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UniProtKB - Q8MSX1 (ENC_DROME)

Entry version 134 (23 Feb 2022)
Sequence version 2 (02 Feb 2004)
Previous versions | rss
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Protein

Protein encore

Gene

enc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the regulation of germline mitosis, karyosome formation, and establishment of dorsoventral (DS) polarity of the egg and embryo. Involved in proper grk mRNA localization and translation in the oocyte. May control germline mitosis by facilitating the cyclin E (CycE) proteolysis by the SCF-ubiquitin-proteasome complex.

2 Publications

Caution

It is uncertain whether Met-1 or Met-143 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Oogenesis

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8MSX1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein encore
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:enc
ORF Names:CG10847
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0004875, enc

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0004875

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000869731 – 1818Protein encoreAdd BLAST1818

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei267Phosphoserine1 Publication1
Modified residuei270Phosphoserine1 Publication1
Modified residuei336Phosphoserine1 Publication1
Modified residuei535Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8MSX1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8MSX1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all germline cells of the germarium including the stem cells and dividing cystocytes.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the germarium, it begins to accumulate preferentially within the future oocyte shortly after formation of the 16-cell cyst. In midoogenesis, it can be seen transiently at the posterior edge of the oocyte, but by stage 9 assumes an anterior localization, and appears to be more concentrated at the dorsal side of the oocyte, above the oocyte nucleus. This pattern of localization is similar to that seen for grk mRNA and protein, though not tightly restricted to the dorsal side.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0004875, Expressed in oocyte and 34 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8MSX1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8MSX1, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hfp; however, given the nuclear localization of hfp, the relevance of such interaction is unclear.

Interacts with CycE, Cul1, and the SCF-proteasome complex.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		69121, 31 interactors

Protein interaction database and analysis system

More...IntActi		Q8MSX1, 2 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0305410

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8MSX1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini444 – 508R3HPROSITE-ProRule annotationAdd BLAST65
Domaini510 – 576SUZPROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 68DisorderedSequence analysisAdd BLAST22
Regioni123 – 282DisorderedSequence analysisAdd BLAST160
Regioni317 – 413DisorderedSequence analysisAdd BLAST97
Regioni557 – 806DisorderedSequence analysisAdd BLAST250
Regioni885 – 916DisorderedSequence analysisAdd BLAST32
Regioni936 – 959DisorderedSequence analysisAdd BLAST24
Regioni1176 – 1249DisorderedSequence analysisAdd BLAST74
Regioni1332 – 1648DisorderedSequence analysisAdd BLAST317
Regioni1684 – 1709DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi123 – 140Polar residuesSequence analysisAdd BLAST18
Compositional biasi154 – 246Polar residuesSequence analysisAdd BLAST93
Compositional biasi258 – 282Polar residuesSequence analysisAdd BLAST25
Compositional biasi340 – 354Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi365 – 413Polar residuesSequence analysisAdd BLAST49
Compositional biasi557 – 573Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi594 – 609Polar residuesSequence analysisAdd BLAST16
Compositional biasi644 – 788Polar residuesSequence analysisAdd BLAST145
Compositional biasi890 – 916Polar residuesSequence analysisAdd BLAST27
Compositional biasi1176 – 1234Polar residuesSequence analysisAdd BLAST59
Compositional biasi1344 – 1359Pro residuesSequence analysisAdd BLAST16
Compositional biasi1376 – 1390Polar residuesSequence analysisAdd BLAST15
Compositional biasi1400 – 1446Polar residuesSequence analysisAdd BLAST47
Compositional biasi1489 – 1521Polar residuesSequence analysisAdd BLAST33
Compositional biasi1577 – 1631Polar residuesSequence analysisAdd BLAST55

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2953, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000168363

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8MSX1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1370.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001374, R3H_dom
IPR036867, R3H_dom_sf
IPR024771, SUZ

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01424, R3H, 1 hit
PF12752, SUZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00393, R3H, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82708, SSF82708, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51061, R3H, 1 hit
PS51673, SUZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: Q8MSX1-1) [UniParc]FASTAAdd to basket
Also known as: D

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSTKSQVAL ATNIPTNLSS AASASTAAAA AAVVVVASAN AAVASSANSS 
        60         70         80         90        100
GVGSGSGPGP GSGAGVSGPV AAGTATAVAT GSTVTAATSV AATTSTSVAT 
       110        120        130        140        150
ISTSCSSSSI NNINNNCGEE CQSAAGSSNL GRQNSFGNRR GNMKGKHLTR 
       160        170        180        190        200
SHAMRESTSP PRTPTPRAAS EQQQQQLQGE QHEHNNNNNI NSSSKAQSAG 
       210        220        230        240        250
RGNSPLMETP AVIVTSQQPQ QQQQQQQQQQ QSVPPKPQQN VPLSNEAEFP 
       260        270        280        290        300
KLSPPKKSGG QHNRTNSNGS GMEFNNNNNS SNKKFVVDMK ANGLDNKPHN 
       310        320        330        340        350
NSSTGVIFNS GMNYKAAERH DRHERHEMSS QNSNLSNNHD EEPYHYEPRG 
       360        370        380        390        400
GGGGKKHRAN TNAKGNKPRL KNLGGSSSGS IDLGGGGGNG NCNNMSNNGQ 
       410        420        430        440        450
SNNSSNNTSG FISRENSSEQ YTDYGGTDLL VFFRDTLNKN PKDRNILLKI 
       460        470        480        490        500
EKDLIDFVQE NSRGCEYRFP PASSYNRMLI HRTAAFFGME HNVDTETQQC 
       510        520        530        540        550
VIVAVAKNTR IPEIRFQSLV RDDARKSILK RDTHSFDEVR QSPYLCPLSL 
       560        570        580        590        600
DRKAKSFEER EEDYDRARSR IFSRTGGNHD GYSGGGGDEE CYGGWEQQQQ 
       610        620        630        640        650
QQKQSQPPRP KRPNGKMLQM QNSTESRDGM RSGGAVPKSH NFGNYGGPPS 
       660        670        680        690        700
SGGPGNNSLP RGDSTNSIKS GRGGFVKQDS TGSTPWRLSP SSSGSIYHYD 
       710        720        730        740        750
PSNLPPNQAL QHSGNQYQSQ NQGNSSSGGY NNYRKSSPHQ QQQSQQQQQS 
       760        770        780        790        800
QQHHQQQLQQ PQQLHQQSSQ QYATTELSCS STESYAEEEA QSPGMECSEG 
       810        820        830        840        850
YESYEQQSLP VQQQLSGNGD SASTKGDDCD SLASATACLS ITTSTSTKNY 
       860        870        880        890        900
DRIEVQKYKN QATSPNIPAC CAVGEKLELE AGLPQEQEQE PMAGPSSSGS 
       910        920        930        940        950
ATSSVGITEL PSSQTPLPMV NQVNCDLQSV SPSTTPYSQC EVKTPSQNHA 
       960        970        980        990       1000
PSAAVEEPKT TTWTYTQSYQ APDGSTVFHT TTTPNGAAPY CATTYQQGPD 
      1010       1020       1030       1040       1050
GSIYAVPQGM VYAAYPQPGV GTAGGASQPL FQLTTSSHPP AQTIFASPEA 
      1060       1070       1080       1090       1100
GAEIPGGTYM IPVFDPAQQP REGLIPAQAI YQTGPGGPGA TTVMPMATAA 
      1110       1120       1130       1140       1150
AYPTAQFATA APNGAPIYQA PLIYSSEPGG GAQLQQLPMA PYPIQYSYPY 
      1160       1170       1180       1190       1200
YHPISYYVPQ QAVAAAPMVA SQPQVGQAPM QQQAPHTGAG TTTGPPTVVS 
      1210       1220       1230       1240       1250
VSGQQHHQPH QQHHQQQQHS SNGSVVTSSA YGTRVKRTPG GGSIHYNPSY 
      1260       1270       1280       1290       1300
TPSSVAHAGG AHHPSAGSAQ IIAAPAASTT TYHALPTLTL AHGGPATGTD 
      1310       1320       1330       1340       1350
LSGAGGAHVY ALPAQHALIP TNIFPYAAAA AAAAGGPGGP PTTPQVVQQA 
      1360       1370       1380       1390       1400
PPPPPQSAPH HALITAAPFY PANGGNMDQG ASQSAPSTPA APGRQAPLFS 
      1410       1420       1430       1440       1450
TPPAPNNGSS GSSSAGGGGN SGGYHSNSST PHYYQGQNSN EGYTSPYEKR 
      1460       1470       1480       1490       1500
NHGGGASGAH SVGVRKPYHP GGYNPRHSVP LGGIPSGAKT PLLNSNNEPT 
      1510       1520       1530       1540       1550
PRASPSSVSL GGASSSGGAN SYPHRGPPPH TMGVKRDNKP NQLPLISGPP 
      1560       1570       1580       1590       1600
PSYAANSSPG VSSYESKPPV RLNAGAASFR SQKSMNQDYR RSVSQRNSPS 
      1610       1620       1630       1640       1650
ANGGGSGSHE SSNNSPNSIV GSQSNSAANT PNAAAPPPPQ PQPTLVSHSG 
      1660       1670       1680       1690       1700
GFVVLDQTTG AAMNASPPSL YGGGGGPNAG ISGGAGASGA AGSNGGHQPG 
      1710       1720       1730       1740       1750
GGGGARSHIP TAQLHHSAAA AAAAAAGSQQ ATAAVLSGVA AAAALGGYNP 
      1760       1770       1780       1790       1800
NGASGVYFKY GQTYFAHPSV ALPNSRRSPS NDIRPQMAQV AGMYPTMMIQ 
      1810 
ARHPSRHPNP NYKGSRPR
Length:1,818
Mass (Da):188,663
Last modified:February 2, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i195C6C1333F5508A
GO
Isoform 2 (identifier: Q8MSX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1612-1800: SNNSPNSIVG...AGMYPTMMIQ → GYNPNGASGV...QANDLHASLP

Note: Splicing donor and acceptor sites between exon 10 and exon 11 are not canonical.Curated
Show »
Length:1,692
Mass (Da):177,468
Checksum:i9FA17F9EC633C1D5
GO
Isoform A (identifier: Q8MSX1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     414-414: R → RVFHQS

Show »
Length:1,823
Mass (Da):189,262
Checksum:iFFF0454157A153C7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8JNJ9A8JNJ9_DROME
Encore, isoform E
enc BB129, Dmel\CG10847, Enc, fs(3)63F-64A, CG10847
1,937Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PBM2M9PBM2_DROME
Encore, isoform G
enc BB129, Dmel\CG10847, Enc, fs(3)63F-64A, CG10847
1,798Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PE05M9PE05_DROME
Encore, isoform H
enc BB129, Dmel\CG10847, Enc, fs(3)63F-64A, CG10847
1,827Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PH77M9PH77_DROME
Encore, isoform F
enc BB129, Dmel\CG10847, Enc, fs(3)63F-64A, CG10847
1,942Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF68440 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAM49887 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118G → A in AAF68440 (PubMed:11044391).Curated1
Sequence conflicti220 – 221Missing in AAF68440 (PubMed:11044391).Curated2
Sequence conflicti251 – 252KL → NV in AAF68440 (PubMed:11044391).Curated2
Sequence conflicti308F → Y in AAF68440 (PubMed:11044391).Curated1
Sequence conflicti577G → D in AAF68440 (PubMed:11044391).Curated1
Sequence conflicti580D → E in AAF68440 (PubMed:11044391).Curated1
Sequence conflicti709A → G in AAF68440 (PubMed:11044391).Curated1
Sequence conflicti882G → A in AAF68440 (PubMed:11044391).Curated1
Sequence conflicti1044I → V in AAF68440 (PubMed:11044391).Curated1
Sequence conflicti1105A → T in AAF68440 (PubMed:11044391).Curated1
Sequence conflicti1523P → Q in AAF68440 (PubMed:11044391).Curated1
Sequence conflicti1761G → V in AAX33393 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032690414R → RVFHQS in isoform A. 1 Publication1
Alternative sequenceiVSP_0093271612 – 1800SNNSP…TMMIQ → GYNPNGASGVYFKYGQTYFA HPSVALPNSRRSPSNDIRPQ MAQVAGMYPTMMIQANDLHA SLP in isoform 2. 1 PublicationAdd BLAST189

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF243382 mRNA Translation: AAF68440.1 Different initiation.
AE014296 Genomic DNA Translation: AAF47799.2
AE014296 Genomic DNA Translation: AAS64963.1
AE014296 Genomic DNA Translation: ABW08455.1
BT021245 mRNA Translation: AAX33393.1
BT050449 mRNA Translation: ACJ13156.1
AY118518 mRNA Translation: AAM49887.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		NP_001097496.1, NM_001104026.2 [Q8MSX1-1]
NP_524765.2, NM_080026.3 [Q8MSX1-1]
NP_995992.1, NM_206270.2 [Q8MSX1-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0073152; FBpp0073011; FBgn0004875 [Q8MSX1-1]
FBtr0073153; FBpp0089267; FBgn0004875 [Q8MSX1-3]
FBtr0112844; FBpp0111757; FBgn0004875 [Q8MSX1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		44543

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG10847

UCSC genome browser

More...UCSCi		CG10847-RA, d. melanogaster [Q8MSX1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF243382 mRNA Translation: AAF68440.1 Different initiation.
AE014296 Genomic DNA Translation: AAF47799.2
AE014296 Genomic DNA Translation: AAS64963.1
AE014296 Genomic DNA Translation: ABW08455.1
BT021245 mRNA Translation: AAX33393.1
BT050449 mRNA Translation: ACJ13156.1
AY118518 mRNA Translation: AAM49887.1 Different initiation.
RefSeqiNP_001097496.1, NM_001104026.2 [Q8MSX1-1]
NP_524765.2, NM_080026.3 [Q8MSX1-1]
NP_995992.1, NM_206270.2 [Q8MSX1-3]

3D structure databases

SMRiQ8MSX1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi69121, 31 interactors
IntActiQ8MSX1, 2 interactors
STRINGi7227.FBpp0305410

PTM databases

iPTMnetiQ8MSX1

Proteomic databases

PaxDbiQ8MSX1

Genome annotation databases

EnsemblMetazoaiFBtr0073152; FBpp0073011; FBgn0004875 [Q8MSX1-1]
FBtr0073153; FBpp0089267; FBgn0004875 [Q8MSX1-3]
FBtr0112844; FBpp0111757; FBgn0004875 [Q8MSX1-1]
GeneIDi44543
KEGGidme:Dmel_CG10847
UCSCiCG10847-RA, d. melanogaster [Q8MSX1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		104374
FlyBaseiFBgn0004875, enc
VEuPathDBiVectorBase:FBgn0004875

Phylogenomic databases

eggNOGiKOG2953, Eukaryota
GeneTreeiENSGT00940000168363
InParanoidiQ8MSX1

Enzyme and pathway databases

SignaLinkiQ8MSX1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		44543, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		44543

Protein Ontology

More...PROi		PR:Q8MSX1

Gene expression databases

BgeeiFBgn0004875, Expressed in oocyte and 34 other tissues
ExpressionAtlasiQ8MSX1, baseline and differential
GenevisibleiQ8MSX1, DM

Family and domain databases

Gene3Di3.30.1370.50, 1 hit
InterProiView protein in InterPro
IPR001374, R3H_dom
IPR036867, R3H_dom_sf
IPR024771, SUZ
PfamiView protein in Pfam
PF01424, R3H, 1 hit
PF12752, SUZ, 1 hit
SMARTiView protein in SMART
SM00393, R3H, 1 hit
SUPFAMiSSF82708, SSF82708, 1 hit
PROSITEiView protein in PROSITE
PS51061, R3H, 1 hit
PS51673, SUZ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENC_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MSX1
Secondary accession number(s): A8JNK0
, B6IDK9, Q5BIH9, Q7KV61, Q9NGQ6, Q9VZM1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: February 23, 2022
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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