UniProtKB - Q8MSX1 (ENC_DROME)
Protein encore
enc
Functioni
Required for the regulation of germline mitosis, karyosome formation, and establishment of dorsoventral (DS) polarity of the egg and embryo. Involved in proper grk mRNA localization and translation in the oocyte. May control germline mitosis by facilitating the cyclin E (CycE) proteolysis by the SCF-ubiquitin-proteasome complex.
2 PublicationsCaution
GO - Molecular functioni
- nucleic acid binding Source: InterPro
GO - Biological processi
- cystoblast division Source: FlyBase
- germarium-derived egg chamber formation Source: FlyBase
- germarium-derived oocyte fate determination Source: FlyBase
- germ-line cyst formation Source: FlyBase
- oocyte dorsal/ventral axis specification Source: FlyBase
- oocyte karyosome formation Source: FlyBase
- oogenesis Source: FlyBase
- regulation of pole plasm oskar mRNA localization Source: FlyBase
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Oogenesis |
Enzyme and pathway databases
SignaLinki | Q8MSX1 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein encore |
Gene namesi | Name:enc ORF Names:CG10847 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0004875, enc |
VEuPathDBi | VectorBase:FBgn0004875 |
Subcellular locationi
Cytoplasm and Cytosol
Note: Colocalizes with grk.
Other locations
- cytoplasm Source: FlyBase
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086973 | 1 – 1818 | Protein encoreAdd BLAST | 1818 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 267 | Phosphoserine1 Publication | 1 | |
Modified residuei | 270 | Phosphoserine1 Publication | 1 | |
Modified residuei | 336 | Phosphoserine1 Publication | 1 | |
Modified residuei | 535 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q8MSX1 |
PTM databases
iPTMneti | Q8MSX1 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | FBgn0004875, Expressed in oocyte and 34 other tissues |
ExpressionAtlasi | Q8MSX1, baseline and differential |
Genevisiblei | Q8MSX1, DM |
Interactioni
Subunit structurei
Interacts with hfp; however, given the nuclear localization of hfp, the relevance of such interaction is unclear.
Interacts with CycE, Cul1, and the SCF-proteasome complex.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 69121, 31 interactors |
IntActi | Q8MSX1, 2 interactors |
STRINGi | 7227.FBpp0305410 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 444 – 508 | R3HPROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 510 – 576 | SUZPROSITE-ProRule annotationAdd BLAST | 67 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 47 – 68 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 123 – 282 | DisorderedSequence analysisAdd BLAST | 160 | |
Regioni | 317 – 413 | DisorderedSequence analysisAdd BLAST | 97 | |
Regioni | 557 – 806 | DisorderedSequence analysisAdd BLAST | 250 | |
Regioni | 885 – 916 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 936 – 959 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1176 – 1249 | DisorderedSequence analysisAdd BLAST | 74 | |
Regioni | 1332 – 1648 | DisorderedSequence analysisAdd BLAST | 317 | |
Regioni | 1684 – 1709 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 123 – 140 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 154 – 246 | Polar residuesSequence analysisAdd BLAST | 93 | |
Compositional biasi | 258 – 282 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 340 – 354 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 365 – 413 | Polar residuesSequence analysisAdd BLAST | 49 | |
Compositional biasi | 557 – 573 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 594 – 609 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 644 – 788 | Polar residuesSequence analysisAdd BLAST | 145 | |
Compositional biasi | 890 – 916 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1176 – 1234 | Polar residuesSequence analysisAdd BLAST | 59 | |
Compositional biasi | 1344 – 1359 | Pro residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1376 – 1390 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1400 – 1446 | Polar residuesSequence analysisAdd BLAST | 47 | |
Compositional biasi | 1489 – 1521 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 1577 – 1631 | Polar residuesSequence analysisAdd BLAST | 55 |
Phylogenomic databases
eggNOGi | KOG2953, Eukaryota |
GeneTreei | ENSGT00940000168363 |
InParanoidi | Q8MSX1 |
Family and domain databases
Gene3Di | 3.30.1370.50, 1 hit |
InterProi | View protein in InterPro IPR001374, R3H_dom IPR036867, R3H_dom_sf IPR024771, SUZ |
Pfami | View protein in Pfam PF01424, R3H, 1 hit PF12752, SUZ, 1 hit |
SMARTi | View protein in SMART SM00393, R3H, 1 hit |
SUPFAMi | SSF82708, SSF82708, 1 hit |
PROSITEi | View protein in PROSITE PS51061, R3H, 1 hit PS51673, SUZ, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSTKSQVAL ATNIPTNLSS AASASTAAAA AAVVVVASAN AAVASSANSS
60 70 80 90 100
GVGSGSGPGP GSGAGVSGPV AAGTATAVAT GSTVTAATSV AATTSTSVAT
110 120 130 140 150
ISTSCSSSSI NNINNNCGEE CQSAAGSSNL GRQNSFGNRR GNMKGKHLTR
160 170 180 190 200
SHAMRESTSP PRTPTPRAAS EQQQQQLQGE QHEHNNNNNI NSSSKAQSAG
210 220 230 240 250
RGNSPLMETP AVIVTSQQPQ QQQQQQQQQQ QSVPPKPQQN VPLSNEAEFP
260 270 280 290 300
KLSPPKKSGG QHNRTNSNGS GMEFNNNNNS SNKKFVVDMK ANGLDNKPHN
310 320 330 340 350
NSSTGVIFNS GMNYKAAERH DRHERHEMSS QNSNLSNNHD EEPYHYEPRG
360 370 380 390 400
GGGGKKHRAN TNAKGNKPRL KNLGGSSSGS IDLGGGGGNG NCNNMSNNGQ
410 420 430 440 450
SNNSSNNTSG FISRENSSEQ YTDYGGTDLL VFFRDTLNKN PKDRNILLKI
460 470 480 490 500
EKDLIDFVQE NSRGCEYRFP PASSYNRMLI HRTAAFFGME HNVDTETQQC
510 520 530 540 550
VIVAVAKNTR IPEIRFQSLV RDDARKSILK RDTHSFDEVR QSPYLCPLSL
560 570 580 590 600
DRKAKSFEER EEDYDRARSR IFSRTGGNHD GYSGGGGDEE CYGGWEQQQQ
610 620 630 640 650
QQKQSQPPRP KRPNGKMLQM QNSTESRDGM RSGGAVPKSH NFGNYGGPPS
660 670 680 690 700
SGGPGNNSLP RGDSTNSIKS GRGGFVKQDS TGSTPWRLSP SSSGSIYHYD
710 720 730 740 750
PSNLPPNQAL QHSGNQYQSQ NQGNSSSGGY NNYRKSSPHQ QQQSQQQQQS
760 770 780 790 800
QQHHQQQLQQ PQQLHQQSSQ QYATTELSCS STESYAEEEA QSPGMECSEG
810 820 830 840 850
YESYEQQSLP VQQQLSGNGD SASTKGDDCD SLASATACLS ITTSTSTKNY
860 870 880 890 900
DRIEVQKYKN QATSPNIPAC CAVGEKLELE AGLPQEQEQE PMAGPSSSGS
910 920 930 940 950
ATSSVGITEL PSSQTPLPMV NQVNCDLQSV SPSTTPYSQC EVKTPSQNHA
960 970 980 990 1000
PSAAVEEPKT TTWTYTQSYQ APDGSTVFHT TTTPNGAAPY CATTYQQGPD
1010 1020 1030 1040 1050
GSIYAVPQGM VYAAYPQPGV GTAGGASQPL FQLTTSSHPP AQTIFASPEA
1060 1070 1080 1090 1100
GAEIPGGTYM IPVFDPAQQP REGLIPAQAI YQTGPGGPGA TTVMPMATAA
1110 1120 1130 1140 1150
AYPTAQFATA APNGAPIYQA PLIYSSEPGG GAQLQQLPMA PYPIQYSYPY
1160 1170 1180 1190 1200
YHPISYYVPQ QAVAAAPMVA SQPQVGQAPM QQQAPHTGAG TTTGPPTVVS
1210 1220 1230 1240 1250
VSGQQHHQPH QQHHQQQQHS SNGSVVTSSA YGTRVKRTPG GGSIHYNPSY
1260 1270 1280 1290 1300
TPSSVAHAGG AHHPSAGSAQ IIAAPAASTT TYHALPTLTL AHGGPATGTD
1310 1320 1330 1340 1350
LSGAGGAHVY ALPAQHALIP TNIFPYAAAA AAAAGGPGGP PTTPQVVQQA
1360 1370 1380 1390 1400
PPPPPQSAPH HALITAAPFY PANGGNMDQG ASQSAPSTPA APGRQAPLFS
1410 1420 1430 1440 1450
TPPAPNNGSS GSSSAGGGGN SGGYHSNSST PHYYQGQNSN EGYTSPYEKR
1460 1470 1480 1490 1500
NHGGGASGAH SVGVRKPYHP GGYNPRHSVP LGGIPSGAKT PLLNSNNEPT
1510 1520 1530 1540 1550
PRASPSSVSL GGASSSGGAN SYPHRGPPPH TMGVKRDNKP NQLPLISGPP
1560 1570 1580 1590 1600
PSYAANSSPG VSSYESKPPV RLNAGAASFR SQKSMNQDYR RSVSQRNSPS
1610 1620 1630 1640 1650
ANGGGSGSHE SSNNSPNSIV GSQSNSAANT PNAAAPPPPQ PQPTLVSHSG
1660 1670 1680 1690 1700
GFVVLDQTTG AAMNASPPSL YGGGGGPNAG ISGGAGASGA AGSNGGHQPG
1710 1720 1730 1740 1750
GGGGARSHIP TAQLHHSAAA AAAAAAGSQQ ATAAVLSGVA AAAALGGYNP
1760 1770 1780 1790 1800
NGASGVYFKY GQTYFAHPSV ALPNSRRSPS NDIRPQMAQV AGMYPTMMIQ
1810
ARHPSRHPNP NYKGSRPR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8JNJ9 | A8JNJ9_DROME | Encore, isoform E | enc BB129, Dmel\CG10847, Enc, fs(3)63F-64A, CG10847 | 1,937 | Annotation score: | ||
M9PBM2 | M9PBM2_DROME | Encore, isoform G | enc BB129, Dmel\CG10847, Enc, fs(3)63F-64A, CG10847 | 1,798 | Annotation score: | ||
M9PE05 | M9PE05_DROME | Encore, isoform H | enc BB129, Dmel\CG10847, Enc, fs(3)63F-64A, CG10847 | 1,827 | Annotation score: | ||
M9PH77 | M9PH77_DROME | Encore, isoform F | enc BB129, Dmel\CG10847, Enc, fs(3)63F-64A, CG10847 | 1,942 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 118 | G → A in AAF68440 (PubMed:11044391).Curated | 1 | |
Sequence conflicti | 220 – 221 | Missing in AAF68440 (PubMed:11044391).Curated | 2 | |
Sequence conflicti | 251 – 252 | KL → NV in AAF68440 (PubMed:11044391).Curated | 2 | |
Sequence conflicti | 308 | F → Y in AAF68440 (PubMed:11044391).Curated | 1 | |
Sequence conflicti | 577 | G → D in AAF68440 (PubMed:11044391).Curated | 1 | |
Sequence conflicti | 580 | D → E in AAF68440 (PubMed:11044391).Curated | 1 | |
Sequence conflicti | 709 | A → G in AAF68440 (PubMed:11044391).Curated | 1 | |
Sequence conflicti | 882 | G → A in AAF68440 (PubMed:11044391).Curated | 1 | |
Sequence conflicti | 1044 | I → V in AAF68440 (PubMed:11044391).Curated | 1 | |
Sequence conflicti | 1105 | A → T in AAF68440 (PubMed:11044391).Curated | 1 | |
Sequence conflicti | 1523 | P → Q in AAF68440 (PubMed:11044391).Curated | 1 | |
Sequence conflicti | 1761 | G → V in AAX33393 (Ref. 4) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032690 | 414 | R → RVFHQS in isoform A. 1 Publication | 1 | |
Alternative sequenceiVSP_009327 | 1612 – 1800 | SNNSP…TMMIQ → GYNPNGASGVYFKYGQTYFA HPSVALPNSRRSPSNDIRPQ MAQVAGMYPTMMIQANDLHA SLP in isoform 2. 1 PublicationAdd BLAST | 189 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF243382 mRNA Translation: AAF68440.1 Different initiation. AE014296 Genomic DNA Translation: AAF47799.2 AE014296 Genomic DNA Translation: AAS64963.1 AE014296 Genomic DNA Translation: ABW08455.1 BT021245 mRNA Translation: AAX33393.1 BT050449 mRNA Translation: ACJ13156.1 AY118518 mRNA Translation: AAM49887.1 Different initiation. |
RefSeqi | NP_001097496.1, NM_001104026.2 [Q8MSX1-1] NP_524765.2, NM_080026.3 [Q8MSX1-1] NP_995992.1, NM_206270.2 [Q8MSX1-3] |
Genome annotation databases
EnsemblMetazoai | FBtr0073152; FBpp0073011; FBgn0004875 [Q8MSX1-1] FBtr0073153; FBpp0089267; FBgn0004875 [Q8MSX1-3] FBtr0112844; FBpp0111757; FBgn0004875 [Q8MSX1-1] |
GeneIDi | 44543 |
KEGGi | dme:Dmel_CG10847 |
UCSCi | CG10847-RA, d. melanogaster [Q8MSX1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF243382 mRNA Translation: AAF68440.1 Different initiation. AE014296 Genomic DNA Translation: AAF47799.2 AE014296 Genomic DNA Translation: AAS64963.1 AE014296 Genomic DNA Translation: ABW08455.1 BT021245 mRNA Translation: AAX33393.1 BT050449 mRNA Translation: ACJ13156.1 AY118518 mRNA Translation: AAM49887.1 Different initiation. |
RefSeqi | NP_001097496.1, NM_001104026.2 [Q8MSX1-1] NP_524765.2, NM_080026.3 [Q8MSX1-1] NP_995992.1, NM_206270.2 [Q8MSX1-3] |
3D structure databases
SMRi | Q8MSX1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 69121, 31 interactors |
IntActi | Q8MSX1, 2 interactors |
STRINGi | 7227.FBpp0305410 |
PTM databases
iPTMneti | Q8MSX1 |
Proteomic databases
PaxDbi | Q8MSX1 |
Genome annotation databases
EnsemblMetazoai | FBtr0073152; FBpp0073011; FBgn0004875 [Q8MSX1-1] FBtr0073153; FBpp0089267; FBgn0004875 [Q8MSX1-3] FBtr0112844; FBpp0111757; FBgn0004875 [Q8MSX1-1] |
GeneIDi | 44543 |
KEGGi | dme:Dmel_CG10847 |
UCSCi | CG10847-RA, d. melanogaster [Q8MSX1-1] |
Organism-specific databases
CTDi | 104374 |
FlyBasei | FBgn0004875, enc |
VEuPathDBi | VectorBase:FBgn0004875 |
Phylogenomic databases
eggNOGi | KOG2953, Eukaryota |
GeneTreei | ENSGT00940000168363 |
InParanoidi | Q8MSX1 |
Enzyme and pathway databases
SignaLinki | Q8MSX1 |
Miscellaneous databases
BioGRID-ORCSi | 44543, 0 hits in 3 CRISPR screens |
GenomeRNAii | 44543 |
PROi | PR:Q8MSX1 |
Gene expression databases
Bgeei | FBgn0004875, Expressed in oocyte and 34 other tissues |
ExpressionAtlasi | Q8MSX1, baseline and differential |
Genevisiblei | Q8MSX1, DM |
Family and domain databases
Gene3Di | 3.30.1370.50, 1 hit |
InterProi | View protein in InterPro IPR001374, R3H_dom IPR036867, R3H_dom_sf IPR024771, SUZ |
Pfami | View protein in Pfam PF01424, R3H, 1 hit PF12752, SUZ, 1 hit |
SMARTi | View protein in SMART SM00393, R3H, 1 hit |
SUPFAMi | SSF82708, SSF82708, 1 hit |
PROSITEi | View protein in PROSITE PS51061, R3H, 1 hit PS51673, SUZ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ENC_DROME | |
Accessioni | Q8MSX1Primary (citable) accession number: Q8MSX1 Secondary accession number(s): A8JNK0 Q9VZM1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 2, 2004 |
Last sequence update: | February 2, 2004 | |
Last modified: | February 23, 2022 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase