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UniProtKB - Q8MIZ1 (CXL10_MACMU)
Protein
C-X-C motif chemokine 10
Gene
CXCL10
Organism
Macaca mulatta (Rhesus macaque)
Status
Functioni
Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity).
By similarityGO - Molecular functioni
- chemokine activity Source: UniProtKB
- CXCR3 chemokine receptor binding Source: UniProtKB
- CXCR chemokine receptor binding Source: GO_Central
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: GO_Central
- cellular response to lipopolysaccharide Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- chemotaxis Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: UniProtKB
- inflammatory response Source: GO_Central
- neutrophil chemotaxis Source: GO_Central
- positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
- regulation of cell population proliferation Source: UniProtKB
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Inflammatory response |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C motif chemokine 10Alternative name(s): 10 kDa interferon gamma-induced protein Short name: Gamma-IP10 Short name: IP-10 Small-inducible cytokine B10 |
Gene namesi | Name:CXCL10 Synonyms:SCYB10 |
Organismi | Macaca mulatta (Rhesus macaque) |
Taxonomic identifieri | 9544 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | By similarityAdd BLAST | 21 | |
ChainiPRO_0000005103 | 22 – 98 | C-X-C motif chemokine 10Add BLAST | 77 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 26 | CitrullineBy similarity | 1 | |
Disulfide bondi | 30 ↔ 57 | By similarity | ||
Disulfide bondi | 32 ↔ 74 | By similarity |
Keywords - PTMi
Citrullination, Disulfide bondInteractioni
GO - Molecular functioni
- chemokine activity Source: UniProtKB
- CXCR3 chemokine receptor binding Source: UniProtKB
- CXCR chemokine receptor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9544.ENSMMUP00000027500 |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine alpha (chemokine CxC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S7MM, Eukaryota |
InParanoidi | Q8MIZ1 |
OrthoDBi | 1548456at2759 |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8MIZ1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNQTAILICC LVFLTLSGIQ GIPLSRTVRC TCISISNQPV NPRSLEKLEI
60 70 80 90
IPPSQFCPHV EIIATMKKKG EKRCLNPESK AIKNLLKAVS KERSKRSP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY044446 mRNA Translation: AAK95955.1 |
RefSeqi | NP_001028064.1, NM_001032892.1 |
Genome annotation databases
GeneIDi | 574243 |
KEGGi | mcc:574243 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY044446 mRNA Translation: AAK95955.1 |
RefSeqi | NP_001028064.1, NM_001032892.1 |
3D structure databases
SMRi | Q8MIZ1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9544.ENSMMUP00000027500 |
Protocols and materials databases
ABCDi | Q8MIZ1, 12 sequenced antibodies |
Genome annotation databases
GeneIDi | 574243 |
KEGGi | mcc:574243 |
Organism-specific databases
CTDi | 3627 |
Phylogenomic databases
eggNOGi | ENOG502S7MM, Eukaryota |
InParanoidi | Q8MIZ1 |
OrthoDBi | 1548456at2759 |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CXL10_MACMU | |
Accessioni | Q8MIZ1Primary (citable) accession number: Q8MIZ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | October 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families