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Entry version 134 (16 Jan 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Symplekin

Gene

Sym

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a protein complex required for cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • mRNA 3'-end processing by stem-loop binding and cleavage Source: FlyBase
  • mRNA polyadenylation Source: FlyBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-109688 Cleavage of Growing Transcript in the Termination Region
R-DME-72163 mRNA Splicing - Major Pathway
R-DME-72187 mRNA 3'-end processing
R-DME-77595 Processing of Intronless Pre-mRNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SymplekinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sym
ORF Names:CG2097
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0037371 Sym

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004219781 – 1165SymplekinAdd BLAST1165

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8MSU4

PRoteomics IDEntifications database

More...
PRIDEi
Q8MSU4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0037371 Expressed in 31 organ(s), highest expression level in embryo

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8MSU4 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Cpsf73 and Cpsf100 forming a core cleavage factor required for both polyadenylated and histone mRNA processing. Interacts with Slbp and Lsm11.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
65914, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q8MSU4, 12 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0078372

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GS3X-ray2.40A19-270[»]
4IMIX-ray2.35A/C19-351[»]
4IMJX-ray2.58A/C19-351[»]
4YGXX-ray2.95A/C19-351[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8MSU4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8MSU4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8MSU4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati23 – 58HEAT 11 PublicationAdd BLAST36
Repeati61 – 95HEAT 21 PublicationAdd BLAST35
Repeati98 – 140HEAT 31 PublicationAdd BLAST43
Repeati147 – 186HEAT 41 PublicationAdd BLAST40
Repeati218 – 257HEAT 51 PublicationAdd BLAST40

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The HEAT repeats have been determined based on 3D-structure analysis and are not detected by sequence-based prediction programs.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Symplekin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1895 Eukaryota
ENOG410XQAS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017045

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000247061

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8MSU4

KEGG Orthology (KO)

More...
KOi
K06100

Identification of Orthologs from Complete Genome Data

More...
OMAi
LQGFTRH

Database of Orthologous Groups

More...
OrthoDBi
386749at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8MSU4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021850 Symplekin/Pta1
IPR032460 Symplekin/Pta1_N
IPR022075 Symplekin_C

The PANTHER Classification System

More...
PANTHERi
PTHR15245:SF20 PTHR15245:SF20, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11935 DUF3453, 1 hit
PF12295 Symplekin_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8MSU4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSIIGRSQF VSETANLFTD EKTATARAKV VDWCNELVIA SPSTKCELLA
60 70 80 90 100
KVQETVLGSC AELAEEFLES VLSLAHDSNM EVRKQVVAFV EQVCKVKVEL
110 120 130 140 150
LPHVINVVSM LLRDNSAQVI KRVIQACGSI YKNGLQYLCS LMEPGDSAEQ
160 170 180 190 200
AWNILSLIKA QILDMIDNEN DGIRTNAIKF LEGVVVLQSF ADEDSLKRDG
210 220 230 240 250
DFSLADVPDH CTLFRREKLQ EEGNNILDIL LQFHGTTHIS SVNLIACTSS
260 270 280 290 300
LCTIAKMRPI FMGAVVEAFK QLNANLPPTL TDSQVSSVRK SLKMQLQTLL
310 320 330 340 350
KNRGAFEFAS TIRGMLVDLG SSTNEIQKLI PKMDKQEMAR RQKRILENAA
360 370 380 390 400
QSLAKRARLA CEQQDQQQRE MELDTEELER QKQKSTRVNE KFLAEHFRNP
410 420 430 440 450
ETVVTLVLEF LPSLPTEVPQ KFLQEYTPIR EMSIQQQVTN ISRFFGEQLS
460 470 480 490 500
EKRLGPGAAT FSREPPMRVK KVQAIESTLT AMEVDEDAVQ KLSEEEFQRK
510 520 530 540 550
EEATKKLRET MERAKGEQTV IEKMKERAKT LKLQEITKPL PRNLKEKFLT
560 570 580 590 600
DAVRRILNSE RQCIKGGVSS KRRKLVTVIA ATFPDNVRYG IMEFILEDIK
610 620 630 640 650
QRIDLAFSWL FEEYSLLQGF TRHTYVKTEN RPDHAYNELL NKLIFGIGER
660 670 680 690 700
CDHKDKIILI RRVYLEAPIL PEVSIGHLVQ LSLDDEFSQH GLELIKDLAV
710 720 730 740 750
LRPPRKNRFV RVLLNFSVHE RLDLRDLAQA HLVSLYHVHK ILPARIDEFA
760 770 780 790 800
LEWLKFIEQE SPPAAVFSQD FGRPTEEPDW REDTTKVCFG LAFTLLPYKP
810 820 830 840 850
EVYLQQICQV FVSTSAELKR TILRSLDIPI KKMGVESPTL LQLIEDCPKG
860 870 880 890 900
METLVIRIIY ILTERVPSPH EELVRRVRDL YQNKVKDVRV MIPVLSGLTR
910 920 930 940 950
SELISVLPKL IKLNPAVVKE VFNRLLGIGA EFAHQTMAMT PTDILVALHT
960 970 980 990 1000
IDTSVCDIKA IVKATSLCLA ERDLYTQEVL MAVLQQLVEV TPLPTLMMRT
1010 1020 1030 1040 1050
TIQSLTLYPR LANFVMNLLQ RLIIKQVWRQ KVIWEGFLKT VQRLKPQSMP
1060 1070 1080 1090 1100
ILLHLPPAQL VDALQQCPDL RPALSEYAES MQDEPMNGSG ITQQVLDIIS
1110 1120 1130 1140 1150
GKSVDVFVTD ESGGYISAEH IKKEAPDPSE ISVISTVPVL TSLVPLPVPP
1160
PIGSDLNQPL PPGED
Length:1,165
Mass (Da):132,077
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFA818C50B2CC847
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF51962.2
AY118592 mRNA Translation: AAM49961.1

NCBI Reference Sequences

More...
RefSeqi
NP_649580.1, NM_141323.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.31227

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0078723; FBpp0078372; FBgn0037371

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40709

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG2097

UCSC genome browser

More...
UCSCi
CG2097-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF51962.2
AY118592 mRNA Translation: AAM49961.1
RefSeqiNP_649580.1, NM_141323.2
UniGeneiDm.31227

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GS3X-ray2.40A19-270[»]
4IMIX-ray2.35A/C19-351[»]
4IMJX-ray2.58A/C19-351[»]
4YGXX-ray2.95A/C19-351[»]
ProteinModelPortaliQ8MSU4
SMRiQ8MSU4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65914, 13 interactors
IntActiQ8MSU4, 12 interactors
STRINGi7227.FBpp0078372

Proteomic databases

PaxDbiQ8MSU4
PRIDEiQ8MSU4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078723; FBpp0078372; FBgn0037371
GeneIDi40709
KEGGidme:Dmel_CG2097
UCSCiCG2097-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
40709
FlyBaseiFBgn0037371 Sym

Phylogenomic databases

eggNOGiKOG1895 Eukaryota
ENOG410XQAS LUCA
GeneTreeiENSGT00390000017045
HOGENOMiHOG000247061
InParanoidiQ8MSU4
KOiK06100
OMAiLQGFTRH
OrthoDBi386749at2759
PhylomeDBiQ8MSU4

Enzyme and pathway databases

ReactomeiR-DME-109688 Cleavage of Growing Transcript in the Termination Region
R-DME-72163 mRNA Splicing - Major Pathway
R-DME-72187 mRNA 3'-end processing
R-DME-77595 Processing of Intronless Pre-mRNAs

Miscellaneous databases

EvolutionaryTraceiQ8MSU4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
40709

Protein Ontology

More...
PROi
PR:Q8MSU4

Gene expression databases

BgeeiFBgn0037371 Expressed in 31 organ(s), highest expression level in embryo
GenevisibleiQ8MSU4 DM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021850 Symplekin/Pta1
IPR032460 Symplekin/Pta1_N
IPR022075 Symplekin_C
PANTHERiPTHR15245:SF20 PTHR15245:SF20, 1 hit
PfamiView protein in Pfam
PF11935 DUF3453, 1 hit
PF12295 Symplekin_C, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYMPK_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MSU4
Secondary accession number(s): Q9VNH4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: October 1, 2002
Last modified: January 16, 2019
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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