UniProtKB - Q8LG77 (IDH6_ARATH)
Protein
Isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrial
Gene
IDH6
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Performs an essential role in the oxidative function of the citric acid cycle.By similarity
Catalytic activityi
- EC:1.1.1.41
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 127 | SubstrateBy similarity | 1 | |
Binding sitei | 137 | SubstrateBy similarity | 1 | |
Binding sitei | 158 | SubstrateBy similarity | 1 | |
Sitei | 165 | Critical for catalysisBy similarity | 1 | |
Sitei | 212 | Critical for catalysisBy similarity | 1 | |
Metal bindingi | 245 | Magnesium or manganeseBy similarity | 1 | |
Binding sitei | 245 | SubstrateBy similarity | 1 | |
Metal bindingi | 269 | Magnesium or manganeseBy similarity | 1 | |
Metal bindingi | 273 | Magnesium or manganeseBy similarity | 1 |
GO - Molecular functioni
- isocitrate dehydrogenase (NAD+) activity Source: TAIR
- magnesium ion binding Source: InterPro
- NAD binding Source: InterPro
GO - Biological processi
- isocitrate metabolic process Source: TAIR
- tricarboxylic acid cycle Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Tricarboxylic acid cycle |
Ligand | Magnesium, Manganese, Metal-binding, NAD |
Enzyme and pathway databases
BRENDAi | 1.1.1.41, 399 |
Names & Taxonomyi
Protein namesi | Recommended name: Isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrial (EC:1.1.1.41)Alternative name(s): IDH-VI Isocitric dehydrogenase 6 NAD(+)-specific ICDH 6 |
Gene namesi | Name:IDH6 Ordered Locus Names:At3g09810 ORF Names:F8A24.14 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G09810 |
TAIRi | locus:2074939, AT3G09810 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Cytosol
- cytosol Source: TAIR
Mitochondrion
- mitochondrion Source: TAIR
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 44 | MitochondrionSequence analysisAdd BLAST | 44 | |
ChainiPRO_0000271292 | 45 – 374 | Isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrialAdd BLAST | 330 |
Proteomic databases
PaxDbi | Q8LG77 |
PRIDEi | Q8LG77 |
ProteomicsDBi | 248619 |
PTM databases
MetOSitei | Q8LG77 |
Expressioni
Tissue specificityi
Ubiquitous. Predominantly expressed in leaves.1 Publication
Gene expression databases
ExpressionAtlasi | Q8LG77, baseline and differential |
Genevisiblei | Q8LG77, AT |
Interactioni
Subunit structurei
Heterooligomer of catalytic and regulatory subunits.
Protein-protein interaction databases
BioGRIDi | 5473, 8 interactors |
STRINGi | 3702.AT3G09810.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the isocitrate and isopropylmalate dehydrogenases family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0785, Eukaryota |
HOGENOMi | CLU_031953_0_1_1 |
InParanoidi | Q8LG77 |
OMAi | IDWDEQF |
OrthoDBi | 868374at2759 |
PhylomeDBi | Q8LG77 |
Family and domain databases
InterProi | View protein in InterPro IPR019818, IsoCit/isopropylmalate_DH_CS IPR004434, Isocitrate_DH_NAD IPR024084, IsoPropMal-DH-like_dom |
Pfami | View protein in Pfam PF00180, Iso_dh, 1 hit |
SMARTi | View protein in SMART SM01329, Iso_dh, 1 hit |
TIGRFAMsi | TIGR00175, mito_nad_idh, 1 hit |
PROSITEi | View protein in PROSITE PS00470, IDH_IMDH, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8LG77-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTMTAFLARR LIGNGSSQIL GTSSSSSGPF ISVSRAFFSS STPIKATLFP
60 70 80 90 100
GDGIGPEIAE SVKQVFTAAD VVIDWDEQFV GTEVDPRTNS FLTWDNLQSV
110 120 130 140 150
LKNKVGLKGP MATPIGKGHR SLNLTLRKEL NLYANVRPCY SLPGYKTRYD
160 170 180 190 200
DVDLITIREN TEGEYSGLEH QVVKGVVESL KIITRKASMR VAEYAFLYAK
210 220 230 240 250
THGRKKVSAI HKANIMQKTD GLFLQCCDEV AAKYPEIYYE KVVIDNCCMM
260 270 280 290 300
LVKNPALFDV LVMPNLYGDI ISDLCAGLVG GLGLTPSMNI GEDGIALAEA
310 320 330 340 350
VHGSAPDIAG MNLANPTALL LSGVMMLRHL KLNKQAEQIH SAIINTIAEG
360 370
KYRTADLGGS STTTDFTKAI CDHL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | M → I in AAM60999 (Ref. 5) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC015985 Genomic DNA Translation: AAF23254.1 CP002686 Genomic DNA Translation: AEE74815.1 AF324664 mRNA Translation: AAG40015.1 AF327427 mRNA Translation: AAG42017.1 AF339723 mRNA Translation: AAK00405.1 AK176269 mRNA Translation: BAD44032.1 AK228113 mRNA Translation: BAF00071.1 AY084425 mRNA Translation: AAM60999.1 |
RefSeqi | NP_850549.1, NM_180218.2 |
Genome annotation databases
EnsemblPlantsi | AT3G09810.1; AT3G09810.1; AT3G09810 |
GeneIDi | 820139 |
Gramenei | AT3G09810.1; AT3G09810.1; AT3G09810 |
KEGGi | ath:AT3G09810 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC015985 Genomic DNA Translation: AAF23254.1 CP002686 Genomic DNA Translation: AEE74815.1 AF324664 mRNA Translation: AAG40015.1 AF327427 mRNA Translation: AAG42017.1 AF339723 mRNA Translation: AAK00405.1 AK176269 mRNA Translation: BAD44032.1 AK228113 mRNA Translation: BAF00071.1 AY084425 mRNA Translation: AAM60999.1 |
RefSeqi | NP_850549.1, NM_180218.2 |
3D structure databases
SMRi | Q8LG77 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 5473, 8 interactors |
STRINGi | 3702.AT3G09810.1 |
PTM databases
MetOSitei | Q8LG77 |
Proteomic databases
PaxDbi | Q8LG77 |
PRIDEi | Q8LG77 |
ProteomicsDBi | 248619 |
Genome annotation databases
EnsemblPlantsi | AT3G09810.1; AT3G09810.1; AT3G09810 |
GeneIDi | 820139 |
Gramenei | AT3G09810.1; AT3G09810.1; AT3G09810 |
KEGGi | ath:AT3G09810 |
Organism-specific databases
Araporti | AT3G09810 |
TAIRi | locus:2074939, AT3G09810 |
Phylogenomic databases
eggNOGi | KOG0785, Eukaryota |
HOGENOMi | CLU_031953_0_1_1 |
InParanoidi | Q8LG77 |
OMAi | IDWDEQF |
OrthoDBi | 868374at2759 |
PhylomeDBi | Q8LG77 |
Enzyme and pathway databases
BRENDAi | 1.1.1.41, 399 |
Miscellaneous databases
PROi | PR:Q8LG77 |
Gene expression databases
ExpressionAtlasi | Q8LG77, baseline and differential |
Genevisiblei | Q8LG77, AT |
Family and domain databases
InterProi | View protein in InterPro IPR019818, IsoCit/isopropylmalate_DH_CS IPR004434, Isocitrate_DH_NAD IPR024084, IsoPropMal-DH-like_dom |
Pfami | View protein in Pfam PF00180, Iso_dh, 1 hit |
SMARTi | View protein in SMART SM01329, Iso_dh, 1 hit |
TIGRFAMsi | TIGR00175, mito_nad_idh, 1 hit |
PROSITEi | View protein in PROSITE PS00470, IDH_IMDH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IDH6_ARATH | |
Accessioni | Q8LG77Primary (citable) accession number: Q8LG77 Secondary accession number(s): Q9SF84 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | January 9, 2007 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families