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UniProtKB - Q8L9J7 (SWET1_ARATH)
Protein
Bidirectional sugar transporter SWEET1
Gene
SWEET1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Mediates both low-affinity uptake and efflux of sugar across the plasma membrane. Can transport glucose, and, to a lower extent, mannose, fructose and galactose.
1 PublicationKineticsi
- KM=9 mM for glucose1 Publication
- Vmax=51.7 pmol/sec/mg enzyme with glucose as substrate (for uptake)1 Publication
pH dependencei
Optimum pH is 8.5 for uptake.1 Publication
GO - Molecular functioni
- sugar transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- carbohydrate transport Source: GO_Central
- protein homooligomerization Source: UniProtKB
Keywordsi
Biological process | Sugar transport, Transport |
Protein family/group databases
TCDBi | 2.A.123.1.9, the sweet, pq-loop, saliva, mtn3 (sweet) family |
Names & Taxonomyi
Protein namesi | Recommended name: Bidirectional sugar transporter SWEET11 PublicationShort name: AtSWEET11 Publication Alternative name(s): Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 11 Publication |
Gene namesi | Name:SWEET11 Publication Ordered Locus Names:At1g21460Imported ORF Names:F24J8.9Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G21460 |
TAIRi | locus:2026997, AT1G21460 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: TAIR
- endoplasmic reticulum membrane Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 6 | ExtracellularSequence analysis | 6 | |
Transmembranei | 7 – 27 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 28 – 41 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 42 – 62 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 63 – 71 | ExtracellularSequence analysis | 9 | |
Transmembranei | 72 – 92 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 93 – 98 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 99 – 119 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 120 – 127 | ExtracellularSequence analysis | 8 | |
Transmembranei | 128 – 148 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 149 – 162 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 163 – 183 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 184 – 187 | ExtracellularSequence analysis | 4 | |
Transmembranei | 188 – 208 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 209 – 247 | CytoplasmicSequence analysisAdd BLAST | 39 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, MembranePathology & Biotechi
Disruption phenotypei
Impaired glucose transport activity.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 23 | P → T: Loss of sugar transport activity associated with reduced plasma membrane localization. 1 Publication | 1 | |
Mutagenesisi | 57 | Y → A: Loss of sugar transport activity associated with reduced plasma membrane localization. 1 Publication | 1 | |
Mutagenesisi | 58 | G → D: Loss of sugar transport activity associated with reduced plasma membrane localization. 1 Publication | 1 | |
Mutagenesisi | 180 | G → D: Loss of sugar transport activity associated with reduced plasma membrane localization. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000404102 | 1 – 247 | Bidirectional sugar transporter SWEET1Add BLAST | 247 |
Proteomic databases
PaxDbi | Q8L9J7 |
Expressioni
Tissue specificityi
Mainly expressed in flowers.1 Publication
Inductioni
Slightly induced by the powdery mildew fungus G.cichoracearum.1 Publication
Gene expression databases
ExpressionAtlasi | Q8L9J7, baseline and differential |
Genevisiblei | Q8L9J7, AT |
Interactioni
Subunit structurei
Forms homooligomers and heterooligomers with SWEET9, SWEET11, SWEET13, SWEET15, SWEET16 and SWEET17.
1 PublicationProtein-protein interaction databases
BioGRIDi | 23983, 15 interactors |
DIPi | DIP-61791N |
IntActi | Q8L9J7, 9 interactors |
STRINGi | 3702.AT1G21460.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 94 | MtN3/slv 1Add BLAST | 88 | |
Domaini | 130 – 213 | MtN3/slv 2Add BLAST | 84 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 221 – 247 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 221 – 239 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the SWEET sugar transporter family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1623, Eukaryota |
HOGENOMi | CLU_048643_1_0_1 |
InParanoidi | Q8L9J7 |
OMAi | VMLFCNA |
OrthoDBi | 1116261at2759 |
PhylomeDBi | Q8L9J7 |
Family and domain databases
InterProi | View protein in InterPro IPR004316, SWEET_sugar_transpr |
Pfami | View protein in Pfam PF03083, MtN3_slv, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8L9J7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNIAHTIFGV FGNATALFLF LAPSITFKRI IKNKSTEQFS GIPYPMTLLN
60 70 80 90 100
CLLSAWYGLP FVSKDNTLVS TINGTGAVIE TVYVLIFLFY APKKEKIKIF
110 120 130 140 150
GIFSCVLAVF ATVALVSLFA LQGNGRKLFC GLAATVFSII MYASPLSIMR
160 170 180 190 200
LVVKTKSVEF MPFFLSLFVF LCGTSWFVYG LIGRDPFVAI PNGFGCALGT
210 220 230 240
LQLILYFIYC GNKGEKSADA QKDEKSVEMK DDEKKQNVVN GKQDLQV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8AX31 | A0A1P8AX31_ARATH | Nodulin MtN3 family protein | SWEET1 AtSWEET1, At1g21460, F24J8.9, F24J8_9 | 202 | Annotation score: |
Sequence cautioni
The sequence AAF87899 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC015447 Genomic DNA Translation: AAF87899.1 Sequence problems. CP002684 Genomic DNA Translation: AEE30104.1 BT004185 mRNA Translation: AAO42204.1 BT005476 mRNA Translation: AAO63896.1 AY088391 mRNA Translation: AAM65929.1 |
PIRi | F86347 |
RefSeqi | NP_564140.1, NM_101997.3 |
Genome annotation databases
EnsemblPlantsi | AT1G21460.1; AT1G21460.1; AT1G21460 |
GeneIDi | 838744 |
Gramenei | AT1G21460.1; AT1G21460.1; AT1G21460 |
KEGGi | ath:AT1G21460 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC015447 Genomic DNA Translation: AAF87899.1 Sequence problems. CP002684 Genomic DNA Translation: AEE30104.1 BT004185 mRNA Translation: AAO42204.1 BT005476 mRNA Translation: AAO63896.1 AY088391 mRNA Translation: AAM65929.1 |
PIRi | F86347 |
RefSeqi | NP_564140.1, NM_101997.3 |
3D structure databases
SMRi | Q8L9J7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 23983, 15 interactors |
DIPi | DIP-61791N |
IntActi | Q8L9J7, 9 interactors |
STRINGi | 3702.AT1G21460.1 |
Protein family/group databases
TCDBi | 2.A.123.1.9, the sweet, pq-loop, saliva, mtn3 (sweet) family |
Proteomic databases
PaxDbi | Q8L9J7 |
Genome annotation databases
EnsemblPlantsi | AT1G21460.1; AT1G21460.1; AT1G21460 |
GeneIDi | 838744 |
Gramenei | AT1G21460.1; AT1G21460.1; AT1G21460 |
KEGGi | ath:AT1G21460 |
Organism-specific databases
Araporti | AT1G21460 |
TAIRi | locus:2026997, AT1G21460 |
Phylogenomic databases
eggNOGi | KOG1623, Eukaryota |
HOGENOMi | CLU_048643_1_0_1 |
InParanoidi | Q8L9J7 |
OMAi | VMLFCNA |
OrthoDBi | 1116261at2759 |
PhylomeDBi | Q8L9J7 |
Miscellaneous databases
PROi | PR:Q8L9J7 |
Gene expression databases
ExpressionAtlasi | Q8L9J7, baseline and differential |
Genevisiblei | Q8L9J7, AT |
Family and domain databases
InterProi | View protein in InterPro IPR004316, SWEET_sugar_transpr |
Pfami | View protein in Pfam PF03083, MtN3_slv, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SWET1_ARATH | |
Accessioni | Q8L9J7Primary (citable) accession number: Q8L9J7 Secondary accession number(s): Q9LPL1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 8, 2011 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families