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UniProtKB - Q8LE59 (IRT3_ARATH)
Protein
Fe(2+) transport protein 3, chloroplastic
Gene
IRT3
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
May play a role in the transport of iron in the plastids.
By similarityGO - Molecular functioni
- iron ion transmembrane transporter activity Source: TAIR
- zinc ion transmembrane transporter activity Source: TAIR
GO - Biological processi
- iron ion homeostasis Source: UniProtKB-KW
- iron ion transport Source: TAIR
- response to nematode Source: TAIR
- zinc ion transmembrane transport Source: GO_Central
- zinc ion transport Source: TAIR
Keywordsi
Biological process | Ion transport, Iron transport, Transport |
Ligand | Iron |
Names & Taxonomyi
Protein namesi | Recommended name: Fe(2+) transport protein 3, chloroplasticAlternative name(s): Fe(II) transport protein 3 Iron-regulated transporter 3 |
Gene namesi | Name:IRT3 Ordered Locus Names:At1g60960 ORF Names:T7P1.10 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G60960 |
TAIRi | locus:2206011, AT1G60960 |
Subcellular locationi
Chloroplast
- chloroplast thylakoid membrane Curated; Multi-pass membrane protein Curated
Chloroplast
- chloroplast thylakoid membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: TAIR
Vacuole
- plant-type vacuole Source: TAIR
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | ? – 64 | LumenalSequence analysis | ||
Transmembranei | 65 – 85 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 86 – 97 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 137 | LumenalSequence analysisAdd BLAST | 19 | |
Transmembranei | 138 – 158 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 159 – 269 | CytoplasmicSequence analysisAdd BLAST | 111 | |
Transmembranei | 270 – 290 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 291 – 301 | LumenalSequence analysisAdd BLAST | 11 | |
Transmembranei | 302 – 322 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 323 – 333 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 334 – 354 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 355 – 369 | LumenalSequence analysisAdd BLAST | 15 | |
Transmembranei | 370 – 390 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 391 – 404 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 405 – 425 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Chloroplast, Membrane, Plastid, ThylakoidPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | ChloroplastSequence analysis | ||
ChainiPRO_0000041638 | ? – 425 | Fe(2+) transport protein 3, chloroplastic |
Proteomic databases
PaxDbi | Q8LE59 |
ProteomicsDBi | 247049 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q8LE59, baseline and differential |
Genevisiblei | Q8LE59, AT |
Structurei
3D structure databases
AlphaFoldDBi | Q8LE59 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 283 – 284 | Heavy metals bindingBy similarity | 2 |
Sequence similaritiesi
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1558, Eukaryota |
HOGENOMi | CLU_027089_3_0_1 |
InParanoidi | Q8LE59 |
OrthoDBi | 981397at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP IPR004698, Zn/Fe_permease_fun/pln |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
TIGRFAMsi | TIGR00820, zip, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8LE59-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFFVDVLWKL VPLYLFGSET KSLSATESIL QIVPEAMAAT SSNVLCNASE
60 70 80 90 100
SDLCRDDSAA FLLKFVAIAS ILLAGAAGVT IPLIGRNRRF LQTDGNLFVT
110 120 130 140 150
AKAFAAGVIL ATGFVHMLAG GTEALKNPCL PDFPWSKFPF PGFFAMIAAL
160 170 180 190 200
ITLFVDFMGT QYYERKQERE ASESVEPFGR EQSPGIVVPM IGEGTNDGKV
210 220 230 240 250
FGEEDSGGIH IVGIHAHAAH HRHSHPPGHD SCEGHSKIDI GHAHAHGHGH
260 270 280 290 300
GHGHGHVHGG LDAVNGARHI VVSQVLELGI VSHSIIIGLS LGVSQSPCTI
310 320 330 340 350
RPLIAALSFH QFFEGFALGG CISQAQFRNK SATIMACFFA LTTPIGIGIG
360 370 380 390 400
TAVASSFNSH SVGALVTEGI LDSLSAGILV YMALVDLIAA DFLSTKMRCN
410 420
FRLQIVSYVM LFLGAGLMSS LAIWA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8ARJ0 | A0A1P8ARJ0_ARATH | Iron regulated transporter 3 | IRT3 ATIRT3, IRON REGULATED TRANSPORTER 3, iron regulated transporter 3, At1g60960, T7P1.10 | 415 | Annotation score: | ||
A0A1P8ARE2 | A0A1P8ARE2_ARATH | Iron regulated transporter 3 | IRT3 ATIRT3, IRON REGULATED TRANSPORTER 3, iron regulated transporter 3, At1g60960, T7P1.10 | 303 | Annotation score: |
Sequence cautioni
The sequence AAG51647 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAM62825 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 21 | K → Q in AAM62825 (Ref. 4) Curated | 1 | |
Sequence conflicti | 55 | R → L in AAM62825 (Ref. 4) Curated | 1 | |
Sequence conflicti | 113 | G → C in AAM62825 (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF369915 Genomic DNA Translation: AAL38438.1 AC018908 Genomic DNA Translation: AAG51647.1 Sequence problems. CP002684 Genomic DNA Translation: AEE33753.1 AY085604 mRNA Translation: AAM62825.1 Different initiation. |
PIRi | B96635 |
RefSeqi | NP_564766.1, NM_104776.5 |
Genome annotation databases
EnsemblPlantsi | AT1G60960.1; AT1G60960.1; AT1G60960 |
GeneIDi | 842387 |
Gramenei | AT1G60960.1; AT1G60960.1; AT1G60960 |
KEGGi | ath:AT1G60960 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF369915 Genomic DNA Translation: AAL38438.1 AC018908 Genomic DNA Translation: AAG51647.1 Sequence problems. CP002684 Genomic DNA Translation: AEE33753.1 AY085604 mRNA Translation: AAM62825.1 Different initiation. |
PIRi | B96635 |
RefSeqi | NP_564766.1, NM_104776.5 |
3D structure databases
AlphaFoldDBi | Q8LE59 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 3702.AT1G60960.1 |
Proteomic databases
PaxDbi | Q8LE59 |
ProteomicsDBi | 247049 |
Genome annotation databases
EnsemblPlantsi | AT1G60960.1; AT1G60960.1; AT1G60960 |
GeneIDi | 842387 |
Gramenei | AT1G60960.1; AT1G60960.1; AT1G60960 |
KEGGi | ath:AT1G60960 |
Organism-specific databases
Araporti | AT1G60960 |
TAIRi | locus:2206011, AT1G60960 |
Phylogenomic databases
eggNOGi | KOG1558, Eukaryota |
HOGENOMi | CLU_027089_3_0_1 |
InParanoidi | Q8LE59 |
OrthoDBi | 981397at2759 |
Miscellaneous databases
PROi | PR:Q8LE59 |
Gene expression databases
ExpressionAtlasi | Q8LE59, baseline and differential |
Genevisiblei | Q8LE59, AT |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP IPR004698, Zn/Fe_permease_fun/pln |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
TIGRFAMsi | TIGR00820, zip, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IRT3_ARATH | |
Accessioni | Q8LE59Primary (citable) accession number: Q8LE59 Secondary accession number(s): Q8W244, Q9C957 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2003 |
Last sequence update: | May 31, 2011 | |
Last modified: | May 25, 2022 | |
This is version 116 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families