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Entry version 108 (02 Dec 2020)
Sequence version 2 (29 May 2007)
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Protein

Probable 6-phosphogluconolactonase 2

Gene

PGL2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).Curated
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase 3, chloroplastic (G6PD3), Glucose-6-phosphate 1-dehydrogenase 1, chloroplastic (G6PD1), Glucose-6-phosphate 1-dehydrogenase (At3g27300), Glucose-6-phosphate 1-dehydrogenase (AXX17_At3g29760), Glucose-6-phosphate 1-dehydrogenase (AT9943_LOCUS769), Glucose-6-phosphate 1-dehydrogenase (G6PD4), Glucose-6-phosphate 1-dehydrogenase 2, chloroplastic (G6PD2), Glucose-6-phosphate 1-dehydrogenase (AXX17_At1g25530), Glucose-6-phosphate 1-dehydrogenase (At5g35790), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g33080), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g33080), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g12520), Glucose-6-phosphate 1-dehydrogenase (AT9943_LOCUS20560), Glucose-6-phosphate 1-dehydrogenase (AT9943_LOCUS19006), Glucose-6-phosphate 1-dehydrogenase (G6PD5), Glucose-6-phosphate 1-dehydrogenase (G6PD5), Glucose-6-phosphate 1-dehydrogenase (AN1_LOCUS23765), Glucose-6-phosphate 1-dehydrogenase (C24_LOCUS23613), Glucose-6-phosphate 1-dehydrogenase (AN1_LOCUS14226), Glucose-6-phosphate 1-dehydrogenase 6, cytoplasmic (G6PD6), Glucose-6-phosphate 1-dehydrogenase (At1g09420), Glucose-6-phosphate 1-dehydrogenase (AXX17_At1g09330), Glucose-6-phosphate 1-dehydrogenase 5, cytoplasmic (G6PD5), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g38480), Glucose-6-phosphate 1-dehydrogenase (AN1_LOCUS1020), Glucose-6-phosphate 1-dehydrogenase (At5g40760), Glucose-6-phosphate 1-dehydrogenase (AT9943_LOCUS2118)
  2. Probable 6-phosphogluconolactonase 5 (PGL5), Probable 6-phosphogluconolactonase 4 (PGL4), Probable 6-phosphogluconolactonase 2 (PGL2), 6-phosphogluconolactonase 3, chloroplastic (PGL3), Probable 6-phosphogluconolactonase 1 (PGL1)
  3. 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic (PGD1), 6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic (PGD3), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At1g57660), 6-phosphogluconate dehydrogenase, decarboxylating (AN1_LOCUS24345), 6-phosphogluconate dehydrogenase, decarboxylating (C24_LOCUS5304), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At5g39410), 6-phosphogluconate dehydrogenase, decarboxylating 2 (PGD2), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At3g01580), 6-phosphogluconate dehydrogenase, decarboxylating (C24_LOCUS24171)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
ARA:AT3G49360-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.1.31, 399

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00115;UER00409

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable 6-phosphogluconolactonase 2Curated (EC:3.1.1.31By similarity)
Short name:
6PGL2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PGL21 Publication
Ordered Locus Names:At3g49360Imported
ORF Names:F2K15.220Imported, T1G12.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT3G49360

The Arabidopsis Information Resource

More...
TAIRi
locus:2082916, AT3G49360

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype under normal growth conditions.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002886691 – 259Probable 6-phosphogluconolactonase 2Add BLAST259

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8LG70

PRoteomics IDEntifications database

More...
PRIDEi
Q8LG70

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
245160

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8LG70, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8LG70, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT3G49360.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8LG70

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3147, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_053947_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8LG70

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERVCAWD

Database of Orthologous Groups

More...
OrthoDBi
1420529at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8LG70

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01400, 6PGL, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005900, 6-phosphogluconolactonase_DevB
IPR006148, Glc/Gal-6P_isomerase
IPR037171, NagB/RpiA_transferase-like
IPR039104, PGLS

The PANTHER Classification System

More...
PANTHERi
PTHR11054, PTHR11054, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01182, Glucosamine_iso, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100950, SSF100950, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01198, pgl, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8LG70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPVKRRVFK TNNEMAVELA KYTADLSSKF CKERGVFTVV LSGGDLIAWL
60 70 80 90 100
WKLLEAPYID SIEWSKWHIF WVDERVCAWD HADSNYKLAY DGFLSKVPVP
110 120 130 140 150
AENIYAIDNG LGAEGNAELA AERYEECLKQ KVNQNIIRTY KSSGFPQFDL
160 170 180 190 200
QLLGMGPDGH MASLFPGHAQ INEKVKWVTS ITDSPKPPSK RITLTLPVIN
210 220 230 240 250
CASYNVMAVC DKEQADSVAA ALNHTKDLPA GRLTADVEVV WFLDQAAASK

LPHGWCSIL
Length:259
Mass (Da):28,863
Last modified:May 29, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA9C421E48BC0CA6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35G → E in AAM61007 (Ref. 4) Curated1
Sequence conflicti42S → Y in AAM61007 (Ref. 4) Curated1
Sequence conflicti99V → I in AAM61007 (Ref. 4) Curated1
Sequence conflicti108D → N in AAM61007 (Ref. 4) Curated1
Sequence conflicti194L → F in AAM61007 (Ref. 4) Curated1
Sequence conflicti218V → A in AAM61007 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC012329 Genomic DNA Translation: AAG52194.1
AL132956 Genomic DNA Translation: CAB66415.1
CP002686 Genomic DNA Translation: AEE78532.1
AK117146 mRNA Translation: BAC41824.1
AY084434 mRNA Translation: AAM61007.1
BT024902 mRNA Translation: ABD91493.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T45841

NCBI Reference Sequences

More...
RefSeqi
NP_190505.1, NM_114796.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G49360.1; AT3G49360.1; AT3G49360

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
824098

Gramene; a comparative resource for plants

More...
Gramenei
AT3G49360.1; AT3G49360.1; AT3G49360

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT3G49360

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012329 Genomic DNA Translation: AAG52194.1
AL132956 Genomic DNA Translation: CAB66415.1
CP002686 Genomic DNA Translation: AEE78532.1
AK117146 mRNA Translation: BAC41824.1
AY084434 mRNA Translation: AAM61007.1
BT024902 mRNA Translation: ABD91493.1
PIRiT45841
RefSeqiNP_190505.1, NM_114796.4

3D structure databases

SMRiQ8LG70
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G49360.1

Proteomic databases

PaxDbiQ8LG70
PRIDEiQ8LG70
ProteomicsDBi245160

Genome annotation databases

EnsemblPlantsiAT3G49360.1; AT3G49360.1; AT3G49360
GeneIDi824098
GrameneiAT3G49360.1; AT3G49360.1; AT3G49360
KEGGiath:AT3G49360

Organism-specific databases

AraportiAT3G49360
TAIRilocus:2082916, AT3G49360

Phylogenomic databases

eggNOGiKOG3147, Eukaryota
HOGENOMiCLU_053947_0_0_1
InParanoidiQ8LG70
OMAiERVCAWD
OrthoDBi1420529at2759
PhylomeDBiQ8LG70

Enzyme and pathway databases

UniPathwayiUPA00115;UER00409
BioCyciARA:AT3G49360-MONOMER
BRENDAi3.1.1.31, 399

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8LG70

Gene expression databases

ExpressionAtlasiQ8LG70, baseline and differential
GenevisibleiQ8LG70, AT

Family and domain databases

CDDicd01400, 6PGL, 1 hit
InterProiView protein in InterPro
IPR005900, 6-phosphogluconolactonase_DevB
IPR006148, Glc/Gal-6P_isomerase
IPR037171, NagB/RpiA_transferase-like
IPR039104, PGLS
PANTHERiPTHR11054, PTHR11054, 1 hit
PfamiView protein in Pfam
PF01182, Glucosamine_iso, 1 hit
SUPFAMiSSF100950, SSF100950, 1 hit
TIGRFAMsiTIGR01198, pgl, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei6PGL2_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8LG70
Secondary accession number(s): Q9SG13
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: December 2, 2020
This is version 108 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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