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Protein

Pectinesterase

Gene
N/A
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts in the modification of cell walls via demethylesterification of cell wall pectin.UniRule annotation

Catalytic activityi

Pectin + n H2O = n methanol + pectate.UniRule annotationSAAS annotation

Pathwayi: pectin degradation

This protein is involved in step 1 of the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Putative pectinesterase/pectinesterase inhibitor 26 (PME26), Putative pectinesterase/pectinesterase inhibitor 28 (PME28), Probable pectinesterase/pectinesterase inhibitor 33 (PME33), Probable pectinesterase/pectinesterase inhibitor 40 (PME40), Probable pectinesterase/pectinesterase inhibitor 13 (PME13), Probable pectinesterase/pectinesterase inhibitor 19 (PME19), Probable pectinesterase/pectinesterase inhibitor 25 (PME25), Probable pectinesterase/pectinesterase inhibitor 34 (PME34), Probable pectinesterase/pectinesterase inhibitor 36 (PME36), Pectinesterase/pectinesterase inhibitor 3 (PME3), Probable pectinesterase/pectinesterase inhibitor 47 (PME47), Probable pectinesterase/pectinesterase inhibitor 12 (PME12), Probable pectinesterase/pectinesterase inhibitor 21 (PME21), Probable pectinesterase/pectinesterase inhibitor 60 (PME60), Probable pectinesterase 66 (PME66), Probable pectinesterase 8 (PME8), Putative pectinesterase 11 (PME11), Probable pectinesterase 15 (PME15), Putative pectinesterase/pectinesterase inhibitor 22 (PME22), Probable pectinesterase 29 (PME29), Putative pectinesterase/pectinesterase inhibitor 38 (PME38), Putative pectinesterase 14 (PME14), Pectinesterase/pectinesterase inhibitor 18 (PME18), Pectinesterase 2 (PME2), Probable pectinesterase/pectinesterase inhibitor 42 (PME42), Probable pectinesterase/pectinesterase inhibitor 64 (PME64), Probable pectinesterase 48 (PME48), Probable pectinesterase/pectinesterase inhibitor 39 (PME39), Probable pectinesterase 53 (PME53), Probable pectinesterase/pectinesterase inhibitor 54 (PME54), Probable pectinesterase 67 (PME67), Putative pectinesterase/pectinesterase inhibitor 24 (PME24), Probable pectinesterase/pectinesterase inhibitor 35 (PME35), Probable pectinesterase/pectinesterase inhibitor VGDH2 (VGDH2), Probable pectinesterase/pectinesterase inhibitor 6 (PME6), Probable pectinesterase/pectinesterase inhibitor 16 (PME16), Probable pectinesterase 50 (PME50), Probable pectinesterase 30 (PME30), Pectinesterase 31 (PME31), Probable pectinesterase/pectinesterase inhibitor 58 (PME58), Probable pectinesterase/pectinesterase inhibitor 32 (PME32), Probable pectinesterase/pectinesterase inhibitor 44 (PME44), Probable pectinesterase/pectinesterase inhibitor 46 (PME46), Probable pectinesterase/pectinesterase inhibitor 23 (PME23), Probable pectinesterase/pectinesterase inhibitor 41 (PME41), Probable pectinesterase 56 (PME56), Probable pectinesterase/pectinesterase inhibitor 59 (PME59), Probable pectinesterase/pectinesterase inhibitor 61 (PME61), Putative pectinesterase/pectinesterase inhibitor 45 (PME45), Pectinesterase 4 (PME4), Probable pectinesterase/pectinesterase inhibitor 20 (PME20), Probable pectinesterase/pectinesterase inhibitor 51 (PME51), Pectinesterase QRT1 (QRT1), Putative pectinesterase 63 (PME63), Probable pectinesterase/pectinesterase inhibitor 7 (PME7), Putative pectinesterase/pectinesterase inhibitor 43 (PME43), Putative pectinesterase 10 (PME10), Probable pectinesterase/pectinesterase inhibitor 17 (PME17), Putative pectinesterase 52 (PME52), Putative pectinesterase 57 (PME57), Pectinesterase 5 (PME5), Pectinesterase 1 (PME1), Probable pectinesterase 55 (PME55), Probable pectinesterase 68 (PME68), Probable pectinesterase 49 (PME49), Pectinesterase PPME1 (PPME1), Pectinesterase (AXX17_At3g36460), Pectinesterase (PMEPCRF), Pectinesterase (AXX17_At5g20800), Pectinesterase (At3g10720), Pectinesterase (AXX17_At5g50310), Pectinesterase (AXX17_At1g11890), Pectinesterase (AXX17_At2g42790), Pectinesterase (AXX17_At3g06710), Pectinesterase (AXX17_At3g10570), Pectinesterase (AXX17_At1g04730), Pectinesterase (AXX17_At2g44780), Pectinesterase (AXX17_At1g48300), Pectinesterase (AXX17_At2g33420), Pectinesterase (AXX17_At2g45340), Pectinesterase (AXX17_At1g24390), Pectinesterase (AXX17_At2g22270), PME26 (AXX17_At3g14890), Pectinesterase (AXX17_At1g11900), Pectinesterase (AXX17_At3g31890), Pectinesterase, Pectinesterase (AXX17_At5g45990), Pectinesterase, Pectinesterase (AXX17_At3g43380), Pectinesterase (At4g15980), Pectinesterase (AXX17_At1g01970), Pectinesterase (F14I3.7), Pectinesterase (AXX17_At5g19650), Pectinesterase (AXX17_At4g02930), Pectinesterase (AXX17_At4g02900), Pectinesterase (At3g14310), Pectinesterase (AXX17_At3g14900), Pectinesterase (AXX17_At3g53530), Pectinesterase (AXX17_At3g30550), Pectinesterase (AXX17_At1g11920), Pectinesterase (PMEPCRA), Pectinesterase (AXX17_At5g04420), Uncharacterized protein (AXX17_At5g27870), Pectinesterase (AXX17_At5g50300), Pectinesterase (AXX17_At2g44790), Pectinesterase (AXX17_At5g04430), Pectinesterase (AXX17_At4g38040), Pectinesterase (AXX17_At4g00230), Uncharacterized protein (AXX17_At5g64270), Uncharacterized protein (AXX17_At5g09310), Pectinesterase (AXX17_At2g33410), Pectinesterase (AXX17_At2g40510), Pectinesterase (AXX17_At4g02940), Pectinesterase (AXX17_At3g41380), Pectinesterase (AXX17_At4g18720), Pectinesterase (AXX17_At3g05190), Plant invertase/pectin methylesterase inhibitor superfamily (At5g09760), Pectinesterase (AXX17_At3g55110), Pectinesterase (AXX17_At2g33420), Pectinesterase (AXX17_At5g47900), Uncharacterized protein (AXX17_At3g05180), Pectinesterase (AXX17_At4g06570), Pectinesterase (At1g53840), Pectinesterase (AXX17_At4g38050), Pectinesterase (AXX17_At3g56460), Pectinesterase (PME44), Pectinesterase (At3g49220), Pectinesterase (AXX17_At3g26070), Pectinesterase (AXX17_At3g17940), Pectinesterase, Plant invertase/pectin methylesterase inhibitor superfamily (At3g49220), Pectinesterase (AXX17_At3g10560), Pectinesterase (AXX17_At5g52320), Pectinesterase (At5g20860), Pectinesterase (At5g26810), Pectinesterase (AXX17_At5g26780), Pectinesterase (AXX17_At2g22280), Pectinesterase (AXX17_At1g48290), Pectinesterase
  2. Probable pectate lyase 13 (PMR6), Putative pectate lyase 21 (At5g55720), Probable pectate lyase 3 (AT59), Putative pectate lyase 17 (At4g22090), Probable pectate lyase 18 (At4g24780), Probable pectate lyase 22 (At5g63180), Probable pectate lyase 16 (At4g22080), Probable pectate lyase 5 (At1g67750), Probable pectate lyase 1 (At1g04680), Putative pectate lyase 14 (At4g13210), Probable pectate lyase 20 (At5g48900), Putative pectate lyase 2 (At1g11920), Probable pectate lyase 6 (At2g02720), Probable pectate lyase 9 (At3g24230), Probable pectate lyase 15 (At4g13710), Probable pectate lyase 4 (At1g30350), Putative pectate lyase 11 (At3g27400), Probable pectate lyase 12 (At3g53190), Probable pectate lyase 7 (At3g01270), Probable pectate lyase 8 (At3g07010), Probable pectate lyase 10 (At3g24670), Probable pectate lyase 19 (At5g15110), Pectate lyase (At3g55140), Pectate lyase, Pectate lyase (At5g09280), Pectate lyase (F11F8_12), Pectate lyase (AXX17_At3g00310), Pectate lyase (At3g27400), Pectate lyase (AXX17_At4g25610), Pectate lyase (AXX17_At1g61710), Pectate lyase, Pectate lyase (AXX17_At5g14600), Pectate lyase (AXX17_At1g30780), Pectate lyase (AXX17_At3g47590), Pectate lyase (AXX17_At3g49720), Pectate lyase (AXX17_At1g04020), Pectate lyase (At3g01270), Pectate lyase (At3g07010), Pectate lyase (AXX17_At5g08800), Pectate lyase (At3g01270), Pectate lyase (T26I12.20), Pectate lyase (AXX17_At3g09180), Pectate lyase (AXX17_At1g15010), Pectate lyase (AXX17_At5g47570), Pectate lyase (AXX17_At3g06910), Pectate lyase, Pectate lyase (AXX17_At5g03700), Pectate lyase (AXX17_At3g26200), Pectate lyase (AXX17_At4g25600), Pectate lyase (AXX17_At4g15660), Pectate lyase (At3g07010), Pectate lyase, Pectate lyase (At3g53190), Pectate lyase (AXX17_At3g49450), Pectate lyase (AXX17_At4g28670), Pectate lyase, Pectate lyase (AXX17_At2g01680), Pectate lyase (At4g13210), Pectate lyase (AXX17_At1g12300), Pectate lyase (At3g09540), Pectate lyase (At4g13710), Pectate lyase (At5g04310), Pectate lyase (AXX17_At4g14900), Pectate lyase (AXX17_At3g29900), Pectate lyase (AXX17_At5g54880), Pectate lyase (At3g55140), Pectate lyase (At3g07010), Pectate lyase (AXX17_At3g26720), Pectate lyase (AXX17_At5g62760), Pectate lyase (At1g14420), Pectate lyase (At5g04310)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway pectin degradation, which is itself part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin, the pathway pectin degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei429PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl esteraseUniRule annotationSAAS annotation, Hydrolase
Biological processCell wall biogenesis/degradationUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00545;UER00823

Names & Taxonomyi

Protein namesi
Recommended name:
PectinesteraseUniRule annotation (EC:3.1.1.11UniRule annotation)
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 52HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell wallUniRule annotation, Membrane, Secreted

PTM / Processingi

Proteomic databases

PRIDEiQ8LA06

Expressioni

Gene expression databases

ExpressionAtlasiQ8LA06 baseline and differential

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili146 – 166Sequence analysisAdd BLAST21

Sequence similaritiesi

In the C-terminal section; belongs to the pectinesterase family.SAAS annotation
In the N-terminal section; belongs to the PMEI family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFEH Eukaryota
COG4677 LUCA

Family and domain databases

Gene3Di1.20.140.40, 1 hit
2.160.20.10, 1 hit
InterProiView protein in InterPro
IPR035513 Invertase/methylesterase_inhib
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR033131 Pectinesterase_Asp_AS
IPR000070 Pectinesterase_cat
IPR006501 Pectinesterase_inhib_dom
IPR018040 Pectinesterase_Tyr_AS
PfamiView protein in Pfam
PF01095 Pectinesterase, 1 hit
PF04043 PMEI, 1 hit
SMARTiView protein in SMART
SM00856 PMEI, 1 hit
SUPFAMiSSF101148 SSF101148, 1 hit
SSF51126 SSF51126, 1 hit
TIGRFAMsiTIGR01614 PME_inhib, 1 hit
PROSITEiView protein in PROSITE
PS00800 PECTINESTERASE_1, 1 hit
PS00503 PECTINESTERASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8LA06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSVNSFKGY GKVDEAQDLA LKKKTRKRLL LLSISVVVLI AVIIAAVVAT
60 70 80 90 100
VVHKNKNEST PSPPPELTPS TSLKAICSVT RFPESCISSI SKLPSSNTTD
110 120 130 140 150
PETLFKLSLK VIIDELDSIS DLPEKLSKET EDERIKSALR VCGDLIEDAL
160 170 180 190 200
DRLNDTVSAI DDEEKKKTLS SSKIEDLKTW LSATVTDHET CFDSLDELKQ
210 220 230 240 250
NKTEYANSTI TQNLKSAMSR STEFTSNSLA IVSKILSALS DLGIPIHRRR
260 270 280 290 300
RLMSHHHQQS VDFEKWARRR LLQTAGLKPD VTVAGDGTGD VLTVNEAVAK
310 320 330 340 350
VPKKSLKMFV IYVKSGTYVE NVVMDKSKWN VMIYGDGKGK TIISGSKNFV
360 370 380 390 400
DGTPTYETAT FAIQGKGFIM KDIGIINTAG AAKHQAVAFR SGSDFSVYYQ
410 420 430 440 450
CSFDGFQDTL YPHSNRQFYR DCDVTGTIDF IFGSAAVVFQ GCKIMPRQPL
460 470 480 490 500
SNQFNTITAQ GKKDPNQSSG MSIQRCTIST NGNVIAPTYL GRPWKEFSTT
510 520 530 540 550
VIMETVIGAV VRPSGWMSWV SGVDPPASIV YGEYKNTGPG SDVTQRVKWA
560 570 580
GYKPVMSDAE AAKFTVATLL HGADWIPATG VINQLS
Length:586
Mass (Da):64,179
Last modified:October 1, 2002 - v1
Checksum:iF58DF3ADC535BE99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY088104 mRNA Translation: AAM65650.1

Similar proteinsi

Entry informationi

Entry nameiQ8LA06_ARATH
AccessioniPrimary (citable) accession number: Q8LA06
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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