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Entry version 96 (25 May 2022)
Sequence version 1 (01 Oct 2002)
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Protein

cGMP-dependent protein kinase

Gene

PKG

Organism
Toxoplasma gondii
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine protein kinase which acts as a downstream effector of the second messenger cGMP (PubMed:11897122, PubMed:12455981).

Plays an essential role in tachyzoite invasion of and egress from host cells (PubMed:28465425, PubMed:30753127, PubMed:31235476).

During invasion of host cells, regulates the apico-basal flux of F-actin probably via Ca2+-mediated activation of CDPK1 (PubMed:30753127).

In tachyzoites, required for microneme secretion (PubMed:26933037, PubMed:28465425).

Required for tachyzoite gliding motility (PubMed:31235476).

6 Publications

Plays an essential role in parasite invasion of and egress from host cells, and microneme secretion.

1 Publication

Dispensable for parasite invasion of and egress from host cells, and microneme secretion.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by cGMP (PubMed:11897122, PubMed:12455981). The cGMP-binding domains acts cooperatively to activate PKG (PubMed:11897122, PubMed:12455981). Inhibited by the antiparasitic small molecule 4-[2-(4-fluorophenyl)-5-(1-methylpiperidine-4-yl)-1Hpyrrol- 3-yl]pyridine (compound 1) (PubMed:11897122, PubMed:12455981).2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=7.3 µM for ATP2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2533',5'-cGMP 1; via amide nitrogen; allosteric activatorBy similarity1
Binding sitei2543',5'-cGMP 1; allosteric activatorBy similarity1
Binding sitei2563',5'-cGMP 1; via amide nitrogen; allosteric activatorBy similarity1
Binding sitei2633',5'-cGMP 1; allosteric activatorBy similarity1
Binding sitei2643',5'-cGMP 1; allosteric activatorBy similarity1
Binding sitei6163',5'-cGMP 2; allosteric activatorBy similarity1
Binding sitei6253',5'-cGMP 2; via amide nitrogen; allosteric activatorBy similarity1
Binding sitei6263',5'-cGMP 2; allosteric activatorBy similarity1
Binding sitei6283',5'-cGMP 2; via amide nitrogen; allosteric activatorBy similarity1
Binding sitei6353',5'-cGMP 2; allosteric activatorBy similarity1
Binding sitei6363',5'-cGMP 2; allosteric activatorBy similarity1
Binding sitei713ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei807Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi690 – 698ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • positive regulation of cell motility Source: UniProtKB
  • protein phosphorylation Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, cGMP, cGMP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.12, 6411

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
cGMP-dependent protein kinase1 Publication (EC:2.7.11.122 Publications)
Alternative name(s):
TgPKG1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PKG1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondiiImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5811 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
ToxoDB:TGARI_311360A
ToxoDB:TGARI_311360B
ToxoDB:TGCAST_311300
ToxoDB:TGCAST_311360A
ToxoDB:TGCAST_311360B
ToxoDB:TGCOUG_311360A
ToxoDB:TGCOUG_311360B
ToxoDB:TGDOM2_286470
ToxoDB:TGDOM2_311300
ToxoDB:TGDOM2_311360A
ToxoDB:TGFOU_311360B
ToxoDB:TGFOU_311360C
ToxoDB:TGFOU_311360D
ToxoDB:TGGT1_311360
ToxoDB:TGMAS_311300
ToxoDB:TGMAS_311360A
ToxoDB:TGMAS_311360C
ToxoDB:TGME49_311360
ToxoDB:TGP89_242070
ToxoDB:TGP89_311360A
ToxoDB:TGP89_311360C
ToxoDB:TGPRC2_311360A
ToxoDB:TGPRC2_311360B
ToxoDB:TGRH88_050830
ToxoDB:TGRUB_242070B
ToxoDB:TGRUB_311360A
ToxoDB:TGRUB_311360C
ToxoDB:TGVAND_311360A
ToxoDB:TGVAND_311360B
ToxoDB:TGVEG_311360

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockout in tachyzoites is lethal (PubMed:12455981). Conditional knockout in tachyzoites impairs lytic growth in host cells (PubMed:28465425, PubMed:31235476). However, parasite intracellular replication is only slightly affected (PubMed:31235476). Impaired microneme secretion, motility and, invasion of and egress from host cells (PubMed:28465425, PubMed:31235476).3 Publications
Impaired growth in host cells (PubMed:28465425). Impaired microneme secretion and, invasion of and egress from host cells (PubMed:28465425).1 Publication
Normal growth in host cells (PubMed:28465425). Microneme secretion and, invasion of and egress from host cells are partially impaired (PubMed:28465425).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1M → A: Loss of isoform 1 expression. 1 Publication1
Mutagenesisi2G → A: Loss of membrane localization. 1 Publication1
Mutagenesisi2Missing : Loss of myristoylation and palmitoylation. Loss of membrane localization. 1 Publication1
Mutagenesisi4C → S: Partial loss of myristoylation. Loss of palmitoylation. Partial loss of membrane localization. 1 Publication1
Mutagenesisi103M → A: Loss of isoform 2 expression. 1 Publication1
Mutagenesisi263R → A: 16% reduction in catalytic activity. 64% and 87% reduction in catalytic activity respectively; when associated with A-382 or A-635. Complete loss of catalytic activity; when associated with A-382 and A-635. 1 Publication1
Mutagenesisi382R → A: 28% reduction in catalytic activity. 64% reduction in catalytic activity; when associated with A-263. Complete loss of catalytic activity; when associated with A-263 and A-635. 1 Publication1
Mutagenesisi635R → A: 77% reduction in catalytic activity. 87% reduction in catalytic activity; when associated with A-263. Complete loss of catalytic activity; when associated with A-263 and A-382. 1 Publication1
Mutagenesisi761T → M or Q: No effect on catalytic activity. No effect on virulence in mouse host. No effect on microneme secretion. Reduces sensitivity to antiparasitic inhibitor compound 1. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004520252 – 994cGMP-dependent protein kinaseAdd BLAST993

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
Lipidationi4S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in tachyzoites (at protein level).3 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q8MMZ7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8MMZ7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini684 – 941Protein kinasePROSITE-ProRule annotationAdd BLAST258
Domaini942 – 994AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 162DisorderedSequence analysisAdd BLAST162
Regioni189 – 305cNMP-binding domain 1PROSITE-ProRule annotationAdd BLAST117
Regioni308 – 407cNMP-binding domain 2PROSITE-ProRule annotationAdd BLAST100
Regioni463 – 539cNMP-binding domain 3PROSITE-ProRule annotationAdd BLAST77
Regioni561 – 660cNMP-binding domain 4PROSITE-ProRule annotationAdd BLAST100
Regioni954 – 976DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 27Polar residuesSequence analysisAdd BLAST21
Compositional biasi110 – 162Basic and acidic residuesSequence analysisAdd BLAST53

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00038, CAP_ED, 4 hits
cd05572, STKc_cGK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961, AGC-kinase_C
IPR018490, cNMP-bd-like
IPR018488, cNMP-bd_CS
IPR000595, cNMP-bd_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR014710, RmlC-like_jellyroll
IPR008271, Ser/Thr_kinase_AS
IPR035014, STKc_cGK

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00027, cNMP_binding, 3 hits
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00100, cNMP, 4 hits
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51206, SSF51206, 4 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00888, CNMP_BINDING_1, 2 hits
PS00889, CNMP_BINDING_2, 3 hits
PS50042, CNMP_BINDING_3, 4 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket
Isoform 1 (identifier: Q8MMZ7-1) [UniParc]FASTAAdd to basket
Also known as: Isoform I1 Publication

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGACISKNSS ARVSRSSALS ASKQTVAASA PPGAAGDETS ATGAAEEASR
60 70 80 90 100
NSLARVDGTR ASAAELERAP DGVCPDREEP GTANAEQGGV TEKKDTRETL
110 120 130 140 150
AGMNSPKTLE AEAQEDDPKR EAPNQDVPSE APEGPKEKPG GDRKPAQKAI
160 170 180 190 200
LKQDDSHTEE EKLNAHLAYR EKTPADFALI QDSLKANLVC SSLNEGEIDA
210 220 230 240 250
LAVAMQFFTF KKGDVVTKQG EPGSYFFIIH SGTFDVLVND KRVNAMDKGK
260 270 280 290 300
AFGEIALIHN TERSATVVAS STEGALWGVQ RHTFRETLKQ LSSRNFAENR
310 320 330 340 350
QFLASVKFFE MLTEAQKNVI TNALVVENFK PGQPIVKEGD AGDVLYILKS
360 370 380 390 400
GKAKVSIGGR EIRMLRKGDY FGERALLYKE PRSATITAEE FTVCVSIGRE
410 420 430 440 450
LLDRVLGNLQ HVLFRNIMVE ALQQSKVYEL FQGDQLSKLI EAAVVKDYGA
460 470 480 490 500
DYVILDKENK TKGIRFFFVL EGELSVYAYT QNPATKEEER KLAATLKRGQ
510 520 530 540 550
AFGEEYVLNP TRPFNHYVKS VGPCKLALFT SSVLTATLGG EDIDETLDFN
560 570 580 590 600
NKRAIIRKMY IFRYLSDHQM TMLIKAFKTV RYMSGEYIIK EGERGTRFFI
610 620 630 640 650
IKAGEVAILK NNKRLRTLGR HDYFGERALL YDKPRTASVC ANSAGVDLWV
660 670 680 690 700
VDKSVFNEII KGPMLAHLEE RIRMQDTKVE FQDLQVVRVV GRGTFGTVKL
710 720 730 740 750
VRHVPTDIRY ALKCVSRRSV IALSQQQHIR LEREIMAEND HPFIIRLVRT
760 770 780 790 800
FRDKEFLYFL TELVTGGELY DAIRKLGLLA RSQAQFYLAS IVLAIEYLHE
810 820 830 840 850
RNIAYRDLKP ENILLDSQGY VKLIDFGCAK KMQGRAYTLV GTPHYMAPEV
860 870 880 890 900
ILGKGYTLTA DTWAFGVCLY EFMCGPLPFG NDAEDQLEIF RDILTGKLVF
910 920 930 940 950
PHYVTDQDAI NLMKRLLCRL PEVRIGCSIN GYKDIKEHAF FGDFDWDKLA
960 970 980 990
GRGLPPPLAP KGETYAEDTE QSSFELDEDD TIVLEDEYDW DKDF
Length:994
Mass (Da):111,255
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1B605605713E296
GO
Isoform 2 (identifier: Q8MMZ7-2) [UniParc]FASTAAdd to basket
Also known as: Isoform II1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Show »
Length:892
Mass (Da):101,139
Checksum:iBE49931092E75348
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118P → L in AAM27174 (PubMed:12455981).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0608991 – 102Missing in isoform 2. CuratedAdd BLAST102

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF413570 mRNA Translation: AAM20901.1
AF448496 Genomic DNA Translation: AAM27174.1

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF413570 mRNA Translation: AAM20901.1
AF448496 Genomic DNA Translation: AAM27174.1

3D structure databases

AlphaFoldDBiQ8MMZ7
SMRiQ8MMZ7
ModBaseiSearch...

Organism-specific databases

VEuPathDBiToxoDB:TGARI_311360A
ToxoDB:TGARI_311360B
ToxoDB:TGCAST_311300
ToxoDB:TGCAST_311360A
ToxoDB:TGCAST_311360B
ToxoDB:TGCOUG_311360A
ToxoDB:TGCOUG_311360B
ToxoDB:TGDOM2_286470
ToxoDB:TGDOM2_311300
ToxoDB:TGDOM2_311360A
ToxoDB:TGFOU_311360B
ToxoDB:TGFOU_311360C
ToxoDB:TGFOU_311360D
ToxoDB:TGGT1_311360
ToxoDB:TGMAS_311300
ToxoDB:TGMAS_311360A
ToxoDB:TGMAS_311360C
ToxoDB:TGME49_311360
ToxoDB:TGP89_242070
ToxoDB:TGP89_311360A
ToxoDB:TGP89_311360C
ToxoDB:TGPRC2_311360A
ToxoDB:TGPRC2_311360B
ToxoDB:TGRH88_050830
ToxoDB:TGRUB_242070B
ToxoDB:TGRUB_311360A
ToxoDB:TGRUB_311360C
ToxoDB:TGVAND_311360A
ToxoDB:TGVAND_311360B
ToxoDB:TGVEG_311360

Enzyme and pathway databases

BRENDAi2.7.11.12, 6411

Family and domain databases

CDDicd00038, CAP_ED, 4 hits
cd05572, STKc_cGK, 1 hit
Gene3Di2.60.120.10, 4 hits
InterProiView protein in InterPro
IPR000961, AGC-kinase_C
IPR018490, cNMP-bd-like
IPR018488, cNMP-bd_CS
IPR000595, cNMP-bd_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR014710, RmlC-like_jellyroll
IPR008271, Ser/Thr_kinase_AS
IPR035014, STKc_cGK
PfamiView protein in Pfam
PF00027, cNMP_binding, 3 hits
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00100, cNMP, 4 hits
SM00220, S_TKc, 1 hit
SUPFAMiSSF51206, SSF51206, 4 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00888, CNMP_BINDING_1, 2 hits
PS00889, CNMP_BINDING_2, 3 hits
PS50042, CNMP_BINDING_3, 4 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKGP_TOXGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MMZ7
Secondary accession number(s): Q8MMP4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2021
Last sequence update: October 1, 2002
Last modified: May 25, 2022
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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