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Protein

Interleukin-31 receptor subunit alpha

Gene

Il31ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (PubMed:24373353). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (PubMed:17379091).3 Publications

GO - Molecular functioni

  • cytokine binding Source: MGI
  • cytokine receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity

Enzyme and pathway databases

ReactomeiR-MMU-6788467 IL-6-type cytokine receptor ligand interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-31 receptor subunit alpha
Short name:
IL-31 receptor subunit alpha
Short name:
IL-31R subunit alpha
Short name:
IL-31R-alpha
Short name:
IL-31RA
Alternative name(s):
GLM-R
Short name:
mGLM-R
Gp130-like monocyte receptor
Short name:
Gp130-like receptor
Novel cytokine receptor 10
Short name:
NR10
ZcytoR17
Gene namesi
Name:Il31ra
Synonyms:Glmr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2180511 Il31ra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 499ExtracellularSequence analysisAdd BLAST481
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Topological domaini521 – 716CytoplasmicSequence analysisAdd BLAST196

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Mice do not develop dermatitis upon Il31 overexpression (PubMed:15184896). Decreased levels of immature myeloid progenitor cells in bone marrow and spleen but normal numbers of circulating blood cells (PubMed:17379091).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000027457319 – 716Interleukin-31 receptor subunit alphaAdd BLAST698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K5B1
PRIDEiQ8K5B1

PTM databases

iPTMnetiQ8K5B1
PhosphoSitePlusiQ8K5B1

Expressioni

Tissue specificityi

Expressed in a subset of dorsal root ganglia neurons (PubMed:16926070, PubMed:24373353, PubMed:25381841). Expressed in spinal cord and trigeminal ganglion (at protein level) (PubMed:25381841). Expressed in skin, testis, bone marrow and thymus (PubMed:15184896).4 Publications

Developmental stagei

Primarily expressed at postnatal day 10 in the dorsal root ganglia where expression gradually increases as the development proceed.1 Publication

Inductioni

Up-regulated in the diseased tissues of a mouse models of allergic asthma and airway hypersensitivity (PubMed:15184896, PubMed:25847241). Up-regulated by IL31 in dorsal root ganglia (PubMed:25381841). Up-regulated by Th2 cytokines IL4 and IL13 in macrophages (PubMed:25847241).3 Publications

Gene expression databases

BgeeiENSMUSG00000050377 Expressed in 33 organ(s), highest expression level in skin epidermis
CleanExiMM_IL31RA
ExpressionAtlasiQ8K5B1 baseline and differential
GenevisibleiQ8K5B1 MM

Interactioni

Subunit structurei

Heterodimer with OSMR. Interacts with JAK1 and STAT3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058045

Structurei

3D structure databases

ProteinModelPortaliQ8K5B1
SMRiQ8K5B1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 115Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST93
Domaini117 – 211Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini213 – 304Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST92
Domaini305 – 403Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST99
Domaini408 – 502Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST95

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJG6 Eukaryota
ENOG410YAI2 LUCA
GeneTreeiENSGT00550000074436
HOVERGENiHBG081788
InParanoidiQ8K5B1
KOiK22630
OMAiCTWSPEK
OrthoDBiEOG091G01XM
TreeFamiTF338122

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SUPFAMiSSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K5B1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWTLALWAFS FLCKFSLAVL PTKPENISCV FYFDRNLTCT WRPEKETNDT
60 70 80 90 100
SYIVTLTYSY GKSNYSDNAT EASYSFPRSC AMPPDICSVE VQAQNGDGKV
110 120 130 140 150
KSDITYWHLI SIAKTEPPII LSVNPICNRM FQIQWKPREK TRGFPLVCML
160 170 180 190 200
RFRTVNSSHW TEVNFENCKQ VCNLTGLQAF TEYVLALRFR FNDSRYWSKW
210 220 230 240 250
SKEETRVTME EVPHVLDLWR ILEPADMNGD RKVRLLWKKA RGAPVLEKTF
260 270 280 290 300
GYHIQYFAEN STNLTEINNI TTQQYELLLM SQAHSVSVTS FNSLGKSQEA
310 320 330 340 350
ILRIPDVHEK TFQYIKSMKA YIAEPLLVVN WQSSIPAVDT WIVEWLPEAA
360 370 380 390 400
MSKFPALSWE SVSQVTNWTI EQDKLKPFTC YNISVYPVLG HRVGEPYSIQ
410 420 430 440 450
AYAKEGTPLK GPETRVENIG LRTATITWKE IPKSARNGFI NNYTVFYQAE
460 470 480 490 500
GGKELSKTVN SHALQCDLES LTRRTSYTVW VMASTRAGGT NGVRINFKTL
510 520 530 540 550
SISVFEIVLL TSLVGGGLLL LSIKTVTFGL RKPNRLTPLC CPDVPNPAES
560 570 580 590 600
SLATWLGDGF KKSNMKETGN SGDTEDVVLK PCPVPADLID KLVVNFENFL
610 620 630 640 650
EVVLTEEAGK GQASILGGEA NEYVTSPSRP DGPPGKSFKE PSVLTEVASE
660 670 680 690 700
DSHSTCSRMA DEAYSELARQ PSSSCQSPGL SPPREDQAQN PYLKNSVTTR
710
EFLVHENIPE HSKGEV
Length:716
Mass (Da):80,580
Last modified:July 27, 2011 - v3
Checksum:i21A539EDCCD1FEFD
GO
Isoform 2 (identifier: Q8K5B1-2) [UniParc]FASTAAdd to basket
Also known as: muZcytoR17x1

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLSSQKGSCSQEPGAAHVQPLGVNAGIM
     624-635: VTSPSRPDGPPG → ILSQEPSCPGHC
     636-716: Missing.

Show »
Length:662
Mass (Da):74,387
Checksum:iA81ED670713D349E
GO
Isoform 3 (identifier: Q8K5B1-3) [UniParc]FASTAAdd to basket
Also known as: muZcytoR17x2

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLSSQKGSCSQEPGAAHVQPLGVNAGIM
     504-520: VFEIVLLTSLVGGGLLL → EYWLQASFWSLLRVGNV
     521-716: Missing.

Show »
Length:547
Mass (Da):62,427
Checksum:i88E1B06BC1F737AD
GO
Isoform 4 (identifier: Q8K5B1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNPLGVNAGIM
     463-482: ALQCDLESLTRRTSYTVWVM → SPQVYYALTAAKSRNSRNLQ
     483-716: Missing.

Show »
Length:492
Mass (Da):56,458
Checksum:i8AA4C0C8E2ED1FA8
GO
Isoform 5 (identifier: Q8K5B1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-481: Missing.

Note: No experimental confirmation available.
Show »
Length:235
Mass (Da):25,133
Checksum:i50928397A1AD126F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YCG5A0A286YCG5_MOUSE
Interleukin-31 receptor subunit alp...
Il31ra
662Annotation score:
A0A286YD69A0A286YD69_MOUSE
Interleukin-31 receptor subunit alp...
Il31ra
165Annotation score:
A0A286YE03A0A286YE03_MOUSE
Interleukin-31 receptor subunit alp...
Il31ra
57Annotation score:
A0A286YDE2A0A286YDE2_MOUSE
Interleukin-31 receptor subunit alp...
Il31ra
635Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159H → R in AAM27959 (PubMed:11877449).Curated1
Sequence conflicti159H → R in AAS82847 (PubMed:15184896).Curated1
Sequence conflicti159H → R in AAS82848 (PubMed:15184896).Curated1
Sequence conflicti159H → R in BAB88745 (Ref. 3) Curated1
Sequence conflicti300A → T in AAM27959 (PubMed:11877449).Curated1
Sequence conflicti300A → T in AAS82847 (PubMed:15184896).Curated1
Sequence conflicti300A → T in AAS82848 (PubMed:15184896).Curated1
Sequence conflicti319K → Q in AAM27959 (PubMed:11877449).Curated1
Sequence conflicti319K → Q in AAS82847 (PubMed:15184896).Curated1
Sequence conflicti319K → Q in AAS82848 (PubMed:15184896).Curated1
Sequence conflicti573D → N in AAM27959 (PubMed:11877449).Curated1
Sequence conflicti573D → N in AAS82847 (PubMed:15184896).Curated1
Sequence conflicti643V → I in AAM27959 (PubMed:11877449).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0228141 – 481Missing in isoform 5. 1 PublicationAdd BLAST481
Alternative sequenceiVSP_0228151M → MLSSQKGSCSQEPGAAHVQP LGVNAGIM in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_0228161M → MNPLGVNAGIM in isoform 4. 1 Publication1
Alternative sequenceiVSP_022817463 – 482ALQCD…TVWVM → SPQVYYALTAAKSRNSRNLQ in isoform 4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_022818483 – 716Missing in isoform 4. 1 PublicationAdd BLAST234
Alternative sequenceiVSP_022819504 – 520VFEIV…GGLLL → EYWLQASFWSLLRVGNV in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_022820521 – 716Missing in isoform 3. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_022821624 – 635VTSPS…DGPPG → ILSQEPSCPGHC in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_022822636 – 716Missing in isoform 2. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486621 mRNA Translation: AAM27959.1
AY509150 mRNA Translation: AAS82847.1
AY509151 mRNA Translation: AAS82848.1
AB083111 mRNA Translation: BAB88745.1
AK030512 mRNA Translation: BAC26998.1
AC154767 Genomic DNA No translation available.
AC159196 Genomic DNA No translation available.
BC066164 mRNA Translation: AAH66164.1
CCDSiCCDS36781.1 [Q8K5B1-1]
RefSeqiNP_647460.2, NM_139299.2 [Q8K5B1-1]
XP_006517684.1, XM_006517621.2 [Q8K5B1-1]
XP_017170988.1, XM_017315499.1 [Q8K5B1-1]
UniGeneiMm.380801

Genome annotation databases

EnsembliENSMUST00000051756; ENSMUSP00000058045; ENSMUSG00000050377 [Q8K5B1-1]
GeneIDi218624
KEGGimmu:218624
UCSCiuc007rwi.2 mouse [Q8K5B1-1]
uc007rwj.1 mouse [Q8K5B1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486621 mRNA Translation: AAM27959.1
AY509150 mRNA Translation: AAS82847.1
AY509151 mRNA Translation: AAS82848.1
AB083111 mRNA Translation: BAB88745.1
AK030512 mRNA Translation: BAC26998.1
AC154767 Genomic DNA No translation available.
AC159196 Genomic DNA No translation available.
BC066164 mRNA Translation: AAH66164.1
CCDSiCCDS36781.1 [Q8K5B1-1]
RefSeqiNP_647460.2, NM_139299.2 [Q8K5B1-1]
XP_006517684.1, XM_006517621.2 [Q8K5B1-1]
XP_017170988.1, XM_017315499.1 [Q8K5B1-1]
UniGeneiMm.380801

3D structure databases

ProteinModelPortaliQ8K5B1
SMRiQ8K5B1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058045

PTM databases

iPTMnetiQ8K5B1
PhosphoSitePlusiQ8K5B1

Proteomic databases

PaxDbiQ8K5B1
PRIDEiQ8K5B1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051756; ENSMUSP00000058045; ENSMUSG00000050377 [Q8K5B1-1]
GeneIDi218624
KEGGimmu:218624
UCSCiuc007rwi.2 mouse [Q8K5B1-1]
uc007rwj.1 mouse [Q8K5B1-3]

Organism-specific databases

CTDi133396
MGIiMGI:2180511 Il31ra

Phylogenomic databases

eggNOGiENOG410IJG6 Eukaryota
ENOG410YAI2 LUCA
GeneTreeiENSGT00550000074436
HOVERGENiHBG081788
InParanoidiQ8K5B1
KOiK22630
OMAiCTWSPEK
OrthoDBiEOG091G01XM
TreeFamiTF338122

Enzyme and pathway databases

ReactomeiR-MMU-6788467 IL-6-type cytokine receptor ligand interactions

Miscellaneous databases

ChiTaRSiIl31ra mouse
PROiPR:Q8K5B1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050377 Expressed in 33 organ(s), highest expression level in skin epidermis
CleanExiMM_IL31RA
ExpressionAtlasiQ8K5B1 baseline and differential
GenevisibleiQ8K5B1 MM

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SUPFAMiSSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIL31R_MOUSE
AccessioniPrimary (citable) accession number: Q8K5B1
Secondary accession number(s): E9QQ31
, Q6EAL6, Q6EAL7, Q6NZF0, Q8BSU3, Q8R501
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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