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UniProtKB - Q8MKL0 (Q8MKL0_DROME)

Entry version 149 (07 Apr 2021)
Sequence version 1 (01 Oct 2002)
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Protein
Submitted name:

LP07082p

Gene

CG30041;CG30043

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • proteolysis Source: GO_Central
Complete GO annotation on QuickGO ...

Protein family/group databases

MEROPS protease database

More...MEROPSi		M28.A09

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LP07082pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CG30041;CG30043Imported
Synonyms:CG13161Imported, Dmel\CG30043Imported
ORF Names:CG30043Imported, Dmel_CG30043Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0050043, CG30043

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 56HelicalSequence analysisAdd BLAST24
Transmembranei383 – 404HelicalSequence analysisAdd BLAST22
Transmembranei416 – 447HelicalSequence analysisAdd BLAST32
Transmembranei459 – 483HelicalSequence analysisAdd BLAST25
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Transmembranei522 – 543HelicalSequence analysisAdd BLAST22
Transmembranei549 – 579HelicalSequence analysisAdd BLAST31
Transmembranei591 – 615HelicalSequence analysisAdd BLAST25
Transmembranei621 – 642HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q8MKL0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0050043, Expressed in midgut and 22 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini150 – 345Peptidase_M28InterPro annotationAdd BLAST196

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2194, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063839

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007536_2_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		RRIFYEH

Database of Orthologous Groups

More...OrthoDBi		248924at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007484, Peptidase_M28

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04389, Peptidase_M28, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8MKL0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEKTDKENP IDTELVESLS LRKGYVRRPR LSWYYAPSFL LLWLALFYAI 
        60         70         80         90        100
VIPLYYRLPD RLTISEESHR PGEFVAERAQ QYLYTYDRIG PKVTGSYANE 
       110        120        130        140        150
VTTVEFLVNE TEKIRAEMRS DLYDLELDVQ SPTGGYVFND MVNMYQGIHN 
       160        170        180        190        200
VIVKLSSKSS QSESYLLLNS HFDSKPGSPG SGDDGTMVVV MMEVLRQMSI 
       210        220        230        240        250
SEIPFEHPIV FLFNGAEENP LQASHGFITQ HKWAEKCKAF INLEVGGSGG 
       260        270        280        290        300
RDLLFQSGPN NPWLMKYYRQ HAKHPFATTM AEEIFQSGVL PSDSDFRIFR 
       310        320        330        340        350
DYGNIAGLDI AQIENGYVYH TAFDTYENVP GRSIQNSGNN VLALVRAYSN 
       360        370        380        390        400
ASELYNTESD DSHAVFFDFL GLFFVYYTET TGIVVNCVIG VLSLVLVGCS 
       410        420        430        440        450
VWRMCHQSEE ASLPQISIWF LSILGLHVVG FLLCICLPLL MAVLFDAGDR 
       460        470        480        490        500
SLTYFTSNWL VFGLYVCPAI IGLVLPLTLY YTLLPNEKLS QAYQLQLSLH 
       510        520        530        540        550
AHLVVQALLA LILTAMGLRS QYLCLISMIF YGGALLINLV STLHDRGYYW 
       560        570        580        590        600
VPIVMFLQVL PFSYFCYLFY MFLVIFIPVL GRNGYSTNPD LIVGLLCGVC 
       610        620        630        640        650
VFFALGFAAQ LINMFRWPKL ILLGLGVMTF IFCMIAVSDV GFPYRAKTNV 
       660        670        680        690        700
MRANCLHTRR IFYEHDGSVS RSDSGYYFNY QDRRAFAPLE DSALDLTGLE 
       710        720        730        740        750
PVANRCDDYV MCGIPCFYYS WCKWRQWDGW LPRESEVILP GELTLDFLGY 
       760        770        780        790        800
TVLESGTVAR YEFELAGPPH MNLFIQPVGS AKVDDWSFVR KMLDEPEEFQ 
       810        820        830        840        850
PPYQIFHSYG TDNTSLKFFI DMEKPDGIFD TPTLELAAVG HWVSFEYERD 
       860        870 
AEAKDFVAAF PDFVHVMEWP SIFKRYIF
Length:878
Mass (Da):100,124
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i32841AA16BEE6AAE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY113375 mRNA Translation: AAM29380.1
AE013599 Genomic DNA Translation: AAM68674.1

NCBI Reference Sequences

More...RefSeqi		NP_725143.1, NM_165889.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0087907; FBpp0087018; FBgn0050043

Database of genes from NCBI RefSeq genomes

More...GeneIDi		246412

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG30043

UCSC genome browser

More...UCSCi		CG30043-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY113375 mRNA Translation: AAM29380.1
AE013599 Genomic DNA Translation: AAM68674.1
RefSeqiNP_725143.1, NM_165889.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein family/group databases

MEROPSiM28.A09

Proteomic databases

PRIDEiQ8MKL0

Genome annotation databases

EnsemblMetazoaiFBtr0087907; FBpp0087018; FBgn0050043
GeneIDi246412
KEGGidme:Dmel_CG30043
UCSCiCG30043-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0050043, CG30043

Phylogenomic databases

eggNOGiKOG2194, Eukaryota
GeneTreeiENSGT00530000063839
HOGENOMiCLU_007536_2_0_1
OMAiRRIFYEH
OrthoDBi248924at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		246412, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		246412

Gene expression databases

BgeeiFBgn0050043, Expressed in midgut and 22 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR007484, Peptidase_M28
PfamiView protein in Pfam
PF04389, Peptidase_M28, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8MKL0_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MKL0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: April 7, 2021
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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