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UniProtKB - Q8LB08 (ADT4_ARATH)
Protein
ADP,ATP carrier protein ER-ANT1
Gene
ER-ANT1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
ADP:ATP antiporter that catalyzes the exchange of ADP and ATP across the endoplasmic reticulum membrane.
1 PublicationCatalytic activityi
- This reaction proceeds in the forward1 Publication direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 83 | ADPBy similarity | 1 | |
Binding sitei | 95 | ADPBy similarity | 1 | |
Binding sitei | 240 | ADPBy similarity | 1 |
GO - Molecular functioni
- ATP:ADP antiporter activity Source: TAIR
GO - Biological processi
- adenine nucleotide transport Source: TAIR
- mitochondrial ADP transmembrane transport Source: InterPro
- mitochondrial ATP transmembrane transport Source: InterPro
- root development Source: TAIR
- seed development Source: TAIR
- shoot system development Source: TAIR
Keywordsi
Biological process | Antiport, Transport |
Protein family/group databases
TCDBi | 2.A.29.1.6, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: ADP,ATP carrier protein ER-ANT1Alternative name(s): ADP/ATP translocase ER-ANT1 Endoplasmic reticulum-adenine nucleotide transporter 1 Short name: ER-ANT1 |
Gene namesi | Name:ER-ANT1 Ordered Locus Names:At5g17400 ORF Names:T10B6_60 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G17400 |
TAIRi | locus:2178925, AT5G17400 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: TAIR
Mitochondrion
- mitochondrial inner membrane Source: InterPro
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 10 – 37 | Helical; Name=1By similarityAdd BLAST | 28 | |
Transmembranei | 78 – 102 | Helical; Name=2By similarityAdd BLAST | 25 | |
Transmembranei | 111 – 131 | Helical; Name=3By similarityAdd BLAST | 21 | |
Transmembranei | 181 – 202 | Helical; Name=4By similarityAdd BLAST | 22 | |
Transmembranei | 216 – 236 | Helical; Name=5By similarityAdd BLAST | 21 | |
Transmembranei | 276 – 296 | Helical; Name=6By similarityAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Disruption phenotypei
Dramatic growth retardation.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000410473 | 1 – 306 | ADP,ATP carrier protein ER-ANT1Add BLAST | 306 |
Proteomic databases
PaxDbi | Q8LB08 |
ProteomicsDBi | 244734 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q8LB08, baseline and differential |
Genevisiblei | Q8LB08, AT |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 8 – 101 | Solcar 1Add BLAST | 94 | |
Repeati | 113 – 205 | Solcar 2Add BLAST | 93 | |
Repeati | 213 – 299 | Solcar 3Add BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 240 – 245 | Important for transport activityBy similarity | 6 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 240 – 245 | Nucleotide carrier signature motifBy similarity | 6 |
Domaini
The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0749, Eukaryota |
HOGENOMi | CLU_015166_12_0_1 |
InParanoidi | Q8LB08 |
OMAi | FSGVCAY |
OrthoDBi | 870903at2759 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002113, ADT_euk_type IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
PANTHERi | PTHR45635, PTHR45635, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00927, ADPTRNSLCASE PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
Q8LB08-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALIGKSERF SADFVMGGAA AIVAKSAAAP IERVKLLLQN QGEMIKTGHL
60 70 80 90 100
IRPYTGLGNC FTRIYREEGV LSFWRGNQAN VIRYFPTQAS NFAFKGYFKN
110 120 130 140 150
LLGCSKEKDG YLKWFAGNVA SGSAAGATTS LFLYHLDYAR TRLGTDAKEC
160 170 180 190 200
SVNGKRQFKG MIDVYRKTLS SDGIKGLYRG FGVSIVGITL YRGMYFGMYD
210 220 230 240 250
TIKPIVLVGS LEGNFLASFL LGWSITTSAG VIAYPFDTLR RRMMLTSGQP
260 270 280 290 300
VKYRNTIHAL REILKSEGFY ALYRGVTANM LLGVAGAGVL AGYDQLHQIA
YKHWVQ
Sequence cautioni
The sequence CAC01735 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL391142 Genomic DNA Translation: CAC01735.1 Sequence problems. CP002688 Genomic DNA Translation: AED92421.1 AY087494 mRNA Translation: AAM65037.1 |
PIRi | T51577 |
RefSeqi | NP_568345.1, NM_121746.4 |
Genome annotation databases
EnsemblPlantsi | AT5G17400.1; AT5G17400.1; AT5G17400 |
GeneIDi | 831606 |
Gramenei | AT5G17400.1; AT5G17400.1; AT5G17400 |
KEGGi | ath:AT5G17400 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL391142 Genomic DNA Translation: CAC01735.1 Sequence problems. CP002688 Genomic DNA Translation: AED92421.1 AY087494 mRNA Translation: AAM65037.1 |
PIRi | T51577 |
RefSeqi | NP_568345.1, NM_121746.4 |
3D structure databases
AlphaFoldDBi | Q8LB08 |
SMRi | Q8LB08 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT5G17400.1 |
Protein family/group databases
TCDBi | 2.A.29.1.6, the mitochondrial carrier (mc) family |
Proteomic databases
PaxDbi | Q8LB08 |
ProteomicsDBi | 244734 |
Genome annotation databases
EnsemblPlantsi | AT5G17400.1; AT5G17400.1; AT5G17400 |
GeneIDi | 831606 |
Gramenei | AT5G17400.1; AT5G17400.1; AT5G17400 |
KEGGi | ath:AT5G17400 |
Organism-specific databases
Araporti | AT5G17400 |
TAIRi | locus:2178925, AT5G17400 |
Phylogenomic databases
eggNOGi | KOG0749, Eukaryota |
HOGENOMi | CLU_015166_12_0_1 |
InParanoidi | Q8LB08 |
OMAi | FSGVCAY |
OrthoDBi | 870903at2759 |
Miscellaneous databases
PROi | PR:Q8LB08 |
Gene expression databases
ExpressionAtlasi | Q8LB08, baseline and differential |
Genevisiblei | Q8LB08, AT |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002113, ADT_euk_type IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
PANTHERi | PTHR45635, PTHR45635, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00927, ADPTRNSLCASE PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ADT4_ARATH | |
Accessioni | Q8LB08Primary (citable) accession number: Q8LB08 Secondary accession number(s): F4KGZ7, Q9LF44 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | May 25, 2022 | |
This is version 114 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families