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UniProtKB - Q8KT65 (Q8KT65_PHOLU)

Entry version 28 (11 Dec 2019)
Sequence version 1 (01 Oct 2002)
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Protein
Submitted name:

Toxin protein

Gene

mcf

Organism
Photorhabdus luminescens (Xenorhabdus luminescens)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Toxin proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mcfImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPhotorhabdus luminescens (Xenorhabdus luminescens)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri29488 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Morganellaceae › Photorhabdus

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8KT65

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1617 – 2276TcdA_TcdB_poreInterPro annotationAdd BLAST660

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili145 – 165Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024769 TcdA/TcdB_pore_forming

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12920 TcdA_TcdB_pore, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8KT65-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASISKDFTN LLNTLIDGQI GAASRQTEWF NMSPDERTDY IKQVDERLQE 
        60         70         80         90        100
MQQSTLSVLA AQHFQMQDNP VSVGDQLQTL QKRRQQMTDV PGTPAINAYK 
       110        120        130        140        150
QQLDRDILLY RRQQTAMTHF DSTWRKVLVM LGPDDSKPLN ATTLRENAVD 
       160        170        180        190        200
KQAKLDTEIK RLEQQLTIQV ADSTFSQKYV TLFSELQAYK DVNARYNALL 
       210        220        230        240        250
KASATEEAAA LGALTKVPQA SDDLPVNISL LMMEERPGYI RMNVALVNAS 
       260        270        280        290        300
TDGRFKDFFL ENGRLVVLTD GVLNFSFGTA ARSLAWQQQY RLKSEPPSFR 
       310        320        330        340        350
SPTYTPIRSV LVKTEFVEKY FANYLVSEST LRGGFKAQLL GNGRKMLLTS 
       360        370        380        390        400
VDRKVPNQIG IQVSGQAPNT TITREVPLAS ALSDLINQNA DIASFRTIGL 
       410        420        430        440        450
EGFRQSSYHP DRDGLFVNIH ELERSVGFAG RQYLLEMPQD NDYLSATPFG 
       460        470        480        490        500
VMSVDGDKVS SSHLSKAQTD TLYQYNAAFF EKLEQLRSGG MKASRLFEGS 
       510        520        530        540        550
IERTAFVQQL VRLLERNHIT PAGVLAPEYP RDNMRDIKGN NLNKVLWEQA 
       560        570        580        590        600
FAASVWRSRD NDPLLFRLAT RLVKNPAVVK VLQNGYVQSD IAQARELLAP 
       610        620        630        640        650
LYEQWRTRAV EAETQRVASA NAAQHPSNPK VHVFDQAEVE RSLDDKLLIL 
       660        670        680        690        700
LLTGPQSLEG TDVQLRPMVE AALLSNEGRS LRKQILFHAL RPVADSFSKA 
       710        720        730        740        750
AAPVNPHAEL GVGKIMINNR LNQPDPYLIL NTSSEEQAYR DGSYLIKDDK 
       760        770        780        790        800
YRSYNQFRPD FKNDATRYMN DLDTPFVGGI SGTTQTVSNV LTELFGGALS 
       810        820        830        840        850
VKQYWQFQMA NAAFMIRNGY HSFFETFYVA ARYEPEGADS IGKEMLQMFD 
       860        870        880        890        900
KYRVEGSKKA LQGKLYDGVM ARVLPIINQG LSAADEFHPP RFTRIGPRPA 
       910        920        930        940        950
LLGQAVKDLE LKAGLTSVGD GFEPRQGSAD IHQFVTDPVL FAKTHTVSAE 
       960        970        980        990       1000
ALVRSGRLPA EGSAQLVKVG SGLYELEYTE QSANDISSSS IPAYFLGYNG 
      1010       1020       1030       1040       1050
PNQANAVPAY VDIPKRTIAG NFLFTGTLSG GSLVVTSLDA NTFRVYHDGR 
      1060       1070       1080       1090       1100
VNSSLLYDNV VMAVDYKDYQ IAGTAEGLAA AYMQYVNHEW QLVLQRQEYQ 
      1110       1120       1130       1140       1150
RDGQMLRLRL RDDEEPLSIQ VADSQVVERN QAQFVAYREQ IHQQLKKVAT 
      1160       1170       1180       1190       1200
QFEVSISGVS DGVYTEGEFS PDHPAIAAWA KLCAEVYDRI NADTKQLVDK 
      1210       1220       1230       1240       1250
RNKLYENRRN TIRRDLINQQ IKQLNITLEY YKAQYDTVLR EAGFVEQSWL 
      1260       1270       1280       1290       1300
WQQIKAKNGS AAVVRIDDTA IQGGGKQRTD SVGERYAISE AYQRGARGTG 
      1310       1320       1330       1340       1350
FSDGLRNFRE IEIPGVDDKM SALEMKRLFL EGKLTSEQQG ALSGRITETS 
      1360       1370       1380       1390       1400
RAEYIDKVLR QTAVFSEDFH DAGSVFDRLV PQDFYLSLVG DRSGGRCYPL 
      1410       1420       1430       1440       1450
VRAMTVALAS GGEAGINSLV QKLFFASADP QAGSSTLLRN SLIKLHSNVE 
      1460       1470       1480       1490       1500
AVQASTELGQ FGLSEVVSRL AATTGTSMFA LNTQNHSMMV GSTVTTEGRR 
      1510       1520       1530       1540       1550
YYFYDPNVGI FAFDNTKSLS RAMEQHLVGR RLAVHYGSFG SKSAPAFNLI 
      1560       1570       1580       1590       1600
EIDTGKMAEV PVGNGLNVAD LTRFEELSSV IGQRRQVEQV MSAQERITED 
      1610       1620       1630       1640       1650
LQLSTALQAF DAEQWGARFE AASTRLAQEH QLDSRWLPII ATTEEQGEGR 
      1660       1670       1680       1690       1700
YRVQFINRDQ PEQTRWLDTD DSTFVEFRRF VDEHMSVLNE HFTLESGRMR 
      1710       1720       1730       1740       1750
PRGGVGEAAP VDGLNAGFAV QALIQWFSDK NRHDAANGMA SPDLATALKV 
      1760       1770       1780       1790       1800
HSYLNFVQMV HGGVQDVIKV TALVRTALRG EVVAAQTSFK EFALSLGHTV 
      1810       1820       1830       1840       1850
NEGVGVLFGG AMIGLDAYEL AHAENDVQKA VFGTQLAFDS ASFVTGAAGI 
      1860       1870       1880       1890       1900
GAGLVGASTA GAVLGGAGVI LGGLAVGFTA LAQAFGAVAE DAKAVGRYFD 
      1910       1920       1930       1940       1950
TVDKAYKGNG YRYDNEKQVL VPLAGAVIKT LDLSKNQIDF DSQYIYRTHS 
      1960       1970       1980       1990       2000
GSTGSGKINY FFWVGDFPRM VHDRGQAIEV RSGIGYKDVS RPLEHGDSNV 
      2010       2020       2030       2040       2050
VILPGTPKSY ISYEYMLLPG ATTRHDAGFD VIRRLEEDKR FDYDFYIFPG 
      2060       2070       2080       2090       2100
EETIRRIHHE YVDTPIEVVL DQRNRQLVAP ELPKELHGFL CYEIKGAGGE 
      2110       2120       2130       2140       2150
YLIGLNEGAK VNLTSDVAST WIIDSSQLAS DSISVSKDQL LVGEKGKEVV 
      2160       2170       2180       2190       2200
VKLYLAQNSQ VLVVNGKGEV RKVDFTSLTA QVISEDASKW QVPGQQIEQH 
      2210       2220       2230       2240       2250
LSDLAKAHQL HGQYVVVENY RHQGRDVGRA FYDVTKDRML FTDTTNEQAK 
      2260       2270       2280       2290       2300
RAQLGAVMGD YAYFYDADNA VAWRVDIATG QVDAQFEPWF NQNAGHISRF 
      2310       2320       2330       2340       2350
WQEGDVVYLA RRYRLKEREA ELGYRIIGDR MELVSAVGDD ALLQLSARIG 
      2360       2370       2380       2390       2400
RHGDELEAIL QGYRSNSTQR GTLMYTLGAR LIQPTSAALV TVFGVDAAGV 
      2410       2420       2430       2440       2450
PHRYWIRTSD GTLIKPNLAP PADQTLHFEA HEQTRSAWQI PADLVLAGSM 
      2460       2470       2480       2490       2500
PLLGGKEVFF FYSKEQKTLF RQEGPGQEVL DANQPSALRV TTPALTNVIN 
      2510       2520       2530       2540       2550
LNGHLVVVTE DGRVARLDAL GQLSYAAVNE HWLKGRIHWW QDLTSVTDGR 
      2560       2570       2580       2590       2600
ATLAVFGVKD TDGKSLLPVW YHNGQVVVAS AALQDKHPQF LGFEVDGSSA 
      2610       2620       2630       2640       2650
RLFEPASGKL YRQPAMTADA LAAAFGTDEV LEASAQLPAA NELEPELHLK 
      2660       2670       2680       2690       2700
AAEQVDAGLR LTTVKGEILL RTHDGKLQLV AVDKDWQQDN LVRLSQALAE 
      2710       2720       2730       2740       2750
VAGQWRVKGV LTLQGDDTQG WFDVGSGQVF SIGGIPATDN LRFIGIAVGK 
      2760       2770       2780       2790       2800
KGAYVYNPTD QMLYQVKESG AQKLNHYADV ERIGSSLLLQ DGGKGDLSPM 
      2810       2820       2830       2840       2850
LIAGVDSVVL HGGAGSDTYR LSQTMWSYYR TVVIDNDDPN QVLDRLIILA 
      2860       2870       2880       2890       2900
VDAEKIFVSR HEDDLMLTDS VNGTVLVIRK VFGSQAVTHR HLQIDLEGSS 
      2910       2920 
SVISVDHLVK GFTRLGTANI GLFELPWAI
Length:2,929
Mass (Da):324,310
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FC5246CE6E00D79
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF503504 Genomic DNA Translation: AAM88787.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503504 Genomic DNA Translation: AAM88787.1

3D structure databases

SMRiQ8KT65
ModBaseiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR024769 TcdA/TcdB_pore_forming
PfamiView protein in Pfam
PF12920 TcdA_TcdB_pore, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8KT65_PHOLU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8KT65
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: December 11, 2019
This is version 28 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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