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Protein

Forkhead box protein P2

Gene

FOXP2

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri344 – 369C2H2-typeAdd BLAST26
DNA bindingi502 – 592Fork-headPROSITE-ProRule annotationAdd BLAST91

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P2
Gene namesi
Name:FOXP2
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918781 – 713Forkhead box protein P2Add BLAST713

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Interacts with FOXP1 (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8MJ99
SMRiQ8MJ99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni386 – 407Leucine-zipperAdd BLAST22
Regioni420 – 424CTBP1-bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi53 – 266Gln-richAdd BLAST214

Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri344 – 369C2H2-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG051657
InParanoidiQ8MJ99

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR032354 FOXP-CC
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF16159 FOXP-CC, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8MJ99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL
60 70 80 90 100
HLQQQQALQA ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT
110 120 130 140 150
PQQMQQILQQ QVLSPQQLQA LLQQQQAVML QQQQLQEFYK KQQEQLHLQL
160 170 180 190 200
LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQH PGKQAKEQQQ
210 220 230 240 250
QQQQQQQLAA QQLVFQQQLL QMQQLQQQQH LLSLQRQGLI SIPPGQAALP
260 270 280 290 300
VQSLPQAGLS PAEIQQLWKE VTGVHSMEDN GIKHGGLDLT TNNSSSTTSS
310 320 330 340 350
TTSKASPPIT HHSIVNGQSS VLNARRDSSS HEETGASHTL YGHGVCKWPG
360 370 380 390 400
CESICEDFGQ FLKHLNNEHA LDDRSTAQCR VQMQVVQQLE IQLSKERERL
410 420 430 440 450
QAMMTHLHMR PSEPKPSPKP LNLVSSVTMS KNMLETSPQS LPQTPTTPTA
460 470 480 490 500
PVTPITQGPS VITPASVPNV GAIRRRHSDK YNIPMSSEIA PNYEFYKNAD
510 520 530 540 550
VRPPFTYATL IRQAIMESSD RQLTLNEIYS WFTRTFAYFR RNAATWKNAV
560 570 580 590 600
RHNLSLHKCF VRVENVKGAV WTVDEVEYQK RRSQKITGSP TLVKNIPTSL
610 620 630 640 650
GYGAALNASL QAALAESSLP LLSNPGLINN ASSGLLQAVH EDLNGSLDHI
660 670 680 690 700
DSNGNSSPGC SPQPHIHSIH VKEEPVIAED EDCPMSLVTT ANHSPELEDD
710
REIEEEPLSE DLE
Length:713
Mass (Da):79,677
Last modified:October 1, 2002 - v1
Checksum:i1F326A13E8019CB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF512948 mRNA Translation: AAN03386.1
AY143180 mRNA Translation: AAN60058.1
AY064597
, AY064583, AY064584, AY064586, AY064585, AY064588, AY064590, AY064592, AY064594, AY064596, AY064595, AY064593, AY064591, AY064589, AY064587 Genomic DNA Translation: AAL57733.1
RefSeqiNP_001266466.1, NM_001279537.1

Genome annotation databases

GeneIDi101150977

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF512948 mRNA Translation: AAN03386.1
AY143180 mRNA Translation: AAN60058.1
AY064597
, AY064583, AY064584, AY064586, AY064585, AY064588, AY064590, AY064592, AY064594, AY064596, AY064595, AY064593, AY064591, AY064589, AY064587 Genomic DNA Translation: AAL57733.1
RefSeqiNP_001266466.1, NM_001279537.1

3D structure databases

ProteinModelPortaliQ8MJ99
SMRiQ8MJ99
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101150977

Organism-specific databases

CTDi93986

Phylogenomic databases

HOVERGENiHBG051657
InParanoidiQ8MJ99

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR032354 FOXP-CC
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF16159 FOXP-CC, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOXP2_GORGO
AccessioniPrimary (citable) accession number: Q8MJ99
Secondary accession number(s): Q5QL02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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