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Protein

Actin-related protein 6

Gene

ARP6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling. Binds to the promoter region of FLC chromatin. Required for the activation of FLC and FLC/MAF genes expression to levels that inhibit flowering, through both histone H3 and H4 acetylation and methylation mechanisms. Involved in several developmental processes including organization of plant organs, leaves formation, flowering time repression, and fertility. Modulates photoperiod-dependent epidermal leaves cell development; promotes cell division in long days, and cell expansion/division in short days. May be involved in the regulation of pathogenesis-related proteins (PRs).6 Publications

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: TAIR

GO - Biological processi

  • actin filament-based process Source: TAIR
  • cell proliferation Source: TAIR
  • chromatin remodeling Source: TAIR
  • defense response Source: UniProtKB-KW
  • negative regulation of flower development Source: TAIR
  • regulation of transcription, DNA-templated Source: TAIR
  • response to osmotic stress Source: TAIR
  • response to temperature stimulus Source: TAIR
  • seed germination Source: TAIR

Keywordsi

Molecular functionChromatin regulator, Developmental protein
Biological processPlant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 6
Alternative name(s):
Protein EARLY IN SHORT DAYS 1
Protein SUPPRESSOR OF FRIGIDA 3
Gene namesi
Name:ARP6
Synonyms:ESD1, SUF3
Ordered Locus Names:At3g33520
ORF Names:T4P3.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G33520
TAIRilocus:2102202 AT3G33520

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Early flowering, leaf serration, production of extra petals and weak apical dominance.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003205351 – 421Actin-related protein 6Add BLAST421

Proteomic databases

PaxDbiQ8LGE3
PRIDEiQ8LGE3

Expressioni

Tissue specificityi

Mostly expressed in flowers, and, to a lower extent, in seedlings, shoot apex, stems, siliques, seeds, and roots (at protein level).4 Publications

Gene expression databases

ExpressionAtlasiQ8LGE3 baseline and differential
GenevisibleiQ8LGE3 AT

Interactioni

Subunit structurei

Component of the SWR1 chromatin-remodeling complex composed of at least ARP6/ESD1/SUF3, PIE1, SWC6, SWC2 and H2AZs (HTA8, HTA9, HTA11). Interacts directly with SWC6/SEF and PIE1. Also interacts with H2A.F/Z proteins.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi8476, 3 interactors
IntActiQ8LGE3, 2 interactors
STRINGi3702.AT3G33520.1

Structurei

3D structure databases

ProteinModelPortaliQ8LGE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP6 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
InParanoidiQ8LGE3
KOiK11662
OMAiEPYFNLP
OrthoDBiEOG09360B4L
PhylomeDBiQ8LGE3

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR030054 Arp6
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF47 PTHR11937:SF47, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8LGE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIVVLDNG GGLIKAGQGG ERDPTTVIPN CLYKPLSSKK FIHPSPLTTL
60 70 80 90 100
SDEIDLTSAA VRRPIDRGYL INSDLQREIW SHLFTSLLHI APSSSSLLLT
110 120 130 140 150
EAPLSIPSVQ RTTDELVFED FGFSSLYIAH PQSLVHLYEA SRQPDSILSK
160 170 180 190 200
TQCSLVVDCG FSFTHAVPVL HNFTLNHAIK RIDLGGKAFT NYLKELVSYR
210 220 230 240 250
SINVMDETFL VDDAKEKLCF VSLDLLRDLR LARNGNTLIK STYVLPDGVT
260 270 280 290 300
HTKGYVKDPQ AAKRFLSLSE KESVVVMDKV GERKKADMNK NEIDLTNERF
310 320 330 340 350
LVPETLFQPA DLGMNQAGLA ECIVRAINSC HSYLQPVLYQ SIILTGGSTL
360 370 380 390 400
FPQLKERLEG ELRPLVPDHF DVKITTQEDP ILGVWRGGSL LASSPDFESM
410 420
CVTKAEYEEL GSARCRRRFF H
Length:421
Mass (Da):46,944
Last modified:October 1, 2002 - v1
Checksum:i9854EDAB8630030F
GO

Sequence cautioni

The sequence AAF03459 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → MG in AAM53246 (PubMed:11891255).Curated1
Sequence conflicti6V → F in AAM53246 (PubMed:11891255).Curated1
Sequence conflicti250T → I in AAK92721 (PubMed:14593172).Curated1
Sequence conflicti250T → I in AAN77965 (PubMed:12566397).Curated1
Sequence conflicti291N → I in AAN77939 (PubMed:12566397).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti230 – 231RL → PP in strain: cv. Lip-0. 2
Natural varianti231L → P in strain: cv. Aa-0. 1 Publication1
Natural varianti248G → S in strain: cv. Goe-2. 1 Publication1
Natural varianti250T → R in strain: cv. Ri-0. 1 Publication1
Natural varianti253K → E in strain: cv. Gre-0 and cv. Kas-1. 1 Publication1
Natural varianti263K → R in strain: cv. Di-0 and cv. Kil-0. 1 Publication1
Natural varianti271K → E in strain: cv. Cl-0. 1 Publication1
Natural varianti280V → D in strain: cv. Yo-0. 1 Publication1
Natural varianti290K → E in strain: cv. Kil-0. 1 Publication1
Natural varianti301L → I in strain: cv. Yo-0. 1 Publication1
Natural varianti308 – 311QPAD → SLQI in strain: cv. Ba-1. 4
Natural varianti310A → S in strain: cv. En-2. 1 Publication1
Natural varianti311D → V in strain: cv. Oy-0. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF507914 mRNA Translation: AAM53246.1
AC009992 Genomic DNA Translation: AAF03459.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE77716.1
AY050786 mRNA Translation: AAK92721.1
AY150426 mRNA Translation: AAN12968.1
AY084321 mRNA Translation: AAM60907.1
AF494760 Genomic DNA Translation: AAN77933.1
AF494761 Genomic DNA Translation: AAN77934.1
AF494765 Genomic DNA Translation: AAN77938.1
AF494766 Genomic DNA Translation: AAN77939.1
AF494767 Genomic DNA Translation: AAN77940.1
AF494770 Genomic DNA Translation: AAN77943.1
AF494772 Genomic DNA Translation: AAN77945.1
AF494773 Genomic DNA Translation: AAN77946.1
AF494774 Genomic DNA Translation: AAN77947.1
AF494776 Genomic DNA Translation: AAN77949.1
AF494777 Genomic DNA Translation: AAN77950.1
AF494782 Genomic DNA Translation: AAN77955.1
AF494789 Genomic DNA Translation: AAN77962.1
AF494792 Genomic DNA Translation: AAN77965.1
AF494796 Genomic DNA Translation: AAN77969.1
BK000425 Genomic DNA Translation: DAA00030.1
RefSeqiNP_566861.1, NM_114070.4
UniGeneiAt.18479
At.18481

Genome annotation databases

EnsemblPlantsiAT3G33520.1; AT3G33520.1; AT3G33520
GeneIDi823150
GrameneiAT3G33520.1; AT3G33520.1; AT3G33520
KEGGiath:AT3G33520

Similar proteinsi

Entry informationi

Entry nameiARP6_ARATH
AccessioniPrimary (citable) accession number: Q8LGE3
Secondary accession number(s): Q8GZL0
, Q8GZL1, Q8GZL2, Q8GZL3, Q8GZL4, Q8GZL5, Q8GZL6, Q8GZL7, Q8GZL8, Q8GZL9, Q8GZM0, Q8GZM1, Q8GZM2, Q8GZM3, Q8GZM4, Q8LKR0, Q949Z7, Q9SRK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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