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Protein

Two-component response regulator ARR14

Gene

ARR14

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi202 – 252Myb-like GARPPROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity Source: TAIR
  • identical protein binding Source: IntAct
  • phosphorelay response regulator activity Source: TAIR

GO - Biological processi

  • cytokinin-activated signaling pathway Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCytokinin signaling pathway, Transcription, Transcription regulation, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Two-component response regulator ARR14
Gene namesi
Name:ARR14
Ordered Locus Names:At2g01760
ORF Names:T8O11.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G01760
TAIRilocus:2065398 AT2G01760

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001322991 – 382Two-component response regulator ARR14Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei634-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Two-component system major event consists of a His-to-Asp phosphorelay between a sensor histidine kinase (HK) and a response regulator (RR). In plants, the His-to-Asp phosphorelay involves an additional intermediate named Histidine-containing phosphotransfer protein (HPt). This multistep phosphorelay consists of a His-Asp-His-Asp sequential transfer of a phosphate group between first an His and an Asp of the HK protein, followed by the transfer to a conserved His of the HPt protein and finally the transfer to an Asp in the receiver domain of the RR protein.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8L9Y3
PRIDEiQ8L9Y3

Expressioni

Tissue specificityi

Predominantly expressed in young leaf tissue.1 Publication

Gene expression databases

ExpressionAtlasiQ8L9Y3 baseline and differential
GenevisibleiQ8L9Y3 AT

Interactioni

Subunit structurei

Binds the target DNA as a monomer.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110, 56 interactors
IntActiQ8L9Y3, 56 interactors
STRINGi3702.AT2G01760.1

Structurei

3D structure databases

ProteinModelPortaliQ8L9Y3
SMRiQ8L9Y3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 128Response regulatoryPROSITE-ProRule annotationAdd BLAST117

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi199 – 202Nuclear localization signalSequence analysis4

Sequence similaritiesi

Belongs to the ARR family. Type-B subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IMXQ Eukaryota
COG0745 LUCA
HOGENOMiHOG000034077
InParanoidiQ8L9Y3
KOiK14491
OMAiVNEESWI
OrthoDBiEOG09360GM0
PhylomeDBiQ8L9Y3

Family and domain databases

CDDicd00156 REC, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR006447 Myb_dom_plants
IPR017053 Response_reg_B-typ_pln
IPR001005 SANT/Myb
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF036392 RR_ARR_type-B, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF52172 SSF52172, 1 hit
TIGRFAMsiTIGR01557 myb_SHAQKYF, 1 hit
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8L9Y3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPINDQFPSG LRILVVDDDT SCLFILEKML LRLMYQVTIC SQADVALTIL
60 70 80 90 100
RERKDSFDLV LSDVHMPGMN GYNLLQQVGL LEMDLPVIMM SVDGRTTTVM
110 120 130 140 150
TGINHGACDY LIKPIRPEEL KNIWQHVVRR KCVMKKELRS SQALEDNKNS
160 170 180 190 200
GSLETVVVSV SECSEESLMK CRNKKKKKKR SVDRDDNEDD LLLDPGNSKK
210 220 230 240 250
SRVVWSIELH QQFVNAVNKL GIDKAVPKRI LELMNVPGLS RENVASHLQK
260 270 280 290 300
FRLYLKRLSG EASQSNDSES TKRYENIQAL VSSGQLHPQT LAALFGQPID
310 320 330 340 350
NHHSASFGVW IPNDNLGRSQ NEHFSVDVSS ASNRPVSVAV HGLSSSANFR
360 370 380
QRGDVNNNRI RQGYGSNVNE ESWILERSSR QR
Length:382
Mass (Da):43,099
Last modified:July 19, 2004 - v2
Checksum:i0374BB7AF011CE49
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8AZZ3A0A1P8AZZ3_ARATH
Two-component response regulator
RR14 ARR14, response regulator 14, At2g01760, T8O11.7, T8O11_7
410Annotation score:
A0A1P8B023A0A1P8B023_ARATH
Response regulator 14
RR14 ARR14, response regulator 14, At2g01760, T8O11.7, T8O11_7
317Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti354D → N in AAM65694 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006069 Genomic DNA Translation: AAD12696.1
CP002685 Genomic DNA Translation: AEC05495.1
AY099726 mRNA Translation: AAM20577.1
AY128887 mRNA Translation: AAM91287.1
AY088149 mRNA Translation: AAM65694.1
PIRiG84428
RefSeqiNP_178285.1, NM_126237.3
UniGeneiAt.42470

Genome annotation databases

EnsemblPlantsiAT2G01760.1; AT2G01760.1; AT2G01760
GeneIDi814707
GrameneiAT2G01760.1; AT2G01760.1; AT2G01760
KEGGiath:AT2G01760

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006069 Genomic DNA Translation: AAD12696.1
CP002685 Genomic DNA Translation: AEC05495.1
AY099726 mRNA Translation: AAM20577.1
AY128887 mRNA Translation: AAM91287.1
AY088149 mRNA Translation: AAM65694.1
PIRiG84428
RefSeqiNP_178285.1, NM_126237.3
UniGeneiAt.42470

3D structure databases

ProteinModelPortaliQ8L9Y3
SMRiQ8L9Y3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110, 56 interactors
IntActiQ8L9Y3, 56 interactors
STRINGi3702.AT2G01760.1

Proteomic databases

PaxDbiQ8L9Y3
PRIDEiQ8L9Y3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G01760.1; AT2G01760.1; AT2G01760
GeneIDi814707
GrameneiAT2G01760.1; AT2G01760.1; AT2G01760
KEGGiath:AT2G01760

Organism-specific databases

AraportiAT2G01760
TAIRilocus:2065398 AT2G01760

Phylogenomic databases

eggNOGiENOG410IMXQ Eukaryota
COG0745 LUCA
HOGENOMiHOG000034077
InParanoidiQ8L9Y3
KOiK14491
OMAiVNEESWI
OrthoDBiEOG09360GM0
PhylomeDBiQ8L9Y3

Miscellaneous databases

PROiPR:Q8L9Y3

Gene expression databases

ExpressionAtlasiQ8L9Y3 baseline and differential
GenevisibleiQ8L9Y3 AT

Family and domain databases

CDDicd00156 REC, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR006447 Myb_dom_plants
IPR017053 Response_reg_B-typ_pln
IPR001005 SANT/Myb
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF036392 RR_ARR_type-B, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF52172 SSF52172, 1 hit
TIGRFAMsiTIGR01557 myb_SHAQKYF, 1 hit
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARR14_ARATH
AccessioniPrimary (citable) accession number: Q8L9Y3
Secondary accession number(s): Q9ZUA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 12, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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