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Entry version 104 (16 Oct 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Membrane protein of ER body-like protein

Gene

MEBL

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Not essential for the accumulation of ER body components, including PYK10.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane protein of ER body-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEBL
Ordered Locus Names:At4g27870
ORF Names:T27E11.110
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G27870

The Arabidopsis Information Resource

More...
TAIRi
locus:2137390 AT4G27870

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei549 – 569Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei573 – 593Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei640 – 660Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei670 – 690Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei702 – 722Helical; Name=5Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004304691 – 761Membrane protein of ER body-like proteinAdd BLAST761

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8LPT3

PRoteomics IDEntifications database

More...
PRIDEi
Q8LPT3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8LPT3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8LPT3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Not induced by NAI1.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8LPT3 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
14187, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8LPT3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT4G27870.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili186 – 206Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 65Poly-Ser9
Compositional biasi618 – 621Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCC1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXJ8 Eukaryota
ENOG41129ND LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000148678

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8LPT3

Database of Orthologous Groups

More...
OrthoDBi
953616at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8LPT3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008217 Ccc1_fam

The PANTHER Classification System

More...
PANTHERi
PTHR31851 PTHR31851, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8LPT3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSAAELTEP TTGTEKLHQP IEVEEDDEQI VDLERKTFRH GKGHDTSVDS
60 70 80 90 100
STITNTSSSS SSSFSGDGGT EETPDFHSNG DGEHTDLVNL EVPELETEIV
110 120 130 140 150
FHQEHDDGKN CIVFFDGEQG SESAGAIPDA HEESQTADLN GEQTQLEPEN
160 170 180 190 200
GSTSEDNERS REIEEVLDGD VSKDLDAVDP LAGEVIEEEV DFEDVEYHDV
210 220 230 240 250
ENMMDKQETH DLYCPNCDSC ITKKVILKRR KRKIRRHELG DSKRPHLTEP
260 270 280 290 300
LFHSEDNLPS LDGGENSANE SFVFKCLSCF TIFIPKGVSS KPIPPRQGVE
310 320 330 340 350
GLKIQPNPQV EATGDSNWFS SIFGLNKKES AIQQGGASSS VLEANPPPRE
360 370 380 390 400
SIVPVVNPSR GNLSPMRKDT TGSAVVQPDA ATSIQVAKSN DTSEIVNNGA
410 420 430 440 450
IVGDGQKFLA PMVEEQTQQK IDNDDSSTAD GNHTSDKGRL SPIQPSHGMS
460 470 480 490 500
ILNTVTNGPD GLKVETTIHE EGAPLLFEGK DTPDTSTADF GLTKVTGVMD
510 520 530 540 550
TGDRGVITGP ANPEIDISAG NLLEEGSLRE PLMRRVVVQG RKLEILKSIV
560 570 580 590 600
YGGLLEAITS LGVISSAAGS GASMLNILVL GLANLLGGLI LIIHNLQELR
610 620 630 640 650
EEEPIRTTTE DNQTNGREEE EGRYKRLLGR RENFTLHATV AILSFIITGI
660 670 680 690 700
LPPVVYYFSF SEKHNKDYKV ASVFGASLFC IVLLAIAKAH VRYPRGSYLK
710 720 730 740 750
SILYYGSIAV SVSGISYVVG NFLEQLLEKH GWSDGSETPV GQMMLSSLMG
760
RKAGFGYSSS Y
Length:761
Mass (Da):82,551
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFF6DA64E8A5BD70
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8B475A0A1P8B475_ARATH
Vacuolar iron transporter (VIT) fam...
At4g27870, T27E11.110, T27E11_110
781Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL08260 differs from that shown. Reason: Frameshift.Curated
The sequence CAB43975 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB81436 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL078579 Genomic DNA Translation: CAB43975.1 Sequence problems.
AL161571 Genomic DNA Translation: CAB81436.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85403.1
AY094391 mRNA Translation: AAM19770.1
BT002626 mRNA Translation: AAO11542.1
AY056404 mRNA Translation: AAL08260.1 Frameshift.

Protein sequence database of the Protein Information Resource

More...
PIRi
T09026

NCBI Reference Sequences

More...
RefSeqi
NP_567789.2, NM_118925.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G27870.1; AT4G27870.1; AT4G27870

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
828900

Gramene; a comparative resource for plants

More...
Gramenei
AT4G27870.1; AT4G27870.1; AT4G27870

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G27870

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078579 Genomic DNA Translation: CAB43975.1 Sequence problems.
AL161571 Genomic DNA Translation: CAB81436.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85403.1
AY094391 mRNA Translation: AAM19770.1
BT002626 mRNA Translation: AAO11542.1
AY056404 mRNA Translation: AAL08260.1 Frameshift.
PIRiT09026
RefSeqiNP_567789.2, NM_118925.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi14187, 1 interactor
IntActiQ8LPT3, 1 interactor
STRINGi3702.AT4G27870.1

PTM databases

iPTMnetiQ8LPT3
SwissPalmiQ8LPT3

Proteomic databases

PaxDbiQ8LPT3
PRIDEiQ8LPT3

Genome annotation databases

EnsemblPlantsiAT4G27870.1; AT4G27870.1; AT4G27870
GeneIDi828900
GrameneiAT4G27870.1; AT4G27870.1; AT4G27870
KEGGiath:AT4G27870

Organism-specific databases

AraportiAT4G27870
TAIRilocus:2137390 AT4G27870

Phylogenomic databases

eggNOGiENOG410IXJ8 Eukaryota
ENOG41129ND LUCA
HOGENOMiHOG000148678
InParanoidiQ8LPT3
OrthoDBi953616at2759
PhylomeDBiQ8LPT3

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8LPT3

Gene expression databases

ExpressionAtlasiQ8LPT3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR008217 Ccc1_fam
PANTHERiPTHR31851 PTHR31851, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEBL_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8LPT3
Secondary accession number(s): Q93ZP6, Q9STN9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 2014
Last sequence update: October 1, 2002
Last modified: October 16, 2019
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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