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Entry version 83 (02 Dec 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Conserved oligomeric Golgi complex subunit 4

Gene

COG4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal Golgi function.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 41 Publication
Short name:
COG complex subunit 41 Publication
Alternative name(s):
Component of oligomeric Golgi complex 41 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COG41 Publication
Ordered Locus Names:At4g01395Imported
ORF Names:F3D13.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G01395

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003634091 – 738Conserved oligomeric Golgi complex subunit 4Add BLAST738

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8L838

PRoteomics IDEntifications database

More...
PRIDEi
Q8L838

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
240914

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8L838, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8L838, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization (Probable).

Interacts with COG2 and COG3 (PubMed:27448097).

1 Publication1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
13234, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8L838, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT4G01400.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8L838

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the COG4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0412, Eukaryota
KOG4197, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014853_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8L838

Identification of Orthologs from Complete Genome Data

More...
OMAi
SECQQRV

Database of Orthologous Groups

More...
OrthoDBi
376278at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013167, COG_su4

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08318, COG4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00762, Cog4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8L838-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEIEQDDAA AETVDSSTVK FGTPEALEYV RSLTDVGAMT RLLHECIAYQ
60 70 80 90 100
RSLDSDLDTL LSQRTELDRN LVQLQRSAEI LDIVKADADH MLGNVRSTCD
110 120 130 140 150
LADQVSGKVR ELDLAQSRVN VTLSRIDAIV ERGNCIEGVK TALESEDYES
160 170 180 190 200
AAKFVQRFLQ IDLQYKDSGS DQSEQLHASK EQLEGIAKKK LLAAIDQRDH
210 220 230 240 250
PTILRFVRLY SPLGMETEGL QLYVGYLKKV IALRGRMEYE NVVELMEQGL
260 270 280 290 300
GQVNFVGCLT NLFKDIVMAI EENDEILRGL CGEDGVAYAI CELQEECDLR
310 320 330 340 350
GSLILKKYMD FRKLAILASD INNSPNLNIL PGGASEGPDP REVELYVEEI
360 370 380 390 400
LSLMQLGEDY TEFMVSKIKS LTSVDPELLP TATKAFRNKS FSKAIQDVTR
410 420 430 440 450
YYVILEGFFM VENVRKAIRI DEHVPDSLTT SMVDDVFYVL QSCLRRAIST
460 470 480 490 500
SNISSVIAVL SYAGSLLGND YHEALQQKIR EPNLGARLFL GGIGVENTGT
510 520 530 540 550
EIATALNNMD VSCEYILKLK HEIEEQCTEV FPAPADRERI KSCLSELGEL
560 570 580 590 600
SSTFKQLLNS GMEQLVATVT PRIRPVLDTV ATISYELTET EYAENEVNDP
610 620 630 640 650
WVQRLLHSVE TNAAWLQPLM TSNNYDSFLH LIIDFIVKRL EVIMMQKRFS
660 670 680 690 700
QLGGLQLDRD TRALVSHFSG MTQRTVRDKF ARLTQMATIL NLEKVSEILD
710 720 730
FWGENSGPMT WRLTPAEVRR VLGLRVEFKP ESIAALKL
Length:738
Mass (Da):82,978
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF9B1B0FDA7B15CE
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC19289 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene has been split into 2 genes: At4g01395 and At4g01400.Curated
The sequence CAB80949 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene has been split into 2 genes: At4g01395 and At4g01400.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF069300 Genomic DNA Translation: AAC19289.1 Sequence problems.
AL161491 Genomic DNA Translation: CAB80949.1 Sequence problems.
CP002687 Genomic DNA Translation: ANM66918.1
AY120763 mRNA Translation: AAM53321.1
BT010336 mRNA Translation: AAQ56779.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C85018
T01377

NCBI Reference Sequences

More...
RefSeqi
NP_001154198.1, NM_001160726.2

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G01395.1; AT4G01395.1; AT4G01395

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
827943

Gramene; a comparative resource for plants

More...
Gramenei
AT4G01395.1; AT4G01395.1; AT4G01395

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G01395

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069300 Genomic DNA Translation: AAC19289.1 Sequence problems.
AL161491 Genomic DNA Translation: CAB80949.1 Sequence problems.
CP002687 Genomic DNA Translation: ANM66918.1
AY120763 mRNA Translation: AAM53321.1
BT010336 mRNA Translation: AAQ56779.1
PIRiC85018
T01377
RefSeqiNP_001154198.1, NM_001160726.2

3D structure databases

SMRiQ8L838
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi13234, 1 interactor
IntActiQ8L838, 1 interactor
STRINGi3702.AT4G01400.1

Proteomic databases

PaxDbiQ8L838
PRIDEiQ8L838
ProteomicsDBi240914

Genome annotation databases

EnsemblPlantsiAT4G01395.1; AT4G01395.1; AT4G01395
GeneIDi827943
GrameneiAT4G01395.1; AT4G01395.1; AT4G01395
KEGGiath:AT4G01395

Organism-specific databases

AraportiAT4G01395

Phylogenomic databases

eggNOGiKOG0412, Eukaryota
KOG4197, Eukaryota
HOGENOMiCLU_014853_2_0_1
InParanoidiQ8L838
OMAiSECQQRV
OrthoDBi376278at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8L838

Gene expression databases

ExpressionAtlasiQ8L838, baseline and differential
GenevisibleiQ8L838, AT

Family and domain databases

InterProiView protein in InterPro
IPR013167, COG_su4
PfamiView protein in Pfam
PF08318, COG4, 1 hit
SMARTiView protein in SMART
SM00762, Cog4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOG4_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8L838
Secondary accession number(s): O81330, Q9M133
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 1, 2002
Last modified: December 2, 2020
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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