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UniProtKB - Q8MJV0 (MYH1_HORSE)
Protein
Myosin-1
Gene
MYH1
Organism
Equus caballus (Horse)
Status
Functioni
Muscle contraction.
By similarityCaution
Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 179 – 186 | ATPSequence analysis | 8 |
GO - Molecular functioni
- actin filament binding Source: InterPro
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- cytoskeletal motor activity Source: InterPro
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Myosin-1Alternative name(s): Myosin heavy chain 1 Myosin heavy chain 2x Short name: MyHC-2x Myosin heavy chain, skeletal muscle, adult 1 |
Gene namesi | Name:MYH1 |
Organismi | Equus caballus (Horse) |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:56450, MYH1 |
Subcellular locationi
Other locations
- myofibril By similarity
Note: Thick filaments of the myofibrils.By similarity
Cytoskeleton
- myosin complex Source: UniProtKB-KW
Other locations
- myofibril Source: UniProtKB-SubCell
- myosin filament Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Thick filamentPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274163 | 1 – 1938 | Myosin-1Add BLAST | 1938 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 64 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 69 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 130 | N6,N6,N6-trimethyllysineSequence analysis | 1 | |
Modified residuei | 389 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 419 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 424 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 625 | PhosphoserineBy similarity | 1 | |
Modified residuei | 756 | Pros-methylhistidineBy similarity | 1 | |
Modified residuei | 1091 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1095 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1161 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1236 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1240 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1242 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1254 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1260 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1285 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1291 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1302 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1305 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1463 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 1466 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1473 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1491 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 1494 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1500 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1513 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1516 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1541 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1553 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1573 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1713 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1725 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1729 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1735 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1738 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
PaxDbi | Q8MJV0 |
PRIDEi | Q8MJV0 |
Interactioni
Subunit structurei
Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
By similarityGO - Molecular functioni
- actin filament binding Source: InterPro
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 9796.ENSECAP00000031274 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 82 | Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST | 50 | |
Domaini | 86 – 781 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 696 | |
Domaini | 784 – 813 | IQPROSITE-ProRule annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 658 – 680 | Actin-bindingBy similarityAdd BLAST | 23 | |
Regioni | 760 – 774 | Actin-bindingBy similarityAdd BLAST | 15 | |
Regioni | 1124 – 1146 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 1152 – 1171 | DisorderedSequence analysisAdd BLAST | 20 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 842 – 1938 | Sequence analysisAdd BLAST | 1097 |
Domaini
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
GeneTreei | ENSGT00940000154760 |
HOGENOMi | CLU_000192_8_1_1 |
InParanoidi | Q8MJV0 |
OMAi | HKYEETH |
OrthoDBi | 47111at2759 |
Family and domain databases
Gene3Di | 1.20.5.370, 4 hits 2.30.30.360, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase IPR014751, XRCC4-like_C |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF02736, Myosin_N, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8MJV0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSDQEMAIF GEAAPYLRKS EKERIEAQNK PFDAKTSVFV ADPKESFVKA
60 70 80 90 100
TVQSREGGKV TAKTEAGATV TVKEDQCFPM NPPKYDKIED MAMMTHLHEP
110 120 130 140 150
AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYNAEVV TAYRGKKRQE
160 170 180 190 200
APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA
210 220 230 240 250
VTGEKKKEEP TSGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF
260 270 280 290 300
IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPDL
310 320 330 340 350
IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAIE ILGFTSDERV
360 370 380 390 400
SIYKLTGAVM HYGNLKFKQK QREEQAEPDG TEVADKAAYL QGLNSADLLK
410 420 430 440 450
ALCYPRVKVG NEFVTKGQTV EQVYNAVGAL AKAVYDKMFL WMVARINQQL
460 470 480 490 500
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE
510 520 530 540 550
QEEYKKEGIE WEFIDFGMDL AACIELIEKP MGIFSILEEE CMFPKATDTS
560 570 580 590 600
FKNKLYEQHL GKSNNFQKPK PVKGKPEAHF SLIHYAGTVD YNITGWLDKN
610 620 630 640 650
KDPLNETVVG LYQKSSVKTL ALLFSGPASA DAEAGGKKGG KKKGSSFQTV
660 670 680 690 700
SALFRENLNK LMTNLRSTHP HFVRCIIPNE TKTPGAMEHE LVLHQLRCNG
710 720 730 740 750
VLEGIRICRK GFPSRILYAD FKQRYKVLNA SAIPEGQFID SKKASEKLLG
760 770 780 790 800
SIDIDHTQYK FGHTKVFFKA GLLGLLEEMR DDKLAQIITR TQARCRGFLA
810 820 830 840 850
RVEYQRMVER RESIFCIQYN VRAFMNVKHW PWMKLYFKIK PLLKSAETEK
860 870 880 890 900
EMANMKEEFE KTKESLAKAE AKRKELEEKM VALMQEKNDL QLQVQAEADS
910 920 930 940 950
LADAEERCDQ LIKTKIQLEA KIKEATERAE DEEEINAELT AKKRKLEDEC
960 970 980 990 1000
SELKKDIDDL ELTLAKVEKE KHATENKVKN LTEEMAGLDE TIAKLTKEKK
1010 1020 1030 1040 1050
ALQEAHQQTL DDLQAEEDKV NTLTKAKTKL EQQVDDLEGS LEQEKKLRMD
1060 1070 1080 1090 1100
LERAKRKLEG DLKLAQESTM DIENDKQQLD EKLKKKEFEM SNLQSKIEDE
1110 1120 1130 1140 1150
QALAMQLQKK IKELQARIEE LEEEIEAERA SRAKAEKQRS DLSRELEEIS
1160 1170 1180 1190 1200
ERLEEAGGAT SAQIEMNKKR EAEFQKMRRD LEEATLQHEA TAAALRKKHA
1210 1220 1230 1240 1250
DSVAELGEQI DNLQRVKQKL EKEKSEMKME IDDLASNMET VSKAKGNLEK
1260 1270 1280 1290 1300
MCRTLEDQLS ELKSKEEEQQ RLVNDLTGQR ARLQTEAGEY SRQLDEKDSL
1310 1320 1330 1340 1350
VSQLSRGKQA FTQQIEELKR QLEEEIKAKS ALAHALQSAR HDCDLLREQY
1360 1370 1380 1390 1400
EEEQEAKAEL QRAMSKANSE VAQWRTKYET DAIQRTEELE EAKKKLAQRL
1410 1420 1430 1440 1450
QDAEEHVEAV NAKCASLEKT KQRLQNEVED LMIDVERTNA ACAALDKKQR
1460 1470 1480 1490 1500
NFDKILSEWK HKYEETHAEL EASQKESRSL STELFKVKNA YEESLDQLET
1510 1520 1530 1540 1550
LKRENKNLQQ EISDLTEQIA EGGKRIHELE KVKKQIEQEK SEIQAALEEA
1560 1570 1580 1590 1600
EASLEHEEGK ILRIQLELNQ VKSEIDRKIA EKDEEIDQLK RNHVRVVETM
1610 1620 1630 1640 1650
QTMLDAEIRS RNDAIRIKKK MEGDLNEMEI QLNHANRMAA EALRNYRNTQ
1660 1670 1680 1690 1700
GILKDTQLHL DDALRGQEDL KEQLAMVERR ANLLQAEIEE LRATLEQTER
1710 1720 1730 1740 1750
SRKIAEQELL DASERVQLLH TQNTSLINTK KKLETDISQL QGEMEDIVQE
1760 1770 1780 1790 1800
AHNAEEKAKK AITDAAMMAE ELKKEQDTSA HLERMKKNLE QTVKDLQHRL
1810 1820 1830 1840 1850
DEAEQLALKG GKKQIQKLEA RVRDLEGEVE SEQKRNVEAV KGLRKHERRV
1860 1870 1880 1890 1900
KELTYQTEED RKNILRLQDL VDKLQSKVKA YKRQAEEAEE QSNVNLSKFR
1910 1920 1930
KIQHELEEAE ERADIAESQV NKLRVKSREV HTKIISEE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2HB31 | A0A3Q2HB31_HORSE | Myosin-1 | MYH1 | 1,940 | Annotation score: | ||
A0A3Q2GYL4 | A0A3Q2GYL4_HORSE | Myosin-1 | MYH1 | 1,937 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB088366 mRNA Translation: BAC05680.1 |
RefSeqi | NP_001075228.1, NM_001081759.1 XP_005597093.1, XM_005597036.2 |
Genome annotation databases
Ensembli | ENSECAT00000026554; ENSECAP00000022162; ENSECAG00000022909 |
GeneIDi | 791235 |
KEGGi | ecb:791235 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB088366 mRNA Translation: BAC05680.1 |
RefSeqi | NP_001075228.1, NM_001081759.1 XP_005597093.1, XM_005597036.2 |
3D structure databases
SMRi | Q8MJV0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9796.ENSECAP00000031274 |
Proteomic databases
PaxDbi | Q8MJV0 |
PRIDEi | Q8MJV0 |
Protocols and materials databases
ABCDi | Q8MJV0, 1 sequenced antibody |
Genome annotation databases
Ensembli | ENSECAT00000026554; ENSECAP00000022162; ENSECAG00000022909 |
GeneIDi | 791235 |
KEGGi | ecb:791235 |
Organism-specific databases
CTDi | 4619 |
VGNCi | VGNC:56450, MYH1 |
Phylogenomic databases
GeneTreei | ENSGT00940000154760 |
HOGENOMi | CLU_000192_8_1_1 |
InParanoidi | Q8MJV0 |
OMAi | HKYEETH |
OrthoDBi | 47111at2759 |
Gene expression databases
ExpressionAtlasi | Q8MJV0, baseline |
Family and domain databases
Gene3Di | 1.20.5.370, 4 hits 2.30.30.360, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase IPR014751, XRCC4-like_C |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF02736, Myosin_N, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MYH1_HORSE | |
Accessioni | Q8MJV0Primary (citable) accession number: Q8MJV0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families