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Entry version 49 (25 May 2022)
Sequence version 1 (01 Oct 2002)
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Protein

Maturation protein A2

Gene
N/A
Organism
Escherichia virus Qbeta (Bacteriophage Q-beta)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Induces host cell lysis (PubMed:11892805, PubMed:29078304).

Inhibits host MurA activity thereby blocking the synthesis of murein precursors necessary for the host cell wall biosynthesis (PubMed:11423662, PubMed:29078304).

May be responsible for the attachment to the host pilus. Makes extensive contacts with the viral genome (PubMed:28111107).

5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCytolysis, Host cell lysis by virus, Host-virus interaction, Viral attachment to host adhesion receptor, Viral attachment to host cell, Viral attachment to host cell pilus, Viral release from host cell, Virus entry into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Maturation protein A2Imported
Short name:
MP
Alternative name(s):
A2 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia virus Qbeta (Bacteriophage Q-beta)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39803 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeLenarviricotaAllassoviricetesLeviviralesLeviviridaeAllolevivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiEscherichia coli [TaxID: 562]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000305125 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000306921 Componenti: Genome
  • UP000185268 Componenti: Genome
  • UP000309733 Componenti: Genome
  • UP000001616 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004388811 – 420Maturation protein A2Add BLAST420

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with host MurA; this interaction inhibits the first step in host cell wall synthesis (PubMed:22934834, PubMed:29078304).

Interacts with the capsid protein (PubMed:28111107, PubMed:29078304).

3 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1420
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8LTE2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni158 – 176RNA-binding1 PublicationAdd BLAST19
Regioni226 – 236RNA-binding1 PublicationAdd BLAST11
Regioni294 – 298RNA-binding1 Publication5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005563, A_protein

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03863, Phage_mat-A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8LTE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKLPRGLRF GADNEILNDF QELWFPDLFI ESSDTHPWYT LKGRVLNAHL
60 70 80 90 100
DDRLPNVGGR QVRRTPHRVT VPIASSGLRP VTTVQYDPAA LSFLLNARVD
110 120 130 140 150
WDFGNGDSAN LVINDFLFRT FAPKEFDFSN SLVPRYTQAF SAFNAKYGTM
160 170 180 190 200
IGEGLETIKY LGLLLRRLRE GYRAVKRGDL RALRRVIQSY HNGKWKPATA
210 220 230 240 250
GNLWLEFRYG LMPLFYDIRD VMLDWQNRHD KIQRLLRFSV GHGEDYVVEF
260 270 280 290 300
DNLYPAVAYF KLKGEITLER RHRHGISYAN REGYAVFDNG SLRPVSDWKE
310 320 330 340 350
LATAFINPHE VAWELTPYSF VVDWFLNVGD ILAQQGQLYH NIDIVDGFDR
360 370 380 390 400
RDIRLKSFTI KGERNGRPVN VSASLSAVDL FYSRLHTSNL PFATLDLDTT
410 420
FSSFKHVLDS IFLLTQRVKR
Length:420
Mass (Da):48,547
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF119F7AC04FF950
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti29F → L in strain: Qbeta_2_FR. 1 Publication1
Natural varianti76S → L in strain: Qbeta_2. 1 Publication1
Natural varianti100D → G in strain: Qbeta_2. 1 Publication1
Natural varianti110N → D in strain: Qbeta_2_FR. 1 Publication1
Natural varianti121F → S in strain: TW18. 1 Publication1
Natural varianti138Q → K in strain: Qbeta_3_FR. 1 Publication1
Natural varianti189S → F in strain: Qbeta_3. 1 Publication1
Natural varianti198A → T in strain: TW18. 1 Publication1
Natural varianti218I → V in strain: Qbeta_3_FR. 1 Publication1
Natural varianti219R → G in strain: Qbeta_1. 1 Publication1
Natural varianti219R → K in strain: TW18. 1 Publication1
Natural varianti246Y → C in strain: TW18. 1 Publication1
Natural varianti254Y → C in strain: Qbeta_3. 1 Publication1
Natural varianti282E → G in strain: Qbeta_3_FR and Qbeta_3. 2 Publications1
Natural varianti331I → M in strain: Qbeta_2. 1 Publication1
Natural varianti360I → V in strain: Qbeta_3_F and Qbeta_3. 2 Publications1
Natural varianti374S → D in strain: TW18. 1 Publication1
Natural varianti389N → S in strain: TW18. 1 Publication1
Natural varianti404F → Y in strain: TW18. 1 Publication1
Natural varianti412F → S in strain: Qbeta_2_FR and Qbeta_3FR. 2 Publications1
Natural varianti418V → I in strain: TW18. 1 Publication1
Natural varianti419K → N in strain: Qbeta_2_FR. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY099114 Genomic RNA Translation: AAM33125.1
FJ483840 Genomic RNA Translation: ACT66729.1
GQ153928 Genomic RNA Translation: ACY07222.1
GQ153929 Genomic RNA Translation: ACY07226.1
GQ153930 Genomic RNA Translation: ACY07230.1
GQ153931 Genomic RNA Translation: ACY07234.1
JF719735 Genomic RNA Translation: AEQ25540.1
JF719736 Genomic RNA Translation: AEQ25544.1
JF719737 Genomic RNA Translation: AEQ25548.1
AB971354 Genomic RNA Translation: BAP18762.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY099114 Genomic RNA Translation: AAM33125.1
FJ483840 Genomic RNA Translation: ACT66729.1
GQ153928 Genomic RNA Translation: ACY07222.1
GQ153929 Genomic RNA Translation: ACY07226.1
GQ153930 Genomic RNA Translation: ACY07230.1
GQ153931 Genomic RNA Translation: ACY07234.1
JF719735 Genomic RNA Translation: AEQ25540.1
JF719736 Genomic RNA Translation: AEQ25544.1
JF719737 Genomic RNA Translation: AEQ25548.1
AB971354 Genomic RNA Translation: BAP18762.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MNTX-ray3.32A/B/C/D2-420[»]
5VLZelectron microscopy4.40EJ1-420[»]
5VM7electron microscopy5.70A1-420[»]
7LHDelectron microscopy4.60M1-420[»]
SMRiQ8LTE2
ModBaseiSearch...
PDBe-KBiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR005563, A_protein
PfamiView protein in Pfam
PF03863, Phage_mat-A, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMATA2_BPQBE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8LTE2
Secondary accession number(s): C8YJH8
, D0U1F1, D0U1F5, D0U1F9, D0U1G3, G4WZR1, G4WZR5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2017
Last sequence update: October 1, 2002
Last modified: May 25, 2022
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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