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Protein
Submitted name:

Beta glycoprotein hormone related polypeptide

Gene

Gpb5

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • protein heterodimerization activity Source: FlyBase

GO - Biological processi

  • hormone-mediated signaling pathway Source: FlyBase

Keywordsi

Molecular functionHormoneSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Beta glycoprotein hormone related polypeptideImported
Submitted name:
Glycoprotein hormone beta 5, isoform CImported
Submitted name:
Glycoprotein hormone beta subunit-related proteinImported
Gene namesi
Name:Gpb5Imported
Synonyms:beta-glycoprotein-hormone-relatedImported, DmbetaImported, Dmel\CG40041Imported, GPB5Imported, gpb5Imported
ORF Names:CG40041Imported, Dmel_CG40041Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0063368 Gpb5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501509930826 – 169Sequence analysisAdd BLAST144

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiFBgn0063368 Expressed in 4 organ(s), highest expression level in head

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 149Cys_knotInterPro annotationAdd BLAST86

Sequence similaritiesi

Belongs to the glycoprotein hormones subunit beta family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410JR7I Eukaryota
ENOG41120VG LUCA
GeneTreeiENSGT00730000111179
OrthoDBiEOG091G0XFH

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8MLY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRIIFFRTL AIFVGTSVVL VSVSSSSLSE IKPMNNGHIV TPLGCHRRVY
60 70 80 90 100
TYKVTQSDLQ GHECWDYVSV WSCWGRCDSS EISDWKFPYK RSFHPVCVHA
110 120 130 140 150
QRQLVVAILK NCHPKAEDSV SKYQYMEAVN CHCQTCSTQD TSCEAPANNE
160
MAGGSRAIMV GADTKNLDY
Length:169
Mass (Da):19,007
Last modified:October 1, 2002 - v1
Checksum:iEB495258E364F4D2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4V4C8Q4V4C8_DROME
Glycoprotein hormone beta 5, isofor...
Gpb5 Dmbeta, Dmel\CG40041, GPB5, gpb5, CG40041 Gpb5 Dmbeta, Dmel\CG40041, GPB5, gpb5, CG40041, Dmel_CG40041
169Annotation score:
M0QVX8M0QVX8_DROME
Glycoprotein hormone beta 5, isofor...
Gpb5 CG40041, Dmbeta, Dmel\CG40041, GPB5, gpb5 Gpb5 CG40041, Dmbeta, Dmel\CG40041, GPB5, gpb5, CG40041, Dmel_CG40041
136Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403389 mRNA Translation: AAM53262.1
AJ440748 mRNA Translation: CAD29446.1
AE014134 Genomic DNA Translation: EDP28156.1
RefSeqiNP_001104334.1, NM_001110864.2
UniGeneiDm.33933

Genome annotation databases

EnsemblMetazoaiFBtr0113776; FBpp0112499; FBgn0063368
GeneIDi3355097
UCSCiCG40041-RC d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403389 mRNA Translation: AAM53262.1
AJ440748 mRNA Translation: CAD29446.1
AE014134 Genomic DNA Translation: EDP28156.1
RefSeqiNP_001104334.1, NM_001110864.2
UniGeneiDm.33933

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0113776; FBpp0112499; FBgn0063368
GeneIDi3355097
UCSCiCG40041-RC d. melanogaster

Organism-specific databases

CTDi3355097
FlyBaseiFBgn0063368 Gpb5

Phylogenomic databases

eggNOGiENOG410JR7I Eukaryota
ENOG41120VG LUCA
GeneTreeiENSGT00730000111179
OrthoDBiEOG091G0XFH

Miscellaneous databases

GenomeRNAii3355097

Gene expression databases

BgeeiFBgn0063368 Expressed in 4 organ(s), highest expression level in head

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8MLY9_DROME
AccessioniPrimary (citable) accession number: Q8MLY9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: October 10, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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