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UniProtKB - Q8MQ74 (Q8MQ74_CAEEL)
Protein
Submitted name:
PHB domain-containing protein
Gene
mec-2
Organism
Caenorhabditis elegans
Status
Functioni
GO - Biological processi
- mechanosensory behavior Source: WormBase
- response to mechanical stimulus Source: WormBase
Names & Taxonomyi
Protein namesi | Submitted name: PHB domain-containing proteinImported |
Gene namesi | Name:mec-2Imported ORF Names:CELE_F14D12.4Imported, F14D12.4Imported |
Organismi | Caenorhabditis elegansImported |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F14D12.4b ; CE30952 ; WBGene00003166 ; mec-2 |
Subcellular locationi
Plasma Membrane
- neuron projection membrane Source: WormBase
Other locations
- integral component of membrane Source: UniProtKB-KW
- neuron projection Source: WormBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 114 – 135 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | WBGene00003166, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues |
ExpressionAtlasi | Q8MQ74, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 139 – 298 | PHBInterPro annotationAdd BLAST | 160 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 67 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 80 – 104 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 84 – 104 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the band 7/mec-2 family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT01030000234614 |
Family and domain databases
Gene3Di | 3.30.479.30, 1 hit |
InterProi | View protein in InterPro IPR043202, Band-7_stomatin-like IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR018080, Band_7/stomatin-like_CS IPR001972, Stomatin_HflK_HflKC_fam |
PANTHERi | PTHR10264, PTHR10264, 1 hit |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit |
PRINTSi | PR00721, STOMATIN |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit |
PROSITEi | View protein in PROSITE PS01270, BAND_7, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
Q8MQ74-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSATMSSARN SVVSLSSNGS VKVETRLVSN ERSSSIQQEG AMLPSSSSKD
60 70 80 90 100
DDLLSTSSDE VENMATRTLQ QLEESTSIIS ANSDDDSVKK EKQAEKDVEK
110 120 130 140 150
GNGKEEKANI QNEFGVCGWI LTILSYLLIF FTLPISACMC IKVVQEYERA
160 170 180 190 200
VIFRLGRLMP GGAKGPGIFF IVPCIDTYRK VDLRVLSFEV PPQEILSKDS
210 220 230 240 250
VTVAVDAVVY FRISNATISV TNVEDAARST KLLAQTTLRN ILGTKTLAEM
260 270 280 290 300
LSDREAISHQ MQTTLDEATE PWGVKVERVE VKDVRLPVQL QRAMAAEAEA
310 320 330 340 350
AREARAKVIV AEGEQKASRA LKEAAEVIAE SPSALQLRYL QTLNSISAEK
360 370 380 390
NSTIIFPFPI DLLSAFLQRT PPKVDNNFAF PTHKAGGIPS SS
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ27433 | MEC2_CAEEL | Mechanosensory protein 2 | mec-2 F14D12.4 | 481 | Annotation score: | ||
H2KZ92 | H2KZ92_CAEEL | PHB domain-containing protein | mec-2 CELE_F14D12.4, F14D12.4 | 317 | Annotation score: | ||
A0A3B1DQJ7 | A0A3B1DQJ7_CAEEL | PHB domain-containing protein | mec-2 CELE_F14D12.4, F14D12.4 | 399 | Annotation score: | ||
A0A3B1DVR7 | A0A3B1DVR7_CAEEL | PHB domain-containing protein | mec-2 CELE_F14D12.4, F14D12.4 | 1,180 | Annotation score: | ||
A0A3B1DVV1 | A0A3B1DVV1_CAEEL | PHB domain-containing protein | mec-2 CELE_F14D12.4, F14D12.4 | 1,172 | Annotation score: | ||
A0A3B1E057 | A0A3B1E057_CAEEL | PHB domain-containing protein | mec-2 CELE_F14D12.4, F14D12.4 | 1,239 | Annotation score: | ||
A0A3B1E3V6 | A0A3B1E3V6_CAEEL | PHB domain-containing protein | mec-2 CELE_F14D12.4, F14D12.4 | 422 | Annotation score: | ||
A0A3B1E3Y0 | A0A3B1E3Y0_CAEEL | PHB domain-containing protein | mec-2 CELE_F14D12.4, F14D12.4 | 1,164 | Annotation score: | ||
A0A3B1E532 | A0A3B1E532_CAEEL | PHB domain-containing protein | mec-2 CELE_F14D12.4, F14D12.4 | 333 | Annotation score: | ||
A0A3B1E553 | A0A3B1E553_CAEEL | PHB domain-containing protein | mec-2 CELE_F14D12.4, F14D12.4 | 414 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284606 Genomic DNA Translation: CCD83469.1 |
RefSeqi | NP_001024566.1, NM_001029395.2 |
Genome annotation databases
EnsemblMetazoai | F14D12.4b.1; F14D12.4b.1; WBGene00003166 |
GeneIDi | 180826 |
UCSCi | F14D12.4a, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284606 Genomic DNA Translation: CCD83469.1 |
RefSeqi | NP_001024566.1, NM_001029395.2 |
3D structure databases
SMRi | Q8MQ74 |
ModBasei | Search... |
Genome annotation databases
EnsemblMetazoai | F14D12.4b.1; F14D12.4b.1; WBGene00003166 |
GeneIDi | 180826 |
UCSCi | F14D12.4a, c. elegans |
Organism-specific databases
CTDi | 180826 |
WormBasei | F14D12.4b ; CE30952 ; WBGene00003166 ; mec-2 |
Phylogenomic databases
GeneTreei | ENSGT01030000234614 |
Gene expression databases
Bgeei | WBGene00003166, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues |
ExpressionAtlasi | Q8MQ74, baseline and differential |
Family and domain databases
Gene3Di | 3.30.479.30, 1 hit |
InterProi | View protein in InterPro IPR043202, Band-7_stomatin-like IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR018080, Band_7/stomatin-like_CS IPR001972, Stomatin_HflK_HflKC_fam |
PANTHERi | PTHR10264, PTHR10264, 1 hit |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit |
PRINTSi | PR00721, STOMATIN |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit |
PROSITEi | View protein in PROSITE PS01270, BAND_7, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8MQ74_CAEEL | |
Accessioni | Q8MQ74Primary (citable) accession number: Q8MQ74 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 1, 2002 |
Last sequence update: | October 1, 2002 | |
Last modified: | September 29, 2021 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |