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Protein

Alcohol dehydrogenase-like 6

Gene

At5g24760

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Zinc 1; catalyticBy similarity1
Metal bindingi55Zinc 1By similarity1
Binding sitei55NADBy similarity1
Binding sitei55SubstrateBy similarity1
Metal bindingi72Zinc 1; catalyticBy similarity1
Binding sitei72SubstrateBy similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi108Zinc 2By similarity1
Metal bindingi116Zinc 2By similarity1
Metal bindingi179Zinc 1; catalyticBy similarity1
Binding sitei228NADBy similarity1
Binding sitei233NADBy similarity1
Binding sitei324NAD; via amide nitrogenBy similarity1
Binding sitei374NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 209NADBy similarity6
Nucleotide bindingi297 – 299NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciARA:AT5G24760-MONOMER
ReactomeiR-ATH-2161541 Abacavir metabolism
R-ATH-5365859 RA biosynthesis pathway
R-ATH-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase-like 6 (EC:1.1.1.1By similarity)
Gene namesi
Ordered Locus Names:At5g24760
ORF Names:T4C12_30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G24760
TAIRilocus:2184575 AT5G24760

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002991881 – 381Alcohol dehydrogenase-like 6Add BLAST381

Proteomic databases

PaxDbiQ8LEB2
PRIDEiQ8LEB2

PTM databases

iPTMnetiQ8LEB2

Expressioni

Gene expression databases

ExpressionAtlasiQ8LEB2 baseline and differential
GenevisibleiQ8LEB2 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT5G24760.1

Structurei

3D structure databases

ProteinModelPortaliQ8LEB2
SMRiQ8LEB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
InParanoidiQ8LEB2
KOiK00001
OMAiSAIVMGC
OrthoDBiEOG09360F82
PhylomeDBiQ8LEB2

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8LEB2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSASSSSFEQ PQVITCNAAV AWRAGEPLVM EEVEVSPPQP LEIRIKVVCT
60 70 80 90 100
SLCRSDLSAW ESQSLLPRIF GHEAAGIVES IGEGVTEFEK GDHVLAVFTG
110 120 130 140 150
ECGSCRHCIS GKSNMCQVLG MERKGLMHSD QKTRFSIKGK PVYHYCAVSS
160 170 180 190 200
FSEYTVVHSG CAVKVDPLAP LHKICLLSCG VAAGLGAAWN VADVQKGSSV
210 220 230 240 250
VIFGLGTVGL SVAQGAKLRG AAQILGVDIN PAKAEQAKTF GVTDFINSND
260 270 280 290 300
LSEPIPQVIK RMTGGGADFS FECVGDTGIA TTALQSCSDG WGMTVTLGVP
310 320 330 340 350
KAKPEVSAHY GLFLSGKSLK GTLFGGWKPK SDLPSLIDKY MNKEIMIDEF
360 370 380
ITHNLSFDEI NKAFVLMREG KCLRCVLHMP K
Length:381
Mass (Da):40,724
Last modified:September 11, 2007 - v2
Checksum:i535CDF294FF6FE1B
GO
Isoform 2 (identifier: Q8LEB2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Note: Derived from EST data. May be due to intron retention. No experimental confirmation available.
Show »
Length:352
Mass (Da):37,705
Checksum:i22846AB03EED8163
GO

Sequence cautioni

The sequence CAC08250 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125G → C in AAM62747 (Ref. 4) Curated1
Sequence conflicti219R → S in AAM62747 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0275861 – 29Missing in isoform 2. CuratedAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL392145 Genomic DNA Translation: CAC08250.1 Sequence problems.
CP002688 Genomic DNA Translation: AED93355.1
CP002688 Genomic DNA Translation: AED93356.1
CP002688 Genomic DNA Translation: AED93357.1
AY079163 mRNA Translation: AAL85002.1
AY094000 mRNA Translation: AAM16261.1
AY085523 mRNA Translation: AAM62747.1
RefSeqiNP_001078619.1, NM_001085150.1 [Q8LEB2-2]
NP_568453.1, NM_122385.5 [Q8LEB2-1]
NP_974831.1, NM_203102.2 [Q8LEB2-2]
UniGeneiAt.43162
At.65844

Genome annotation databases

EnsemblPlantsiAT5G24760.1; AT5G24760.1; AT5G24760 [Q8LEB2-1]
AT5G24760.2; AT5G24760.2; AT5G24760 [Q8LEB2-2]
AT5G24760.3; AT5G24760.3; AT5G24760 [Q8LEB2-2]
GeneIDi832545
GrameneiAT5G24760.1; AT5G24760.1; AT5G24760 [Q8LEB2-1]
AT5G24760.2; AT5G24760.2; AT5G24760 [Q8LEB2-2]
AT5G24760.3; AT5G24760.3; AT5G24760 [Q8LEB2-2]
KEGGiath:AT5G24760

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiADHL6_ARATH
AccessioniPrimary (citable) accession number: Q8LEB2
Secondary accession number(s): Q3E967, Q8RV10, Q9FT42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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