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Entry version 142 (02 Jun 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Protein ACCELERATED CELL DEATH 6

Gene

ACD6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dose-dependent activator of the defense response against virulent pathogens, including bacteria, fungi and oomycetes, that acts in a positive feedback loop with the defense signal salicylic acid (SA) (PubMed:14507999, PubMed:20520716, PubMed:10488236, PubMed:16297071, PubMed:19144005).

Regulates the salicylic acid (SA) signaling pathway leading to cell death and modulating cell fate (e.g. cell enlargement and/or cell division) (PubMed:14507999, PubMed:10488236, PubMed:11722764).

In response to SA signaling, triggers the accumulation of FLS2 at the plasma membrane, thus priming defenses (PubMed:24923602).

Involved in SA-dependent freezing signaling and tolerance (PubMed:19959255).

8 Publications

Miscellaneous

Sequence variations impacting defense responses are observed between cultivars. Enhanced resistance is correlated with a substantial reduction in vegetative biomass.1 Publication
The dominant gain-of-function mutant acd6-1 and over-expressing plant ACD6-o is dwarf and shows spontaneous cell death and increased disease resistance, as well as increased defenses and better responsiveness to salicylic acid (SA). These symptoms are SA-dependent (PubMed:14507999, PubMed:20520716, PubMed:10488236, PubMed:16297071, PubMed:19144005). In acd6-1, constitutively high free and total SA levels leading to collapsed dead cells with adjacent enlarged cells in the palisade parenchyma cell layer. This phenotype is absent in NahG background, in which SA is degraded (PubMed:11722764). Strong accumulation of camalexin (an anti-fungal compound) and SA in acd6-1 (PubMed:19144005). The mutant acd6-1 exhibits freezing sensitivity, this sensitivity is suppressed in nahG background (PubMed:19959255).7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPlant defense

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.43.1.14, the cadmium tolerance efflux pump (ctep) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ACCELERATED CELL DEATH 61 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACD61 Publication
Ordered Locus Names:At4g14400Imported
ORF Names:dl3240wImported, FCAALL.190Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT4G14400

The Arabidopsis Information Resource

More...
TAIRi
locus:2129690, AT4G14400

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 456CytoplasmicCuratedAdd BLAST456
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Topological domaini478 – 492ExtracellularCuratedAdd BLAST15
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 537CytoplasmicCuratedAdd BLAST24
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Topological domaini559 – 577ExtracellularCuratedAdd BLAST19
Transmembranei578 – 598HelicalSequence analysisAdd BLAST21
Topological domaini599 – 602CytoplasmicCurated4
Transmembranei603 – 623HelicalSequence analysisAdd BLAST21
Topological domaini624 – 638ExtracellularCuratedAdd BLAST15
Transmembranei639 – 659HelicalSequence analysisAdd BLAST21
Topological domaini660 – 670CytoplasmicCuratedAdd BLAST11

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Reduced responsiveness to benzothiazole (BTH) and upon P. syringae infection with reduced salicylic acid (SA) levels and increased disease susceptibility and attenuated defenses (PubMed:14507999). Increased sensitivity to biotrophic fungi (e.g. Golovinomyces orontii T1 and G. cichoracearum UCSC1), biotrophic oomycetes (e.g. Hyaloperonospora arabidopsidis Noco2) and hemi-biotrophic bacteria (e.g. Pseudomonas syringae pv. tomato DC3000) (PubMed:20520716).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi73G → D in E46; suppression of acd6-1-conferred phenotypes and increased P. syringae susceptibility. 1 Publication1
Mutagenesisi142A → V in E11; suppression of acd6-1-conferred phenotypes and increased P. syringae susceptibility. 1 Publication1
Mutagenesisi186A → V in E19; suppression of acd6-1-conferred phenotypes and increased P. syringae susceptibility. 1 Publication1
Mutagenesisi269A → V in E38; suppression of acd6-1-conferred phenotypes and increased P. syringae susceptibility. 1 Publication1
Mutagenesisi300L → F in E3; suppression of acd6-1-conferred phenotypes and increased P. syringae susceptibility. 1 Publication1
Mutagenesisi303G → E in E4; suppression of acd6-1-conferred phenotypes and increased P. syringae susceptibility. Aberrant complex formation leading to reduced subcellular location at the plasma membrane. 2 Publications1
Mutagenesisi307G → E in E1; suppression of acd6-1-conferred phenotypes and increased P. syringae susceptibility. Aberrant complex formation leading to reduced subcellular location at the plasma membrane. 2 Publications1
Mutagenesisi311G → E in E7; suppression of acd6-1-conferred phenotypes and increased P. syringae susceptibility. 1 Publication1
Mutagenesisi348E → K in E44; suppression of acd6-1-conferred phenotypes and increased P. syringae susceptibility. Aberrant complex formation leading to reduced subcellular location at the plasma membrane. 2 Publications1
Mutagenesisi498A → T in E27; suppression of acd6-1-conferred phenotypes and increased P. syringae susceptibility. 1 Publication1
Mutagenesisi508A → T in E35; suppression of acd6-1-conferred phenotypes and increased P. syringae susceptibility. 1 Publication1
Mutagenesisi550S → F in E14; suppression of acd6-1-conferred phenotypes and increased P. syringae susceptibility. 1 Publication1
Mutagenesisi557L → F in E40; suppression of acd6-1-conferred phenotypes and increased P. syringae susceptibility. 1 Publication1
Mutagenesisi591L → F in acd6-1; gain-of-function leading to SA-dependent spontaneous cell death and increased disease resistance. Stronger accumulation at the plasma membrane. 2 Publications1
Mutagenesisi638S → F in E25; suppression of acd6-1-conferred phenotypes and increased P. syringae susceptibility. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004345341 – 670Protein ACCELERATED CELL DEATH 6Add BLAST670

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8LPS2

PRoteomics IDEntifications database

More...
PRIDEi
Q8LPS2

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
244547 [Q8LPS2-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8LPS2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Basal expression requires light and salicylic acid (SA).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression in leaves increases with age.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Accumulates in systemic uninfected tissues during Pseudomonas syringae infection or upon benzothiazole (BTH) treatment. Induced by light, but repressed by dark (PubMed:14507999). Accumulates upon MG132 treatment, a proteasome inhibitor. Target of endoplasmic reticulum-associated degradation (ERAD) when ubiquitinated (PubMed:24923602).2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8LPS2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8LPS2, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of large complexes containing, at least, FLS2, HSP70 and ACD6 in endoplasmic reticulum, plasma membrane and soluble fraction. Associated with HSP70 proteins during endoplasmic reticulum-associated degradation (ERAD). Reduced complex levels upon benzothiazole (BTH) treatment.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT4G14400.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8LPS2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati66 – 95ANK 1Sequence analysisAdd BLAST30
Repeati100 – 129ANK 2Sequence analysisAdd BLAST30
Repeati134 – 163ANK 3Sequence analysisAdd BLAST30
Repeati182 – 211ANK 4Sequence analysisAdd BLAST30
Repeati216 – 248ANK 5Sequence analysisAdd BLAST33
Repeati260 – 290ANK 6Sequence analysisAdd BLAST31
Repeati295 – 325ANK 7Sequence analysisAdd BLAST31
Repeati329 – 358ANK 8Sequence analysisAdd BLAST30
Repeati363 – 391ANK 9Sequence analysisAdd BLAST29
Repeati399 – 428ANK 10Sequence analysisAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 47DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi29 – 44Polar residuesSequence analysisAdd BLAST16

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8LPS2

Database of Orthologous Groups

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OrthoDBi
1156472at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8LPS2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR032846, ACD6
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR026961, PGG_dom

The PANTHER Classification System

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PANTHERi
PTHR24177:SF322, PTHR24177:SF322, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12796, Ank_2, 2 hits
PF13962, PGG, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00248, ANK, 9 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8LPS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSSGADLDR IEAQRSMLVS HDQRKDFSHS GGVGTTSPTG DTEPVPKFRT
60 70 80 90 100
NLKLSDLFAL PGEDVEMTPE IFGGMSNGEK ECLEKLRSNG TPMERVKSNT
110 120 130 140 150
GDSILHIAAK WGHLELVKEI IFECPCLLFE QNSSRQTPLH VATHGGHTKV
160 170 180 190 200
VEALVASVTS ALASLSTEES EGLNPHVLKD EDGNTALYYA IEGRYLEMAT
210 220 230 240 250
CLVNADKDAP FLGNNKGISS LYEAVDAGNK FEDLVKAILK TTDDNVDREV
260 270 280 290 300
RKFNLDSKLQ GNKHLAHVAL KAKSIGVLDV ILDEYPSLMD EQDEDGRTCL
310 320 330 340 350
SYGASIGYYK GLCNILNRST KGVYVCDQDG SFPIHSAAKN EHYEIIKEFI
360 370 380 390 400
KRCPASKYLL NRLGQNILHV AAKNEASLTA YMLMHDKDTK HLGVGQDVDG
410 420 430 440 450
NTPLHLAVMN WDFDSITCLA SRNHEILKLR NKSGLRARDI AESEVKPNYI
460 470 480 490 500
FHERWTLALL LYAIHSSGFE SVKSLTIQSV PLDPKKNRHY VNALLVVAAL
510 520 530 540 550
VATVTFAAGF TIPGGYISDS KKPNLGRATL ATNPTLFIFL LFDILAMQSS
560 570 580 590 600
VATICTLIWA QLGDLALILK SLHVALPLLL FSLLCMPVAF LFGVITAIAH
610 620 630 640 650
VKWLLVTISI ISGGFFLFAI FILGPHVMLQ RSHLPPSSGI FLKTFMLTID
660 670
ISELFVILIK ACFGCVACSE
Length:670
Mass (Da):73,527
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EAD26D13EE25BB5
GO
Isoform 2 (identifier: Q8LPS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Show »
Length:604
Mass (Da):66,397
Checksum:iB2C10D045A81FA9F
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB10219 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78482 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti347K → E in BAD94307 (Ref. 8) Curated1
Sequence conflicti362R → G in BAC43653 (PubMed:11910074).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0579431 – 66Missing in isoform 2. Add BLAST66

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY344843 mRNA Translation: AAQ24110.1
Z97336 Genomic DNA Translation: CAB10219.1 Sequence problems.
AL161538 Genomic DNA Translation: CAB78482.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE83437.1
CP002687 Genomic DNA Translation: AEE83438.1
CP002687 Genomic DNA Translation: AEE83439.1
AK119077 mRNA Translation: BAC43653.1
AY094416 mRNA Translation: AAM19791.1
BT002281 mRNA Translation: AAN72292.1
AK316751 mRNA Translation: BAH19473.1
AK175409 mRNA Translation: BAD43172.1
AK176809 mRNA Translation: BAD44572.1
AK221386 mRNA Translation: BAD94307.1
HM214854 Genomic DNA Translation: ADJ38625.1
HM214855 Genomic DNA Translation: ADJ38626.1

Protein sequence database of the Protein Information Resource

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PIRi
A71406

NCBI Reference Sequences

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RefSeqi
NP_567430.1, NM_117519.4 [Q8LPS2-1]
NP_849381.1, NM_179050.2 [Q8LPS2-2]
NP_849382.1, NM_179051.1 [Q8LPS2-2]

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT4G14400.1; AT4G14400.1; AT4G14400 [Q8LPS2-1]
AT4G14400.2; AT4G14400.2; AT4G14400 [Q8LPS2-2]
AT4G14400.3; AT4G14400.3; AT4G14400 [Q8LPS2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
827085

Gramene; a comparative resource for plants

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Gramenei
AT4G14400.1; AT4G14400.1; AT4G14400 [Q8LPS2-1]
AT4G14400.2; AT4G14400.2; AT4G14400 [Q8LPS2-2]
AT4G14400.3; AT4G14400.3; AT4G14400 [Q8LPS2-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT4G14400

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344843 mRNA Translation: AAQ24110.1
Z97336 Genomic DNA Translation: CAB10219.1 Sequence problems.
AL161538 Genomic DNA Translation: CAB78482.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE83437.1
CP002687 Genomic DNA Translation: AEE83438.1
CP002687 Genomic DNA Translation: AEE83439.1
AK119077 mRNA Translation: BAC43653.1
AY094416 mRNA Translation: AAM19791.1
BT002281 mRNA Translation: AAN72292.1
AK316751 mRNA Translation: BAH19473.1
AK175409 mRNA Translation: BAD43172.1
AK176809 mRNA Translation: BAD44572.1
AK221386 mRNA Translation: BAD94307.1
HM214854 Genomic DNA Translation: ADJ38625.1
HM214855 Genomic DNA Translation: ADJ38626.1
PIRiA71406
RefSeqiNP_567430.1, NM_117519.4 [Q8LPS2-1]
NP_849381.1, NM_179050.2 [Q8LPS2-2]
NP_849382.1, NM_179051.1 [Q8LPS2-2]

3D structure databases

SMRiQ8LPS2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G14400.1

Protein family/group databases

TCDBi9.A.43.1.14, the cadmium tolerance efflux pump (ctep) family

PTM databases

iPTMnetiQ8LPS2

Proteomic databases

PaxDbiQ8LPS2
PRIDEiQ8LPS2
ProteomicsDBi244547 [Q8LPS2-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
827085

Genome annotation databases

EnsemblPlantsiAT4G14400.1; AT4G14400.1; AT4G14400 [Q8LPS2-1]
AT4G14400.2; AT4G14400.2; AT4G14400 [Q8LPS2-2]
AT4G14400.3; AT4G14400.3; AT4G14400 [Q8LPS2-2]
GeneIDi827085
GrameneiAT4G14400.1; AT4G14400.1; AT4G14400 [Q8LPS2-1]
AT4G14400.2; AT4G14400.2; AT4G14400 [Q8LPS2-2]
AT4G14400.3; AT4G14400.3; AT4G14400 [Q8LPS2-2]
KEGGiath:AT4G14400

Organism-specific databases

AraportiAT4G14400
TAIRilocus:2129690, AT4G14400

Phylogenomic databases

eggNOGiKOG0504, Eukaryota
InParanoidiQ8LPS2
OrthoDBi1156472at2759
PhylomeDBiQ8LPS2

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8LPS2

Gene expression databases

ExpressionAtlasiQ8LPS2, baseline and differential
GenevisibleiQ8LPS2, AT

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR032846, ACD6
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR026961, PGG_dom
PANTHERiPTHR24177:SF322, PTHR24177:SF322, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF13962, PGG, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 9 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACD6_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8LPS2
Secondary accession number(s): B9DFF6
, D9IWZ2, O23296, Q56YD7, Q682F8, Q8GW50
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: October 1, 2002
Last modified: June 2, 2021
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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