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Entry version 118 (02 Jun 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

Gene

ALG10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc2-PP-Dol. Can complement an ALG10-deficient yeast mutant.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.Curated
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT59, Glycosyltransferase Family 59

Transport Classification Database

More...
TCDBi
9.B.231.1.5, the die2/alg10 glycosyl transferase (die2/alg10) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferaseCurated (EC:2.4.1.2561 Publication)
Alternative name(s):
Alpha-1,2-glucosyltransferase ALG10 homologCurated
Protein HOMOLOG OF YEAST ALG101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALG101 Publication
Ordered Locus Names:At5g02410Imported
ORF Names:T1E22_170Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G02410

The Arabidopsis Information Resource

More...
TAIRi
locus:2180162, AT5G02410

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4CytoplasmicCurated4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 57LumenalCuratedAdd BLAST32
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 99CytoplasmicCuratedAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 124LumenalCurated4
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 170CytoplasmicCuratedAdd BLAST25
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 285LumenalCuratedAdd BLAST94
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Topological domaini307 – 311CytoplasmicCurated5
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 355LumenalCuratedAdd BLAST23
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377 – 400CytoplasmicCuratedAdd BLAST24
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Topological domaini422 – 428LumenalCurated7
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 472CytoplasmicCuratedAdd BLAST23
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 509LumenalCuratedAdd BLAST16

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Small plants with reduced leaf size. Hypoglycosylation of glycoproteins leading to ER stress and activation of the unfolded protein response (UPR). Increased sensitivity to salt stress.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_50057036281 – 509Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferaseAdd BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi351N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8L638

PRoteomics IDEntifications database

More...
PRIDEi
Q8L638

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
244984

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8L638, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G02410.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni210 – 254DisorderedSequence analysisAdd BLAST45

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ALG10 glucosyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2642, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017053_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8L638

Identification of Orthologs from Complete Genome Data

More...
OMAi
FWVVVFM

Database of Orthologous Groups

More...
OrthoDBi
476469at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8L638

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016900, Alg10

The PANTHER Classification System

More...
PANTHERi
PTHR12989, PTHR12989, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04922, DIE2_ALG10, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF028810, Alpha1_2_glucosyltferase_Alg10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8L638-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKLAVAAIT SLWVIPMSII VNHIVPEPYM DEIFHVPQAQ QYCNGNFRSW
60 70 80 90 100
DPMITTPPGL YYLSLAHVAS LFPGMLLMEN TSQSFSEACS TSVLRSTNAV
110 120 130 140 150
SAVLCGVLVY EIIRFLGPNL SDRKATFMAL VMSLYPLHWF FTFLYYTDVA
160 170 180 190 200
SLTAVLAMYL TCLKRRYVLS ALFGTLAVFI RQTNVVWMLF VACSGILDFT
210 220 230 240 250
LDSSKQKGKQ EVNQELHQSS NKKGATLRSN LRKRKSDISS DTSDPFNHGQ
260 270 280 290 300
TVPSTEDTSD LVYDIYTVIS TSWNLKWRIL IKFSPFIFVV VAFGIFILWN
310 320 330 340 350
GGIVLGAKEA HVVSLHFAQI MYFSLVSALF TAPLHFSVNQ LRHQFHQLHR
360 370 380 390 400
NWSLSLILTL VALVAGFVSV HFFSLAHPYL LADNRHYPFY LWRKIINAHW
410 420 430 440 450
LMKYILVPVY VYSWFSILTL LAKTRRQTWI LVYFLATCGV LVPTPLIEFR
460 470 480 490 500
YYTIPFYLFM LHSCVRSSSF ATWLLIGTIF VSINVFTMAM FLFRPFKWSH

EDGVQRFIW
Length:509
Mass (Da):58,439
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCAEBD9F82E2548E7
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB85546 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KJ138711 mRNA Translation: AHL38651.1
AL162874 Genomic DNA Translation: CAB85546.1 Sequence problems.
CP002688 Genomic DNA Translation: AED90469.1
AY099540 mRNA Translation: AAM20392.1
BT002117 mRNA Translation: AAN72128.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T48262

NCBI Reference Sequences

More...
RefSeqi
NP_195861.2, NM_120319.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G02410.1; AT5G02410.1; AT5G02410

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
831764

Gramene; a comparative resource for plants

More...
Gramenei
AT5G02410.1; AT5G02410.1; AT5G02410

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G02410

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ138711 mRNA Translation: AHL38651.1
AL162874 Genomic DNA Translation: CAB85546.1 Sequence problems.
CP002688 Genomic DNA Translation: AED90469.1
AY099540 mRNA Translation: AAM20392.1
BT002117 mRNA Translation: AAN72128.1
PIRiT48262
RefSeqiNP_195861.2, NM_120319.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT5G02410.1

Protein family/group databases

CAZyiGT59, Glycosyltransferase Family 59
TCDBi9.B.231.1.5, the die2/alg10 glycosyl transferase (die2/alg10) family

Proteomic databases

PaxDbiQ8L638
PRIDEiQ8L638
ProteomicsDBi244984

Genome annotation databases

EnsemblPlantsiAT5G02410.1; AT5G02410.1; AT5G02410
GeneIDi831764
GrameneiAT5G02410.1; AT5G02410.1; AT5G02410
KEGGiath:AT5G02410

Organism-specific databases

AraportiAT5G02410
TAIRilocus:2180162, AT5G02410

Phylogenomic databases

eggNOGiKOG2642, Eukaryota
HOGENOMiCLU_017053_1_0_1
InParanoidiQ8L638
OMAiFWVVVFM
OrthoDBi476469at2759
PhylomeDBiQ8L638

Enzyme and pathway databases

UniPathwayiUPA00378

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8L638

Gene expression databases

ExpressionAtlasiQ8L638, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR016900, Alg10
PANTHERiPTHR12989, PTHR12989, 1 hit
PfamiView protein in Pfam
PF04922, DIE2_ALG10, 1 hit
PIRSFiPIRSF028810, Alpha1_2_glucosyltferase_Alg10, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALG10_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8L638
Secondary accession number(s): Q9LZ85
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2016
Last sequence update: October 1, 2002
Last modified: June 2, 2021
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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