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Entry version 74 (16 Jan 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Oxygen-regulated protein 1

Gene

RP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation, Sensory transduction, Vision

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oxygen-regulated protein 1
Alternative name(s):
Retinitis pigmentosa RP1 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000974081 – 2105Oxygen-regulated protein 1Add BLAST2105

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8MJ05

PRoteomics IDEntifications database

More...
PRIDEi
Q8MJ05

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the doublecortin domains) with microtubules. Interacts with RP1L1 (By similarity). Interacts with MAK (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
158304, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000014879

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8MJ05

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8MJ05

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 118Doublecortin 1PROSITE-ProRule annotationAdd BLAST83
Domaini153 – 232Doublecortin 2PROSITE-ProRule annotationAdd BLAST80

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The doublecortin domains, which mediate interaction with microtubules, are required for regulation of microtubule polymerization and function in photoreceptor differentiation.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1181 Eukaryota
KOG3757 Eukaryota
ENOG410ZE6Q LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018173

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8MJ05

KEGG Orthology (KO)

More...
KOi
K19538

Database of Orthologous Groups

More...
OrthoDBi
894392at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01617 DCX, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.20.230, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
IPR033013 Rp1
IPR040163 RP1/RP1L1

The PANTHER Classification System

More...
PANTHERi
PTHR23005 PTHR23005, 1 hit
PTHR23005:SF4 PTHR23005:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03607 DCX, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00537 DCX, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF89837 SSF89837, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50309 DC, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8MJ05-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETPSTSFS MVRRISSEGQ LPSPRQLGIT QPVVAKRISF YKSGDPQFGG
60 70 80 90 100
VRVVLNPRSF KTFDALLDNL SGKVPLPFGV RNISTPRGRH SITRLEELED
110 120 130 140 150
GQSYLCSHGR KVQPVDLDKA RRRPRPWLSS RALSTHVQRG PAPAAPGMLR
160 170 180 190 200
APRRLVVFRN GDPKTRRAIV LNRRVTQSFE VFLQYLTQVM QRPVTKLYAT
210 220 230 240 250
DGRKVPSLQA VILSSGAVVA AGREPFKPGN YDIQKYLLPA RLPGISRRVY
260 270 280 290 300
PKGNARSESR KMSTHVSSSP TSQIYSLSSE KMQNNDSYSD HSFASENYLA
310 320 330 340 350
LEKNDSQNLL IYPSEDDVEK SIIFNQDGTM TVEMKIRFKI KEEETIKWTT
360 370 380 390 400
TLCRADLSNN GEKSEINSLP GRTDDRSSGV KITACSLSAD VSPLEKGGSQ
410 420 430 440 450
VDSLAEEANT QVKDQDVETG SSTSWENPAL DTDATQGTQD RVKHRFYRPP
460 470 480 490 500
TPGPRRVRQK KSVIGSVTLV SETEVQEKMI GQFSYNEERK DWENKSEYHM
510 520 530 540 550
VTHSCSKMSS VSNRPILVQV DNDEQVASSL ERKKESRLLK SSAVSAGVVE
560 570 580 590 600
ITSQKTLEMS HNGGLPQTTS EKSIVEEGIV DNVIADNKAR VRNLRTYGNT
610 620 630 640 650
DDRSSPFLGD AAHFSSNNPG TDKTISKTPA SVGNSTVTTR IDQLIHEFSH
660 670 680 690 700
CGLTKLPENE KQISSSVASK KKMKSQQHVI NSQHQAGEMA TKRIPRKNKR
710 720 730 740 750
MNTRGRIAQE TILRDSHSSL KGAILCEKDL HASDTVIESN YFSSKGNNPV
760 770 780 790 800
NSRNFPRNKL NTIHKPKIQG LLARRKSRPL NKVNLGGPTK REIGQGEKVF
810 820 830 840 850
SHNEIGCCKN TFENQNLFHL FNFLEQKPNA FCGPESQAET ASWYLRGTSK
860 870 880 890 900
RSLVSKVNNS HITLRSQKKQ KRDKLKSDTT VSKEHVTTRA NSLASLEKAV
910 920 930 940 950
FPENVTHHSV QSYVQRWLQN LSPQAALQLG KSAPVYKKER GVASYNNGFL
960 970 980 990 1000
PGNSSHTSSG KRNDSILQSN RHTTKSASLT GDNLGKRVGM SFDKNSSEEL
1010 1020 1030 1040 1050
IQDHCESQTD SLNDTYLLSV HEFCTLSQSA TDDPNAKSQV SAAKSGQEMS
1060 1070 1080 1090 1100
LVYKDINLAA KGPSVETAVQ VDLEGDTPQH LSPVQLLHQL QALVPSSPKA
1110 1120 1130 1140 1150
QNGVVQMPGP LSEVPFPSLI RNSSTNVLLA WLLVLTLKGG VSSFCPGDAL
1160 1170 1180 1190 1200
KATSGSSEAL ALLEVLKHIA VTEEADDLKA AVASLVESTT NHSGLTEKEQ
1210 1220 1230 1240 1250
DVGPIGLSAN CSTPNIQIIP QCAENEKTQK ISLDGSHTAG EEVSEVCVTA
1260 1270 1280 1290 1300
VTRSPRKMGT VVKTYPPEET CHLSEDSFPS DDCTMDQTSM NKACFLGDIS
1310 1320 1330 1340 1350
SLTEAVSSHE GCAYEQNHIY ERADNLELTK ELERVDEVQK DRNILADPGC
1360 1370 1380 1390 1400
KHGSNMLVSH QSASSLSPCG SFQNTTESEL DGEHSFLDKS ESCSLKKFQD
1410 1420 1430 1440 1450
KSVYTSFDKE DSKTSEEPGS TTNSMTSSER NVSEMESFEE LENQNTDIFN
1460 1470 1480 1490 1500
IKVNSGEQVT EELIREELEA GKSLELIEVS SRNDAEEGKD GVICETISRK
1510 1520 1530 1540 1550
LVTPPSLVFC YDSKQNMEKE PSEGETETKV RKMVESLEAG SSAESPLNFK
1560 1570 1580 1590 1600
SGLRRSGTSD WSDYRQNSEN EPSYKASSNG PSDSDEEMTP EKECNKGFVK
1610 1620 1630 1640 1650
RTIEKLYGKA EMMRPFFFRW IYTHISGLSC DSVEFQGTGK VGLYDPEGQS
1660 1670 1680 1690 1700
LGSLERVSSN STVLQKFPEQ KRDKCDVNNV RASYPREDIA EHGTKQNDHK
1710 1720 1730 1740 1750
TILRDREEGV LIDKGKWLLK ENHLLRLSSP ECSGPCGHAD TTSVDTLLDN
1760 1770 1780 1790 1800
SSTEVPYSHF GNLAPGPNMA ELSSSELEEL TQPPELRCNY FNVPHCSDSE
1810 1820 1830 1840 1850
PFHDDELDTQ DEACAQEREP NHPAEEKGNL RSERVCTSAT HVFASAGNKV
1860 1870 1880 1890 1900
HPVSDGAVRN QPLAGSNVIH GALQEGDSLD KLYNICGQHC PILTVINQPV
1910 1920 1930 1940 1950
NEEHRGFAYC KDSDVENSLS LQLWMKIHPC LRHSSKTMFR DKNNKTISRR
1960 1970 1980 1990 2000
ALTDNAVGNT HVWPHFNNTF DLMDRRRKLK QSNCLGLEEE NNFNKFQSYL
2010 2020 2030 2040 2050
KNFLHTLLLV VGQVNSNPQD PSSQTKEFFE VVDENNNLLN SRFQNSGTNL
2060 2070 2080 2090 2100
NQVVREHSYH LSFEMLGQAR LFCQVETFLG ISNRNILEMF YIFEDENLFI

WEEEN
Length:2,105
Mass (Da):233,979
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73D0C3785842DDF5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY034785 mRNA Translation: AAK58442.1

NCBI Reference Sequences

More...
RefSeqi
NP_776383.1, NM_173958.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Bt.11214

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
280916

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:280916

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034785 mRNA Translation: AAK58442.1
RefSeqiNP_776383.1, NM_173958.1
UniGeneiBt.11214

3D structure databases

ProteinModelPortaliQ8MJ05
SMRiQ8MJ05
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi158304, 1 interactor
STRINGi9913.ENSBTAP00000014879

Proteomic databases

PaxDbiQ8MJ05
PRIDEiQ8MJ05

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280916
KEGGibta:280916

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6101

Phylogenomic databases

eggNOGiKOG1181 Eukaryota
KOG3757 Eukaryota
ENOG410ZE6Q LUCA
HOVERGENiHBG018173
InParanoidiQ8MJ05
KOiK19538
OrthoDBi894392at2759

Family and domain databases

CDDicd01617 DCX, 2 hits
Gene3Di3.10.20.230, 2 hits
InterProiView protein in InterPro
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
IPR033013 Rp1
IPR040163 RP1/RP1L1
PANTHERiPTHR23005 PTHR23005, 1 hit
PTHR23005:SF4 PTHR23005:SF4, 1 hit
PfamiView protein in Pfam
PF03607 DCX, 2 hits
SMARTiView protein in SMART
SM00537 DCX, 2 hits
SUPFAMiSSF89837 SSF89837, 2 hits
PROSITEiView protein in PROSITE
PS50309 DC, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRP1_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MJ05
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2002
Last modified: January 16, 2019
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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