMLVSTEILR QRDIKQRASI IEKYISIALE
1810 1820 1830 1840 1850
YLSLWNFNGI MQVLSSLHSE PISRLSATWA KVSQRSMDCF YELSRLMLPE
1860 1870 1880 1890 1900
SNYLPLRTAL ASQKPNTIIQ ASPLYPNISA YMVHTVCPTI PFLGALIADL
1910 1920 1930 1940 1950
SQTCTENPTF ISSGGEKMIN ILRVKRLSKK MKMFKEYKEM PTQYLPALTT
1960 1970 1980 1990 2000
IPLQYYEHYV NDLKALDSLQ IDRLSDIERK LEIICEKNGT TNDDKEKGDE
2010 2020 2030 2040 2050
NGGGLTSSNF FGNGSDELTE RDWTILLTNA SVIAYNRGDV VMEENAINTH
2060 2070 2080 2090 2100
LYRIKSGAIS VEKKDKEGIN CKVATMFAPK MFGEMSFLGN KTTARLTVDE
2110 2120 2130 2140 2150
ESDLYVMDIP FLNNLFNGHP RLGAKFYKIM ANQLAIRLKN LPWSKPKNTT
2160 2170 2180 2190 2200
GGSSSSNQSA GPDNILGTTP TGISSSGGGL TSLLNQNLSS IMSLSNSNTP
2210 2220 2230 2240 2250
PASPRVMTTP TLPSPPAPLQ SPPTSGISSP TTTTSTTTDQ QKINNTIFQN
2260 2270 2280 2290 2300
VHPTINVHRT SSSANLVSPH GRPSNSGFGH SSGGERTINK DPHQRDSGSM
2310 2320 2330 2340 2350
DKPILSLGSG GTPRGDGARS GSISYLGRTQ TSTSPLNEGL SGGQQPVMKK
2360 2370 2380 2390 2400
NDQEFCQRFA LVDEIVIKDY PCSLNRSGRL YISQQHVCFY SKFFGYKTKK
2410 2420 2430 2440 2450
VIPFKNIDKL ICINVNQIEL TRLKNTVPSN YRLTFQTGKD REDAFSMIHI
2460 2470 2480 2490 2500
LWDSSKVSNS SSDEIKNKLA AERKKVNNLT LKTRSNKNKG DELTKEDWEL
2510 2520 2530 2540 2550
IGCEGSRSST FKKDEVIIRE GERMQKIFQI GKGVCRIEKS VPVAPGSSEM
2560 2570 2580 2590 2600
KKVVLGTMKQ DDTFGEITYL LNGETTADVI ADTDQTEVYT IEGQFVNILF
2610 2620 2630
DLNPALASKW FKYLATALNK TLIERESQLY A
Length:2,631
Mass (Da):294,127
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BB7AABD0A637701
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF481923 Genomic DNA Translation: AAM34041.1
AAFI02000175 Genomic DNA Translation: EAL61887.1

NCBI Reference Sequences

More...
RefSeqi
XP_635392.1, XM_630300.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL61887; EAL61887; DDB_G0291079

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8627976

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0291079

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF481923 Genomic DNA Translation: AAM34041.1
AAFI02000175 Genomic DNA Translation: EAL61887.1
RefSeqiXP_635392.1, XM_630300.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0191359

Proteomic databases

PaxDbiQ8MVR1

Genome annotation databases

EnsemblProtistsiEAL61887; EAL61887; DDB_G0291079
GeneIDi8627976
KEGGiddi:DDB_G0291079

Organism-specific databases

dictyBaseiDDB_G0291079 gbpC

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
COG1100 LUCA
InParanoidiQ8MVR1
OMAiTHEPNSR

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8MVR1

Family and domain databases

CDDicd00038 CAP_ED, 2 hits
cd06224 REM, 1 hit
Gene3Di1.10.10.10, 1 hit
1.10.840.10, 1 hit
2.30.29.30, 1 hit
2.60.120.10, 2 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR032171 COR
IPR000591 DEP_dom
IPR004182 GRAM
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR014710 RmlC-like_jellyroll
IPR020859 ROC_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00027 cNMP_binding, 2 hits
PF16095 COR, 1 hit
PF00610 DEP, 1 hit
PF02893 GRAM, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00568 GRAM, 1 hit
SM00369 LRR_TYP, 2 hits
SM00147 RasGEF, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48366 SSF48366, 1 hit
SSF51206 SSF51206, 2 hits
SSF52540 SSF52540, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 2 hits
PS50186 DEP, 1 hit
PS51450 LRR, 4 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS51424 ROC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGBPC_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MVR1
Secondary accession number(s): Q54F62
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: October 1, 2002
Last modified: October 16, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again