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Entry version 102 (25 May 2022)
Sequence version 1 (01 Oct 2002)
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Protein

Protein IQ-DOMAIN 31

Gene

IQD31

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity).

Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity).

May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein IQ-DOMAIN 311 Publication
Short name:
AtIQD311 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IQD311 Publication
Ordered Locus Names:At1g74690Imported
ORF Names:F1M20.37Imported, F25A4.33Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G74690

The Arabidopsis Information Resource

More...
TAIRi
locus:2019205, AT1G74690

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003241241 – 587Protein IQ-DOMAIN 31Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei79PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8L4D8

PRoteomics IDEntifications database

More...
PRIDEi
Q8L4D8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
228834

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8L4D8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8L4D8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8L4D8, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to multiple calmodulin (CaM) in the presence of Ca2+ and CaM-like proteins.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
29027, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8L4D8, 2 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G74690.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q8L4D8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8L4D8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini112 – 140IQ 1PROSITE-ProRule annotationAdd BLAST29
Domaini141 – 163IQ 2PROSITE-ProRule annotationAdd BLAST23
Domaini164 – 188IQ 3PROSITE-ProRule annotationAdd BLAST25

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni57 – 80DisorderedSequence analysisAdd BLAST24
Regioni149 – 159Calmodulin-binding1 PublicationAdd BLAST11
Regioni344 – 587DisorderedSequence analysisAdd BLAST244

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi176 – 183Nuclear localization signalPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi355 – 411Basic and acidic residuesSequence analysisAdd BLAST57
Compositional biasi421 – 435Polar residuesSequence analysisAdd BLAST15
Compositional biasi437 – 492Basic and acidic residuesSequence analysisAdd BLAST56
Compositional biasi540 – 559Polar residuesSequence analysisAdd BLAST20
Compositional biasi560 – 587Basic and acidic residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IQD family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTUQ, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026881_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8L4D8

Identification of Orthologs from Complete Genome Data

More...
OMAi
NTIQVNW

Database of Orthologous Groups

More...
OrthoDBi
533192at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8L4D8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025064, DUF4005
IPR000048, IQ_motif_EF-hand-BS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13178, DUF4005, 1 hit
PF00612, IQ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015, IQ, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096, IQ, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8L4D8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKSTKWLKN VLLGKKTSKS SGSKDKERVV SGKEVLVTSK VEESDVVSDL
60 70 80 90 100
PSFEVAETNT VDRSGGMLET QNVGPEEISD DEIELPEGKS TDSQNVAPVQ
110 120 130 140 150
DHSLSDAERI QREIAATSVQ AAFRGYLARR AFWALKGIIR LQALIRGHLV
160 170 180 190 200
RRQAVATLFS VMGIVRLQAF ARGREIRKSD IGVQVYRKCR LQLLQGNKLA
210 220 230 240 250
NPTDAYLGIK KLTANAFAQK LLASSPKVLP VHAYDTSNPN SNLIWLENWS
260 270 280 290 300
ASCFWKPVPQ PKKTISRKPQ NRLLVEAESA KPKKSVRKVP ASNFESSSVQ
310 320 330 340 350
TSFEFEKPKR SFRKVSSQSI EPPAVEDPQI ELEKVKRSLR KVHNPVVESS
360 370 380 390 400
IQPQRSPRKE VEKPKLGVEK TRESSYPLVH ETAEEPVNVC DEKKKQEISE
410 420 430 440 450
QPEEEVHALE MEVHTPGPLE TNEALDSSLV NQIDSNEKAM VEEKPSMEKD
460 470 480 490 500
TKEEKTPKPN NKENSAGKEN QKSRKKGSAT SKTEREESNG HHETSPSIPS
510 520 530 540 550
YMQATKSAKA KLRLQGSPKS AEQDGTEKAT VPRRHSLPSP GNGRITSHSP
560 570 580
RTTRLANSGD KTGNKKEKPL LSSREGNAKT TPAERKR
Length:587
Mass (Da):65,200
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CF17E73C810DBEB
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD55302 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG52386 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC008263 Genomic DNA Translation: AAD55302.1 Sequence problems.
AC011765 Genomic DNA Translation: AAG52386.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE35622.1
AY099679 mRNA Translation: AAM20530.1
AY128860 mRNA Translation: AAM91260.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B96776

NCBI Reference Sequences

More...
RefSeqi
NP_177607.2, NM_106127.5

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G74690.1; AT1G74690.1; AT1G74690

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
843808

Gramene; a comparative resource for plants

More...
Gramenei
AT1G74690.1; AT1G74690.1; AT1G74690

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G74690

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008263 Genomic DNA Translation: AAD55302.1 Sequence problems.
AC011765 Genomic DNA Translation: AAG52386.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE35622.1
AY099679 mRNA Translation: AAM20530.1
AY128860 mRNA Translation: AAM91260.1
PIRiB96776
RefSeqiNP_177607.2, NM_106127.5

3D structure databases

AlphaFoldDBiQ8L4D8
SMRiQ8L4D8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi29027, 2 interactors
IntActiQ8L4D8, 2 interactors
STRINGi3702.AT1G74690.1

PTM databases

iPTMnetiQ8L4D8

Proteomic databases

PaxDbiQ8L4D8
PRIDEiQ8L4D8
ProteomicsDBi228834

Genome annotation databases

EnsemblPlantsiAT1G74690.1; AT1G74690.1; AT1G74690
GeneIDi843808
GrameneiAT1G74690.1; AT1G74690.1; AT1G74690
KEGGiath:AT1G74690

Organism-specific databases

AraportiAT1G74690
TAIRilocus:2019205, AT1G74690

Phylogenomic databases

eggNOGiENOG502QTUQ, Eukaryota
HOGENOMiCLU_026881_0_0_1
InParanoidiQ8L4D8
OMAiNTIQVNW
OrthoDBi533192at2759
PhylomeDBiQ8L4D8

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8L4D8

Gene expression databases

ExpressionAtlasiQ8L4D8, baseline and differential
GenevisibleiQ8L4D8, AT

Family and domain databases

InterProiView protein in InterPro
IPR025064, DUF4005
IPR000048, IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF13178, DUF4005, 1 hit
PF00612, IQ, 2 hits
SMARTiView protein in SMART
SM00015, IQ, 2 hits
PROSITEiView protein in PROSITE
PS50096, IQ, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIQD31_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8L4D8
Secondary accession number(s): Q9CA49, Q9SSF5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: May 25, 2022
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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