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UniProtKB - Q8MS69 (Q8MS69_DROME)
Protein
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
Gene
Dmel\CG9596
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
UniRule annotationGO - Biological processi
- tRNA methylation Source: InterPro
Keywordsi
Biological process | tRNA processingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6UniRule annotationARBA annotation |
Gene namesi | Name:Dmel\CG9596Imported ORF Names:CG9596Imported, Dmel_CG9596Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0031832, CG9596 |
VEuPathDBi | VectorBase:FBgn0031832 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- nucleus Source: GO_Central
Other locations
- tRNA (m1A) methyltransferase complex Source: GO_Central
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0031832, Expressed in multi-cellular organism and 50 other tissues |
Interactioni
Subunit structurei
Heterotetramer.
UniRule annotationProtein-protein interaction databases
IntActi | Q8MS69, 2 interactors |
STRINGi | 7227.FBpp0078961 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 284 – 339 | DisorderedSequence analysisAdd BLAST | 56 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 118 – 138 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 294 – 311 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 312 – 339 | Basic and acidic residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG1416, Eukaryota |
GeneTreei | ENSGT00390000008327 |
HOGENOMi | CLU_010916_0_3_1 |
OMAi | TFHNRTE |
OrthoDBi | 543764at2759 |
Family and domain databases
Gene3Di | 3.40.50.150, 1 hit |
InterProi | View protein in InterPro IPR029063, SAM-dependent_MTases IPR017423, TRM6 |
PANTHERi | PTHR12945, PTHR12945, 1 hit |
Pfami | View protein in Pfam PF04189, Gcd10p, 1 hit |
PIRSFi | PIRSF038170, tRNA_m1A_mtfrase, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8MS69-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATEEDIPRI QLGDYIVIQR QKYTKLQKFG SLDTTATLGK ETLELKSLLD
60 70 80 90 100
QPYGSTFKMC VKETKPGKRG AQRQHTLELC SETELRSTRE VLGISSSGAD
110 120 130 140 150
NRDIRDDGEA QTLKPEDIAQ LREECNDSSK IIEKLVENSK TFHNRTEYSQ
160 170 180 190 200
EKYLLKKEKK YFEFVQIRQP TIRLMLDIFY RQDSEKVMGI RVDTLSQIIS
210 220 230 240 250
YSGVCGFGSY LLYESGTNGL LPAAMLNSIG AGTEGTLVHM HPGNVPQKQA
260 270 280 290 300
LSALKLPLEQ QQRCVSVNLY SVLREFYQGG DAKATDIPVV EPSENEPQET
310 320 330 340 350
QLETPTEEQP EAIEPTTKKP KLDESNSGRE GAKGPPRWHL ENKRATALMH
360 370 380 390 400
AEFDSLVVAA KEHPSNILQA LLPLVKPSRP VVVFSTCKEL LQETFMELKT
410 420 430 440
TGKVTGLHLT SNWLRTYQIL PNRTHPEVNM SGNSGYLLTG YTLR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF52404.2 AY119050 mRNA Translation: AAM50910.1 AE014134 Genomic DNA Translation: AAS64646.1 AE014134 Genomic DNA Translation: AHN54194.1 |
RefSeqi | NP_001285679.1, NM_001298750.1 NP_609048.2, NM_135204.3 NP_995638.1, NM_205916.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0079332; FBpp0078961; FBgn0031832 FBtr0343162; FBpp0309857; FBgn0031832 FBtr0343163; FBpp0309858; FBgn0031832 |
GeneIDi | 33920 |
KEGGi | dme:Dmel_CG9596 |
UCSCi | CG9596-RB, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF52404.2 AY119050 mRNA Translation: AAM50910.1 AE014134 Genomic DNA Translation: AAS64646.1 AE014134 Genomic DNA Translation: AHN54194.1 |
RefSeqi | NP_001285679.1, NM_001298750.1 NP_609048.2, NM_135204.3 NP_995638.1, NM_205916.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q8MS69, 2 interactors |
STRINGi | 7227.FBpp0078961 |
Genome annotation databases
EnsemblMetazoai | FBtr0079332; FBpp0078961; FBgn0031832 FBtr0343162; FBpp0309857; FBgn0031832 FBtr0343163; FBpp0309858; FBgn0031832 |
GeneIDi | 33920 |
KEGGi | dme:Dmel_CG9596 |
UCSCi | CG9596-RB, d. melanogaster |
Organism-specific databases
FlyBasei | FBgn0031832, CG9596 |
VEuPathDBi | VectorBase:FBgn0031832 |
Phylogenomic databases
eggNOGi | KOG1416, Eukaryota |
GeneTreei | ENSGT00390000008327 |
HOGENOMi | CLU_010916_0_3_1 |
OMAi | TFHNRTE |
OrthoDBi | 543764at2759 |
Miscellaneous databases
BioGRID-ORCSi | 33920, 1 hit in 1 CRISPR screen |
GenomeRNAii | 33920 |
Gene expression databases
Bgeei | FBgn0031832, Expressed in multi-cellular organism and 50 other tissues |
Family and domain databases
Gene3Di | 3.40.50.150, 1 hit |
InterProi | View protein in InterPro IPR029063, SAM-dependent_MTases IPR017423, TRM6 |
PANTHERi | PTHR12945, PTHR12945, 1 hit |
Pfami | View protein in Pfam PF04189, Gcd10p, 1 hit |
PIRSFi | PIRSF038170, tRNA_m1A_mtfrase, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8MS69_DROME | |
Accessioni | Q8MS69Primary (citable) accession number: Q8MS69 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 1, 2002 |
Last sequence update: | October 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |