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Entry version 156 (16 Oct 2019)
Sequence version 2 (02 Feb 2004)
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Protein

Brain tumor protein

Gene

brat

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A NHL-domain family protein that functions a translational repressor to inhibit cell proliferation (PubMed:11274060). Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR (PubMed:11274060). Probably recruited by other proteins to repress translation of other mRNAs in other tissues (PubMed:11274060). Involved in the regulation of ribosomal RNA synthesis and cell growth (PubMed:11807032). Participates in abdominal segmentation and imaginal disk development (PubMed:11274060). During neuroblast division, segregates asymmetrically and inhibits self-renewal of one of the two daughter cells (PubMed:16564014). Together with the asymmetrically segregating transcription factor prospero ensures that the daughter cell will stop growing, exit the cell cycle, and differentiate into neurons possibly by modulating the function of dm in ganglion mother cells (GMC) (PubMed:11807032, PubMed:16564014). Restrics developmental potential of type II intermediary neuronal progenitor (INP) cells playing a role in proliferation and maturation of the neuroblasts (PubMed:24550111, PubMed:14561773, PubMed:22143802, PubMed:18342578).7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri174 – 222B box-type 1PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri323 – 366B box-type 2PROSITE-ProRule annotationAdd BLAST44

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranslation regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Brain tumor protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:brat
ORF Names:CG10719
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0010300 brat

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

In larval brain, results in deregulated cell cycle and defective differentiation of immature intermediate neuroblast progenitors ultimately leading to overgrowth and proliferation (PubMed:16564014, PubMed:18342578). RNAi-mediated knockdown in the larval brain results in overproliferation of type II neuroblast cells on the dorsal side of the larval brains but had no effect in the type I neuroblast lineage in the ventral nerve cord (PubMed:22143802, PubMed:18342578).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi802H → L in bratfs3; induces production of tumor-like neoplasms in the larval brain. Disrupts interaction with nos and pum. 1
Mutagenesisi829Y → A: Disrupts recruitment by pum. 1 Publication1
Mutagenesisi847R → A: Disrupts recruitment by pum. 1 Publication1
Mutagenesisi859Y → A: Does not affect recruitment by pum. 1 Publication1
Mutagenesisi860G → D in bratts1; induces production of tumor-like neoplasms in the larval brain. Disrupts interaction with nos and pum. 1
Mutagenesisi875R → A: Disrupts recruitment by pum. 1 Publication1
Mutagenesisi970E → A: Does not affect recruitment by pum. 1 Publication1
Mutagenesisi1012D → A: Does not affect recruitment by pum. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002203681 – 1037Brain tumor proteinAdd BLAST1037

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8MQJ9

PRoteomics IDEntifications database

More...
PRIDEi
Q8MQJ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed during embryogenesis, mainly in nervous tissues. Expressed in the embryonic central and peripheral nervous systems including the embryonic brain. In third instar larva it is expressed in the larval central nervous system including the brain and the ventral ganglion, in two glands (the ring gland and the salivary gland, and in parts of the foregut) the gastric caeca and the proventriculus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0010300 Expressed in 61 organ(s), highest expression level in cleaving embryo

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8MQJ9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8MQJ9 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with nos and pum (PubMed:11274060). Acts via the formation of a quaternary complex composed of pum, nos, brat and the 3'-UTR mRNA of hb (PubMed:11274060). Not recruited by nos and pum to cyclin B 3'-UTR mRNA (PubMed:11274060). Might interact with mira; the interaction seems to be important for brat localization during mitosis (PubMed:16564014).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q27IR04EBI-414123,EBI-15707124

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
61181, 54 interactors

Database of interacting proteins

More...
DIPi
DIP-37857N

Protein interaction database and analysis system

More...
IntActi
Q8MQJ9, 4 interactors

Molecular INTeraction database

More...
MINTi
Q8MQJ9

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0293081

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11037
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8MQJ9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8MQJ9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati767 – 810NHL 1Add BLAST44
Repeati814 – 859NHL 2Add BLAST46
Repeati860 – 901NHL 3Add BLAST42
Repeati902 – 944NHL 4Add BLAST43
Repeati945 – 988NHL 5Add BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 175Ser-richAdd BLAST173
Compositional biasi259 – 325Gln-richAdd BLAST67
Compositional biasi579 – 600His-richAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The NHL repeats form six-bladed beta-propeller that mediate the interaction with the pumilio repeats of pum, and are essential for translational effector function.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri174 – 222B box-type 1PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri323 – 366B box-type 2PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2177 Eukaryota
ENOG410XQJ4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170685

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8MQJ9

KEGG Orthology (KO)

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KOi
K11997

Identification of Orthologs from Complete Genome Data

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OMAi
IYRYVQV

Database of Orthologous Groups

More...
OrthoDBi
489543at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8MQJ9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00021 BBOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001258 NHL_repeat
IPR013017 NHL_repeat_subgr
IPR000315 Znf_B-box

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01436 NHL, 4 hits
PF00643 zf-B_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00336 BBOX, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51125 NHL, 5 hits
PS50119 ZF_BBOX, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8MQJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSPTPSLD SMRGGANSIE SYEHAGYLSD SPLTLSGSSP PASDSAICSD
60 70 80 90 100
EYTGGSSVKS RSEVTVINGH HPISASVSSS SSASSSSCSS SSSSSSSSSS
110 120 130 140 150
SSSSTSGLSG CGSTSSSVIS ANNVASSNGP GVIGSNLQSS NNGGNSGISS
160 170 180 190 200
LVVGAGKGSN SSSNSSSSNT SANGSPPRCT ACKSKCSDAV AKCFECQSYL
210 220 230 240 250
CANCVTAHEF MHCFNGHNVC LIKGFEASTT GTPLSVGSPS NNPASNEFKY
260 270 280 290 300
ASSLTMMLQQ QQQLDSQQQQ QQQQLLPAQP MSQLSKIVLA AAAQANSQEQ
310 320 330 340 350
QREDSIYGSL HPQQQQQQQQ QQQRQLFCPR HKQELLKFSC RTCCILVCKE
360 370 380 390 400
CIVLEHSTGL HELENVQSPG MTTSTGSTAN ESALQTLLAD MRGKIGEIVG
410 420 430 440 450
IAGNSDQNLT KVKLQYQKAH NELNETHQFF ASMLDERKTE LLKELETLYT
460 470 480 490 500
AKVNSNNSWQ QRSRDLIDKG LATCEAVERS PAPPSSLLTE ALLLRKSLEQ
510 520 530 540 550
QLQTGIQEMQ LPFEIEFMSN YQSIQAGVRN TFGYIRANSS DGGPTGMSLT
560 570 580 590 600
SNGHGKQPPI ARPTQSASNS SASSAGSGHH GHHQQSHHHG HHNHHQTAHH
610 620 630 640 650
QQLQAQSSLH GLGLGLSGAS LLDSSSSAGG AVGAFSNGGL LLGGRDRNAL
660 670 680 690 700
AVEQHFGELM PKRGGGGYTG SNGSATSAVA HYNPYEKWSN GGSDNLFSSV
710 720 730 740 750
TSGVSGSSAV ADAFASLSAV GGSVVSGAGA GGSTVSSESL LDLTNKLLSA
760 770 780 790 800
TIYPPKSQIK RQKMIYHCKF GEFGVMEGQF TEPSGVAVNA QNDIIVADTN
810 820 830 840 850
NHRIQIFDKE GRFKFQFGEC GKRDSQLLYP NRVAVVRNSG DIIVTERSPT
860 870 880 890 900
HQIQIYNQYG QFVRKFGATI LQHPRGVTVD NKGRIIVVEC KVMRVIIFDQ
910 920 930 940 950
NGNVLHKFGC SKHLEFPNGV VVNDKQEIFI SDNRAHCVKV FNYEGQYLRQ
960 970 980 990 1000
IGGEGITNYP IGVGINSNGE ILIADNHNNF NLTIFTQDGQ LISALESKVK
1010 1020 1030
HAQCFDVALM DDGSVVLASK DYRLYIYRYV QLAPVGM
Length:1,037
Mass (Da):110,366
Last modified:February 2, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B829CD924139DDF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E8NHB3E8NHB3_DROME
Brain tumor, isoform F
brat anon-37CDa, BRAT, Brat, brat-RA, Cf
1,037Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9MSJ1M9MSJ1_DROME
Brain tumor, isoform E
brat anon-37CDa, BRAT, Brat, Cf, Dmel\CG10719
1,061Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM76183 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti591H → Y in ABA86472 (PubMed:16120803).Curated1
Sequence conflicti643G → S in AAF13928 (PubMed:10949924).Curated1
Sequence conflicti643G → S in AAF13929 (PubMed:10949924).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF119332 mRNA Translation: AAF03086.1
AF195870 Genomic DNA Translation: AAF13926.1
AF195871 Genomic DNA Translation: AAF13927.1
AF195872 Genomic DNA Translation: AAF13928.1
AF195873 Genomic DNA Translation: AAF13929.1
AB022432 mRNA Translation: BAA82071.1
AE014134 Genomic DNA Translation: AAN11027.1
AE014134 Genomic DNA Translation: AAS64719.1
AY122207 mRNA Translation: AAM52719.1
AY129441 mRNA Translation: AAM76183.1 Different initiation.
DQ138866 Genomic DNA Translation: ABA86472.1

NCBI Reference Sequences

More...
RefSeqi
NP_001286083.1, NM_001299154.1
NP_476945.1, NM_057597.4
NP_599129.1, NM_134302.2
NP_995726.1, NM_206004.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081158; FBpp0080702; FBgn0010300
FBtr0081159; FBpp0080703; FBgn0010300
FBtr0081160; FBpp0089239; FBgn0010300
FBtr0344846; FBpp0311161; FBgn0010300

Database of genes from NCBI RefSeq genomes

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GeneIDi
35197

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG10719

UCSC genome browser

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UCSCi
CG10719-RC d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119332 mRNA Translation: AAF03086.1
AF195870 Genomic DNA Translation: AAF13926.1
AF195871 Genomic DNA Translation: AAF13927.1
AF195872 Genomic DNA Translation: AAF13928.1
AF195873 Genomic DNA Translation: AAF13929.1
AB022432 mRNA Translation: BAA82071.1
AE014134 Genomic DNA Translation: AAN11027.1
AE014134 Genomic DNA Translation: AAS64719.1
AY122207 mRNA Translation: AAM52719.1
AY129441 mRNA Translation: AAM76183.1 Different initiation.
DQ138866 Genomic DNA Translation: ABA86472.1
RefSeqiNP_001286083.1, NM_001299154.1
NP_476945.1, NM_057597.4
NP_599129.1, NM_134302.2
NP_995726.1, NM_206004.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q7FX-ray1.95A/B756-1037[»]
4ZLRX-ray2.30A/B756-1037[»]
5EX7X-ray2.60A758-1037[»]
6J9RX-ray2.50A/B376-511[»]
SMRiQ8MQJ9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi61181, 54 interactors
DIPiDIP-37857N
IntActiQ8MQJ9, 4 interactors
MINTiQ8MQJ9
STRINGi7227.FBpp0293081

Proteomic databases

PaxDbiQ8MQJ9
PRIDEiQ8MQJ9

Genome annotation databases

EnsemblMetazoaiFBtr0081158; FBpp0080702; FBgn0010300
FBtr0081159; FBpp0080703; FBgn0010300
FBtr0081160; FBpp0089239; FBgn0010300
FBtr0344846; FBpp0311161; FBgn0010300
GeneIDi35197
KEGGidme:Dmel_CG10719
UCSCiCG10719-RC d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
35197
FlyBaseiFBgn0010300 brat

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG410XQJ4 LUCA
GeneTreeiENSGT00940000170685
InParanoidiQ8MQJ9
KOiK11997
OMAiIYRYVQV
OrthoDBi489543at2759
PhylomeDBiQ8MQJ9

Enzyme and pathway databases

ReactomeiR-DME-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
brat fly
EvolutionaryTraceiQ8MQJ9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
35197

Protein Ontology

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PROi
PR:Q8MQJ9

Gene expression databases

BgeeiFBgn0010300 Expressed in 61 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiQ8MQJ9 baseline and differential
GenevisibleiQ8MQJ9 DM

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001258 NHL_repeat
IPR013017 NHL_repeat_subgr
IPR000315 Znf_B-box
PfamiView protein in Pfam
PF01436 NHL, 4 hits
PF00643 zf-B_box, 1 hit
SMARTiView protein in SMART
SM00336 BBOX, 2 hits
PROSITEiView protein in PROSITE
PS51125 NHL, 5 hits
PS50119 ZF_BBOX, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRAT_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MQJ9
Secondary accession number(s): A4V0U9
, Q0E8P2, Q2XXZ6, Q8MR02, Q9U633, Q9U634, Q9U635, Q9U636, Q9Y1W4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: October 16, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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