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Entry version 61 (11 Dec 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Oxygen-regulated protein 1

Gene

RP1

Organism
Papio hamadryas (Hamadryas baboon)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation, Sensory transduction, Vision

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oxygen-regulated protein 1
Alternative name(s):
Retinitis pigmentosa RP1 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPapio hamadryas (Hamadryas baboon)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9557 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000974121 – 2152Oxygen-regulated protein 1Add BLAST2152

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8MJ06

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the doublecortin domains) with microtubules.

Interacts with RP1L1 (By similarity).

Interacts with MAK (By similarity).

By similarity

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8MJ06

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 118Doublecortin 1PROSITE-ProRule annotationAdd BLAST83
Domaini154 – 233Doublecortin 2PROSITE-ProRule annotationAdd BLAST80

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The doublecortin domains, which mediate interaction with microtubules, are required for regulation of microtubule polymerization and function in photoreceptor differentiation.By similarity

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.20.230, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
IPR040163 RP1/RP1L1/DCX

The PANTHER Classification System

More...
PANTHERi
PTHR23005 PTHR23005, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03607 DCX, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00537 DCX, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF89837 SSF89837, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50309 DC, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8MJ06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDTPSTGFS IIHPTSSEDQ VPPPRHLSLT HPVVAKRISF YKSGDPQFGG
60 70 80 90 100
VRVVVNPRSF KSFDALLDNL SRKVPLPFGV RNISTPRGRH SITRLEELED
110 120 130 140 150
GESYLCSHGR KVQPVDLDKA RRRPRPWLSS RAISAQAPPH PVAVAAPGKP
160 170 180 190 200
RAPRSLVVFR NGDPKTRRTV LLSRRVTQSF EAFLQHLTEV MQRPVVKLYA
210 220 230 240 250
TDGRRVPSLQ AVILSSGAVV AAGREPFKPG NYDIQKYLLP ARLPGISQRV
260 270 280 290 300
YPKGNAKSES RKISTHMSSS SRSQIYSVSS EKTHNNDCYL DYSFVPENYL
310 320 330 340 350
ALEKSDSQNL PIYPSEDDIE KSIIFNQDGT MTVEMKVRFR IKEEETIKWT
360 370 380 390 400
TTVSKTGPSN NDEKSEMSFP GRTESRSSGL KLAACSFSAD VSPMERSSDQ
410 420 430 440 450
EGSLPEEINI QTTDEEAETC SSASWENATV DTDITQGTQD QAKHRFYRPP
460 470 480 490 500
TPGLRRVRQK KSVIGSVTLV SETEVQEKMI GQFSYSEERE SGENKSEYHM
510 520 530 540 550
FAHSCSKMSA VSNKPVLVQI NNNDQMEESL LERKKENRLL KSSAISAGVI
560 570 580 590 600
EITSQKMLEM SHNNGLPSTI SNNSIVEEGV VDSMVSDNKT GIKNFRAYDN
610 620 630 640 650
TNDRFSPISA DATHFSSTNS GTDKNISEAT ASETSSTVTA RIDRLINEFA
660 670 680 690 700
QCGLTKLPKN EKKILSSVAS KKKKKSLQQA INSRYQDGQL ATKGILNKNE
710 720 730 740 750
RINTRGRIRK EMILQDSDSR LKGGILCEED LQTSDTVIES NTFCSKSNLN
760 770 780 790 800
SMISKNFHRN KLNTTQNSKV QGLLTKRKSK SLKKVSLGAP KKREICQGDK
810 820 830 840 850
VFPHNESKYC KSTFENKSLF HVFNILEQKP KYFYAPQSQA EVASGYLRGM
860 870 880 890 900
AKKSLVTDSH ITLRSQKKQK GDKLKASAVV SKQHATTRAN SLASLKKPDF
910 920 930 940 950
PEDIAHHSVQ NYIQSWLQNI NPYPTLKPIK SAPVCRNEMS VVNCNNNSFP
960 970 980 990 1000
GNDPHKSSGK INNFVMESNK HITKIASLTG DNLCKEGDKS FIASDTGEED
1010 1020 1030 1040 1050
LHETQVGSLN DAYLVSLHEH CTLSQSAIND RNTKRHIAAE KSGPEKKLVY
1060 1070 1080 1090 1100
QEINLARKRQ SVEAAIQVDP IEEETPKDLL PVLMLHQLQA SVPGISKTQN
1110 1120 1130 1140 1150
GVVQMPGSLA NVPFHSAICN SSTNLLLAWL LVLNLKGSMN SFCQVDAHKT
1160 1170 1180 1190 1200
INKSSETLAL LEILKHIAIT EEADDLKAAV ANLVESTTSH FGLSEKEQDV
1210 1220 1230 1240 1250
VPLDLSANCS TVSIQSVPKC SENERTQRIS SLDGDCSASE ACAPEVCVLE
1260 1270 1280 1290 1300
VTCSPCETWT VNKTYPPKET CNPSDTHFPS DGYGVDQTSM NKACFLGEVC
1310 1320 1330 1340 1350
SLTDTVFSNK ACAQKENHIY EGACPTVETY VPVSVCNTID FFNSKENTYT
1360 1370 1380 1390 1400
DNLESTEELE RGDDIQKDLN ILTDPEYKNG FNTLVSHQNV SNLSSCRLCL
1410 1420 1430 1440 1450
SEKEAELDKK HSSLDDFKNC SLKKFQDENA YTSFDMEEPR TSEEPGSITN
1460 1470 1480 1490 1500
SMTSSERNIS ELESFEELEN PDTDIFNTVV NGGEQATEEL IQEELEASKT
1510 1520 1530 1540 1550
LELIDISGKN VMEEKRRNGI IYEIISKRLA TPPSLVFCYD SKQNREKETN
1560 1570 1580 1590 1600
EGETKMVKMM VKSMEAGSYS ESSPDLKKCI KSPVTSDWSD YRPDSDSEQP
1610 1620 1630 1640 1650
YKTSSDDPND SGELAQEKEY NIGFVKRAIE KLYGKADIIK PSFFPGSTRK
1660 1670 1680 1690 1700
SQVCPYNSVE FQCSRKASLY DSEGQSFGSS EQVSTSSPML QEFQEERQDK
1710 1720 1730 1740 1750
CDVNGVRNDY YGGDIVEPGT KQNDHSRILT DIEEGVLIDK GKWLLKENHL
1760 1770 1780 1790 1800
LRMSSENPGM CGNADTTSVD TLLDNNSSEV PYSHFGNLAP VPVMDELSSS
1810 1820 1830 1840 1850
ELEELTQPLE LKCNYFNMPH GSDSEPFHED VHNETCAKER IANHHTEERG
1860 1870 1880 1890 1900
NNHQSERVCT SVTHSFTSAS NKVYPVSDDA IKNQPLPGSN MIHGTLQEAD
1910 1920 1930 1940 1950
SLDKLYALCG QHCPILTVII QPVNEEDRGF AYRKESDIEN FLGFYLWMKI
1960 1970 1980 1990 2000
HPYLLQTDKK VFREENNKAS MRQNHIDNAI GDIFDQFYFN NTFDLMGKRR
2010 2020 2030 2040 2050
KQKRINFLEL EEEGNLKKFQ PDLKERLCMN FLHTSLLVVS NMNSDTQDLS
2060 2070 2080 2090 2100
SQTNEMFKAV DENNNLLNTG FQGSRTNLNQ IVRENTNCHY FFEMLGQACL
2110 2120 2130 2140 2150
LDICQVETSL NISNRNTLEE LCMFEGENLF IWEEEDILNL TDLESSREQE

DL
Length:2,152
Mass (Da):241,002
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i574BD771E8B14C4C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY034784 mRNA Translation: AAK58441.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034784 mRNA Translation: AAK58441.1

3D structure databases

SMRiQ8MJ06
ModBaseiSearch...

Proteomic databases

PRIDEiQ8MJ06

Family and domain databases

Gene3Di3.10.20.230, 2 hits
InterProiView protein in InterPro
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
IPR040163 RP1/RP1L1/DCX
PANTHERiPTHR23005 PTHR23005, 1 hit
PfamiView protein in Pfam
PF03607 DCX, 2 hits
SMARTiView protein in SMART
SM00537 DCX, 2 hits
SUPFAMiSSF89837 SSF89837, 2 hits
PROSITEiView protein in PROSITE
PS50309 DC, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRP1_PAPHA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MJ06
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2002
Last modified: December 11, 2019
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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