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Protein
Submitted name:

Toxin protein

Gene

mcf

Organism
Photorhabdus luminescens (Xenorhabdus luminescens)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Toxin proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mcfImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPhotorhabdus luminescens (Xenorhabdus luminescens)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri29488 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaePhotorhabdus

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1617 – 2276TcdA_TcdB_poreInterPro annotationAdd BLAST660

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili145 – 165Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024769 TcdA/TcdB_pore_forming

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12920 TcdA_TcdB_pore, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8KT65-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASISKDFTN LLNTLIDGQI GAASRQTEWF NMSPDERTDY IKQVDERLQE
60 70 80 90 100
MQQSTLSVLA AQHFQMQDNP VSVGDQLQTL QKRRQQMTDV PGTPAINAYK
110 120 130 140 150
QQLDRDILLY RRQQTAMTHF DSTWRKVLVM LGPDDSKPLN ATTLRENAVD
160 170 180 190 200
KQAKLDTEIK RLEQQLTIQV ADSTFSQKYV TLFSELQAYK DVNARYNALL
210 220 230 240 250
KASATEEAAA LGALTKVPQA SDDLPVNISL LMMEERPGYI RMNVALVNAS
260 270 280 290 300
TDGRFKDFFL ENGRLVVLTD GVLNFSFGTA ARSLAWQQQY RLKSEPPSFR
310 320 330 340 350
SPTYTPIRSV LVKTEFVEKY FANYLVSEST LRGGFKAQLL GNGRKMLLTS
360 370 380 390 400
VDRKVPNQIG IQVSGQAPNT TITREVPLAS ALSDLINQNA DIASFRTIGL
410 420 430 440 450
EGFRQSSYHP DRDGLFVNIH ELERSVGFAG RQYLLEMPQD NDYLSATPFG
460 470 480 490 500
VMSVDGDKVS SSHLSKAQTD TLYQYNAAFF EKLEQLRSGG MKASRLFEGS
510 520 530 540 550
IERTAFVQQL VRLLERNHIT PAGVLAPEYP RDNMRDIKGN NLNKVLWEQA
560 570 580 590 600
FAASVWRSRD NDPLLFRLAT RLVKNPAVVK VLQNGYVQSD IAQARELLAP
610 620 630 640 650
LYEQWRTRAV EAETQRVASA NAAQHPSNPK VHVFDQAEVE RSLDDKLLIL
660 670 680 690 700
LLTGPQSLEG TDVQLRPMVE AALLSNEGRS LRKQILFHAL RPVADSFSKA
710 720 730 740 750
AAPVNPHAEL GVGKIMINNR LNQPDPYLIL NTSSEEQAYR DGSYLIKDDK
760 770 780 790 800
YRSYNQFRPD FKNDATRYMN DLDTPFVGGI SGTTQTVSNV LTELFGGALS
810 820 830 840 850
VKQYWQFQMA NAAFMIRNGY HSFFETFYVA ARYEPEGADS IGKEMLQMFD
860 870 880 890 900
KYRVEGSKKA LQGKLYDGVM ARVLPIINQG LSAADEFHPP RFTRIGPRPA
910 920 930 940 950
LLGQAVKDLE LKAGLTSVGD GFEPRQGSAD IHQFVTDPVL FAKTHTVSAE
960 970 980 990 1000
ALVRSGRLPA EGSAQLVKVG SGLYELEYTE QSANDISSSS IPAYFLGYNG
1010 1020 1030 1040 1050
PNQANAVPAY VDIPKRTIAG NFLFTGTLSG GSLVVTSLDA NTFRVYHDGR
1060 1070 1080 1090 1100
VNSSLLYDNV VMAVDYKDYQ IAGTAEGLAA AYMQYVNHEW QLVLQRQEYQ
1110 1120 1130 1140 1150
RDGQMLRLRL RDDEEPLSIQ VADSQVVERN QAQFVAYREQ IHQQLKKVAT
1160 1170 1180 1190 1200
QFEVSISGVS DGVYTEGEFS PDHPAIAAWA KLCAEVYDRI NADTKQLVDK
1210 1220 1230 1240 1250
RNKLYENRRN TIRRDLINQQ IKQLNITLEY YKAQYDTVLR EAGFVEQSWL
1260 1270 1280 1290 1300
WQQIKAKNGS AAVVRIDDTA IQGGGKQRTD SVGERYAISE AYQRGARGTG
1310 1320 1330 1340 1350
FSDGLRNFRE IEIPGVDDKM SALEMKRLFL EGKLTSEQQG ALSGRITETS
1360 1370 1380 1390 1400
RAEYIDKVLR QTAVFSEDFH DAGSVFDRLV PQDFYLSLVG DRSGGRCYPL
1410 1420 1430 1440 1450
VRAMTVALAS GGEAGINSLV QKLFFASADP QAGSSTLLRN SLIKLHSNVE
1460 1470 1480 1490 1500
AVQASTELGQ FGLSEVVSRL AATTGTSMFA LNTQNHSMMV GSTVTTEGRR
1510 1520 1530 1540 1550
YYFYDPNVGI FAFDNTKSLS RAMEQHLVGR RLAVHYGSFG SKSAPAFNLI
1560 1570 1580 1590 1600
EIDTGKMAEV PVGNGLNVAD LTRFEELSSV IGQRRQVEQV MSAQERITED
1610 1620 1630 1640 1650
LQLSTALQAF DAEQWGARFE AASTRLAQEH QLDSRWLPII ATTEEQGEGR
1660 1670 1680 1690 1700
YRVQFINRDQ PEQTRWLDTD DSTFVEFRRF VDEHMSVLNE HFTLESGRMR
1710 1720 1730 1740 1750
PRGGVGEAAP VDGLNAGFAV QALIQWFSDK NRHDAANGMA SPDLATALKV
1760 1770 1780 1790 1800
HSYLNFVQMV HGGVQDVIKV TALVRTALRG EVVAAQTSFK EFALSLGHTV
1810 1820 1830 1840 1850
NEGVGVLFGG AMIGLDAYEL AHAENDVQKA VFGTQLAFDS ASFVTGAAGI
1860 1870 1880 1890 1900
GAGLVGASTA GAVLGGAGVI LGGLAVGFTA LAQAFGAVAE DAKAVGRYFD
1910 1920 1930 1940 1950
TVDKAYKGNG YRYDNEKQVL VPLAGAVIKT LDLSKNQIDF DSQYIYRTHS
1960 1970 1980 1990 2000
GSTGSGKINY FFWVGDFPRM VHDRGQAIEV RSGIGYKDVS RPLEHGDSNV
2010 2020 2030 2040 2050
VILPGTPKSY ISYEYMLLPG ATTRHDAGFD VIRRLEEDKR FDYDFYIFPG
2060 2070 2080 2090 2100
EETIRRIHHE YVDTPIEVVL DQRNRQLVAP ELPKELHGFL CYEIKGAGGE
2110 2120 2130 2140 2150
YLIGLNEGAK VNLTSDVAST WIIDSSQLAS DSISVSKDQL LVGEKGKEVV
2160 2170 2180 2190 2200
VKLYLAQNSQ VLVVNGKGEV RKVDFTSLTA QVISEDASKW QVPGQQIEQH
2210 2220 2230 2240 2250
LSDLAKAHQL HGQYVVVENY RHQGRDVGRA FYDVTKDRML FTDTTNEQAK
2260 2270 2280 2290 2300
RAQLGAVMGD YAYFYDADNA VAWRVDIATG QVDAQFEPWF NQNAGHISRF
2310 2320 2330 2340 2350
WQEGDVVYLA RRYRLKEREA ELGYRIIGDR MELVSAVGDD ALLQLSARIG
2360 2370 2380 2390 2400
RHGDELEAIL QGYRSNSTQR GTLMYTLGAR LIQPTSAALV TVFGVDAAGV
2410 2420 2430 2440 2450
PHRYWIRTSD GTLIKPNLAP PADQTLHFEA HEQTRSAWQI PADLVLAGSM
2460 2470 2480 2490 2500
PLLGGKEVFF FYSKEQKTLF RQEGPGQEVL DANQPSALRV TTPALTNVIN
2510 2520 2530 2540 2550
LNGHLVVVTE DGRVARLDAL GQLSYAAVNE HWLKGRIHWW QDLTSVTDGR
2560 2570 2580 2590 2600
ATLAVFGVKD TDGKSLLPVW YHNGQVVVAS AALQDKHPQF LGFEVDGSSA
2610 2620 2630 2640 2650
RLFEPASGKL YRQPAMTADA LAAAFGTDEV LEASAQLPAA NELEPELHLK
2660 2670 2680 2690 2700
AAEQVDAGLR LTTVKGEILL RTHDGKLQLV AVDKDWQQDN LVRLSQALAE
2710 2720 2730 2740 2750
VAGQWRVKGV LTLQGDDTQG WFDVGSGQVF SIGGIPATDN LRFIGIAVGK
2760 2770 2780 2790 2800
KGAYVYNPTD QMLYQVKESG AQKLNHYADV ERIGSSLLLQ DGGKGDLSPM
2810 2820 2830 2840 2850
LIAGVDSVVL HGGAGSDTYR LSQTMWSYYR TVVIDNDDPN QVLDRLIILA
2860 2870 2880 2890 2900
VDAEKIFVSR HEDDLMLTDS VNGTVLVIRK VFGSQAVTHR HLQIDLEGSS
2910 2920
SVISVDHLVK GFTRLGTANI GLFELPWAI
Length:2,929
Mass (Da):324,310
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FC5246CE6E00D79
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF503504 Genomic DNA Translation: AAM88787.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503504 Genomic DNA Translation: AAM88787.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR024769 TcdA/TcdB_pore_forming
PfamiView protein in Pfam
PF12920 TcdA_TcdB_pore, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8KT65_PHOLU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8KT65
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: December 20, 2017
This is version 26 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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