UniProtKB - Q8LPT1 (AB6B_ARATH)
Protein
ABC transporter B family member 6
Gene
ABCB6
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 447 – 454 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1193 – 1200 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
Keywordsi
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | ARA:AT2G39480-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: ABC transporter B family member 6Short name: ABC transporter ABCB.6 Short name: AtABCB6 Alternative name(s): Multidrug resistance protein 6 P-glycoprotein 6 |
Gene namesi | Name:ABCB6 Synonyms:MDR6, PGP6 Ordered Locus Names:At2g39480 ORF Names:F12L6.14 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G39480 |
TAIRi | locus:2039747, AT2G39480 |
Subcellular locationi
Other locations
- Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation
Golgi apparatus
- Golgi apparatus Source: TAIR
Nucleus
- nucleus Source: TAIR
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: TAIR
Other locations
- plasmodesma Source: TAIR
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 84 – 104 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 139 – 159 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 212 – 231 | HelicalPROSITE-ProRule annotationAdd BLAST | 20 | |
Transmembranei | 236 – 258 | HelicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Transmembranei | 310 – 330 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 351 – 371 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 840 – 860 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 880 – 900 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 958 – 978 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 982 – 1002 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1061 – 1081 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1102 – 1122 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000227917 | 1 – 1407 | ABC transporter B family member 6Add BLAST | 1407 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 291 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 449 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 663 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 727 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 767 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1178 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1260 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1346 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q8LPT1 |
PRIDEi | Q8LPT1 |
ProteomicsDBi | 244627 |
PTM databases
iPTMneti | Q8LPT1 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q8LPT1, baseline and differential |
Genevisiblei | Q8LPT1, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 3871, 2 interactors |
IntActi | Q8LPT1, 2 interactors |
STRINGi | 3702.AT2G39480.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 86 – 379 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 294 | |
Domaini | 412 – 647 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 236 | |
Domaini | 835 – 1123 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 289 | |
Domaini | 1158 – 1395 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 238 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0055, Eukaryota |
HOGENOMi | CLU_000604_17_2_1 |
InParanoidi | Q8LPT1 |
OrthoDBi | 186078at2759 |
PhylomeDBi | Q8LPT1 |
Family and domain databases
Gene3Di | 1.20.1560.10, 3 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8LPT1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMISRGLFGW SPPHIQPLTP VSEVSEPPES PSPYLDPGAE HGGTGTAAQA
60 70 80 90 100
DDEEEMEEPE EMEPPPAAVP FSQLFACADR FDWVLMVFGS VAAAAHGTAL
110 120 130 140 150
IVYLHYFAKI VQVLAFPTDS DHLISDDQFN RLLELSLTIV YIAGGVFISG
160 170 180 190 200
WIEVSCWILT GERQTAVIRS KYVQVLLNQD MSFFDTYGNN GDIVSQVLSD
210 220 230 240 250
VLLIQSALSE KVGNYIHNMA TFISGLIIGF VNCWEIALIT LATGPFIVAA
260 270 280 290 300
GGISNIFLHR LAENIQDAYA EAASIAEQAV SYVRTLYAFT NETLAKYSYA
310 320 330 340 350
TSLQATLRYG ILISLVQGLG LGFTYGLAIC SCAMQLWIGR FFVIHHRANG
360 370 380 390 400
GEIITALFAV ILSGLGLNQA ATNFYSFDQG RIAAYRLFEM ISRSSSGTNQ
410 420 430 440 450
EGIILSAVQG NIEFRNVYFS YLSRPEIPIL SGFYLTVPAK KAVALVGRNG
460 470 480 490 500
SGKSSIIPLM ERFYDPTLGE VLLDGENIKN LKLEWLRSQI GLVTQEPALL
510 520 530 540 550
SLSIRENIAY GRDATLDQIE EAAKKAHAHT FISSLEKGYE TQVGKTGLTL
560 570 580 590 600
TEEQKIKLSI ARAVLLDPTI LLLDEVTGGL DFEAERVVQE ALDLLMLGRS
610 620 630 640 650
TIIIARRLSL IRNADYIAVM EEGQLLEMGT HDELINLGNL YAELLKCEEA
660 670 680 690 700
TKLPRRMPVR NYNDSAAFQA ERDSSAGRGF QEPSSPKMAK SPSLQRGHNV
710 720 730 740 750
FRSQELCFNS EESPNDHSPA PEKLGENGSS LDVGEKEPTI KRQDSFEMRL
760 770 780 790 800
PELPKIDIQC PQRQKSNGSD PESPISPLLI SDPQNERSHS QTFSRPLGHS
810 820 830 840 850
DDTSASVKVA KDGQHKEPPS FWRLAQLSFP EWLYAVLGSI GAAIFGSFNP
860 870 880 890 900
LLAYVIALVV TTYYTSKGSH LREEVDKWCL IIACMGIVTV VANFLQHFYF
910 920 930 940 950
GIMGEKMTER VRRMMFSAML RNEVGWYDEE ENSPDTLSMR LANDATFVRA
960 970 980 990 1000
AFSNRLSIFI QDSFAVIVAI LIGLLLGWRL ALVALATLPV LTLSAIAQKL
1010 1020 1030 1040 1050
WLAGFSKGIQ EMHRKASLVL EDAVRNIYTV VAFCAGNKVM ELYRLQLQRI
1060 1070 1080 1090 1100
LRQSFFHGMA IGFAFGFSQF LLFACNALLL WYTALSVDRR YMKLSTALTE
1110 1120 1130 1140 1150
YMVFSFATFA LVEPFGLAPY ILKRRRSLAS VFEIIDRVPT IEPDDTSALS
1160 1170 1180 1190 1200
PPNVYGSIEL KNIDFCYPTR PEVLVLSNFS LKVNGGQTVA VVGVSGSGKS
1210 1220 1230 1240 1250
TIISLIERYY DPVAGQVLLD GRDLKSYNLR WLRSHMGLIQ QEPIIFSTTI
1260 1270 1280 1290 1300
RENIIYARHN ASEAEMKEAA RIANAHHFIS SLPHGYDTHI GMRGVELTQG
1310 1320 1330 1340 1350
QKQRIAIARV VLKNAPILLI DEASSSIESE SSRVVQEALD TLIMGNKTTI
1360 1370 1380 1390 1400
LIAHRVAMMR HVDNIVVLNG GKIVEEGTHD CLAGKNGLYV RLMQPHFGKN
LRRHQLI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8AZ84 | A0A1P8AZ84_ARATH | p-glycoprotein 6 | ABCB6 ATP-binding cassette B6, P-glycoprotein 6, PGP6, At2g39480, F12L6.14 | 1,227 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 58 | E → G in AAM19777 (PubMed:14593172).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004218 Genomic DNA Translation: AAC27839.1 CP002685 Genomic DNA Translation: AEC09685.1 AY094398 mRNA Translation: AAM19777.1 |
PIRi | T00558 |
RefSeqi | NP_181480.1, NM_129506.2 |
Genome annotation databases
EnsemblPlantsi | AT2G39480.1; AT2G39480.1; AT2G39480 |
GeneIDi | 818533 |
Gramenei | AT2G39480.1; AT2G39480.1; AT2G39480 |
KEGGi | ath:AT2G39480 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004218 Genomic DNA Translation: AAC27839.1 CP002685 Genomic DNA Translation: AEC09685.1 AY094398 mRNA Translation: AAM19777.1 |
PIRi | T00558 |
RefSeqi | NP_181480.1, NM_129506.2 |
3D structure databases
SMRi | Q8LPT1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 3871, 2 interactors |
IntActi | Q8LPT1, 2 interactors |
STRINGi | 3702.AT2G39480.1 |
PTM databases
iPTMneti | Q8LPT1 |
Proteomic databases
PaxDbi | Q8LPT1 |
PRIDEi | Q8LPT1 |
ProteomicsDBi | 244627 |
Genome annotation databases
EnsemblPlantsi | AT2G39480.1; AT2G39480.1; AT2G39480 |
GeneIDi | 818533 |
Gramenei | AT2G39480.1; AT2G39480.1; AT2G39480 |
KEGGi | ath:AT2G39480 |
Organism-specific databases
Araporti | AT2G39480 |
TAIRi | locus:2039747, AT2G39480 |
Phylogenomic databases
eggNOGi | KOG0055, Eukaryota |
HOGENOMi | CLU_000604_17_2_1 |
InParanoidi | Q8LPT1 |
OrthoDBi | 186078at2759 |
PhylomeDBi | Q8LPT1 |
Enzyme and pathway databases
BioCyci | ARA:AT2G39480-MONOMER |
Miscellaneous databases
PROi | PR:Q8LPT1 |
Gene expression databases
ExpressionAtlasi | Q8LPT1, baseline and differential |
Genevisiblei | Q8LPT1, AT |
Family and domain databases
Gene3Di | 1.20.1560.10, 3 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AB6B_ARATH | |
Accessioni | Q8LPT1Primary (citable) accession number: Q8LPT1 Secondary accession number(s): O80635 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | March 21, 2006 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families