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Entry version 125 (07 Oct 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Putative ferric-chelate reductase 1 homolog

Gene

CG8399

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative ferric-chelate reductases reduce Fe3+ to Fe2+ before its transport from the endosome to the cytoplasm.1 Publication

Caution

The cytochrome b561 domain lacks the conserved His residue that binds iron in the heme. The reductase activity is therefore unsure in vivo.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
5.B.2.2.3, the eukaryotic cytochrome b561 (cytb561) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative ferric-chelate reductase 1 homolog (EC:1.-.-.-)
Short name:
DmSDR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CG8399
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0034067, CG8399

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei408 – 428Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei452 – 472Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei480 – 500Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei515 – 535Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei548 – 568Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei616 – 636Helical; Name=7Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003148471 – 647Putative ferric-chelate reductase 1 homologAdd BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8MSU3

PRoteomics IDEntifications database

More...
PRIDEi
Q8MSU3

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8MSU3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0034067, Expressed in second segment of antenna (Drosophila) and 35 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8MSU3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8MSU3, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086349

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8MSU3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 195ReelinPROSITE-ProRule annotationAdd BLAST171
Domaini245 – 368DOMONPROSITE-ProRule annotationAdd BLAST124
Domaini372 – 570Cytochrome b561PROSITE-ProRule annotationAdd BLAST199

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FRRS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4293, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170494

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028305_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8MSU3

Identification of Orthologs from Complete Genome Data

More...
OMAi
PATDTHC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8MSU3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08544, Reeler, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.4060, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006593, Cyt_b561/ferric_Rdtase_TM
IPR005018, DOMON_domain
IPR002861, Reeler_dom
IPR042307, Reeler_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03188, Cytochrom_B561, 1 hit
PF03351, DOMON, 1 hit
PF02014, Reeler, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00665, B561, 1 hit
SM00664, DoH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50939, CYTOCHROME_B561, 1 hit
PS50836, DOMON, 1 hit
PS51019, REELIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8MSU3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMQALTMRSW LATLVTALLA VAIWPDPGQS LPQGAPETVC DTMLPFHSGG
60 70 80 90 100
SVLPQNSVSP FSVETSSSTL GQGQTLRVDL TGVPAGLSFG GYMIQARNRN
110 120 130 140 150
PPHQIIGQFG PARDGTIKLM NCENSVNNSA THSNAGPKQQ VILEWQSPVD
160 170 180 190 200
FLGQVVFNAT IAQSYNEFWV GVPSQPVQIV RRDLSAAPPL PTQSPSAPAG
210 220 230 240 250
TTRAPYVPPS YVAPNNVVAV SSDPIYNGCG QSKNCFGFPD GCVATKSCTS
260 270 280 290 300
ITVVTVRGDV FEFEIQSGKG TNAAYVAVGL SDDAKMGDDL TTECVPENGR
310 320 330 340 350
VNLYSSLTSA SPYSAVRSNV NQNSARLLDA SIVDGVIYCR VQRDAVTNVQ
360 370 380 390 400
GRTFDLRNGK YHLLVASGSS LKENSVGYHD IGRLPSAQPI NLAEVQDLSG
410 420 430 440 450
SSRLLIQLHG AFMIAAWIGT TSLGIIFARY FKQTWVGSQS CGTDQWFAWH
460 470 480 490 500
RLLMVTTWSL TVAAYVLIWV ELKQAVWHAH SIIGLITVIL CFIQPIGALF
510 520 530 540 550
RPGPNDKKRP YFNWGHWLGG NLAHILGIVT IFFSVKLPKA ELPEWMDWIL
560 570 580 590 600
VSFVVVHVLV HLIFSIGGMA SERHLSQRAN TFQMGDMSHH QQHAMRNGMS
610 620 630 640
MERKMDAPYA GMRKGLLGVY GVVLILFVTV LILLVVLAPI EQFLGKS
Length:647
Mass (Da):70,285
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBBBDD090AFDF301D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LGL5A0A0B4LGL5_DROME
Uncharacterized protein, isoform B
sdr2 anon-EST:ParkEST009, Dmel\CG8399, SDR2, CG8399, Dmel_CG8399
656Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58074.2
AY118595 mRNA Translation: AAM49964.1

NCBI Reference Sequences

More...
RefSeqi
NP_611079.2, NM_137235.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087207; FBpp0086349; FBgn0034067

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36768

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8399

UCSC genome browser

More...
UCSCi
CG8399-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58074.2
AY118595 mRNA Translation: AAM49964.1
RefSeqiNP_611079.2, NM_137235.3

3D structure databases

SMRiQ8MSU3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0086349

Protein family/group databases

TCDBi5.B.2.2.3, the eukaryotic cytochrome b561 (cytb561) family

PTM databases

SwissPalmiQ8MSU3

Proteomic databases

PaxDbiQ8MSU3
PRIDEiQ8MSU3

Genome annotation databases

EnsemblMetazoaiFBtr0087207; FBpp0086349; FBgn0034067
GeneIDi36768
KEGGidme:Dmel_CG8399
UCSCiCG8399-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0034067, CG8399

Phylogenomic databases

eggNOGiKOG4293, Eukaryota
GeneTreeiENSGT00940000170494
HOGENOMiCLU_028305_0_0_1
InParanoidiQ8MSU3
OMAiPATDTHC
PhylomeDBiQ8MSU3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36768, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36768

Protein Ontology

More...
PROi
PR:Q8MSU3

Gene expression databases

BgeeiFBgn0034067, Expressed in second segment of antenna (Drosophila) and 35 other tissues
ExpressionAtlasiQ8MSU3, baseline and differential
GenevisibleiQ8MSU3, DM

Family and domain databases

CDDicd08544, Reeler, 1 hit
Gene3Di2.60.40.4060, 1 hit
InterProiView protein in InterPro
IPR006593, Cyt_b561/ferric_Rdtase_TM
IPR005018, DOMON_domain
IPR002861, Reeler_dom
IPR042307, Reeler_sf
PfamiView protein in Pfam
PF03188, Cytochrom_B561, 1 hit
PF03351, DOMON, 1 hit
PF02014, Reeler, 1 hit
SMARTiView protein in SMART
SM00665, B561, 1 hit
SM00664, DoH, 1 hit
PROSITEiView protein in PROSITE
PS50939, CYTOCHROME_B561, 1 hit
PS50836, DOMON, 1 hit
PS51019, REELIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRRS1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MSU3
Secondary accession number(s): Q9V7I1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: October 7, 2020
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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