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Entry version 148 (11 Dec 2019)
Sequence version 1 (01 Oct 2002)
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Protein
Submitted name:

Epidermal growth factor receptor pathway substrate clone 15, isoform C

Gene

Eps-15

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi178 – 189PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi326 – 337PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported
LigandCalciumPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Epidermal growth factor receptor pathway substrate clone 15, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Eps-15Imported
Synonyms:anon-WO0118547.85Imported, Dmel\CG16932Imported, EH1Imported, EPS-15Imported, eps-15Imported, EPS15Imported, Eps15Imported, eps15Imported, i31Imported
ORF Names:CG16932Imported, Dmel_CG16932Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0035060 Eps-15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8MMD3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0035060 Expressed in 33 organ(s), highest expression level in eye disc (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8MMD3 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8MMD3 DM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 112EHInterPro annotationAdd BLAST101
Domaini45 – 80EF-handInterPro annotationAdd BLAST36
Domaini133 – 221EHInterPro annotationAdd BLAST89
Domaini165 – 200EF-handInterPro annotationAdd BLAST36
Domaini313 – 348EF-handInterPro annotationAdd BLAST36
Domaini314 – 403EHInterPro annotationAdd BLAST90
Domaini352 – 382EF-handInterPro annotationAdd BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni209 – 248DisorderedSequence analysisAdd BLAST40
Regioni619 – 656DisorderedSequence analysisAdd BLAST38
Regioni678 – 790DisorderedSequence analysisAdd BLAST113
Regioni818 – 840DisorderedSequence analysisAdd BLAST23
Regioni919 – 944DisorderedSequence analysisAdd BLAST26
Regioni1055 – 1085DisorderedSequence analysisAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili424 – 500Sequence analysisAdd BLAST77
Coiled coili508 – 542Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi216 – 237Pro-richSequence analysisAdd BLAST22
Compositional biasi626 – 656PolarSequence analysisAdd BLAST31
Compositional biasi737 – 768Pro-richSequence analysisAdd BLAST32
Compositional biasi1063 – 1085PolyampholyteSequence analysisAdd BLAST23

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0998 Eukaryota
ENOG410XTDR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170943

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00052 EH, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12763 EF-hand_4, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 4 hits
SM00027 EH, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 4 hits
PS50031 EH, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8MMD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVDFARVCG KHIGVYEAYY KLIDPKGTGA IEAMTAAKFL KKSGLSDVVL
60 70 80 90 100
SRIWDLSDPS GKGFLDKPGF FVALKLVSLS QAGQVASMAN IYLDIANPPK
110 120 130 140 150
LGELPKTMPS RIQTVPVASG GVANGDWSIG VIDRLKYEQL FESLHPSNGM
160 170 180 190 200
LPGNKVKGVL MDSKLPMSIL GTIWDLADQD KDGNLDMHEF VVAMHLVYQT
210 220 230 240 250
LQKRTIPSVL PPELRKPGGA GPPPKPAMPP PPAGAAMPRA PSGEGFGDGG
260 270 280 290 300
FVANFPKDIA PPAAIPPLPV AVPPMTRIPP VGAVSSQPLI QTDPLIPIGA
310 320 330 340 350
PVMANADWVV TPADLKRFEE IFRQSDLDKD GLVSGLEVKD IFIKSGIPQR
360 370 380 390 400
SLADIWALCD TNQSGKLTVE QFALAMWFVE RKQRGVDPPH VLNANMVPPS
410 420 430 440 450
MRATVAGVDL QPQEVKPTYS NPELEMISKE IEELARERRV LETEIAQKEA
460 470 480 490 500
DVRIKNGEVR SLQSELDTLT ATLKQLENQR GEAQKRLDDL QAQVTKIRDQ
510 520 530 540 550
CHMQEVTINE QEGELNAKRS ELQKLKDEEA SLQKEYDSNN RELSKLTNHL
560 570 580 590 600
QATQLQISSV RSMVTQLLET QRQMTDALLI CRAAMENQNA ELVSEYQLKI
610 620 630 640 650
EPDFDEARKT LTKEVQLPKD DPFEENNSGA ANQATNGFGS DPFSGQPVNK
660 670 680 690 700
PAISTGFDDS FNMSSGFDSG FDAFGQSGAG SAFGQTQRDP FGSDAFAANK
710 720 730 740 750
SNAITPEPGK DDFGSDPFAA LHAPTGQGQV LSPNAQKSGP PPRPESPSPA
760 770 780 790 800
LPPKKSKVPP PRPAPPRAAQ PTGGFGSGGG GGFADFDDFD NKNQRTADVK
810 820 830 840 850
LETKAVVSVF DAFGEIGTRK APTPSLITGP TDFKDDPFKD YRYEDPFSIK
860 870 880 890 900
DPFAEEGEEE LSEGKGADHK RNFAEDFSSG DEIGSAAKTL SNIVNNNSIK
910 920 930 940 950
PKAATPLNND LLQQFDAFNL NSSPAPSHHS GTSYHSNSKP SHDSQTALDA
960 970 980 990 1000
FADFDDFAAT LATTGGSGAA TTATTTGNTK LNNSFFDAFN DNFSVIQSSS
1010 1020 1030 1040 1050
VPTGVVRPND QRAKAFDAFN DNFEDQFKTS PNANFAKFDG FEAHNFSSDF
1060 1070 1080 1090 1100
GNASFGTTGK EKQNGQVDKK FQSKEPVKDK FAADYSKPES FDADLEEALK

RSVLDN
Length:1,106
Mass (Da):119,607
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CA71F68C5486F2A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E3CTP7E3CTP7_DROME
Epidermal growth factor receptor pa...
Eps-15 anon-WO0118547.85, Dmel\CG16932, EH1, EPS-15, eps-15
792Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9W111Q9W111_DROME
Epidermal growth factor receptor pa...
Eps-15 anon-WO0118547.85, Dmel\CG16932, EH1, EPS-15, eps-15
1,253Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8MMD2Q8MMD2_DROME
Epidermal growth factor receptor pa...
Eps-15 anon-WO0118547.85, Dmel\CG16932, EH1, EPS-15, eps-15
1,232Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAM70792.1

NCBI Reference Sequences

More...
RefSeqi
NP_726481.1, NM_166686.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0072433; FBpp0072338; FBgn0035060

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
37961

UCSC genome browser

More...
UCSCi
CG16932-RC d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAM70792.1
RefSeqiNP_726481.1, NM_166686.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ8MMD3

Genome annotation databases

EnsemblMetazoaiFBtr0072433; FBpp0072338; FBgn0035060
GeneIDi37961
UCSCiCG16932-RC d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
37961
FlyBaseiFBgn0035060 Eps-15

Phylogenomic databases

eggNOGiKOG0998 Eukaryota
ENOG410XTDR LUCA
GeneTreeiENSGT00940000170943

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
37961

Gene expression databases

BgeeiFBgn0035060 Expressed in 33 organ(s), highest expression level in eye disc (Drosophila)
ExpressionAtlasiQ8MMD3 differential
GenevisibleiQ8MMD3 DM

Family and domain databases

CDDicd00052 EH, 3 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
PfamiView protein in Pfam
PF12763 EF-hand_4, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SM00027 EH, 3 hits
SUPFAMiSSF47473 SSF47473, 3 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 4 hits
PS50031 EH, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8MMD3_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MMD3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: December 11, 2019
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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