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Entry version 102 (10 Feb 2021)
Sequence version 2 (06 Dec 2005)
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Protein

PP2A regulatory subunit TAP46

Gene

TAP46

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the positive regulation of the TOR signaling pathway (PubMed:21216945, PubMed:25399018). Acts as a negative regulator of PP2A catalytic activity (PubMed:10517853, PubMed:21216945, PubMed:24357600). Plays a positive role in the ABA-regulated inhibition of germination, probably throught its interaction with ABI5 (PubMed:24357600).4 Publications

Miscellaneous

Plants over-expressing TAP46 exhibit an increased abscisic acid (ABA) sensitivity in seed germination and a reduced PP2A activity (PubMed:24357600). Over-expression of TAP46 also leads to the stimulation of the overall plant growth and the increased nitrogen-assimilating activities (PubMed:25399018).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PP2A regulatory subunit TAP461 Publication
Alternative name(s):
2A phosphatase-associated protein of 46 kDaCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAP461 Publication
Ordered Locus Names:At5g53000Imported
ORF Names:MNB8.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G53000

The Arabidopsis Information Resource

More...
TAIRi
locus:2168392, AT5G53000

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi plants show the formation of spontaneous disease-like nectrotic lesions leading to premature cell death. The defective plants also display a strong reduction in protein synthesis, the induction of autophagy and nitrogen mobilization.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002186221 – 405PP2A regulatory subunit TAP46Add BLAST405

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by TOR kinase in vitro.1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8LDQ4

PRoteomics IDEntifications database

More...
PRIDEi
Q8LDQ4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
234181

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous (PubMed:10517853). Highly expressed in seed, and particularly in the embryo (PubMed:24357600).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed during seed maturation.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By chilling (PubMed:10517853). By abscisic acid (ABA) (PubMed:24357600).2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8LDQ4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8LDQ4, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the 36 kDa catalytic subunit (subunit C) of PP2A (PubMed:10517853).

Interacts with PP2A1 and PP2A2 (PubMed:24357600).

Interacts with PP2A3, PPX1 and FYPP1 (PubMed:21216945, PubMed:24357600).

Interacts with FYPP3 and ABI5 (PubMed:24357600).

Interacts with ATPK1/S6K1 and ATPK2/S6K2 (PubMed:25399018).

Interacts with TIP41L (By similarity).

By similarity4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
20624, 38 interactors

Protein interaction database and analysis system

More...
IntActi
Q8LDQ4, 34 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT5G53000.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8LDQ4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IGBP1/TAP42 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2830, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041824_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8LDQ4

Identification of Orthologs from Complete Genome Data

More...
OMAi
PFILTKD

Database of Orthologous Groups

More...
OrthoDBi
1348942at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8LDQ4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.540, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038511, TAP42/TAP46-like_sf
IPR007304, TAP46-like

The PANTHER Classification System

More...
PANTHERi
PTHR10933, PTHR10933, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04177, TAP42, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8LDQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGLAMEEMP LSVLFEQARK IHLAASESGV DQDVVKKGCE MFQKCEDMIG
60 70 80 90 100
KLALFSSNET KEDISTNNLK YLLVPYYLAE LTEKIIQEDR IQIVKASYAK
110 120 130 140 150
LKEFFSFCEA MELVPDEELE ASSRGGSGAP ADRRALKIAR FKRQKAAEAK
160 170 180 190 200
LLEIKERKER RGRSTKASAL STPVESGEDD IPDDDSEEER EAWLSSINLA
210 220 230 240 250
ICKAIDLLEM LKREEEMLSA IKERQLKDGE GGFSRDALDD RTKKAETWHR
260 270 280 290 300
DAAARIQYSK PAQPITCATF AQDVLEGRAS VSQGHEHKNQ PLIFGPASIV
310 320 330 340 350
GGPLSTERER MIAQVFQPSH RMPTMCIEDA GLTEMNIMND WQEQTKKAIE
360 370 380 390 400
EATTSWYNDK PLRRKEEDEE DDDEDEEAVM KARAFDDWKD DNPRGAGNKK

LTPCG
Length:405
Mass (Da):45,663
Last modified:December 6, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE31201DC5BECADB0
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA97140 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti376 – 378EEA → DEP in AAM63076 (Ref. 5) Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF133708 mRNA Translation: AAD39930.1
AB018116 Genomic DNA Translation: BAA97140.1 Sequence problems.
CP002688 Genomic DNA Translation: AED96288.1
BT004072 mRNA Translation: AAO42099.1
BT006150 mRNA Translation: AAP04135.1
AY085863 mRNA Translation: AAM63076.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T52307

NCBI Reference Sequences

More...
RefSeqi
NP_568783.1, NM_124679.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G53000.1; AT5G53000.1; AT5G53000

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
835379

Gramene; a comparative resource for plants

More...
Gramenei
AT5G53000.1; AT5G53000.1; AT5G53000

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G53000

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133708 mRNA Translation: AAD39930.1
AB018116 Genomic DNA Translation: BAA97140.1 Sequence problems.
CP002688 Genomic DNA Translation: AED96288.1
BT004072 mRNA Translation: AAO42099.1
BT006150 mRNA Translation: AAP04135.1
AY085863 mRNA Translation: AAM63076.1
PIRiT52307
RefSeqiNP_568783.1, NM_124679.3

3D structure databases

SMRiQ8LDQ4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi20624, 38 interactors
IntActiQ8LDQ4, 34 interactors
STRINGi3702.AT5G53000.1

Proteomic databases

PaxDbiQ8LDQ4
PRIDEiQ8LDQ4
ProteomicsDBi234181

Genome annotation databases

EnsemblPlantsiAT5G53000.1; AT5G53000.1; AT5G53000
GeneIDi835379
GrameneiAT5G53000.1; AT5G53000.1; AT5G53000
KEGGiath:AT5G53000

Organism-specific databases

AraportiAT5G53000
TAIRilocus:2168392, AT5G53000

Phylogenomic databases

eggNOGiKOG2830, Eukaryota
HOGENOMiCLU_041824_0_0_1
InParanoidiQ8LDQ4
OMAiPFILTKD
OrthoDBi1348942at2759
PhylomeDBiQ8LDQ4

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8LDQ4

Gene expression databases

ExpressionAtlasiQ8LDQ4, baseline and differential
GenevisibleiQ8LDQ4, AT

Family and domain databases

Gene3Di1.25.40.540, 1 hit
InterProiView protein in InterPro
IPR038511, TAP42/TAP46-like_sf
IPR007304, TAP46-like
PANTHERiPTHR10933, PTHR10933, 1 hit
PfamiView protein in Pfam
PF04177, TAP42, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAP46_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8LDQ4
Secondary accession number(s): Q9LVV2, Q9XHD0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: February 10, 2021
This is version 102 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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