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Protein

Homeobox protein Hox-C12

Gene

Hoxc12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi212 – 271HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C12
Alternative name(s):
Homeobox protein Hox-3.8
Gene namesi
Name:Hoxc12
Synonyms:Hox-3.8, Hoxc-12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96194 Hoxc12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002488401 – 280Homeobox protein Hox-C12Add BLAST280

Proteomic databases

MaxQBiQ8K5B8
PaxDbiQ8K5B8
PRIDEiQ8K5B8

PTM databases

iPTMnetiQ8K5B8
PhosphoSitePlusiQ8K5B8

Expressioni

Gene expression databases

BgeeiENSMUSG00000050328 Expressed in 16 organ(s), highest expression level in pelvic girdle bone/zone
CleanExiMM_HOXC12

Interactioni

Protein-protein interaction databases

BioGridi200384, 8 interactors
STRINGi10090.ENSMUSP00000051003

Structurei

3D structure databases

ProteinModelPortaliQ8K5B8
SMRiQ8K5B8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231177
HOVERGENiHBG052050
InParanoidiQ8K5B8
KOiK09297
OMAiEPCNGYS
OrthoDBiEOG091G0HNN
PhylomeDBiQ8K5B8
TreeFamiTF351604

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K5B8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV
60 70 80 90 100
CSLPWPSAEP CNGYPQPYLG SPVSLNPPFG RTCELARVED SKGYYREPCA
110 120 130 140 150
EGGGGGLKRE ERGREPGAGP GAALLQLEPS GPPALGFKYD YTASGGGGDG
160 170 180 190 200
STGPPHDPPS CQSLESDSSS SLLNEGNKSA SAGDPGSLVS PLNPGGGLSA
210 220 230 240 250
SGAPWYPIHS RSRKKRKPYS KLQLAELEGE FLVNEFITRQ RRRELSDRLN
260 270 280
LSDQQVKIWF QNRRMKKKRL LLREQALSFF
Length:280
Mass (Da):30,345
Last modified:October 1, 2002 - v1
Checksum:iF42405EFC51AE60B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448482 mRNA Translation: AAM28679.1
BC120845 mRNA Translation: AAI20846.1
BC120847 mRNA Translation: AAI20848.1
CCDSiCCDS27891.1
RefSeqiNP_034593.1, NM_010463.1
UniGeneiMm.221179

Genome annotation databases

EnsembliENSMUST00000055562; ENSMUSP00000051003; ENSMUSG00000050328
GeneIDi15421
KEGGimmu:15421
UCSCiuc007xww.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448482 mRNA Translation: AAM28679.1
BC120845 mRNA Translation: AAI20846.1
BC120847 mRNA Translation: AAI20848.1
CCDSiCCDS27891.1
RefSeqiNP_034593.1, NM_010463.1
UniGeneiMm.221179

3D structure databases

ProteinModelPortaliQ8K5B8
SMRiQ8K5B8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200384, 8 interactors
STRINGi10090.ENSMUSP00000051003

PTM databases

iPTMnetiQ8K5B8
PhosphoSitePlusiQ8K5B8

Proteomic databases

MaxQBiQ8K5B8
PaxDbiQ8K5B8
PRIDEiQ8K5B8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055562; ENSMUSP00000051003; ENSMUSG00000050328
GeneIDi15421
KEGGimmu:15421
UCSCiuc007xww.1 mouse

Organism-specific databases

CTDi3228
MGIiMGI:96194 Hoxc12

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231177
HOVERGENiHBG052050
InParanoidiQ8K5B8
KOiK09297
OMAiEPCNGYS
OrthoDBiEOG091G0HNN
PhylomeDBiQ8K5B8
TreeFamiTF351604

Miscellaneous databases

PROiPR:Q8K5B8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050328 Expressed in 16 organ(s), highest expression level in pelvic girdle bone/zone
CleanExiMM_HOXC12

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXC12_MOUSE
AccessioniPrimary (citable) accession number: Q8K5B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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