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Protein

Forkhead box protein P2

Gene

FOXP2

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri347 – 372C2H2-typeAdd BLAST26
DNA bindingi505 – 595Fork-headPROSITE-ProRule annotationAdd BLAST91

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P2
Gene namesi
Name:FOXP2
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918841 – 716Forkhead box protein P2Add BLAST716

Proteomic databases

PaxDbiQ8MJA0

Expressioni

Gene expression databases

BgeeiENSPTRG00000019608 Expressed in 4 organ(s), highest expression level in prefrontal cortex

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Interacts with FOXP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000033573

Structurei

3D structure databases

ProteinModelPortaliQ8MJA0
SMRiQ8MJA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni389 – 410Leucine-zipperAdd BLAST22
Regioni423 – 427CTBP1-bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi53 – 269Gln-richAdd BLAST217

Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri347 – 372C2H2-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4385 Eukaryota
COG5025 LUCA
HOGENOMiHOG000092089
HOVERGENiHBG051657
InParanoidiQ8MJA0
KOiK09409
OMAiETKLCVC
OrthoDBiEOG091G08HY
TreeFamiTF326978

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR032354 FOXP-CC
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF16159 FOXP-CC, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8MJA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL
60 70 80 90 100
HLQQQQALQA ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT
110 120 130 140 150
PQQMQQILQQ QVLSPQQLQA LLQQQQAVML QQQQLQEFYK KQQEQLHLQL
160 170 180 190 200
LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQHPGKQAKE
210 220 230 240 250
QQQQQQQQQQ LAAQQLVFQQ QLLQMQQLQQ QQHLLSLQRQ GLISIPPGQA
260 270 280 290 300
ALPVQSLPQA GLSPAEIQQL WKEVTGVHSM EDNGIKHGGL DLTTNNSSST
310 320 330 340 350
TSSTTSKASP PITHHSIVNG QSSVLNARRD SSSHEETGAS HTLYGHGVCK
360 370 380 390 400
WPGCESICED FGQFLKHLNN EHALDDRSTA QCRVQMQVVQ QLEIQLSKER
410 420 430 440 450
ERLQAMMTHL HMRPSEPKPS PKPLNLVSSV TMSKNMLETS PQSLPQTPTT
460 470 480 490 500
PTAPVTPITQ GPSVITPASV PNVGAIRRRH SDKYNIPMSS EIAPNYEFYK
510 520 530 540 550
NADVRPPFTY ATLIRQAIME SSDRQLTLNE IYSWFTRTFA YFRRNAATWK
560 570 580 590 600
NAVRHNLSLH KCFVRVENVK GAVWTVDEVE YQKRRSQKIT GSPTLVKNIP
610 620 630 640 650
TSLGYGAALN ASLQAALAES SLPLLSNPGL INNASSGLLQ AVHEDLNGSL
660 670 680 690 700
DHIDSNGNSS PGCSPQPHIH SIHVKEEPVI AEDEDCPMSL VTTANHSPEL
710
EDDREIEEEP LSEDLE
Length:716
Mass (Da):80,061
Last modified:October 1, 2002 - v1
Checksum:i3169A2786B42F79F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF512947 mRNA Translation: AAN03385.1
AF515051 Genomic DNA Translation: AAN03409.1
AF515052 Genomic DNA Translation: AAN03410.1
AY143178 mRNA Translation: AAN60056.1
AY064549 mRNA Translation: AAL57735.1
AY064565
, AY064551, AY064552, AY064553, AY064554, AY064555, AY064556, AY064557, AY064558, AY064559, AY064560, AY064561, AY064562, AY064563, AY064564 Genomic DNA Translation: AAL57731.1
RefSeqiNP_001009020.1, NM_001009020.3
UniGeneiPtr.6303

Genome annotation databases

GeneIDi449627
KEGGiptr:449627

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF512947 mRNA Translation: AAN03385.1
AF515051 Genomic DNA Translation: AAN03409.1
AF515052 Genomic DNA Translation: AAN03410.1
AY143178 mRNA Translation: AAN60056.1
AY064549 mRNA Translation: AAL57735.1
AY064565
, AY064551, AY064552, AY064553, AY064554, AY064555, AY064556, AY064557, AY064558, AY064559, AY064560, AY064561, AY064562, AY064563, AY064564 Genomic DNA Translation: AAL57731.1
RefSeqiNP_001009020.1, NM_001009020.3
UniGeneiPtr.6303

3D structure databases

ProteinModelPortaliQ8MJA0
SMRiQ8MJA0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000033573

Proteomic databases

PaxDbiQ8MJA0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi449627
KEGGiptr:449627

Organism-specific databases

CTDi93986

Phylogenomic databases

eggNOGiKOG4385 Eukaryota
COG5025 LUCA
HOGENOMiHOG000092089
HOVERGENiHBG051657
InParanoidiQ8MJA0
KOiK09409
OMAiETKLCVC
OrthoDBiEOG091G08HY
TreeFamiTF326978

Gene expression databases

BgeeiENSPTRG00000019608 Expressed in 4 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR032354 FOXP-CC
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF16159 FOXP-CC, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOXP2_PANTR
AccessioniPrimary (citable) accession number: Q8MJA0
Secondary accession number(s): Q8MHX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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