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Protein

Multiple coagulation factor deficiency protein 2 homolog

Gene

Mcfd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi80 – 911PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi128 – 1392PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-5694530 Cargo concentration in the ER
R-MMU-948021 Transport to the Golgi and subsequent modification

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple coagulation factor deficiency protein 2 homolog
Alternative name(s):
Neural stem cell-derived neuronal survival protein
Gene namesi
Name:Mcfd2
Synonyms:Sdnsf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2183439 Mcfd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000416027 – 145Multiple coagulation factor deficiency protein 2 homologAdd BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K5B2
MaxQBiQ8K5B2
PaxDbiQ8K5B2
PeptideAtlasiQ8K5B2
PRIDEiQ8K5B2

PTM databases

iPTMnetiQ8K5B2
PhosphoSitePlusiQ8K5B2

Expressioni

Gene expression databases

BgeeiENSMUSG00000024150 Expressed in 293 organ(s), highest expression level in pancreas
CleanExiMM_MCFD2
ExpressionAtlasiQ8K5B2 baseline and differential
GenevisibleiQ8K5B2 MM

Interactioni

Subunit structurei

Interacts in a calcium-dependent manner with LMAN1.By similarity

Protein-protein interaction databases

IntActiQ8K5B2, 4 interactors
MINTiQ8K5B2
STRINGi10090.ENSMUSP00000024963

Structurei

3D structure databases

ProteinModelPortaliQ8K5B2
SMRiQ8K5B2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 102EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini115 – 145EF-hand 2PROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4065 Eukaryota
ENOG41124J6 LUCA
GeneTreeiENSGT00390000003130
HOGENOMiHOG000113497
HOVERGENiHBG060762
InParanoidiQ8K5B2
KOiK20364
OMAiISHVHKE
OrthoDBiEOG091G0ZJA
PhylomeDBiQ8K5B2
TreeFamiTF315801

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8K5B2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLQLLRAP LLCVLLWVFC APGARAHDHG ADVHHGSVGL DKSTVHDQEH
60 70 80 90 100
IMEHLEGVID QPEAEMSPQE LQLHYFKMHD YDGNSLLDGL ELSIAITHVH
110 120 130 140
KEEGSEQAPV MSEDELVSII DGVLRDDDKN NDGYIDYAEF AKSLQ
Length:145
Mass (Da):16,168
Last modified:October 1, 2002 - v1
Checksum:iEB654BA9B76E0269
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z1G3D3Z1G3_MOUSE
Multiple coagulation factor deficie...
Mcfd2
131Annotation score:
D3Z6A4D3Z6A4_MOUSE
Multiple coagulation factor deficie...
Mcfd2
120Annotation score:
D3YVL4D3YVL4_MOUSE
Multiple coagulation factor deficie...
Mcfd2
74Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF475283 mRNA Translation: AAM28464.1
AK033139 mRNA Translation: BAC28169.1
AK075781 mRNA Translation: BAC35955.1
AK077139 mRNA Translation: BAC36638.1
AK077631 mRNA Translation: BAC36914.1
AK141599 mRNA Translation: BAE24757.1
AK151803 mRNA Translation: BAE30702.1
CCDSiCCDS29015.1
RefSeqiNP_647456.1, NM_139295.3
NP_789778.1, NM_176808.5
XP_006523964.1, XM_006523901.3
UniGeneiMm.30251

Genome annotation databases

EnsembliENSMUST00000024963; ENSMUSP00000024963; ENSMUSG00000024150
ENSMUST00000129616; ENSMUSP00000123352; ENSMUSG00000024150
ENSMUST00000144236; ENSMUSP00000121820; ENSMUSG00000024150
GeneIDi193813
KEGGimmu:193813
UCSCiuc008dur.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF475283 mRNA Translation: AAM28464.1
AK033139 mRNA Translation: BAC28169.1
AK075781 mRNA Translation: BAC35955.1
AK077139 mRNA Translation: BAC36638.1
AK077631 mRNA Translation: BAC36914.1
AK141599 mRNA Translation: BAE24757.1
AK151803 mRNA Translation: BAE30702.1
CCDSiCCDS29015.1
RefSeqiNP_647456.1, NM_139295.3
NP_789778.1, NM_176808.5
XP_006523964.1, XM_006523901.3
UniGeneiMm.30251

3D structure databases

ProteinModelPortaliQ8K5B2
SMRiQ8K5B2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K5B2, 4 interactors
MINTiQ8K5B2
STRINGi10090.ENSMUSP00000024963

PTM databases

iPTMnetiQ8K5B2
PhosphoSitePlusiQ8K5B2

Proteomic databases

EPDiQ8K5B2
MaxQBiQ8K5B2
PaxDbiQ8K5B2
PeptideAtlasiQ8K5B2
PRIDEiQ8K5B2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024963; ENSMUSP00000024963; ENSMUSG00000024150
ENSMUST00000129616; ENSMUSP00000123352; ENSMUSG00000024150
ENSMUST00000144236; ENSMUSP00000121820; ENSMUSG00000024150
GeneIDi193813
KEGGimmu:193813
UCSCiuc008dur.2 mouse

Organism-specific databases

CTDi90411
MGIiMGI:2183439 Mcfd2

Phylogenomic databases

eggNOGiKOG4065 Eukaryota
ENOG41124J6 LUCA
GeneTreeiENSGT00390000003130
HOGENOMiHOG000113497
HOVERGENiHBG060762
InParanoidiQ8K5B2
KOiK20364
OMAiISHVHKE
OrthoDBiEOG091G0ZJA
PhylomeDBiQ8K5B2
TreeFamiTF315801

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-5694530 Cargo concentration in the ER
R-MMU-948021 Transport to the Golgi and subsequent modification

Miscellaneous databases

ChiTaRSiMcfd2 mouse
PROiPR:Q8K5B2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024150 Expressed in 293 organ(s), highest expression level in pancreas
CleanExiMM_MCFD2
ExpressionAtlasiQ8K5B2 baseline and differential
GenevisibleiQ8K5B2 MM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMCFD2_MOUSE
AccessioniPrimary (citable) accession number: Q8K5B2
Secondary accession number(s): Q3U9G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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