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Entry version 110 (17 Jun 2020)
Sequence version 1 (01 Oct 2002)
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Protein
Submitted name:

Uncharacterized protein

Gene

C18C4.7

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:C18C4.7Imported, CELE_C18C4.7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
C18C4.7e ; CE30729 ; WBGene00015968

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8MNV5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00015966 Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8MNV5 differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8MNV5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni383 – 414DisorderedSequence analysisAdd BLAST32
Regioni792 – 815DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili11 – 45Sequence analysisAdd BLAST35
Coiled coili55 – 132Sequence analysisAdd BLAST78
Coiled coili139 – 173Sequence analysisAdd BLAST35
Coiled coili191 – 260Sequence analysisAdd BLAST70
Coiled coili272 – 292Sequence analysisAdd BLAST21
Coiled coili300 – 334Sequence analysisAdd BLAST35
Coiled coili463 – 497Sequence analysisAdd BLAST35
Coiled coili505 – 525Sequence analysisAdd BLAST21
Coiled coili537 – 567Sequence analysisAdd BLAST31
Coiled coili587 – 614Sequence analysisAdd BLAST28
Coiled coili626 – 702Sequence analysisAdd BLAST77
Coiled coili911 – 959Sequence analysisAdd BLAST49
Coiled coili996 – 1022Sequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JRG4 Eukaryota
ENOG41112XK LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011277_0_0_1

Database of Orthologous Groups

More...
OrthoDBi
1671247at2759

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8MNV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLSKQQPHD VNALLAEKQE LRKQLDREQN EKQELFMQIN SMIAKLADSG
60 70 80 90 100
DQDEINRLKS DVNSLKRELE AEKIASNAEA ARLKSELQKA KNEIQDSIKD
110 120 130 140 150
GDSEKDAMEQ EIENLQRQLN IKTASLQSLM LAKSDSSKTD KLSEENETLK
160 170 180 190 200
LKVEDLQKQV SSFMSQMQDK NSEIQKMKDA ISVNDVSRQN MDSLSEKLSE
210 220 230 240 250
MDRTLREEQQ QKSQLRSQTE TLKNALSTSE STLSMLKDKL AQFEQNALDL
260 270 280 290 300
KNENAQMKTS TRESILFESG RIKELQQALS DEKDNNAILN VQLREKDGKI
310 320 330 340 350
DRIQVDLLAA ESRAQQAEED VRDMKERIIT SKKDDDSNNL LQDELRRTEE
360 370 380 390 400
KYQQAQKKIE NLDETIKQQE TQIRDLGRSL DEAKRQLQKM SEQRQNEEVA
410 420 430 440 450
RQGEDSARSM EEKATKEEIK KLKSQVQLQQ QLEQDLELQK KRVQELTEQR
460 470 480 490 500
KVLESKASVA DEFGTLMSSL NSLREENRQY EEETRSLQTN IRTLQDEVYQ
510 520 530 540 550
HQDAITEWKN RAEKAEEYIE KENHRVQNAS SSHDADITRL ENEKTQMEEA
560 570 580 590 600
LEKADQEKDQ AIREASESVR VMKREMTEAS ITSDRQIQSL KEKVDSLTRE
610 620 630 640 650
LESSRRRMEQ LQEDQTKFLG SHDETKAEMM KDLHEAQDEI EKLTNQAGQL
660 670 680 690 700
KSKNETLTTE LEDSQNLCER LKAQYEKADK KYEETKVQLR EAEDLADRLQ
710 720 730 740 750
AAQILSGNVE SKFSDMQKES KIEMERILDN HNKELEKLRE ELKKSHTEHT
760 770 780 790 800
SLESVLEEQQ NELAQLQDQL REEKEQSSNL LVLNQKIEKS EKEKERLEEQ
810 820 830 840 850
IRSHTSQNSD TSKTISDLED KISELLKTND LLALDVQKLS KSLDSKDQQL
860 870 880 890 900
KEAEDEKNLM LEEVQALQNA TPSDSAEIAE LTTENARLAG ELLKSHSAAE
910 920 930 940 950
RSLQMEKEKI SKQFEERLKT ANLEKTRLAS ELQMADSRKN TLEKQVDELQ
960 970 980 990 1000
SQVETAERKL KSSTPIAPPR SNTRTISNMS AMTNWTQADF SECEDLTRLR
1010 1020
TEIDKQKRLI IVLRRKLQGL QQ
Length:1,022
Mass (Da):118,466
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i939520B2D5EA107B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2KYV8H2KYV8_CAEEL
Uncharacterized protein
C18C4.7, CELE_C18C4.7
1,046Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C3A0A0A2C9C3A0_CAEEL
Uncharacterized protein
C18C4.7, CELE_C18C4.7
1,348Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C3J8A0A2C9C3J8_CAEEL
Uncharacterized protein
C18C4.7, CELE_C18C4.7
1,152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C3R1A0A2C9C3R1_CAEEL
Uncharacterized protein
C18C4.7, CELE_C18C4.7
1,178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD65107.1

NCBI Reference Sequences

More...
RefSeqi
NP_741538.1, NM_171457.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C18C4.7e.1; C18C4.7e.1; WBGene00015968

UCSC genome browser

More...
UCSCi
C18C4.5b c. elegans

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD65107.1
RefSeqiNP_741538.1, NM_171457.3

3D structure databases

SMRiQ8MNV5
ModBaseiSearch...

Proteomic databases

EPDiQ8MNV5

Genome annotation databases

EnsemblMetazoaiC18C4.7e.1; C18C4.7e.1; WBGene00015968
UCSCiC18C4.5b c. elegans

Organism-specific databases

WormBaseiC18C4.7e ; CE30729 ; WBGene00015968

Phylogenomic databases

eggNOGiENOG410JRG4 Eukaryota
ENOG41112XK LUCA
HOGENOMiCLU_011277_0_0_1
OrthoDBi1671247at2759

Gene expression databases

BgeeiWBGene00015966 Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues
ExpressionAtlasiQ8MNV5 differential

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8MNV5_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MNV5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: June 17, 2020
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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