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Protein

GTPase Der

Gene

der

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / JCM 1002 / NBRC 13953 / NCIMB 11778)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GTPase that plays an essential role in the late steps of ribosome biogenesis.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTP 1UniRule annotation8
Nucleotide bindingi57 – 61GTP 1UniRule annotation5
Nucleotide bindingi119 – 122GTP 1UniRule annotation4
Nucleotide bindingi181 – 188GTP 2UniRule annotation8
Nucleotide bindingi228 – 232GTP 2UniRule annotation5
Nucleotide bindingi293 – 296GTP 2UniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase DerUniRule annotation
Alternative name(s):
GTP-binding protein EngAUniRule annotation
Gene namesi
Name:derUniRule annotation
Synonyms:engA
Ordered Locus Names:Ldb0852
OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / JCM 1002 / NBRC 13953 / NCIMB 11778)
Taxonomic identifieri390333 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001259 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001790021 – 435GTPase DerAdd BLAST435

Interactioni

Subunit structurei

Associates with the 50S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi390333.Ldb0852

Structurei

3D structure databases

ProteinModelPortaliQ8KH12
SMRiQ8KH12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 167EngA-type G 1Add BLAST164
Domaini175 – 350EngA-type G 2Add BLAST176
Domaini351 – 435KH-likeUniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DKZ Bacteria
COG1160 LUCA
HOGENOMiHOG000242861
KOiK03977
OMAiFCNLPQY

Family and domain databases

Gene3Di3.30.300.20, 1 hit
HAMAPiMF_00195 GTPase_Der, 1 hit
InterProiView protein in InterPro
IPR031166 G_ENGA
IPR016484 GTP-bd_EngA
IPR006073 GTP_binding_domain
IPR032859 KH_dom-like
IPR015946 KH_dom-like_a/b
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
PfamiView protein in Pfam
PF14714 KH_dom-like, 1 hit
PF01926 MMR_HSR1, 2 hits
PIRSFiPIRSF006485 GTP-binding_EngA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR03594 GTPase_EngA, 1 hit
TIGR00231 small_GTP, 2 hits
PROSITEiView protein in PROSITE
PS51712 G_ENGA, 2 hits

Sequencei

Sequence statusi: Complete.

Q8KH12-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLPIVAIVG QPNVGKSTLF NRIINERVAI VEDRPGVTRD RNYARASWMG
60 70 80 90 100
HQFSIIDTGG ITWEDSTIDE EIRAQAEIAI EEADVIVMLA DASQGVTSLD
110 120 130 140 150
ERIAHLLYRA DKPVLLAVNK ADNPEQRTDI YDFYSLGLGD PIPVSGSHGT
160 170 180 190 200
GIGDLLDEVV KNFSPDAEKT EEGVISFSVI GRPNVGKSSI VNRLLGEERV
210 220 230 240 250
IVANEEGTTR DAIDTPFVKD GTKFRVVDTA GIRRRGKVYE KTEKYSVMRA
260 270 280 290 300
MSAMERSDVA ILVLDASTGI REQDKHVAGY AHEAGLGMII AVNKWDLPKK
310 320 330 340 350
DSSSGKDFEA VIREEFSYLD YAPIVFVSAK TGKNIDQLPK MVKEVYENKN
360 370 380 390 400
QRIQSSVLND LLLEASRLVP APMVKGKRLR VYYMTQVKTN PPTFVVFCND
410 420 430
PELMHFSYQR FLINQLRENF DFTGTPIKIL PRKRK
Length:435
Mass (Da):48,624
Last modified:October 1, 2002 - v1
Checksum:i0D3C7982C92B244F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY094626 Genomic DNA Translation: AAM22484.1
CR954253 Genomic DNA Translation: CAI97674.1
RefSeqiWP_003624291.1, NZ_JQAV01000008.1

Genome annotation databases

EnsemblBacteriaiCAI97674; CAI97674; Ldb0852
GeneIDi4084811
KEGGildb:Ldb0852
PATRICifig|390333.13.peg.1889

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY094626 Genomic DNA Translation: AAM22484.1
CR954253 Genomic DNA Translation: CAI97674.1
RefSeqiWP_003624291.1, NZ_JQAV01000008.1

3D structure databases

ProteinModelPortaliQ8KH12
SMRiQ8KH12
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi390333.Ldb0852

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI97674; CAI97674; Ldb0852
GeneIDi4084811
KEGGildb:Ldb0852
PATRICifig|390333.13.peg.1889

Phylogenomic databases

eggNOGiENOG4105DKZ Bacteria
COG1160 LUCA
HOGENOMiHOG000242861
KOiK03977
OMAiFCNLPQY

Family and domain databases

Gene3Di3.30.300.20, 1 hit
HAMAPiMF_00195 GTPase_Der, 1 hit
InterProiView protein in InterPro
IPR031166 G_ENGA
IPR016484 GTP-bd_EngA
IPR006073 GTP_binding_domain
IPR032859 KH_dom-like
IPR015946 KH_dom-like_a/b
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
PfamiView protein in Pfam
PF14714 KH_dom-like, 1 hit
PF01926 MMR_HSR1, 2 hits
PIRSFiPIRSF006485 GTP-binding_EngA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR03594 GTPase_EngA, 1 hit
TIGR00231 small_GTP, 2 hits
PROSITEiView protein in PROSITE
PS51712 G_ENGA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDER_LACDA
AccessioniPrimary (citable) accession number: Q8KH12
Secondary accession number(s): Q1GAJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 1, 2002
Last modified: October 10, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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