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Entry version 139 (18 Sep 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Homeodomain-interacting protein kinase 1

Gene

hpk-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase required in the somatic gonadal cells to regulate germline proliferation during larval development and in adulthood (PubMed:23904186). Plays a role in the development/differentiation of gonadal distal tip cells (PubMed:23904186). Required for normal lifespan in a pha-4 and mxl-2-dependent manner (PubMed:26791749, PubMed:29036198). Also contributes to survival following heat or oxidative stress (PubMed:26791749). Prevents sumoylation and inactivation of heat shock transcription factor hsf-1 which enhances hsf-1-dependent transcriptional induction of chaperones in response to heat shock (PubMed:29036198). Also required for hormetic extension of longevity in response to heat stress (PubMed:29036198). Provides protection against polyglutamine aggregate formation and associated locomotory toxicity (PubMed:29036198). Also contributes to longevity by promoting autophagy under nutrient stress conditions through induction of autophagosome formation and autophagy gene expression (PubMed:29036198).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei176ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei272Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi153 – 161ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processAutophagy
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-3899300 SUMOylation of transcription cofactors
R-CEL-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8MQ70

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeodomain-interacting protein kinase 11 Publication (EC:2.7.11.1By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hpk-1Imported
ORF Names:F20B6.8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
F20B6.8a ; CE04430 ; WBGene00001994 ; hpk-1
F20B6.8b ; CE30961 ; WBGene00001994 ; hpk-1
F20B6.8c ; CE30962 ; WBGene00001994 ; hpk-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Enhanced sensitivity to heat and oxidative stress with reduced survival under both conditions (PubMed:26791749, PubMed:29036198). Following exposure to gamma irradiation, no effect on DNA damage response in the germline but significantly reduced embryonic survival (PubMed:26791749). Significantly reduced lifespan with a more rapid decline in body movement and pharyngeal pumping, indicative of accelerated aging (PubMed:26791749, PubMed:29036198). Premature accumulation of polyglutamine aggregates and increased polyglutamine-associated paralysis at day 8 of adulthood (PubMed:29036198). RNAi-mediated knockdown results in small and underdeveloped germlines with a reduction in the number of cells in G2/M stages (PubMed:23904186). RNAi-mediated knockdown from the L1 larval stage onwards results in shortened lifespan while RNAi-mediated knockdown initiated at the L4 larval stage decreases lifespan to a smaller but significant extent (PubMed:29036198). RNAi-mediated knockdown in the intestine, hypodermis or neurons reduces lifespan while RNAi-mediated knockdown in muscle cells does not (PubMed:29036198).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004329991 – 846Homeodomain-interacting protein kinase 1Add BLAST846

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8MQ70

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8MQ70

PeptideAtlas

More...
PeptideAtlasi
Q8MQ70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed during embryogenesis (PubMed:12618396, PubMed:29036198). Expression becomes more restricted during larval development (PubMed:29036198). L3 larvae display robust expression in many head and motor neurons, and lower levels of expression in the intestine and the seam cells of the hypodermis (PubMed:29036198). By late L4 stage, expression is largely restricted to neurons and is maintained in nerve cells of the head and nerve cord during adulthood (PubMed:29036198). Expressed in adult pharyngeal cells, hypodermal cells, gonadal sheath cells and distal tip cells but not in germline cells (PubMed:23904186).3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by heat stress (PubMed:23904186, PubMed:26791749, PubMed:29036198). Transcription from the hpk-1 promoter is not altered by heat shock treatment, suggesting that heat shock affects hpk-1 levels through a post-transcriptional mechanism (PubMed:26791749). Induction is greatest in hypodermal seam cells and neurons with much lower levels of induction in intestinal cells (PubMed:29036198).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001994 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q8MQ70, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.F20B6.8b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8MQ70

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini147 – 483Protein kinasePROSITE-ProRule annotationAdd BLAST337

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi719 – 726Poly-GlnSequence analysis8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0667 Eukaryota
ENOG410XPET LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164472

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000020268

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8MQ70

KEGG Orthology (KO)

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KOi
K08826

Identification of Orthologs from Complete Genome Data

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OMAi
EVLCSPY

Database of Orthologous Groups

More...
OrthoDBi
369079at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8MQ70

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform bImported (identifier: Q8MQ70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPKRKNSGQS TDLNSRSPKT IDEALRILAP PQALLVQSQL NLTAPANPFS
60 70 80 90 100
IQKAPGTSSD NEQRAPKRRA DEEAVNAVPK NLLTTSSTFA RAVIPAAPAI
110 120 130 140 150
SSANNKMAPQ SVTATAKTTT NRGKVSGEGE YQLIKNEVLC SPYGNQYEVL
160 170 180 190 200
EFLGKGTFGQ VVKAWKKGTS EIVAIKILKK HPSYARQGQI EVSILSRLSN
210 220 230 240 250
ENSEEFNFVR AFECFNHKSH TCLVFEMLEQ NLYDFLKQNK FMPLPLNAIR
260 270 280 290 300
PILFQVLTAL LKLKSLGLIH ADLKPENIML VDPQQQPYRV KVIDFGSASH
310 320 330 340 350
RSKAVTNTYL QSRYYRAPEI ILGLPFNESI DMWSLGCVIA ELFLGWPLYP
360 370 380 390 400
GSSEYDQIRF IIQTQGLPPT SMLESASKLH RFFKEVKSES PNHTNVGGSY
410 420 430 440 450
YRLKTVEEYE ASSSTAKSKE TRKYIFNVID DISRVCYGFE SDPVEHLCDR
460 470 480 490 500
IDRQEFVDVL KKMLVLNPDF RITPAEGLES KFVTMTHING YNFANYVHEA
510 520 530 540 550
HKRMEICRKP GPAMATPYRA ANVATPITPV EKPPAPKLQQ PMIAVLPQLN
560 570 580 590 600
QIAATNIPPV PTQPDLTNLM HHYSQMAAAT GSAATAAQFF YQPLPPAPLF
610 620 630 640 650
QYAQLHHPFA ARPPHFLSLA TPSHMVPQFV PVPIMDPSML QGQWPPGAAQ
660 670 680 690 700
QFAVLANDIM RVPAPQGINQ MFASTPQTFS LPQFLSSSIP SATTAFNGNA
710 720 730 740 750
PNIPFPEENS SWALGTAAQQ QQQQAQRAQS MINGNVKVKP LAAQPKKNSP
760 770 780 790 800
APSVITLSSD EDSNGAGSSN SGSTTRTGAV NPVRNDTLPM GNTIKTEDIL
810 820 830 840
VPPTTFDGQL PNLQYFPGSH LFDPKTVAGL LPNPFLDTSH IPRAFN
Note: No experimental confirmation available.Curated
Length:846
Mass (Da):93,228
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i946D937A5F568951
GO
Isoform aImported (identifier: Q8MQ70-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MPKRKNSGQS...TAPANPFSIQ → MNFHFTLDNDRKRRRSLSIDIDINFND

Note: No experimental confirmation available.Curated
Show »
Length:821
Mass (Da):90,925
Checksum:iFAC3892BAED52606
GO
Isoform cImported (identifier: Q8MQ70-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:740
Mass (Da):81,987
Checksum:i5A21935994F2BF84
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0576411 – 106Missing in isoform c. CuratedAdd BLAST106
Alternative sequenceiVSP_0576421 – 52MPKRK…PFSIQ → MNFHFTLDNDRKRRRSLSID IDINFND in isoform a. CuratedAdd BLAST52

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO081186 Genomic DNA Translation: CCD69762.1
FO081186 Genomic DNA Translation: CCD69761.1
FO081186 Genomic DNA Translation: CCD69763.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T34232

NCBI Reference Sequences

More...
RefSeqi
NP_741761.1, NM_171662.5 [Q8MQ70-1]
NP_741762.1, NM_171663.1 [Q8MQ70-2]
NP_741763.1, NM_171664.5 [Q8MQ70-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F20B6.8a.1; F20B6.8a.1; WBGene00001994 [Q8MQ70-2]
F20B6.8b.1; F20B6.8b.1; WBGene00001994 [Q8MQ70-1]
F20B6.8c.1; F20B6.8c.1; WBGene00001994 [Q8MQ70-3]
F20B6.8c.2; F20B6.8c.2; WBGene00001994 [Q8MQ70-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
180695

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F20B6.8

UCSC genome browser

More...
UCSCi
F20B6.8c.5 c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081186 Genomic DNA Translation: CCD69762.1
FO081186 Genomic DNA Translation: CCD69761.1
FO081186 Genomic DNA Translation: CCD69763.1
PIRiT34232
RefSeqiNP_741761.1, NM_171662.5 [Q8MQ70-1]
NP_741762.1, NM_171663.1 [Q8MQ70-2]
NP_741763.1, NM_171664.5 [Q8MQ70-3]

3D structure databases

SMRiQ8MQ70
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8MQ70, 1 interactor
STRINGi6239.F20B6.8b

Proteomic databases

EPDiQ8MQ70
PaxDbiQ8MQ70
PeptideAtlasiQ8MQ70

Genome annotation databases

EnsemblMetazoaiF20B6.8a.1; F20B6.8a.1; WBGene00001994 [Q8MQ70-2]
F20B6.8b.1; F20B6.8b.1; WBGene00001994 [Q8MQ70-1]
F20B6.8c.1; F20B6.8c.1; WBGene00001994 [Q8MQ70-3]
F20B6.8c.2; F20B6.8c.2; WBGene00001994 [Q8MQ70-3]
GeneIDi180695
KEGGicel:CELE_F20B6.8
UCSCiF20B6.8c.5 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180695
WormBaseiF20B6.8a ; CE04430 ; WBGene00001994 ; hpk-1
F20B6.8b ; CE30961 ; WBGene00001994 ; hpk-1
F20B6.8c ; CE30962 ; WBGene00001994 ; hpk-1

Phylogenomic databases

eggNOGiKOG0667 Eukaryota
ENOG410XPET LUCA
GeneTreeiENSGT00940000164472
HOGENOMiHOG000020268
InParanoidiQ8MQ70
KOiK08826
OMAiEVLCSPY
OrthoDBi369079at2759
PhylomeDBiQ8MQ70

Enzyme and pathway databases

ReactomeiR-CEL-3899300 SUMOylation of transcription cofactors
R-CEL-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SignaLinkiQ8MQ70

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8MQ70

Gene expression databases

BgeeiWBGene00001994 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIPK_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MQ70
Secondary accession number(s): Q19632, Q8MQ69
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2015
Last sequence update: October 1, 2002
Last modified: September 18, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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