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Entry version 61 (22 Apr 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Oxygen-regulated protein 1

Gene

RP1

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation, Sensory transduction, Vision

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oxygen-regulated protein 1
Alternative name(s):
Retinitis pigmentosa RP1 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39432 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeSaimiriinaeSaimiri
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233220 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Whole Genome Shotgun Assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000974131 – 2149Oxygen-regulated protein 1Add BLAST2149

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8MJ03

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the doublecortin domains) with microtubules.

Interacts with RP1L1 (By similarity).

Interacts with MAK (By similarity).

By similarity

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8MJ03

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 118Doublecortin 1PROSITE-ProRule annotationAdd BLAST83
Domaini152 – 231Doublecortin 2PROSITE-ProRule annotationAdd BLAST80

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The doublecortin domains, which mediate interaction with microtubules, are required for regulation of microtubule polymerization and function in photoreceptor differentiation.By similarity

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.20.230, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
IPR040163 RP1/RP1L1/DCX

The PANTHER Classification System

More...
PANTHERi
PTHR23005 PTHR23005, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03607 DCX, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00537 DCX, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF89837 SSF89837, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50309 DC, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8MJ03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDTPSTGFS MIHPTSSEGQ VPSPRHLSLT HPVVAKRISF YKSGDPQFGG
60 70 80 90 100
VRVVVNPRSF KSFDALLDNL SRKVPLPFGV RNISTPRGRH SITRLEELED
110 120 130 140 150
GESYLCSHGR KVQPVDLDKA RRRPRPWLSS RAVSTHAPPH SVAAPGMPRA
160 170 180 190 200
PRSLVVFRNG DPKTRRAVLL SRKVTQSFEA FLQHLTEVMQ RPVVKLYATD
210 220 230 240 250
GRRVPSLQAV ILSSGAVVAA GREPFKPGNY DIQKYLLPAR LPGISQRVYP
260 270 280 290 300
KGNGKSESRK ISTHMASSSR SQIYSVSSEK THNNDCYLDY SFVPENYLAL
310 320 330 340 350
EKNDSQNLPI YPSEDDVEKS IIFNQDGTMT VEMKVRFRIK EEETIKWTTT
360 370 380 390 400
VSKTGPSNND EKSEMSFPGR TESRSSGLKL AACSFSADVS PTERSSNQEG
410 420 430 440 450
SLAEEINIQM TDQEAETCSS ASWENATVDT DIIQGTQDQA KHRFYRPPTP
460 470 480 490 500
GLRRVRQKKS VIGSVTLVSE TEVQEKMIGQ FSYSEERESG ENKSEYHMFT
510 520 530 540 550
HSCSKMSSVS NKPVLVQINN SDQMEESSLE RKKENRLLKS SAISAGVIEI
560 570 580 590 600
TSQKMLELSH NNGLPSTISN NSIVEEDVVD SVVSDNKTGI KNLRTYGNTS
610 620 630 640 650
DRFSPVSADA THFSSNKSRA DKNISEAPAS VASSTVTARI DRLINEFAQC
660 670 680 690 700
GLTKLPKTEK KILSSVASKK KKKKSQQQAI NSRYQDGQLA TTGILNKNER
710 720 730 740 750
INAGGRITKE MILQDSDSPL KGGVLCEEDL RTSETVIESN TFCSKSNLNP
760 770 780 790 800
MISKNFHRNK LNTTQNSKVQ GLLTKRKSRP LRKISLGTPK KREIGQGDKV
810 820 830 840 850
FPHNESKYSK STCENKSLFH VFNLLEQKPK HFSGPRSQAE VASGYLRGMA
860 870 880 890 900
KKSLVSKVTD SHITLKSQKK QKGDKLKASA ILSKQHAATR ANSLASLKKP
910 920 930 940 950
DFPEDIAHPS VQTYIQNWLH NINPYPTLKP IKSAPVCKNE ISVVNCNNSF
960 970 980 990 1000
SGNDPHTSSG KINNFVMESN KHITKIASLT GDNLCKEGDK SFIANDTGED
1010 1020 1030 1040 1050
LCETQVGSLN DAYLVSLHEH CTSPQSAIND RNTKSRISPE KSGPEINLVY
1060 1070 1080 1090 1100
QEINLAKKRQ SVEAAIQVDP IEEDTPKDLL PVLMLHQLQA SVPSTPKTQN
1110 1120 1130 1140 1150
GVVRMPGSLA DVSFPSAICN SSTNLLLAWL LVLNLKGSMN SFCQGDAHKT
1160 1170 1180 1190 1200
TNKSSETLAL LEILKHIAIT EEADDLKAAV ANLVESTTNH FGLSEKEQDT
1210 1220 1230 1240 1250
VPIDLSANCS IVNIQSVPKC NENEGTQGIF SFDGGCSAVE ACAPEVCVLE
1260 1270 1280 1290 1300
LTYPPREVCT VNKAYVPKET CNLSDTFFPS DGYTVDRTSM NKACFVGEVC
1310 1320 1330 1340 1350
SLTDTVFSDK ACAQKENHIY EGACATDETC VPVDVCNTTG FLNSKQNTYT
1360 1370 1380 1390 1400
DNLESTEELE RGDDVQKDLN ILTDPEYKNG FNTLVSHQNV SNLSPCGLCV
1410 1420 1430 1440 1450
SEEAEFDKKH SSADDFKNCS LNLFQDKNAY TSFDMEEPRT SEEPGSVTNS
1460 1470 1480 1490 1500
VTSSERNISE LESFEELENQ DTDIFNTEIN VGEKATEEFI QEEIEASKTL
1510 1520 1530 1540 1550
ELLDISSKNI MVEERKNGII YETISKRLAT PPSLVFCYDS KQNNEKETNE
1560 1570 1580 1590 1600
GETNMVKMMV KSMETGSYSE SSPDMKKCIK SPVTSDWSDY RPDSDSEQAY
1610 1620 1630 1640 1650
KTSSDDPNDS GELEKEYNIG FVKRAIEKLY GKADIIKPSF FPGSTRKSQV
1660 1670 1680 1690 1700
CPYNSVEFQC TRRASLYDSE GQSFGSSERV SSSSPVLQEF QEEGQDKCDI
1710 1720 1730 1740 1750
NHVRNNYCGG DIVEPGTKEN DHSRVLTDIE EGVLIDKGKW LLKENHLLRM
1760 1770 1780 1790 1800
SYENPGVCGN ADTTSVDTLL DNNSSEVPYS HFGNLAPGPT MDELSSSELE
1810 1820 1830 1840 1850
ELTQPLELKC NYFKMPHGSD SEPFHEDLLG VHNETCDKER IANHHTEEKC
1860 1870 1880 1890 1900
PHQSERICTS VTHSFMSAGN KVYPVSDDAI KNQPLPGSNM IHGTLQETDS
1910 1920 1930 1940 1950
LDKLYALCGQ HCPILTVTIQ PVNEEDRGFA YRKESDIENF LGFYLWMKIH
1960 1970 1980 1990 2000
PYLLQTDKNM FREENNKASM RKNLINNATG DIFDEFYFSN IFDLMDKRRK
2010 2020 2030 2040 2050
QKRINFLELQ EAGNLKKFQP DLKERFCMYF LHTSSLVVGN MNSNTQDLSS
2060 2070 2080 2090 2100
QTNEIFKAVD ENNNLLNNRF QGSRTNLNQV VRENISRYFF EMLGQACLLD
2110 2120 2130 2140
ICQVETSLNI SNRNILEELC MFEDENIFIW EEEDILNLTD LESSREQDL
Length:2,149
Mass (Da):239,837
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02CDCA902C3A9823
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY034787 mRNA Translation: AAK58444.1

NCBI Reference Sequences

More...
RefSeqi
NP_001266942.1, NM_001280013.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101034977

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034787 mRNA Translation: AAK58444.1
RefSeqiNP_001266942.1, NM_001280013.1

3D structure databases

SMRiQ8MJ03
ModBaseiSearch...

Proteomic databases

PRIDEiQ8MJ03

Genome annotation databases

GeneIDi101034977

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6101

Family and domain databases

Gene3Di3.10.20.230, 2 hits
InterProiView protein in InterPro
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
IPR040163 RP1/RP1L1/DCX
PANTHERiPTHR23005 PTHR23005, 1 hit
PfamiView protein in Pfam
PF03607 DCX, 2 hits
SMARTiView protein in SMART
SM00537 DCX, 2 hits
SUPFAMiSSF89837 SSF89837, 2 hits
PROSITEiView protein in PROSITE
PS50309 DC, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRP1_SAIBB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MJ03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2002
Last modified: April 22, 2020
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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