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Entry version 105 (31 Jul 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Nuclear pore complex protein NUP62

Gene

NUP62

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein NUP621 Publication
Alternative name(s):
Nucleoporin 62Imported
Short name:
NP62
Protein EMBRYO DEFECTIVE 2766
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUP621 Publication
Synonyms:EMB2766Imported
Ordered Locus Names:At2g45000Imported
ORF Names:T14P1.20Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G45000

The Arabidopsis Information Resource

More...
TAIRi
locus:2055547 AT2G45000

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004310841 – 739Nuclear pore complex protein NUP62Add BLAST739

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8L7F7

PRoteomics IDEntifications database

More...
PRIDEi
Q8L7F7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8L7F7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8L7F7 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the nuclear pore complex (NPC). The NPC has an eight-fold symmetrical structure comprising a central transport channel and two rings, the cytoplasmic and nuclear rings, to which eight filaments are attached. The cytoplasmic filaments have loose ends, while the nuclear filaments are joined in a distal ring, forming a nuclear basket. NPCs are highly dynamic in configuration and composition, and can be devided in 3 subcomplexes, the NUP62 subcomplex, the NUP107-160 subcomplex and the NUP93 subcomplex, containing approximately 30 different nucleoporin proteins.

Interacts with NUP58 and the importin KPNB1.

1 Publication2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4444, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q8L7F7, 2 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT2G45000.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8L7F7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati6 – 712
Repeati17 – 1822
Repeati50 – 5132
Repeati52 – 5342
Repeati68 – 6952
Repeati70 – 7162
Repeati78 – 7972
Repeati80 – 8182
Repeati91 – 9292
Repeati93 – 94102
Repeati108 – 109112
Repeati110 – 111122
Repeati124 – 125132
Repeati141 – 142142
Repeati159 – 160152
Repeati174 – 175162
Repeati186 – 187172
Repeati207 – 208182
Repeati221 – 222192
Repeati248 – 249202
Repeati271 – 272212
Repeati280 – 281222
Repeati308 – 309232
Repeati366 – 367242
Repeati426 – 427252
Repeati449 – 450262

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni6 – 45026 X 2 AA repeats of F-GAdd BLAST445

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili584 – 674Sequence analysisAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 522Ser-richPROSITE-ProRule annotationAdd BLAST514
Compositional biasi397 – 523Thr-richPROSITE-ProRule annotationAdd BLAST127

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats.Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nucleoporin NSP1/NUP62 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2196 Eukaryota
ENOG410XT5X LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000030354

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8L7F7

KEGG Orthology (KO)

More...
KOi
K14306

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMMSKQV

Database of Orthologous Groups

More...
OrthoDBi
1420505at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026010 NSP1/NUP62
IPR007758 Nucleoporin_NSP1_C

The PANTHER Classification System

More...
PANTHERi
PTHR12084 PTHR12084, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05064 Nsp1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8L7F7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGFPFGQSN SVGGFSFGSS SATNSSSASS TTSPLSFSFN QSSNPSSTGF
60 70 80 90 100
GFGSSVSSTP ASSTTPSFGF GASSTPSFGF GSSASSSTPS FGFGSSASVT
110 120 130 140 150
PASTTPSFGF GTAASSSAPA PSLFGSSTTN ASSAAPGSSP FGFVTSSASS
160 170 180 190 200
TATPSSSLFG APASSAATPS SSPFGAAPAS GSTPLFGSSP SLFSAPSSAS
210 220 230 240 250
ASNSSLFGAS SSAATSTSPL FGAPSSATGA TPSFSVASSA PGSSSSIFGA
260 270 280 290 300
TGSSPSFSVA SSASGSSPSI FGATGSSPFF GSSSSAGSTP SLFASSSSGA
310 320 330 340 350
TTSSPSPFGV STFNSSSTSN TSNASASPFS ASTGFSFLKS TASSTTSSTT
360 370 380 390 400
PSAPPQTASS SSSFSFGTSA NSGFNLSTGS SAAPASSTSG AVFSIATTTT
410 420 430 440 450
TSSSTPAATS APASSAPAST MAFPSFGVTS SATNTTPASS AATFSTTGFG
460 470 480 490 500
LASSTPATGS TNSFTGFAVP KTSTPASSSQ PQTTSPAFSF SLPSSTSTTA
510 520 530 540 550
PATSSATTTQ TTLVVPSSSG TSTAVAPVAG SPKLPSEITG KTVEEIIKEW
560 570 580 590 600
NTELQERTGR FRKQANAIAE WDKRILQNRD VLLRLEIEVA KVVETQSSLE
610 620 630 640 650
RQLELIETHQ QEVDKALQSM EEEAERIYND ERKSLLDDEA ASTRDAMYEQ
660 670 680 690 700
SELVERELEH MTEQIRSIIQ SVNANQGGEL EAIDGMSPLD VVVRILNNQL
710 720 730
SSLMWIDEKA EEFSSRIQKI ALQGSGGDRE LMAPKHWMS
Length:739
Mass (Da):73,482
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD4DEADB5C786357
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL69462 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence AAL86303 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP002685 Genomic DNA Translation: AEC10495.1
AY133874 mRNA Translation: AAM91808.1
AY074646 mRNA Translation: AAL69462.1 Sequence problems.
AY080620 mRNA Translation: AAL86303.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...
PIRi
D84885

NCBI Reference Sequences

More...
RefSeqi
NP_850429.1, NM_180098.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G45000.1; AT2G45000.1; AT2G45000

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
819108

Gramene; a comparative resource for plants

More...
Gramenei
AT2G45000.1; AT2G45000.1; AT2G45000

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G45000

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002685 Genomic DNA Translation: AEC10495.1
AY133874 mRNA Translation: AAM91808.1
AY074646 mRNA Translation: AAL69462.1 Sequence problems.
AY080620 mRNA Translation: AAL86303.1 Sequence problems.
PIRiD84885
RefSeqiNP_850429.1, NM_180098.3

3D structure databases

SMRiQ8L7F7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi4444, 9 interactors
IntActiQ8L7F7, 2 interactors
STRINGi3702.AT2G45000.1

PTM databases

iPTMnetiQ8L7F7

Proteomic databases

PaxDbiQ8L7F7
PRIDEiQ8L7F7

Genome annotation databases

EnsemblPlantsiAT2G45000.1; AT2G45000.1; AT2G45000
GeneIDi819108
GrameneiAT2G45000.1; AT2G45000.1; AT2G45000
KEGGiath:AT2G45000

Organism-specific databases

AraportiAT2G45000
TAIRilocus:2055547 AT2G45000

Phylogenomic databases

eggNOGiKOG2196 Eukaryota
ENOG410XT5X LUCA
HOGENOMiHOG000030354
InParanoidiQ8L7F7
KOiK14306
OMAiEMMSKQV
OrthoDBi1420505at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8L7F7

Gene expression databases

ExpressionAtlasiQ8L7F7 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR026010 NSP1/NUP62
IPR007758 Nucleoporin_NSP1_C
PANTHERiPTHR12084 PTHR12084, 1 hit
PfamiView protein in Pfam
PF05064 Nsp1_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUP62_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8L7F7
Secondary accession number(s): Q9SHD8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 26, 2014
Last sequence update: October 1, 2002
Last modified: July 31, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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