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Entry version 105 (17 Jun 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Vacuolar cation/proton exchanger 5

Gene

CAX5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Vacuolar cation/proton exchanger (CAX). Translocates Ca2+ and other metal ions into vacuoles using the proton gradient formed by H+-ATPase and H+-pyrophosphatase (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Calcium transport, Ion transport, Transport
LigandCalcium

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH36 Glycoside Hydrolase Family 36

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar cation/proton exchanger 5
Alternative name(s):
Ca(2+)/H(+) antiporter CAX5
Ca(2+)/H(+) exchanger 5
Protein CATION EXCHANGER 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAX5
Ordered Locus Names:At1g55730
ORF Names:F20N2.14, F20N2.16, F20N2.30
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G55730

The Arabidopsis Information Resource

More...
TAIRi
locus:2020462 AT1G55730

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 69CytoplasmicSequence analysisAdd BLAST68
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 97ExtracellularSequence analysis7
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 129CytoplasmicSequence analysisAdd BLAST11
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Topological domaini151 – 165ExtracellularSequence analysisAdd BLAST15
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Topological domaini187 – 197CytoplasmicSequence analysisAdd BLAST11
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 231ExtracellularSequence analysisAdd BLAST13
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 286CytoplasmicSequence analysisAdd BLAST34
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 311ExtracellularSequence analysis4
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 354CytoplasmicSequence analysisAdd BLAST22
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 384ExtracellularSequence analysis9
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 412CytoplasmicSequence analysis7
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 441ExtracellularSequence analysis8

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedSequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002701542 – 441Vacuolar cation/proton exchanger 5Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineSequence analysis1
Lipidationi3S-palmitoyl cysteineSequence analysis1
Lipidationi4S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8L783

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
223953

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8L783

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8L783 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8L783 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
27247, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT1G55730.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni139 – 174Cation selectionSequence analysisAdd BLAST36
Regioni333 – 368Cation selectionSequence analysisAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1397 Eukaryota
COG0387 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008721_2_1_1

KEGG Orthology (KO)

More...
KOi
K07300

Identification of Orthologs from Complete Genome Data

More...
OMAi
CCKVPAL

Database of Orthologous Groups

More...
OrthoDBi
727723at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8L783

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004713 CaH_exchang
IPR004798 CAX
IPR004837 NaCa_Exmemb

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01699 Na_Ca_ex, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00846 caca2, 1 hit
TIGR00378 cax, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8L783-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCCKVPALI QAQVEMGLVN DVEHKSLFRR DTDSPERKAA SLMEQGSLSA
60 70 80 90 100
SFRECSTKTP NNSVLQSFKI VILSNKLNLL LPFGPLAILL HYLTDNKGWI
110 120 130 140 150
FLLSLVGITP LAERLGYATE QLACYTGSTV GGLLNATFGN VTELIISIFA
160 170 180 190 200
LKSGMIRVVQ LTLLGSILSN MLLVLGCAFF CGGLVFSQKE QVFDKGNAVV
210 220 230 240 250
NSGLLLMAVM GLLFPAVLHY THSEVHAGSS ELALSRFSSC IMLVAYAAYL
260 270 280 290 300
FFQLKSQPSS YTPLTEETNQ NEETSDDDED PEISKWEAII WLSILTAWVS
310 320 330 340 350
LLSGYLVDAI EGASVSWKIP ISFISVILLP IVGNAAEHAG AIMFAMKDKL
360 370 380 390 400
DLSLGVAIGS SIQISMFAVP FCVVIGWMMG AQMDLNFQLF ETATLFITVI
410 420 430 440
VVAFFLQEGT SNYFKGLMLI LCYLIVAASF FVHEDPHQDD I
Length:441
Mass (Da):48,096
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0319778C9C6476F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4I1W9F4I1W9_ARATH
Plant invertase/pectin methylestera...
At1g55770, F20N2.16
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF79504 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene has been split into 2 genes: At1g55730 and At1g55740.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC002328 Genomic DNA Translation: AAF79504.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE33290.1
CP002684 Genomic DNA Translation: AEE33291.1
AY136416 mRNA Translation: AAM97082.1
BT006591 mRNA Translation: AAP31935.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C96599

NCBI Reference Sequences

More...
RefSeqi
NP_001031196.1, NM_001036119.2
NP_175969.2, NM_104449.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G55730.1; AT1G55730.1; AT1G55730
AT1G55730.2; AT1G55730.2; AT1G55730

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
842022

Gramene; a comparative resource for plants

More...
Gramenei
AT1G55730.1; AT1G55730.1; AT1G55730
AT1G55730.2; AT1G55730.2; AT1G55730

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G55730

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002328 Genomic DNA Translation: AAF79504.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE33290.1
CP002684 Genomic DNA Translation: AEE33291.1
AY136416 mRNA Translation: AAM97082.1
BT006591 mRNA Translation: AAP31935.1
PIRiC96599
RefSeqiNP_001031196.1, NM_001036119.2
NP_175969.2, NM_104449.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi27247, 1 interactor
STRINGi3702.AT1G55730.1

Protein family/group databases

CAZyiGH36 Glycoside Hydrolase Family 36

PTM databases

iPTMnetiQ8L783

Proteomic databases

PaxDbiQ8L783
ProteomicsDBi223953

Genome annotation databases

EnsemblPlantsiAT1G55730.1; AT1G55730.1; AT1G55730
AT1G55730.2; AT1G55730.2; AT1G55730
GeneIDi842022
GrameneiAT1G55730.1; AT1G55730.1; AT1G55730
AT1G55730.2; AT1G55730.2; AT1G55730
KEGGiath:AT1G55730

Organism-specific databases

AraportiAT1G55730
TAIRilocus:2020462 AT1G55730

Phylogenomic databases

eggNOGiKOG1397 Eukaryota
COG0387 LUCA
HOGENOMiCLU_008721_2_1_1
KOiK07300
OMAiCCKVPAL
OrthoDBi727723at2759
PhylomeDBiQ8L783

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8L783

Gene expression databases

ExpressionAtlasiQ8L783 baseline and differential
GenevisibleiQ8L783 AT

Family and domain databases

InterProiView protein in InterPro
IPR004713 CaH_exchang
IPR004798 CAX
IPR004837 NaCa_Exmemb
PfamiView protein in Pfam
PF01699 Na_Ca_ex, 2 hits
TIGRFAMsiTIGR00846 caca2, 1 hit
TIGR00378 cax, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAX5_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8L783
Secondary accession number(s): Q9LFZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2002
Last modified: June 17, 2020
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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